Scientists from the Florida campus of The Scripps Research Institute have identified a normally small subset of immune cells that may play a major role in the development of Crohn’s disease generally and in disease-associated steroid resistance specifically.
Scientists from The Scripps Research Institute have revealed an atomic-level view of a genetic defect that causes a form of muscular dystrophy, myotonic dystrophy type 2, and have used this information to design drug candidates with potential to counter those defects—and reverse the disease.
Scientists at The Scripps Research Institute have demonstrated a drug-discovery strategy with a double payoff—it enables the rapid selection of chemical compounds that have a desired effect on cells and also highlights how the compounds work.
Researchers have used new techniques and one of the brightest X-ray sources on the planet to map the 3-D structure of an important cellular gatekeeper in a more natural state than possible before.
An experimental compound developed by scientists from The Scripps Research Institute's Florida campus is capable of significantly reducing joint inflammation in animal models of rheumatoid arthritis.
Avian influenza virus H7N9, which killed several dozen people in China earlier this year, has not yet acquired the changes needed to infect humans easily, according to a new study by scientists at The Scripps Research Institute.
Scientists at The Scripps Research Institute have discovered a natural mechanism that cells use to protect mitochondria, the tiny but essential “power plants” that provide chemical energy for cells throughout the body.
Scientists at The Scripps Research Institute have determined the most detailed picture yet of a crucial part of the hepatitis C virus, which the virus uses to infect liver cells. The new data reveal unexpected structural features of this protein.
Researchers at The Scripps Research Institute (TSRI) have solved the structure of a key protein in the Nipah virus, which could pave the way for the development of a much-needed antiviral drug.
The Scripps Research Institute has appointed Irv Geffen as director of major gift and planned giving in Scripps Florida’s Office of Philanthropy. Before joining TSRI, Geffen was vice president and director of wealth management at Sabadell Bank & Trust in Palm Beach.
The generic drug gabapentin, widely prescribed for epilepsy and some kinds of pain, appears safe and effective in treating alcohol dependence. The finding comes from a 150-patient randomized, placebo-controlled, double blind clinical trial conducted by scientists at The Scripps Research Institute.
Scientists at The Scripps Research Institute (TSRI) and Weill Cornell Medical College of have determined the first atomic-level structure of the tripartite HIV envelope protein—long considered one of the most difficult targets in structural biology and of great value for medical science.
A scientist from The Scripps Research Institute (TSRI) Florida campus has won a $1 million from the National Institute of General Medical Sciences to develop a series of tests that could point the way to new ways to find therapies for a host of debilitating diseases,
A promising technique for treating human eye disease has proven effective in preclinical studies and may lead to new treatments to prevent blindness, according to experiments conducted at The Scripps Research Institute. The studies involved controlling the actions of microRNAs.
The National Institutes of Health renewed its prestigious Clinical and Translational Science Award with the Scripps Translational Science Institute for $29 million to support innovative research in genomics, wireless technology and bioinformatics toward individualizing medicine.
The Scripps Research Institute Board of Trustees has elected two new members: Horacio Valeiras of La Jolla, CA, who is managing partner of investment firm HAV Capital, and Bernard Saint-Donat of New York, who is president of financial consulting firm Saint-Donat & Co.
Scientists at The Scripps Research Institute have discovered key details of a brain-to-body signaling circuit that enables roundworms to lose weight independently of food intake, and there are reasons to suspect the circuit exists in a similar form in humans and other mammals.
A team led by scientists at The Scripps Research Institute has identified key signaling proteins in the inflammation process that contribute to the development of inflammatory diseases such as rheumatoid arthritis, psoriasis, sepsis and inflammatory bowel diseases.
Scientists at The Scripps Research Institute have identified a set of compounds that may be used to treat multiple sclerosis (MS) in a new way. Unlike existing MS therapies that suppress the immune system, the compounds boost a population of progenitor cells that can repair MS-damaged nerve fibers.
Chemists at The Scripps Research Institute have devised a new technique for connecting drug molecules to antibodies to make advanced therapies.
Scientists from the Florida campus of The Scripps Research Institute have identified a new drug candidate for an inherited form of cancer with no known cure.
Scientists from the Florida campus of The Scripps Research Institute have discovered some key features that explain just what turns on a protein that is considered to be a master regulator of how the human body uses and stores energy.
Scientists at The Scripps Research Institute report a highly programmable and controlled platform for preparing and experimentally probing synthetic cellular structures.
A team led by scientists at The Scripps Research Institute has created the first comprehensive roadmap of the protein interactions that enable cells in the pancreas to produce, store and secrete the hormone insulin.
Scott Hansen, PhD, an assistant professor in the Department of Molecular Therapeutics on the Florida campus of The Scripps Research Institute, has won a prestigious New Innovator Award from the National Institutes of Health.
Highlighting an important but unexplored area of evolution, scientists at The Scripps Research Institute (TSRI) have found evidence that, over hundreds of millions of years, an essential protein has evolved chiefly by changing how it moves, rather than by changing its basic molecular structure. The work has implications not only for the understanding of protein evolution, but also for the design of antibiotics and other drugs that target the protein in question.
