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Newswise:Video Embedded from-cavefish-to-humans-evolution-of-metabolism-in-cavefish-may-provide-insight-into-treatments-for-a-host-of-diseases-such-as-diabetes-heart-disease-and-stroke
VIDEO
11-May-2022 9:55 AM EDT
From Cavefish to Humans: Evolution of Metabolism in Cavefish May Provide Insight Into Treatments for a Host of Diseases Such as Diabetes, Heart Disease, and Stroke
Stowers Institute for Medical Research

New research examines how cavefish developed unique metabolic adaptations to survive in nutrient-scarce environments. The study created a genome-wide map of liver tissue for two independent colonies of cavefish along with river fish to understand how cavefish metabolism evolved and how this may be applicable for humans.

   
Released: 15-Apr-2022 11:05 AM EDT
Registration now open for EMBO Lab Leadership Course at Stowers Institute
Stowers Institute for Medical Research

This course provides tools, techniques and insight tailored specifically to the laboratory/research setting.

Released: 22-Mar-2022 10:30 AM EDT
Biomed Valley Discoveries Announces Poster Presentations on Ulixertinib (BVD-523) at the AACR Annual Meeting 2022
BioMed Valley Discoveries

BioMed Valley Discoveries (BVD) announced today they will present four posters at the upcoming American Association for Cancer Research (AACR) Annual Meeting, taking place April 8-13, 2022, in New Orleans, Louisiana.

Newswise: Stowers Institute recruits distinguished developmental biologist
Released: 15-Dec-2021 11:00 AM EST
Stowers Institute recruits distinguished developmental biologist
Stowers Institute for Medical Research

The Stowers Institute for Medical Research announced today that Tatjana Sauka-Spengler, PhD, a renowned developmental biologist who has led a research lab at the University of Oxford for the past ten years, will join the Institute in the first quarter of 2022. She will also join the faculty of the Graduate School of the Stowers Institute.

Newswise:Video Embedded master-developmental-genes-play-role-in-adulthood-according-to-new-study
VIDEO
Released: 18-Nov-2021 10:45 AM EST
Master developmental genes play role in adulthood, according to new study
Stowers Institute for Medical Research

Among their many extraordinary feats, some planarian flatworms reproduce by tearing off pieces of themselves to regenerate new worms. Now, researchers at the Stowers Institute for Medical Research have discovered that this process is controlled by Hox genes, a family of genes known to orchestrate important aspects of early development.

31-Aug-2021 2:05 PM EDT
TRACS set the stage in flatworm regeneration
Stowers Institute for Medical Research

In this study, the Sánchez Alvarado Lab shows that whole-body regeneration involves transcriptional changes in cells from all three germ layers (muscle, epidermis, and intestine) of the body, and that tissue from areas distant from, as well as nearby to the site of injury, contribute to the process of regeneration.

Released: 7-Jun-2021 2:30 PM EDT
Virginia G. Stowers, 1930-2021
Stowers Institute for Medical Research

Stowers Institute Co-Founder Virginia Stowers, 1930-2021

Released: 26-Apr-2021 9:00 AM EDT
Discovery of an elusive cell type in fish sensory organs
Stowers Institute for Medical Research

The Piotrowski Lab has reported newly identified invasive ionocytes in the sensory organs of larval and adult zebrafish fish that may provide clues to how sensory organs continue to function in changing environments.

   
Released: 29-Mar-2021 4:05 PM EDT
Decoding smell
Stowers Institute for Medical Research

Since the beginning of the pandemic, a loss of smell has emerged as one of the telltale signs of COVID-19.

Released: 18-Feb-2021 2:00 PM EST
Explainable AI for decoding genome biology
Stowers Institute for Medical Research

Researchers at the Stowers Institute for Medical Research, in collaboration with colleagues at Stanford University and Technical University of Munich have developed advanced explainable artificial intelligence (AI) in a technical tour de force to decipher regulatory instructions encoded in DNA. In a report published online February 18, 2021, in Nature Genetics, the team found that a neural network trained on high-resolution maps of protein-DNA interactions can uncover subtle DNA sequence patterns throughout the genome and provide a deeper understanding of how these sequences are organized to regulate genes.

