Feature Channels: Biotech

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Hitomi Nagayama, Jun Ooi

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Li-E Zhu, Hui-Ping Huang, Yi-Peng Cai, Yan Wang, Bao-Hua Xu, Mao-Bai Liu, Xue-Mei Wu

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Rajib Shome, Plaboni Sen, Siddhartha Sankar Ghosh

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Factor Bioscience Inc., a Cambridge-based biotechnology company focused on developing mRNA and cell-engineering technologies, announced its participation in the American Society of Gene & Cell Therapy (ASGCT) 25th Annual Meeting to be held in Washington, D.C. from May 16-19, 2022.

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Background Relapse is the leading cause of death from myeloid malignancies after allogeneic hematopoietic stem cell transplantation (HSCT). Azacitidine has gained attention in recent years in the prophylaxis of relapsed refractory hematologic …

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Conditioning with treosulfan and fludarabine (Treo/Flu) has been proven to be feasible and efficient in several types of malignancies before allogeneic hematopoietic stem cell transplantation (allo-HSCT). Given its favorable reduced …

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It is known that Rho GTPases control different aspects of the biology of skin stem cells (SSCs). However, little information is available on the role of their upstream regulators under normal and tumorigenic conditions in this process. To address this …

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… Given the important function of PTBP1 in directing lineage choice in diverse stem cell systems and the overall relevance of mRNA splicing in hematopoiesis, we hypothesized that PTBP1 might play a role as a regulator of posttranscriptional …

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… To investigate the status of the T-cell compartment of UPN1 up to 51 years post-HSCT in the context of a stem cell boost at 37 years after HSCT, we aimed to combine detailed phenotyping with TCR repertoire analysis. Development of a T-cell-focused …

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Jing Yuan, Zhen-Zhen Wang, Han-Yun Ren, Fu-Xu Wang

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The Organ-on-a-Chip (OoC) technology shows great potential to revolutionize the drugs development pipeline by mimicking the physiological environment and functions of human organs. The translational value of OoC is further enhanced when …

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… for Atg5, the stem cell loss in vivo was more pronounced than in vitro, suggesting that additional cell populations likely depend upon Atg5 function to support ileum health. We first tested whether ATG5-dependent WNT signaling was required for …

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… With Select-seq, we analyse the cancer stem cell-like microniches in relation to the tumour microenvironment of triple-negative breast cancer patients. We identify alternative splice variants, perform complementarity-determining region analysis of …

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Over the last 30 years, allogeneic haematopoietic stem cell transplantation (allo‐HSCT) has been adopted as a therapeutic strategy for many inborn errors of metabolism (IEM), due to the ability of donor‐derived cells to provide life‐long enzyme delivery to …

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Youxiang Su, Nianhu Li, Jian Xin, Shang Gao, Yun Song, Xintian Qu, Yan Liu, Xiusen Ma

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Renal fibrosis is a common pathological process of chronic kidney diseases induced by multiple factors. Hypoxic pretreatment of mesenchymal stem cells can enhance the efficacy of secreted extracellular vesicles (MSC-EVs) on various diseases, but it …

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Despite advances in the understanding of the pathophysiology of cytomegalovirus (CMV) infection, it remains as one of the most common infectious complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT). The aim of this study …

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Ross Ferguson, Vasanta Subramanian

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Robert Thimme, Matthias Reinscheid, Hendrik Luxenburger, Vivien Karl, Anne Graeser, Sebastian Giese, Kevin Ciminski, David Reeg, Valerie Oberhardt, Natascha Röhlen, Julia Lang-Meli, Kathrin Heim, Nina Gross, Christina Baum, Siegbert Rieg, Claudius Speer, Florian Emmerich, Susanne Breisinger, Daniel Steinmann, Bertram Bengsch, Tobias Boettler, Georg Kochs, Martin Schwemmle, Christoph Neumann-Haefelin, Maike Hofmann

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Zai-Ling Yang, Xiang-Qing Zhu, Tian Chuan, Zhao Jing, Guang-Ping Ruan, Pan Hang, He Jie, Wang Kai, Wang Wei, Xing-Hua Pan

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… Also, and most importantly, when comparing results across laboratories we need to bear in mind that no embryonic stem cell line is a tabula rasa. Different cell lines have been shown to exhibit biases in differentiation potential (Ortmann et al., 2020) …

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… has led to the development of trophoblast stem cell lines which retain the capacity to … –OFF switch to regulate various hallmark processes of stem cell biology like self-renewal [15, 16… pools with temporal replenishment of the trophoblast stem cell hub …

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Multi-drug resistance remains a critical issue in cancer treatment that hinders the effective use of chemotherapeutic drugs. The active components of traditional Chinese medicine have been applied as adjuvants to accentuate the anticancer …

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Xiao-Liang Liu, Chuan-Jian Zhang, Jing-Jing Shi, Qin-Fei Ke, Yu-Wei Ge, Zhen-An Zhu, Ya-Ping Guo

