Scientists at The Scripps Research Institute have discovered the molecular mechanism by which the deadly Ebola virus assembles, providing potential new drug targets. Surprisingly, the study showed that the same molecule that assembles and releases new viruses also rearranges itself into different shapes, with each shape controlling a different step of the virus’s life cycle.
A small group of immune-regulating molecules, when overproduced even moderately, can trigger the blood cancers known as lymphomas, according to a new study led by scientists from The Scripps Research Institute.
Professor Paul Robbins, of The Scripps Research Institute, will be principal investigator of the new five-year study, which will focus on identifying just how damage that accumulates over time drives the human aging process. Scientists from the University of Pittsburgh and the University of California, Riverside, will also participate in the study.
Scientists at The Scripps Research Institute have decoded an important molecular signal that guides the development of a key region of the brain known as the neocortex.
Scientists from the Jupiter campus of The Scripps Research Institute have shown a novel way to dramatically raise the potency of drug candidates targeting RNA, resulting in a 2,500-fold improvement in potency and significantly increasing their potential as therapeutic agents.
Scientists from the Florida campus of The Scripps Research Institute have described findings that could enable the development of more effective drugs for addiction with fewer side effects.
Scientists at The Scripps Research Institute have achieved the first efficient chemical synthesis of ingenol, a highly complex, plant-derived compound that has long been of interest to drug developers for its anticancer potential.
Scientists at The Scripps Research Institute have discovered a new type of chemical modification that affects numerous proteins within mammalian cells. The modification appears to work as a regulator of important cellular processes including the metabolism of glucose.
Biologists at The Scripps Research Institute have made a significant discovery that could lead to a new therapeutic strategy for Parkinson’s disease. The findings focus on an enzyme known as parkin, whose absence causes an early-onset form of Parkinson’s disease.
Sigma-Aldrich Corporation today announced a partnership with The Scripps Research Institute (TSRI) to fund research and provide immediate, day-of-publication access to TSRI researchers’ discoveries for the synthesis and analysis of potential drugs.
An international team led by scientists at The Scripps Research Institute has determined and analyzed the three-dimensional atomic structure of the human glucagon receptor, which helps regulate glucose levels in the bloodstream and is the target of potential therapeutic agents for type 2 diabetes.
An international group of scientists has shown that a drug candidate designed by scientists from the Florida campus of The Scripps Research Institute significantly increases exercise endurance in animal models.
Scientists at The Scripps Research Institute have published one of the first laboratory studies of MDPV, an emerging recreational drug that has been sold as “bath salts.” The TSRI researchers found evidence that it could be more addictive than methamphetamine, one of the most addictive substances to date.
Professors Donna Blackmond, PhD, and Gerald Joyce, MD, PhD, of The Scripps Research Institute have been named Simons Investigators for the Collaboration on the Origins of Life, sponsored by the Simons Foundation.
For the first time, scientists from the Florida campus of The Scripps Research Institute have identified small molecules that allow for complete control over a genetic defect responsible for the most common adult onset form of muscular dystrophy.
Valery Fokin, professor at The Scripps Research Institute, has been awarded a prestigious grant from the Russian government for $3.75 million over three years, with a possible two-year renewal, to fund establishment of a laboratory at the Moscow Institute of Physics and Technology.
A team led by scientists at The Scripps Research Institute has identified a family of tiny RNA molecules that work as powerful regulators of the immune response in mammals. Mice who lack these RNA molecules lose their normal infection-fighting ability, whereas mice that overproduce them develop a fatal autoimmune syndrome.
Scientists from the Florida campus of The Scripps Research Institute have shown in animal models that brain damage caused by the loss of a single copy of a gene during very early childhood development can cause a lifetime of behavioral and intellectual problems.
Neuroscientists at The Scripps Research Institute have filled in a significant gap in the scientific understanding of how neurons mature, pointing to a better understanding of some developmental brain disorders.
Scientists from the Florida campus of The Scripps Research Institute have found a compound that could counter Parkinson’s disease in two ways at once. In a new study published recently online ahead of print by the journal ACS Chemical Biology, the scientists describe a “dual inhibitor” that attacks a pair of proteins closely associated with development of Parkinson’s disease.
In this week’s issue of Nature, scientists at The Scripps Research Institute report their discovery of an important trick that a well-known intrinsically disordered protein uses to expand and control its functionality.
Scientists from the Florida campus of The Scripps Research Institute have been awarded more than $1.4 million from the National Cancer Institute of the National Institutes of Health to create a potential new drug to attack the malignant cells that cause chronic lymphocytic leukemia (CLL), the most common leukemia in the Western world.
An international team led by scientists at The Scripps Research Institute, the Howard Hughes Medical Institute and Albert Einstein College of Medicine of Yeshiva University has identified a highly promising new anti-tuberculosis compound that attacks the tuberculosis (TB) bacterium in two different ways.
Scientists at The Scripps Research Institute have found evidence that an emotion-related brain region called the central amygdala—whose activity promotes feelings of malaise and unhappiness—plays a major role in sustaining cocaine addiction.
Scientists at The Scripps Research Institute have identified key triggers of an important cancer-blocking mechanism in cells. Termed “oncogene-induced senescence,” this mechanism can block most cancer types and is commonly experienced when incipient skin cancers turn instead into slow-growing moles.
Humans have been raising cows for their meat, hides and milk for millennia. Now it appears that the cow immune system also has something to offer. A new study led by scientists from The Scripps Research Institute (TSRI) focusing on an extraordinary family of cow antibodies points to new ways to make human medicines.
