For outstanding contributions to engineering of biomimetic tissue-on-chip technologies and organoids for disease modeling and regenerative medicine, ASU's Mehdi Nikkhah has been inducted as a Fellow into the American Institute for Medical and Biomedical Engineering.
BACKGROUNDThe bone remodeling during orthodontic treatment for malocclusion often requires a long duration of around two to three years, which also may lead to some complications such as alveolar bone resorption or tooth root resorption. Lo
Cumulative evidence suggests that O-linked β-N-acetylglucosaminylation (O-GlcNAcylation) plays an important regulatory role in pathophysiological processes. Although the regulatory mechanisms of O-GlcNAcylation in tumors have been graduall
BACKGROUNDMesenchymal stem cells (MSCs) modulated by various exogenous signals have been applied extensively in regenerative medicine research. Notably, nanosecond pulsed electric fields (nsPEFs), characterized by short duration and high st
BACKGROUNDStem cell transplantation is a promising therapeutic option for curing perianal fistula in Crohn’s disease (CD). Anti-tumor necrotic factor (TNF) therapy combined with drainage procedure is effective as well. However, previous s
Mesenchymal stromal cells (MSCs) hold great promise for tissue regeneration in debilitating disorders. Despite reported improvements, the short-term outcomes of MSC transplantation, which is possibly linked to poor cell survival, demand ext
BACKGROUNDThe self-assembly of solid organs from stem cells has the potential to greatly expand the applicability of regenerative medicine. Stem cells can self-organise into microsized organ units, partially modelling tissue function and re
Mesenchymal stem cells (MSCs) are stem/progenitor cells capable of self-renewal and differentiation into osteoblasts, chondrocytes and adipocytes. The transformation of multipotent MSCs to adipocytes mainly involves two subsequent steps fro
High glucose (HG) culture conditions in vitro and persistent exposure to hyperglycemia in diabetes patients are detrimental to stem cells, analogous to any other cell type in our body. It interferes with diverse signaling pathways, i.e. mam
The annual meeting will feature more than 40 regular, late-breaking and clinical trial abstracts from UCLA physicians and scientists, who will present their latest work in key areas of translational and basic scientific research, including new compounds and drug targets, combination immunotherapy approaches, updated organoid models, survivorship research and more.
The blue whale genome was published in the journal Molecular Biology and Evolution, and the Etruscan shrew genome was published in the journal Scientific Data.
A study has unveiled that exosomes, extracted from adipose mesenchymal stem cells (ADSC-Exos), markedly speed up the healing process of skin wounds in diabetic mice. This discovery tackles the pressing global health issue of diabetic wounds, notorious for precipitating grave complications and impairments.
This study discovers that upon induction of different autophagy processes, mitochondria immediately import calcium and calcium concentrations at the ER membrane start to fluctuate. The major calcium import channel in the inner mitochondrial membrane, mitochondrial calcium uniporter (MCU), is required for mitophagy-inducer-initiated mitochondrial calcium uptake. Inhibiting MCU accelerates mitophagy. In neurons derived from a Parkinson’s patient, mitophagy-inducer-triggered mitochondrial calcium influx is faster, which may slow the ensuing mitophagy.
As we age, our hematopoietic (blood-forming) stem cells (HSCs) become less able to produce new red and white blood cells and other vital blood components—contributing to chronic inflammation and accelerating the onset of blood cancers and degenerative diseases.
Reuben Kapur, director of the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine, is working to discover new treatments that will improve patient care.
Children’s Hospital Los Angeles has received a multi-year $6 million award from the California Institute for Regenerative Medicine (CIRM) to develop innovative stem cell approaches to treat children and adolescents with recurrent solid tumors. The Cancer and Blood Disease Institute (CBDI) is a recognized leader in pediatric cancer care and research.
Individuals with Williams syndrome have a gregarious “cocktail party” personality, while those with the opposite genetic alteration, in contrast, tend to have autistic traits and are prone to struggle socially. Research from UC San Diego sheds new light on the gene responsible.
Irvine, Calif., Feb. 26, 2024 — The University of California, Irvine has received a five-year, $4 million grant from the California Institute for Regenerative Medicine to establish a shared resources lab in the Sue & Bill Gross Stem Cell Research Center. The facility will offer essential technologies and training for the development of novel in vitro stem cell-based modeling that will serve researchers across the campus and the state.
Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population. They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing. An increasing number of biom
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