MRI and an emerging field of medicine called radiomics could help to characterize the heterogeneity of cancer cells within a tumor and allow for a better understanding of the causes and progression of a person’s individual disease, according to a Penn Medicine study.
Patients with acute lymphoblastic leukemia (ALL) or acute myeloid leukemia (AML) who are treated with anthracyclines are at a heightened risk of heart failure—most often within one year of exposure to the chemotherapy treatment.
An experimental, off-the-shelf immunotherapy that combines a targeted antibody and chemotherapy can lead to potentially durable responses in multiple myeloma patients whose disease has relapsed or is resistant to other standard therapies
Researchers at Penn Medicine created a new mouse model that allows investigators to closely track the defects in sperm from the early stages of sperm development through fertilization and on. The model can lead to a better understanding of not only infertility in men—and ways to potentially reverse it.
A genetic variant in the gene transthyretin (TTR) is a more significant cause of heart failure than previously believed. The study also revealed that a disease caused by this genetic variant, called hereditary transthyretin amyloid cardiomyopathy, is significantly underdiagnosed.
The antibiotic vancomycin alters the gut microbiome in a way that can help prime the immune system to more effectively attack tumor cells after radiation therapy
A new, experimental immunotherapy can put patients with B-cell non-Hodgkin lymphoma (NHL) that is resistant to or has come back after multiple other therapies, including CAR T therapy, into remission.
Jeff Krieger didn’t ride off into the sunset. Even though he was finishing up his final radiation treatment for prostate cancer, the 64-year-old didn’t have anything so cliché on his mind.
Soft tissue sarcoma cells stop a key metabolic process which allows them to multiply and spread, and so restarting that process could leave these cancers vulnerable to a variety of treatments
With no national standard to measure drug treatment facilities, new research reveals opportunities to learn from patients to help create metrics.
Communities in the United States that experienced the most economic distress in the wake of the Great Recession saw a significant increase in death rates from heart disease and strokes among middle-aged people, according to a new multi-institution study led by researchers at Penn Medicine.
Women who are diagnosed with peripartum cardiomyopathy (PPCM) during late pregnancy or within a month following delivery are more likely to experience restored cardiac function and improved outcomes compared to those who are diagnosed later in the postpartum period.
By nudging doctors to consider a screening for breast or colorectal cancer, order rates jumped significantly, but patient completion rates didn’t change
Heliobacter pylori infection, quite common around the world, is linked to gastric cancer. Now, a Penn study shows that successfully wiping out the infection lowers the cancer risk.
Taller people have an increased risk of developing atrial fibrillation, according to a new Penn Medicine study. The research is the among the first to demonstrate that height may be a causal—not correlated—risk factor for AFib.
Researchers discovered that a protein called CoRest, a neural repressor that is also found in humans, plays a central role in determining the social behavior of ants. The study also revealed that worker ants called Majors can be reprogrammed to perform the foraging role—generally reserved for their sisters.
Researchers from Penn compare a lymphoma-dose regimen of rituximab to a rheumatoid arthritis regimen for the treatment of pemphigus.
Genetically editing a cancer patient’s immune cells using CRISPR/Cas9 technology, then infusing those cells back into the patient appears safe and feasible based on early data from the first-ever clinical trial to test the approach in humans in the United States.
Researchers genetically engineered CAR T cells with molecular tags, which they were able to monitor in an animal model using position emission tomography (PET) imaging.
Researchers determined the themes associated with loneliness on Twitter so that it could be identified in users who don't specifically tweet about it.
A blood test that measures the amount of cell-free DNA (cfDNA) in the bloodstream – called a liquid biopsy – correlates with how patients will progress after they are diagnosed with glioblastoma (GBM), the deadliest and most common primary brain tumor in adults
To end the HIV epidemic in the US, the use of behavioral and social science research—combined with biomedical strategies—is essential, according to a series of new papers in JAIDS. The 15 article supplement was co-edited by two faculty members in the Perelman School of Medicine at the University of Pennsylvania.
The newly developed system prioritizes patients so that cancer doctors have conversations about their values and goals before it is too late.
A new analysis challenges the longstanding notion that tuberculous infection is a life-long infection that could strike at any time and cause tuberculosis
An international team of experts led by researchers in the Perelman School of Medicine at the University of Pennsylvania and University of Glasgow has been awarded a $9.7 million, five-year grant from the National Institute of Neurological Disorders and Stroke (NINDS) and National Institute for Aging (NIA) to establish CONNECT-TBI—a program spanning 12 institutions which will study traumatic brain injury (TBI) and related neurodegenerative diseases.
A new study, led by researchers at Penn Medicine, revealed a surprising pathway that shows alcohol byproducts travel to the brain to promote addiction memory. The findings are published in Nature.
The 2018 federal Right to Try Act allows patients with a life-threatening illness to be treated with drugs that have not yet been approved by the Food and Drug Administration (FDA). Many in the oncology community say Right to Try strips away important regulatory protections and view the move as a risky step bound to create ethical dilemmas for physicians whose goal is to guide patients toward safe and appropriate treatment decisions. Oncology is one field at the forefront of requests for unapproved drugs. An interdisciplinary team of bioethicists, oncologists, and lawyers from Penn Medicine and other institutions penned a commentary published online this week in the Journal of Clinical Oncology to offer recommendations to help oncologists navigate this new “Right to Try” world, while maintaining their ethical obligations to patients.