Current immune suppressants have major drawbacks, but a team from The Scripps Research Institute has demonstrated a new technique that may lead to a better way to selectively repress unwanted immune reactions without disabling the immune system as a whole.
The Esther B. O'Keeffe Charitable Foundation has made a $250,000 donation to The Scripps Research Institute to fund neuroscience training and public outreach on the Florida campus.
Marshall M. Criser III, president of AT&T Florida, and James E. LaBelle, chief medical officer and corporate senior vice president of Scripps Health in San Diego, have been elected to The Scripps Research Institute Board of Trustees.
Scientists at The Scripps Research Institute have devised a powerful new technique for finding antibodies that have a desired biological effect. The newly reported technique should greatly speed the process of discovering medicines, diagnostics and laboratory reagents.
Ardem Patapoutian, professor in the Dorris Neuroscience Center at The Scripps Research Institute, has been named a Howard Hughes Medical Institute (HHMI) Investigator, based on demonstrated potential to contribute significantly to biomedical science.
A team led by scientists at The Scripps Research Institute has found how to boost or inhibit a gene-silencing mechanism that normally serves as a major controller of cells’ activities. The discovery could lead to a powerful new class of drugs against viral infections, cancers and other diseases.
The Scripps Research Institute (TSRI) today announced a five-year agreement with Janssen Pharmaceuticals, Inc. (Janssen) to collaborate on focused research projects in the infectious disease area, with the initial project targeting the influenza virus. Under the agreement Janssen will receive certain license rights to the results of the research. Janssen Pharmaceuticals will collaborate in the research on influenza through its Crucell Vaccine Institute.
Scientists at The Scripps Research Institute (TSRI) have reported successful preclinical tests of a new vaccine against heroin. The vaccine targets heroin and its psychoactive breakdown products in the bloodstream, preventing them from reaching the brain.
Solving the structure of a critical human molecule involved in cancer, scientists at The Scripps Research Institute (TSRI) have found what they call a good example of structural conservation—dissimilar genes that keep very similar shapes.
Scientists from the Florida campus of The Scripps Research Institute have uncovered how an enzyme co-factor can bestow specificity on a class of proteins with otherwise nonspecific biochemical activity. Proteins can have more than one function, but they often need to be very specific in their action or they create cellular havoc, possibly leading to disease.
Scientists from The Scripps Research Institute, Florida campus; Columbia University and the University of Florida, Gainesville, have developed a novel strategy to isolate and characterize a substantial number of RNAs transported from the cell-body of neuron to the synapse, the small gap separating neurons that enables cell to cell communication.
In a serendipitous discovery, scientists at The Scripps Research Institute have found a way to turn bone marrow stem cells directly into brain cells.
The Scripps Research Institute has contracted with former Palm Beach County Commissioner Karen Marcus to provide advice and assistance in community and government relations.
Scientists at The Scripps Research Institute have made a counterintuitive finding that may lead to new ways to clear persistent infection that is the hallmark of such diseases as AIDS, hepatitis B and hepatitis C.
Scientists at The Scripps Research Institute have shed light on one of the major toxic mechanisms of Alzheimer’s disease. The discoveries could lead to a much better understanding of the Alzheimer’s process and how to prevent it.
Scientists at The Scripps Research Institute have illuminated the mechanism at the heart of one of the most useful processes in modern chemistry. A reaction that is robust and easy to perform, it is widely employed to synthesize new pharmaceuticals, biological probes, new materials and other products.
The Scripps Research Institute has appointed Laura Solt as assistant professor at the Florida campus. Previously, Solt was a research associate and a member of the laboratory of Professor Thomas Burris at Scripps Florida.
Scientists from the Florida campus of The Scripps Research Institute have for the first time identified a pair of drugs already approved for human use that show anti-prion activity and, for one of them, great promise in treating rare and universally fatal disorders, such as Creutzfeldt-Jakob disease, caused by misfolded proteins called prions.
A trio of scientists from The Scripps Research Institute has created the first-ever fully interactive advanced organic chemistry textbook, called "The Portable Chemist’s Consultant: A Survival Guide for Discovery, Process, and Radiolabeling," for industrial chemists working toward new drugs and other goals, as well as organic chemistry students
A team led by scientists from The Scripps Research Institute and the International AIDS Vaccine Initiative has unveiled a new technique for vaccine design that could be particularly useful against HIV and other fast-changing viruses.
As part of an unprecedented national effort to develop new drugs to treat neurological disorders, scientists from the Florida campus of The Scripps Research Institute have been awarded an innovative grant from the National Institute of Neurological Disorders and Stroke to help people break their addiction to nicotine.
Using a broad spectrum of analytical tools, scientists from the Florida campus of The Scripps Research Institute have uncovered a class of novel compounds that can alter cell signaling activity, resulting in a variety of responses including a strong anti-inflammatory effect.
A team including scientists from The Scripps Research Institute, the University of North Carolina at Chapel Hill and the Chinese Academy of Sciences has determined and analyzed the high-resolution atomic structures of two kinds of human serotonin receptor.
Philanthropist, businessman and community leader John Moores has given The Scripps Research Institute (TSRI) approximately $2 million to fund the development of a new field test for Onchocerciasis, or river blindness, a parasitic infection that affects tens of millions of people in Africa, Latin America and other tropical regions.
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