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Continuing an ongoing effort to respond to the public health crisis of intentional violence, the University of Chicago Medicine and Advocate Christ Medical Center are joining forces to form Southland RISE (Resilience Initiative to Strengthen and Empower), a new collaborative designed to better care for individuals, families and communities on the South Side and south suburban communities.

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A leading clinical and research psychologist at the University of Chicago Medicine has been awarded a $3.8 million grant from the National Institute of Alcohol Abuse and Alcoholism (NIAAA) — a division of the National Institutes of Health — to understand alcohol responses in individuals who have problems controlling their drinking.

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The University of Chicago will lead the NRG Oncology Statistics and Data Management Center, which is receiving six more years of funding from the National Cancer Institute.

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A unique approach that provides an ecosystem of trauma-informed care for children and their families who are critically injured or exposed to violence on the South Side of Chicago is getting a big boost, thanks to a $9.1 million gift to the University of Chicago Medicine by the Ellen & Ronald Block Family Foundation and the Hassenfeld Family Foundation.

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A UChicago-based team working with collaborators in Bangladesh identified a new genetic variant linked to arsenic metabolism and toxicity.

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A novel approach appears to be an effective alternative to immunosuppressive therapies for acute and chronic intestinal disease.

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In a national survey, hospital pharmacy managers report a lack of advance notice, frequent drug shortages, hoarding and even rationing. Improving the supply of generic medications and creating novel strategies to manage scarce drugs is needed.

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The American Association for Cancer Research honors Susan Cohn, MD, for her leadership in clinical trials to improve treatment and survival for neuroblastoma.

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The University of Chicago Pritzker School of Medicine retained top rankings in the U.S. News & World Report annual review of the country’s top medical schools. Of the 120 accredited medical schools surveyed by U.S. News for its 2020 edition, Pritzker placed No. 16 (up from No. 18 last year) for research and No. 18 (up from No. 39) for primary care training.

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A new study published in Nature Ecology and Evolution led by scientists from the University of Chicago challenges one of the classic assumptions about how new proteins evolve.

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A new study from the University of Chicago Medicine shows African-American communities were the only racial/ethnic group to have consistent disparities in geographic access to trauma centers. A new Level 1 trauma center at UChicago Medicine, which opened in 2018, reduced those racial disparities in the city 7 fold.

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Two older drugs, designed for other purposes, produced promising results in the treatment of mice with triple negative breast cancer.

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Research published in the American Journal of Public Health shows CommunityRx helps patients gain confidence finding health resources in their own neighborhoods.

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The University of Chicago Medicine has received re-certification by the QOPI Certification Program LLC, a wholly owned subsidiary of the American Society of Clinical Oncology, Inc.

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New research by neuroscientists at the University of Chicago shows that as neurons process information about texture from the skin, they each respond differently to various features of a surface, creating a high-dimensional representation of texture in the brain.

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Identifying molecular pathways that boost the immune response to tumor neoantigens opens up new ways to develop and amplify cancer immunotherapy.

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Advancing Health Equity: Leading Care, Payment, and Systems Transformation is a national program to reduce and eliminate disparities in health care through innovative Medicaid payment and contracting models.

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Ballmer Group, the philanthropic organization founded by Connie and Steve Ballmer, is giving $4.2 million to University of Chicago’s TMW Center for Early Learning + Public Health to fund its work that develops a model for a community-wide approach to promote cognitive and language development in young children.

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Paleontologists at the University of Chicago have discovered the first detailed fossil of a hagfish, the slimy, eel-like carrion feeders of the ocean. The 100-million-year-old fossil helps answer questions about when these ancient, jawless fish branched off the evolutionary tree from the lineage that gave rise to modern-day jawed vertebrates, including bony fish and humans.

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Multiple sclerosis is a demyelinating inflammatory disorder in which autoreactive T cells migrate into the central nervous tissue and damage oligodendrocytes and myelin, which protect nerve cells. Sephin1 prolongs a cytoprotective response in oligodendrocytes, protecting those cells and myelin from this inflammatory attack. It dampens central nervous system inflammation, limits myelin damage and reduces the reactivation of T cells.

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New research from the University of Chicago shows that healthy infants have intestinal bacteria that prevent the development of food allergies.

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Hospitals often prioritize patient testing and treatment over the restorative virtues of patient sleep. Frequent overnight awakenings, however, can cause complications. The SIESTA study found that a commitment to sleep-friendly routines and changes to the electronic health record system could reduce nighttime disruptions and improve the patient experience.

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Two 29-year-old patients from Michigan and Illinois are recovering following back-to-back triple-organ transplants to replace their failing hearts, livers and kidneys, marking a first in U.S. health care history.

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Working with nine animal models, researchers find a preference for stability over energy conservation during speed-related gait transitions.

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In a new study published in Nature Communications, a team of scientists from UChicago demonstrated the application of tRNA sequencing to gut microbiome samples from mice that were fed either a low-fat or high-fat diet.