Released: 13-Jan-2021 2:00 PM EST
A niche for the eye
Stowers Institute for Medical Research

What if the degenerative eye conditions that lead to glaucoma, corneal dystrophy, and cataracts could be detected and treated before vision is impaired? Recent findings from the lab of Investigator Ting Xie, PhD, at the Stowers Institute for Medical Research point to the ciliary body as a key to unlocking this possibility.

Released: 17-Nov-2020 3:05 PM EST
Small differences, big impact
Stowers Institute for Medical Research

In a new study, researchers at the Stowers Institute for Medical Research have identified a handful of variations in an amino acid sequence critical for retaining the ancestral function of a gene over the course of 600 million years of evolution.

Released: 17-Aug-2020 12:05 PM EDT
Survival of the fit-ish
Stowers Institute for Medical Research

It can be hard to dispute the common adage ‘survival of the fittest’. After all, “most of the genes in the genome are there because they’re doing something good,” says Sarah Zanders, PhD, assistant investigator at the Stowers Institute for Medical Research. But, she says, “others are just there because they’ve figured out a way to be there.”

3-Aug-2020 10:55 AM EDT
Scientists use CRISPR to knock down gene messages early in development
Stowers Institute for Medical Research

Researchers at the Stowers Institute for Medical Research in Kansas City, Missouri, and the Andalusian Center of Developmental Biology at Pablo de Olavide University in Seville, Spain, have harnessed the technology to target gene messages (messenger RNA) involved in early vertebrate development.

Released: 28-Jul-2020 12:15 PM EDT
BioMed Valley Discoveries’ ulixertinib (BVD-523), a first-in-class ERK inhibitor cancer therapy, receives Fast Track designation and launches Phase II trial in collaboration with Cmed and Strata Oncology
BioMed Valley Discoveries

BioMed Valley Discoveries (BVD), a clinical stage biotechnology company, announces the receipt of Fast Track designation from the US Food and Drug Administration (FDA) for investigation of the ERK inhibitor ulixertinib (BVD-523) as a treatment for patients with non-colorectal, solid tumors that harbor BRAF mutations G469A/V, L485W, or L597Q. BVD has launched a Phase II multi-center study of ulixertinib for patients with advanced malignancies harboring these atypical (non-V600) BRAF alterations or a MEK alteration.

15-Jul-2020 4:25 PM EDT
Immune system adaptations in cavefish may provide autoimmune disease insight
Stowers Institute for Medical Research

Cavefish may not seem like a big deal. They’re small, they live in tucked away places humans rarely go, and they’re common enough that you can find them on every continent except Antarctica. But researchers from the Stowers Institute for Medical Research see them as a potential way to understand more about the rise in autoimmune diseases in humans.

15-Jun-2020 2:40 PM EDT
Persistent DNA damage in the placenta affects pregnancy outcomes
Stowers Institute for Medical Research

Scientists at the Stowers Institute for Medical Research have shown that a dysfunctional placenta can play a previously unrecognized role during the earliest stages of development in mouse models of Cornelia de Lange syndrome. People with this rare genetic disorder often harbor mutations in cohesins, ring-like proteins that help DNA organize and repair itself.

   
Released: 27-Apr-2020 5:35 PM EDT
Joan W. Conaway elected to the National Academy of Sciences
Stowers Institute for Medical Research

The Stowers Institute for Medical Research is pleased to announce that Joan Weliky Conaway, PhD, a Stowers Investigator since 2001, has been elected a member of the prestigious National Academy of Sciences (NAS) for her distinguished and continuing achievements in original scientific research. The recognition reflects the exceptional productivity and impact of the research program co-led by Conaway and her lifelong collaborator and husband Ron Conaway, PhD.

Released: 20-Apr-2020 3:55 PM EDT
What’s old is new again
Stowers Institute for Medical Research

Drug resistance is a major obstacle in cancer treatment—leading to relapse for many patients. In a new study, published online April 20, 2020, in Nature Cell Biology, researchers from the Stowers Institute for Medical Research, Children’s Mercy Kansas City, and The University of Kansas Cancer Center report on a promising new strategy to overcome drug resistance in leukemia, using targeted doses of the widely-used chemotherapy drug doxorubicin.

9-Apr-2020 4:00 PM EDT
Technologies Converge on Interacting Surfaces in Protein Complexes
Stowers Institute for Medical Research

Researchers at the Stowers Institute for Medical Research have fine-tuned a method to pinpoint surfaces within large multi-protein complexes that are close to, and likely to be directly interacting with, one another.



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