Focus: Hidden - Pennsylvania

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High blood pressure is among the most common medical conditions in the United States. It’s also among the most treatable.

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The vast majority of patients with neurodegenerative disorders do not have specific gene mutations, but a single misbehaving protein – called TDP-43 – seems to be at the heart of these diseases. Pitt researchers have found a way to recreate and rescue TDP-43 pathology in a dish.

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New research shows that fluctuation and severity of depressive symptoms are much better at predicting risk of suicidal behavior in at-risk young adults.

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A team led by José Bauermeister, PhD, MPH, Presidential Professor of Nursing and Director of the Program on Sexuality, Technology, & Action Research (PSTAR), at the University of Pennsylvania School of Nursing (Penn Nursing) designed the My Desires & Expectations (myDEx) tool to address cognitive and emotional factors that influence YGBMSM sexual decision-making when seeking partners online.

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New preclinical findings from extensive cell and animal studies suggest that cysteamine bitartrate, a drug already used for a rare kidney disease, could benefit patients with some mitochondrial disorders. No proven effective treatments yet exist for these complex conditions with severe energy deficiency

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Inductees include Wei Chen, Northwestern University; Charles J. Kuehmann, SpaceX and Tesla Motors; Christopher A. Schuh, Massachusetts Institute of Technology; Sheldon Lee Semiatin, U.S. Air Force Research Laboratory; and John G. Speer, Colorado School of Mines in Golden, Colorado.

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Most middle-aged and older adults recover their ability to live independently within a year after surgery for hip fracture, reports a study in the Journal of Orthopaedic Trauma. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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A single dose of a PD-1 inhibitor before surgery for melanoma can put patients in remission.

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Nine patients at Penn Medicine have been cured of the Hepatitis C virus (HCV) following lifesaving heart transplants from deceased donors who were infected with the disease, according to a study published in the American Journal of Transplantation.

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Both CT angiography and transcranial Doppler have limited accuracy in detecting cerebral vasospasm and predicting delayed cerebral ischemia (DCI) in patients with subarachnoid hemorrhage (SAH) due to ruptured aneurysm, reports a study in the inaugural edition of Critical Care Explorations, the official open-access journal of the Society of Critical Care Medicine (SCCM). The journal is published in the Lippincott portfolio by Wolters Kluwer.

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Efforts to understand costs and openly share information on healthcare prices played a key role in a major Arizona health system's successful turnaround from a financial crisis, according to a feature article in the Spring issue of Frontiers of Health Services Management, an official publication of the American College of Healthcare Executives (ACHE). This journal is published in the Lippincott portfolio by Wolters Kluwer.

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Similar to leaky pipes, veins, as they return blood to the heart, sometimes fail to close completely. They stretch out and subsequently leak near the surface of the skin, creating spider or varicose veins that may cause discomfort.

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Study in JNCCN finds coronary artery disease costs increase dramatically in patients who are diagnosed with cancer.

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Patients were found to often be willing to share their Google search histories with medical researchers, revealing that many do searches on their health concerns long before deciding to go to the hospital.

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A pair of new studies has provided new insight into the challenges faced by children on the autism spectrum who exhibit symptoms of attention deficit/hyperactivity disorder (ADHD). According to the findings from researchers at Children’s Hospital of Philadelphia (CHOP), these children have difficulty with adaptive behavior, a key measure of independence.

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Cancer clinical trials are an important option for patients with cancer. Yet, once a trial ends, patients still need care plans. Little is known at what point during clinical trial transitions to initiate advance planning discussions or how to educate research teams to communicate with and prepare patient-participants and their families for the next steps after they leave a cancer clinical trial.

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Patients taking diuretics are often at risk for low potassium levels, which can put patients at an increased risk of death from cardiac arrhythmias or other causes. But researchers from the Perelman School of Medicine at the University of Pennsylvania found that taking prescription potassium supplements can reduce these patients’ risk by nearly 10 percent as daily outdoor temperatures increase—a time when patients may be at highest risk due to loss of potassium while sweating. These findings are detailed in a study published today in BMJ Open.

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A new animal study describes how cells that become alveoli, the tiny compartments in which gas exchange occurs in the lung, begin their specialized roles very early in prenatal life. Investigating the fetal signaling pathways active in this biological event may offer future opportunities to treat lung damage caused by prematurity and other lung injuries.