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This Backstory describes the development of a research article published in Cell Stem Cell that was originally submitted to Community Review, a program wherein a manuscript is simultaneously considered at multiple Cell Press journals. The article, a

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… reside in the RZ, a known location for stem cells 5,11 , and that FoxA2+ cells are located in close proximity to the SOC, which is viewed as a signaling center of RZ stemness 10 , we asked whether FoxA2+ cells are different than the previously …

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… stem cell … stem cell state, accompanied by altered niche requirements and a mature chief cell/secretory phenotype. Following the constitutive expression of p57 in vivo, chief cells showed an impaired injury response. Thus, p57 is a gatekeeper …

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… In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells. … In this …

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Limited stem cells, poor stretchability and mismatched interface fusion have plagued the reconstruction of cranial defects by cell-free scaffolds. Here, we designed an instantly fixable and self-adaptive scaffold by dopamine-modified hyaluronic acid …

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The honor recognizes biomaterials research that significantly benefits patient health and outcomes.

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… programs maintaining stem cell integrity have been identified, safety mechanisms eliminating malignant HSPCs from the stem cell pool … HSPCs and antigen-specific CD4 + T cells, causing stem cell proliferation, differentiation, and specific exhaustion …

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By developing a 3D spheroid system for hPSC-hepatocytes differentiation and combining it with genomic approaches, Jaenisch and colleagues identified a role for THRB in regulating hPSC-hepatocytes maturation through chromatin-remodeling complex pBAF.

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Xu et al. demonstrated feasibility of modeling early heart failure using induced pluripotent stemcell-derived cardiomyocytes from patients with HLHS. They observed that heart failure is linked to increased apoptosis, mitochondrial dysfunction, redox

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Theunissen et al. describe a methodology for deriving self-renewing 3D trophoblast organoids from naive human pluripotent stem cells. They demonstrate that stem-cell-derived trophoblast organoids model human placental development, X chromosome inact

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… In order to obtain the highest yield of mesenchymal stem cell-derived nanovesicles (MSC-NVs), we employed a serial extrusion approach using polycarbonate membrane filters with 5 μm, 1 μm, 0.4 μm, and 0.2 μm pore sizes …

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Cardiovascular diseases (CVDs) are globally known to be important causes of mortality and disabilities. Common treatment strategies for CVDs, such as pharmacological therapeutics impose serious challenges due to the failure of …

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The high mortality rate of malignant pleural mesothelioma led to study the mechanisms for chemoresistance. The cancer stem cell (CSC) model has been proposed to explain chemoresistance. CSCs are characterized by self-renewal …

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In this issue of Cell Stem Cell, Ma et al. demonstrate that the activation of the nuclear receptor thyroid hormone receptor beta (NR1A2) improves the differentiation status of hepatocyte-like cells derived from human pluripotent stem cells.

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bstract: Placenta-derived stem cells (PDSCs) offer the advantages of possessing mesenchymal and embryonic traits, broad differentiation potential, large-scale availability, and no ethical constraints in their utilization in therapeutic applications. Elevated protein synthesis and consequently enhanced protein maintenance networks become necessary both due to the requirement to maintain stemness and respond to different stresses.

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In this issue of Cell Stem Cell, a new study by Rostovskaya et al. (2022) uses human stem cells to understand the formation of the amnion, a vital extraembryonic tissue that encircles the fetus during gestation. They provide insight into human amnio

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In this review, Shao and Fu outline recent progress in reconstructing multiscale structural orders in embryoids and organoids and discuss conceptual and technological frameworks useful for innovating bioengineering-directed approaches to achieve next

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In this review, Qazi et al. describe advances in the engineering of hydrogels to explore complex biological processes, such as development, disease, and wound healing. They specifically highlight the spatiotemporal control over hydrogel biochemical

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The intrahepatic bile ducts consist of a complex branching morphology. Here, Roos et al. demonstrate that a branching tubular architecture can be induced in human adult intrahepatic cholangiocyte organoids. These BRCOs faithfully recapitulate aspect

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In this issue of Cell Stem Cell, Xu et al. demonstrate that induced pluripotent stem cell-derived cardiomyocytes from patients with hypoplastic left heart syndrome exhibit mitochondrial dysfunction and can be used for disease modeling. In addition,

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Antigen presentation is typically regarded as the domain of immune cells such as dendritic cells and B cells. Hernandez-Malmierca et al. (2022) upend this notion by observing that hematopoietic stem and progenitor cells process and present antigen v

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The success of stem cell transplantation depends upon the coordinated sequence of stem cell renewal, differentiation, assembly, and maintenance of long-term function. Advances in biomaterials can improve pre-/post-transplantation outcomes by integrat

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Haas and colleagues show that hematopoietic stem cells (HSCs) act as antigen-presenting cells. The presentation of immunogenic antigens triggers a bidirectional interaction with antigen-specific CD4+ T cells, resulting in the rapid exhaustion of dis