INVITATION TO COVER

STAYING SHARP INTO YOUR SIXTIES, SEVENTIES, AND BEYOND: THE ART & SCIENCE OF SUCCESSFUL AGING

A PENN Medicine Media Seminar

As a nation we are living longer than ever before, but are we living better? Can we afford what a longer life expectancy brings us? Declining physical and cognitive function doesn't always have to be inevitable; mental ability and independence can be maintained and improved. Patients and caregivers alike cannot only age gracefully, but happily and actively.

This special media seminar, being held in conjunction with the Institute on Aging of the University of Pennsylvania, invites you to discover the latest research and treatment strategies that help older Americans negotiate the medical and social challenges for successful aging.

"¢ Going Beyond Diet and Exercise: What are the proven factors associated with the risk of developing cognitive impairment and what lifestyles and activities can thwart the process."¢ Knowing When It's Time to Ask for Help: How proper in-home assessments can help a loved one stay as healthy, independent and safe as possible for as long as possible " and to know when it's time to seek professional home or hospice care or assisted living."¢ Voting Woes of Older Americans in Long-term Care Settings " Older adults are at the mercy of others when it comes to exercising their right to vote. However, the logistical and geographical barriers can be knocked down. "¢ Where the Next Generation of Treatments Will Come From: What limitations face big pharma and the biotech companies as they race to find new treatments for diseases of aging and how is academic based research already poised to fill the gap.

WHEN: June 18, 200712 " 1:30 p.m.Lunch will be served.

WHERE: The Institute on Aging of the University of PennsylvaniaAt The Ralston Center3615 Chestnut Street, 2nd FloorConference Room 241Phila., PA 19104

FREE Lot Parking is Available Adjacent to the Ralston Center. Enter via Ludlow St., between 36th & 347th Streets.University City Map: http://pennhealth.com/hup/vi_files/hup_maps/campus.html

WHO & WHAT: Healthy Brain Aging: Successful Strategies to Help Stave Off Age-related DementiasJohn Q. Trojanowski, MD, PhD, Director, Institute on Aging and Penn's Alzheimer's Disease Center

Designing a Healthy Home Environment for Seniors John M. Bruza, MDClinical Assistant Professor, Geriatric Medicine

How Can We Help Older Americans Overcome Serious Access Limitations in Exercising Their Right to Vote?Jason Karlawish, MD,Associate Professor of Medicine and Medical Ethics

Ensuring a Pharmacology Remedy: Limitations of Big Pharma's Pipeline and the Emerging Role of Academic Medical Centers in Finding New Treatments for the Diseases of Aging Introduction by: Virginia M.Y. Lee, PhD, MDADirector, Center for Neurodegenerative Disease Research

Kurt Brunden, PhD,Director, Drug Discovery, Center for Neurodegenerative Disease Research

FOR MORE INFORMATION & TO REGISTER: Contact Olivia Fermano at (215) 349-5653 or [email protected]

PENN Medicine is a $3.5 billion enterprise dedicated to the related missions of medical education, biomedical research, and excellence in patient care. PENN Medicine consists of the University of Pennsylvania School of Medicine (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System.

Penn's School of Medicine is currently ranked #3 in the nation in U.S. News & World Report's survey of top research-oriented medical schools; and, according to most recent data from the National Institutes of Health, received over $379 million in NIH research funds in the 2006 fiscal year. Supporting 1,400 fulltime faculty and 700 students, the School of Medicine is recognized worldwide for its superior education and training of the next generation of physician-scientists and leaders of academic medicine.

The University of Pennsylvania Health System includes three hospitals — its flagship hospital, the Hospital of the University of Pennsylvania, rated one of the nation's "Honor Roll" hospitals by U.S. News & World Report; Pennsylvania Hospital, the nation's first hospital; and Penn Presbyterian Medical Center — a faculty practice plan; a primary-care provider network; two multi-specialty satellite facilities; and home care and hospice.

Mission of the IOAThe mission of the Institute of Aging (IOA) is to improve the health of the elderly by:increasing the quality and quantity of clinical and basic research " as well as educational programs " that focus on normal aging and age-related diseases at the University of Pennsylvania School of Medicine and across the entire Penn campus.