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An international phase-2 trial of a CAR-T cell therapy—to be published on-line Dec. 1 in the New England Journal of Medicine (and presented at the ASH annual meeting in San Diego)—found that 52% of patients responded favorably to the therapy; 40% had a complete response and 12% had a partial response. One year later, 65% of those patients were relapse-free, including 79% of complete responders. The median progression-free survival “has not been reached.”

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Controlled ingestion of peanut protein could help build tolerance in peanut allergy sufferers. Authors of a new study published in the New England Journal of Medicine say an oral immunotherapy drug they tested could be the first FDA-approved medication of its kind for people with peanut allergy. The medication, called AR101, is derived from peanut protein.

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An analysis of Twitter data from the U.S. shows that social media usage largely mirrors daily work schedules and school calendars. The data reflect the amount of “social jet lag” caused when social demands make people wake up much earlier than their biological rhythms would prefer.

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In the current issue of the Proceedings of the National Academy of Sciences, a team of physicians, geneticists and biologists describes a previously unknown genetic factor— a common non-coding sequence of DNA—that can either raise or reduce the risk of coronary artery disease or ischemic stroke.

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Collaboration aims to improve outcomes for the community’s youngest children, from their first day of life

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A new study by scientists from the University of Chicago shows how cyanobacteria, or bacteria that produce energy through photosynthesis like plants, change the way they grow and divide in response to different levels of light.

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By combining the experimental anti-cancer antibody known as 5F9 with the anti-cancer antibody rituximab, researchers managing a phase 1b clinical trial were able to induce a positive response in 11 out of 22 people with relapsed/refractory non-Hodgkin’s lymphoma. Eight of the 22 patients went into complete remission from their cancers.

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The $50,000 MacLean Center Prize in Clinical Ethics and Health Outcomes, the largest in clinical medical ethics, was awarded this year to Emory University's William Foege, MD, MPH.

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In a new study published in Nature, scientists from the University of Chicago show how a common RNA modification plays an important role in the process of learning and memory formation.

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ACCSIS-Chicago—led by University of Chicago cancer specialists Karen Kim, MD, MS, and Blase Polite, MD, MPP—has been awarded nearly $6 million over five years to test novel ways to improve CRC screening and follow-up among groups that have not been screened.

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New research by scientists from the University of Chicago shows that just one gene controls whether a certain species of butterfly has white or yellow spots on its wings.

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Nearly 120 million prescriptions for a thyroid medicine called levothyroxine are filled each year, but many patients with hypothyroidism never get the benefit. A new study pinpoints a consistent inherited mutation that prevents the only current treatment from doing its job.

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A new study comparing DNA and RNA data from Nigerian breast cancer patients to patients in a United States database found that aggressive molecular features were far more prevalent in tumors from women of African ancestry than women of European ancestry. Those differences could explain disparities in breast cancer mortality for black women across the African Diaspora and hasten a shift to precisely targeted therapies.

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A team of researchers at the University of Chicago has received a $3.4 million grant from the National Institutes of Health. The funding will help the team develop robotic arms patients can control with their minds that receive sensory feedback from attached prosthetic hands.

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Researchers have identified an independent prognostic factor, cancer/testis antigen 45, that is associated with extended disease-free survival for women with advanced ovarian cancer. Patients with high levels of CT45 in their tumors lived more than seven times as long as patients who lacked sufficient CT45.

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A study in Nature Biomedical Engineering shows that skin stem cells, modified via CRISPR and transplanted back to donor mice, can protect addicted mice from cocaine-seeking and overdose.

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Getting magnetic resonance imaging (MRI) scans twice a year instead of one annual mammogram is far more effective at detecting early breast cancers in young women with a high-risk genetic profile than mammograms alone, according to a research team based at the University of Chicago Medicine and the University of Washington, Seattle.

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The majority of partnered, home-dwelling people in the U.S. with dementia are sexually active, according to a University of Chicago Medicine study out this week in the Journal of the American Geriatrics Society.

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The University of Chicago Medicine and Almoosa Specialist Hospital, a private hospital in the Al-Ahsa region of Saudi Arabia offering comprehensive medical care, have signed a collaboration agreement.

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Ovarian cancer cells that interact with cancer-associated fibroblasts can mobilize glycogen as an energy source, leading to proliferation, invasion and metastasis. Blocking glycogen mobilization in cancer cells might reduce tumor spread.

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Interactions between radiation therapy and the immune system can improve cancer treatment. The cellular carnage caused by radiation attracts scavengers, such as dendritic cells, that present cancer cell fragments to T cells. This study suggests novel ways to improve treatment by using radiation to boost immunotherapy.

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According to a new study, about one in five children regularly use prescription medications, and nearly one in 12 of those children are at risk for experiencing a harmful drug- drug interaction.

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The University of Chicago Medicine and Humana Inc. have entered into a value-based agreement designed to offer a coordinated, patient-centered experience to help Humana Medicare Advantage members achieve their best health.

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A study that enrolled more than 2,000 Nigerian women found that disparities in breast cancer mortality disproportionately impact women of African ancestry. Nigerian women with mutations in breast cancer genes have higher risks than women in the U.S. with mutations in the same genes. Inherited breast cancer plays a bigger role in Nigeria.