A new study led by researchers at the UNC School of Medicine unravels the structure of TAS2R14, a taste receptor that allows us to taste bitter substances. In addition to solving the protein structure, the findings could help scientists develop drugs that targeting taste receptors.
Perinatal mental illness is a leading cause of death during pregnancy and the first postpartum year in the U.S. Alison Stuebe, MD, MSc, professor of maternal fetal medicine in the Department of Obstetrics and Gynecology at the UNC School of Medicine, authored a study with colleagues on how a holistic approach comprising seven domains can foster conditions for women and birthing people to thrive.
A new study, led by researchers at the UNC School of Medicine and collaborators from the NIH Broadening Experiences in Scientific Training (NIH BEST) consortium, examined career confidence in graduate and postdoctoral trainees and explored how to better support international trainees across a diverse array of career paths.
A landmark study, led by Yen-Yu Ian Shih, PhD, at the UNC School of Medicine, shows how neurochemicals can influence blood vessels. The new findings may alter how researchers interpret results from functional magnetic resonance imaging.
Researchers at the UNC School of Medicine have found that a metabolic enzyme called Acetyl-CoA Carboxylase causes T cells to store fat when they are in solid tumors, rather than burning fat for energy.
Researchers investigating how exactly the brain processes the incoming stream of information from the heart and lungs, discovered that specific neurons in the thalamus are actively involved in processing cardiac and respiratory signals.
Klaus Hahn, PhD, the Ronald G. Thurman Distinguished Professor of Pharmacology at the UNC School of Medicine, will co-lead this Chan Zuckerberg Initiative project with colleagues at Duke University and North Carolina State University.
The FDA has approved two medications for the treatment of eosinophilic esophagitis (EoE)—the first oral medication tailored for adults and the exclusive therapeutic option for children. Evan Dellon, MD, MPH, internationally known for his work with EoE, and colleagues continue to focus on optimizing usage for effective, personalized outcomes.
New research at the UNC School of Medicine provides new insights into the brain processes that underlie cocaine addiction. The findings are crucial for developing new therapeutics and identifying an imaging marker for cocaine use disorders.
Published in the New England Journal of Medicine, Seth A. Berkowitz, MD, MPH, associate professor of medicine at the UNC School of Medicine, wrote perspective piece on how medically tailored meals address health consequences of food insecurity.
Stage one results from the OUtMATCH clinical trial, published in the New England Journal of Medicine, show that a monoclonal antibody, omalizumab, increased the amount of peanut, tree nuts, egg, milk and wheat that multi-food allergic children as young as age one could consume without an allergic reaction. Edwin Kim, MD, Corinne Keet, MD, PhD, and Mike Kulis, PhD, are contributing authors.
A research study named Early Check has screened 1,000 newborns after birth in an effort to help identify rare conditions early, provide treatment, give parents educational information, and connect families with specialists throughout the state of North Carolina.
UNC Lineberger Comprehensive Cancer Center has been selected as one of nine national research sites for the National Cancer Institute’s newly launched Cancer Screening Research Network, which will evaluate promising and emerging cancer screening technologies.
A new clinical trial, led by clinicians and researchers at the UNC School of Medicine, show that the combination of the drug vorinostat and immunotherapy may modestly shrink the latent HIV reservoir, but more work needs to be done in the field to create a cure.
In an effort five years in the making, UNC School of Medicine cell biologist Sarah Cohen, PhD, and Rockefeller University’s Ian Windham, PhD, describe the interplay between fats and proteins in brain cells and how their dysfunction contributes to the development of late-onset Alzheimer’s disease.
The UNC School of Medicine is on pace to become one of the few sites in the United States to incorporate intestinal ultrasound as an imaging technique for managing Inflammatory Bowel Disease.
Sydney and Sheridan Taylor of Durham, North Carolina, have lived with this rare genetic disorder all of their lives.
Chirag Desai, MD, FACS, an abdominal organ transplant and hepatobiliary-pancreatic surgeon at UNC Hospitals, performed a “domino” liver transplant, which helped two patients from a single donor without splitting a liver.
Catalina Berenblum Tobi, a 4th-year medical student, and Mara Buchbinder, PhD, professor and vice chair of social medicine at the UNC School of Medicine, recently published research about the words pediatricians use when describing inflammatory bowel disease to patients and how they affect patient perceptions of illness.
This research from UNC-Chapel Hill, published in the journal Nature Communications, opens the door to researching this wirelessly controlled patch to deliver on-demand treatments for neurodegenerative disorders, including Alzheimer’s disease.
Antibiotic overuse can lead to antibiotic resistance, a global health problem. But UNC School of Medicine scientists with Duke School of Medicine colleagues have documented another culprit in clinical antibiotic failure: bacterial persister cells.
Leslie B. Vosshall, PhD, the Robin Chemers Neustein Professor of Neurogenetics and Behavior at The Rockefeller University, will receive the Perl-UNC Neuroscience Prize for her work on receptors that drive host-seeking behavior in the mosquito.
Doctors at the UNC School of Medicine and Cincinnati Children’s collaborate to develop an innovative, patient-initiated online platform designed to remove the penicillin allergy label from misdiagnosed pediatric patients.
Researchers in the UNC School of Medicine’s Department of Psychiatry have found that enlarged perivascular spaces in the brains of babies, caused by an accumulation of excess cerebrospinal fluid, have a 2.2 times greater chance of developing autism later in life.
A new study led by Walker Redd, MD, at the UNC School of Medicine, examines how multiple factors contribute to the miscommunication and understanding of the digestive disease, microscopic colitis.