Six faculty members from the Perelman School of Medicine at the University of Pennsylvania have been elected to the National Academy of Medicine (NAM), one of the nation's highest honors in biomedicine.
As part of an effort to improve long-term outcomes, a national team led by a researcher at Penn Medicine has launched a study--funded by a $9.8 million grant from the NIH--to better understand clinical and biological processes that occur after transplant and lead to the development of these complications.
Patients with a high risk of dying after surgery, including those with multiple chronic diseases, benefit from undergoing general or vascular procedures at a major teaching hospital as opposed to a non-teaching hospital, according to a study from researchers at Penn Medicine and CHOP.
Researchers at Penn Medicine discovered that a protein called ANT is critical for a quality control process called mitophagy—which helps to ensure the integrity of the mitochondria network by removing damaged mitochondria—and found that ANT mutations that lead to a defective quality control system cause heart disease
Researchers showed in animal models that spinal discs' default injury response can be temporarily stopped to allow for better treatment
Women who are health policy or health services researchers face a significant disparity in social media influence compared to their male peers, according to a new study from researchers in the Perelman School of Medicine at the University of Pennsylvania. Although the average number of tweets among all researchers tend to be consistent, women trail behind men in follower counts, regardless of how active they are on Twitter. The findings, which hold implications for larger questions around gender disparities in academic medicine, are published today in JAMA Internal Medicine.
Penn Medicine researchers explore a T cell's path to exhaustion and what triggers it.
The total amount of opioids dispensed per new opioid prescription decreased by 22 percent in Penn Medicine outpatient practices in New Jersey after the state passed a law limiting prescriptions to a five-day supply for new opioid prescriptions. Penn Medicine implemented an electronic health record (EMR) alert, or “nudge,” to notify clinicians if that limit had been reached. The study, published online today in the Journal of General Internal Medicine, is one of the first evaluations of a state law’s impact on prescribing outcomes, and is the first report of an EMR being used to make compliance with prescribing limits easier. Importantly, after the prescribing limit and alert went into effect there was no evidence to suggest pain control worsened.
A special type of PET scan used for imaging the brains of patients with Parkinson’s could be revolutionary for drug development and treatment.
As tumor cells multiply, they often spawn tens of thousands of genetic mutations. Figuring out which ones are the most promising to target with immunotherapy is like finding a few needles in a haystack. Now a new model hand-picks those needles so they can be leveraged in more effective, customized cancer vaccines.
Penn Medicine study shows patients who use online platforms connected to their health records are more likely to take preventative health measures.
A gene therapy being developed at Penn Medicine to treat Duchenne muscular dystrophy (DMD) successfully and safely stopped the severe muscle deterioration associated with the rare, genetic disease in both small and large animal models, according to a first-of-its-kind study.
Penn Medicine has been awarded five grants from the NIH HEAL Initiative, totaling more than $22 million to apply scientific solutions to reverse the national opioid crisis.
A new scientific statement from the American Heart Association identifies the risks and benefits of using novel interventional devices compared to anticoagulation alone to treat patients with pulmonary embolism.
As research involving the transplantation of human “mini-brains”—known as brain organoids—into animals to study disease continues to expand, so do the ethical debates around the practice. A new paper published in Cell Stem Cell by researchers from Penn Medicine and the Department of Veterans Affairs sought to clarify the abilities of brain organoids and suggests an ethical framework that better defines and contextualizes these organoids and establishes thresholds for their use.
A National Institute on Aging grant will support Penn’s Center for Neurodegenerative Disease Research to study the underlying genetic connections between Alzheimer's Disease, Parkinson's Disease, and Dementia.
A trigger system powered by predictive analytics increased palliative care consultations by 74 percent after implementation
Within six months of the FDA's move to restrict the label of two immunotherapies, usage of those therapies among oncologists dropped by about 50 percent, according to a new study from researchers in the Abramson Cancer Center at the University of Pennsylvania.
A novel vaccine at Penn Medicine protected almost all animal subjects exposed to the herpes virus
Treating non-Hodgkin’s lymphoma (NHL) patients with radiation therapy as an additional treatment while they wait for their CAR T cells to be manufactured may reduce the risk of CAR T therapy side effects once it is administered.
Blood pressure levels in hypertension patients was not improved when they were issued electronic pill bottles or took part in automated texting programs.
A new $3 million grant to support a clinical trial evaluating a combination therapy to prevent triple-negative breast cancer from recurring, which will be led in the clinic by Angela DeMichele, MD, MSCE, the Alan and Jill Miller Professor in Breast Cancer Excellence in the Abramson Cancer Center (ACC) at the University of Pennsylvania and co-director of the ACC’s 2-PREVENT Translational Center of Excellence. The grant was awarded by Stand Up 2 Cancer (SU2C) in partnership with Genentech, and will be administered by the organization’s scientific partner, the American Association for Cancer Research (AACR).
Kidneys from donors who were infected with the Hepatitis C virus (HCV) function just as well as uninfected kidneys throughout the first year following transplantation, according to a new Penn Medicine study.
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