Deep Brain Stimulation May Improve Cognition in Dementia, Other Neurodegenerative Diseases
Article ID: 615416
Released: 20-Mar-2014 4:00 PM EDT
Source Newsroom: American Association of Neurological Surgeons (AANS)
Newswise — SAN FRANCISCO (April 7, 2014) — Intralaminar thalamic deep brain stimulation (ILN-DBS) has been shown to improve cognition and spatial memory acquisition. Could it have a similar effect in dementia and other neurodegenerative diseases that cause severe cognitive dysfunction?
That was the question researchers addressed in the study Intralaminar Thalamic Deep Brain Stimulation Ameliorates the Memory Deficit and the Dendritic Regression in β-Amyloid Infusion Rats, led by Sheng-Tzung Tsai, MD. Dr. Tsai presented the team’s findings today during the 82nd Annual Scientific Meeting of the American Association of Neurological Surgeons (AANS),
Dr. Tsai said: “We implanted an intraventricular β-amyloid protein infusion pump and deep brain stimulation electrodes over rats’ skulls and achieved target accuracy. To elucidate anatomical neural plasticity, we used an intracellular dye injection method to delineate the dendritic spine of neurons over the cortex and hippocampus.” According to Dr. Tsai, growing evidence shows the efficacy of deep brain stimulation in patients with neuropsychiatric diseases. “In the future, we aim to identify a correlation between arousal status and memory acquisition and the detailed mechanism underlying this cognitive improvement. We may achieve optimal DBS strategy for patients with cognitive impairment.”
Study co-authors include Li-Jin Chen, PhD; Shin-Yuan Chen, MD, MSc; and Guo-Fang Tseng, PhD.
Disclosure: The author reported no conflicts of interest.
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Founded in 1931 as the Harvey Cushing Society, the American Association of Neurological Surgeons (AANS) is a scientific and educational association with nearly 8,600 members worldwide. The AANS is dedicated to advancing the specialty of neurological surgery in order to provide the highest quality of neurosurgical care to the public. All active members of the AANS are certified by the American Board of Neurological Surgery, the Royal College of Physicians and Surgeons (Neurosurgery) of Canada or the Mexican Council of Neurological Surgery, AC. Neurological surgery is the medical specialty concerned with the prevention, diagnosis, treatment and rehabilitation of disorders that affect the entire nervous system including the spinal column, spinal cord, brain and peripheral nerves. For more information, visit www.AANS.org.