Research led by first and second authors Aaron C. Viser, Adelaide R. Cooke, and corresponding author Anne F. Peery, MD, associate professor of medicine at the UNC School of Medicine, reveals how a screening tool can measure the prevalence of malnutrition among patients at the UNC Multidisciplinary Inflammatory Bowel Disease Clinic.
The joint study between the UNC School of Medicine and the Orange County Health Department has been awarded a $21 million funding award from the Patient-Centered Outcomes Research Institute (PCORI) to make pregnancy and birth safer for North Carolinians with hypertensive disorders of pregnancy.
The clinical trial, led by Mirnela Byku, MD, PhD, MBA, at the UNC School of Medicine, found that excluding aspirin from the antithrombotic regimen in patients with a levitated left ventricular assist device is safe.
A new meta-analysis led by Micheal Sandbank, PhD, an assistant professor at the UNC School of Medicine, reveals a crucial need for more high-quality early intervention studies to help clinicians understand how to better support children diagnosed with the condition.
Susanna Stroik, PhD, and Dale Ramsden, PhD, in the Department of Biochemistry and Biophysics at the UNC School of Medicine, have learned more about an enzyme found to be overly expressed in patients with hereditary breast cancer, ovarian cancer, and prostate cancer.
Analyses led by Corinne Keet, MD, PhD, at the University of North Carolina School of Medicine, of two longitudinal studies reveal how an increased level of an antibody called immunoglobin (IgE) to cow’s milk is associated to cardiovascular-related death.
UNC Health is the only academic healthcare system in North Carolina and the South participating in the randomized trial, which aims to assess the safety and efficacy of a combination immunotherapy for newly diagnosed glioblastoma patients.
An international research team, including Jonathan C. Schisler, PhD, in the UNC School of Medicine, has found how SARS-CoV-2 causes widespread “energy outages” throughout major organs, and how these effects contribute to debilitating long COVID symptoms.
Matthew Miller, MD, Daniel Rubinstein, MD, and Hussam Banna, MD, from the UNC School of Medicine joined forces to perform the first corneal neurotization procedure at UNC, a life-changing surgery for patients who have neurotrophic keratitis.
Children’s hospital care is now concentrated in fewer locations, because of a shift in children's care from general hospitals to higher volume children's specialty centers, and this has important implications for hospital planning and readiness, according to a new study led Michael Steiner, MD, MPH, of UNC Health.
UNC School of Medicine researchers led an international team of researchers to conduct the largest-ever meta-analyses of genome-wide association studies (GWAS) to investigate the genetic architecture of PPD.
A clinical study led by Edwin Kim, MD, at the UNC School of Medicine, showed how Peanut Sublingual Immunotherapy (Peanut SLIT) is safe and effective in children ranging from 1-to-4 years of age. Remission of peanut allergy was also possible after three months of stopping the treatment.
A groundbreaking study presented today by University of North Carolina (UNC) School of Medicine researchers at the XXIV FIGO World Congress of Gynecology and Obstetrics could revolutionize pregnancy care, especially in areas with limited resources.
Researchers in the UNC School of Medicine have developed an AI model that can predict whether or not cancerous tissue has been fully removed from the body during breast cancer surgery.
Led by scientists at UNC-Chapel Hill and UC-San Francisco, research reveals new non-coding genetic variants associated with Alzheimer’s disease functioning in microglia – brain cells already implicated in the progression of this often-fatal neurodegenerative condition.
Scientists revealed the intercellular choreography that governs protein regulation, including how unwanted proteins are tagged for degradation, an important player in human health and disease.
Ron Alterovitz, PhD, in the UNC Computer Science Department, and Jason Akulian, MD MPH, in the UNC School of Medicine, have shown that their steerable lung robot can autonomously maneuver the intricacies of the lung, while avoiding important lung structures.
An international study has revealed strong associations between oral health and survival among people diagnosed with head and neck cancer. Specifically, better oral health, as evidenced by the number of natural teeth and dental visits prior to the time of diagnosis, was associated with increased survival.
Scientists figuring out which of the 5,000-plus genetic variants associated with schizophrenia have an actual causal effect in the development of the condition. Some of genetic variants regulate or alter the expression of genes involved in the condition.
A phase 2 study, led by Thomas W. Ferkol, MD, at the UNC School of Medicine, demonstrates safety and efficacy of idrevloride with hypertonic saline for treatment of primary ciliary dyskinesia, a rare genetic disorder that can lead to permanent lung damage.
Over the years, dedicated sickle cell disease programs and research initiatives have greatly improved patient care and life expectancy. But, giving these patients the care they require still presents a number of challenges, including inadequate funding for sickle cell programs, lack of research, and limited access to healthcare.
Anxiety remains one of the most diagnosed clinical symptoms in adolescence and is a potent precursor to and exacerbator of substance use disorder. Through this NIH-funded study, UNC Chapel Hill researchers will examine the neural and physiological mechanisms associated with emergence of substance use in adolescence who experience anxiety.
The new observation, made by UNC School of Medicine’s Stephan Moll, MD, and Jacquelyn Baskin-Miller, MD, suggests that a life-threatening blood clotting disorder can be caused by an infection with adenovirus, one of the most common respiratory viruses in pediatric and adult patients.
UNC School of Medicine researchers Angela Wahl, PhD, Balfour Sartor MD, J. Victor Garcia, PhD, and colleagues created a germ-free mouse model to evaluate the role of the microbiome in the infection, replication, and pathogenesis of HIV and the Epstein-Barr virus, the virus that can cause mononucleosis and other serious diseases.
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