A new method to produce accurate computer models of molecules, developed by scientists on the Florida campus of The Scripps Research Institute, combines existing formulas in a kind of algorithmic stew to gain a better picture of molecular structural diversity that is then used to eliminate errors and improve the final model.
Scientists at The Scripps Research Institute have discovered an important process by which special immune cells in the skin help heal wounds.
Chemist Phil S. Baran of The Scripps Research Institute (TSRI) has won a 2013 MacArthur Fellowship, sometimes called a “genius grant.”
Researchers at The Scripps Research Institute (TSRI) discovered that an antibody that binds and neutralizes HIV likely also targets the body’s own “self” proteins. This finding could complicate the development of HIV vaccines designed to elicit this protective antibody, called 4E10, and others like it, as doing so might be dangerous or inefficient.
Scientists at The Scripps Research Institute have found a way to make dramatic improvements to the cancer cell-killing power of vinblastine, one of the most successful chemotherapy drugs of the past few decades.
A team of Chinese and US scientists has determined the high-resolution atomic structure of a cell-surface receptor that most strains of HIV use to get into human immune cells. The researchers also showed where maraviroc, an HIV drug, attaches to cells and blocks HIV’s entry.
Scientists from the Florida campus of The Scripps Research Institute have found a group of proteins essential to the formation of long-term memories.
Chemists at The Scripps Research Institute have found a way to apply a “foundational reaction” of organic chemistry to a stubborn class of chemicals, in a transformation that has been thought impossible for a century.
For the first time, scientists from the Florida campus of The Scripps Research Institute have been able to erase dangerous drug-associated memories in mice and rats without affecting other more benign memories. The surprising discovery points to a clear and workable method to disrupt unwanted memories while leaving the rest intact.
A team led by scientists from The Scripps Research Institute have shown that a protein once thought to inhibit the growth of tumors is instead required for initial tumor growth. The findings could point to a new approach to cancer treatment.
Scientists from the Florida campus of The Scripps Research Institute have shown that a well-known cancer-causing gene implicated in a number of malignancies plays a far more critical role in non-small cell lung cancer, the most common form of the disease, than previously thought.
Scientists at The Scripps Research Institute (TSRI) have found a way to apply a powerful new DNA-editing technology more broadly than ever before. “This is one of the hottest tools in biology, and we’ve now found a way to target it to any DNA sequence,” said Carlos F. Barbas III, the Janet and Keith Kellogg II Chair in Molecular Biology and Professor in the Department of Chemistry at TSRI.
Scientists at The Scripps Research Institute have discovered the molecular mechanism by which the deadly Ebola virus assembles, providing potential new drug targets. Surprisingly, the study showed that the same molecule that assembles and releases new viruses also rearranges itself into different shapes, with each shape controlling a different step of the virus’s life cycle.
A small group of immune-regulating molecules, when overproduced even moderately, can trigger the blood cancers known as lymphomas, according to a new study led by scientists from The Scripps Research Institute.
Professor Paul Robbins, of The Scripps Research Institute, will be principal investigator of the new five-year study, which will focus on identifying just how damage that accumulates over time drives the human aging process. Scientists from the University of Pittsburgh and the University of California, Riverside, will also participate in the study.
Scientists at The Scripps Research Institute have decoded an important molecular signal that guides the development of a key region of the brain known as the neocortex.
Scientists from the Jupiter campus of The Scripps Research Institute have shown a novel way to dramatically raise the potency of drug candidates targeting RNA, resulting in a 2,500-fold improvement in potency and significantly increasing their potential as therapeutic agents.
Scientists from the Florida campus of The Scripps Research Institute have described findings that could enable the development of more effective drugs for addiction with fewer side effects.
Scientists at The Scripps Research Institute have achieved the first efficient chemical synthesis of ingenol, a highly complex, plant-derived compound that has long been of interest to drug developers for its anticancer potential.
Scientists at The Scripps Research Institute have discovered a new type of chemical modification that affects numerous proteins within mammalian cells. The modification appears to work as a regulator of important cellular processes including the metabolism of glucose.
Biologists at The Scripps Research Institute have made a significant discovery that could lead to a new therapeutic strategy for Parkinson’s disease. The findings focus on an enzyme known as parkin, whose absence causes an early-onset form of Parkinson’s disease.
Sigma-Aldrich Corporation today announced a partnership with The Scripps Research Institute (TSRI) to fund research and provide immediate, day-of-publication access to TSRI researchers’ discoveries for the synthesis and analysis of potential drugs.
An international team led by scientists at The Scripps Research Institute has determined and analyzed the three-dimensional atomic structure of the human glucagon receptor, which helps regulate glucose levels in the bloodstream and is the target of potential therapeutic agents for type 2 diabetes.
An international group of scientists has shown that a drug candidate designed by scientists from the Florida campus of The Scripps Research Institute significantly increases exercise endurance in animal models.
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