Early results from a University of North Carolina at Chapel Hill School of Medicine study may determine if drugs called Cox-2 inhibitors, a newer type of non-aspirin pain medicine now widely prescribed for arthritis symptoms, may benefit men with recurrent prostate cancer.
Scientists have found an unexpected way to turn off a cellular enzyme involved in the progression of several types of human cancers.
New research shows that treatment with nitric oxide after storage may dramatically improve the viability of transplanted livers.
Results from a new study of tumor genetics may give doctors valuable information in deciding how aggressively to treat patients with head and neck cancer.
Scientists have found that a protein discovered 3 years ago in the male reproductive tract is a potent anti-bacterial agent. In addition to protecting against invading bacteria, the protein may aid fertilization by protecting sperm from harmful organisms in the female reproductive tract.
In studying a virus that causes the skin cancer Kaposi's sarcoma, scientists have identified a viral gene that switches on cellular genes involved in promoting tumor cell growth and metastasis throughout the body.
Early results from a pioneering study indicate that small uterine fibroids are associated with an increased risk of miscarriage.
Dr. Blossom A. Damania, assistant professor of microbiology and immunology is this year's recipient of the Gertrude B. Elion Cancer Research Award, sponsored by the American Association for Cancer Research.
The American Society for Pharmacology and Experimental Therapeutics has named Dr. David P. Siderovski, assistant professor of pharmacology, the recipient of the 2004 John J. Abel Award.
With a recent nod from federal officials, a research grant to a pioneering neuroscientist entered its 48th year.
First-year medical students are finding less need to adjust a traditional microscope in their histology curriculum. Instead, they are using their computers and a unique DVD virtual microscope to study the exacting science concerned with the minute structure of cells, tissues and organs.
New research may hold keys to improving the safety of human gene therapy. The study showed that the messenger can be as important as the message: Viruses genetically engineered for use as delivery vehicles for transferring therapeutic genes into the body may alone influence gene expression.
In a pioneering project, scientists are developing a voluntary DNA registry to study the link among environmental exposures, genetic susceptibility and human disease.
Exposure to endotoxin, a bacterial substance found commonly in outdoor and indoor air, makes mite-allergic asthmatics more sensitive to house dust and may place them at increased risk of asthma attack.
In its latest attempt to reduce the number of new HIV infections nationwide, the federal government is locating prevention programs squarely in the treatment setting. Selected to address the challenge is the Center for Infectious Diseases at the University of North Carolina at Chapel Hill School of Medicine.
For the first time in 15 years, busy and time-pressured doctors seeking the most current information on everyday medical problems have a solid alternative to the exhaustive and massive texts currently in use.
University of North Carolina at Chapel Hill scientists have discovered a unique protein on the surface membrane of plant cells, one that apparently contains both "on" and "off" molecular switches. Apart from its unique structure, the protein may be the first cell surface membrane receptor ever discovered in plants that regulates a key protein complex involved in cell growth and division.
A cellular protein identified by scientists may be the crucial molecular element for gene silencing. The research findings add important knowledge to the understanding of epigenetic signals. These chemical signals affect the modulation of gene expression throughout the genome.
New research has identified a cellular enzyme that helps regulate the synthesis of proteins essential to cell functioning throughout the life of the organism.
New research has identified two genes that play key roles in regulating blood vessel development, angiogenesis, the molecular program by which endothelial cells lining blood vessels develop or differentiate from their precursor stem cells.
The world's first human test of a vaccine against the prevalent subtype of HIV in sub-Saharan African and Asia, where millions have the virus that causes AIDS, is now under way.
A new study by gene therapy scientists may lead to an effective long-term treatment for preventing seizures associated with a common form of epilepsy.
A new study from the University of North Carolina at Chapel Hill describes the emergence and spread of a virulent form of dengue virus from the Indian subcontinent to Latin America, including Mexico.
A new study links a protein discovered a few years ago at the University of North Carolina at Chapel Hill with formation of scar tissue that occurs after injury to nerve cells in the brain or spinal cord.
A form of gene therapy created and produced at the University of North Carolina at Chapel Hill and approved by the U.S. Food and Drug Administration has been given to children with a rare, inherited neurological disorder.
Study led by University of North Carolina Scientist records world's slowest spontaneous biological reaction, 1 trillion years. Study highlights enzyme catalysis power and holds implications for life's beginnings and targeted drug design.
New research led by a University of North Carolina at Chapel Hill scientist shows for the first time how Mycobacterium tuberculosis, the germ responsible for TB, uses a system for releasing proteins to help it survive the lungs' immune defenses to spread and cause disease.
A study at the University of North Carolina at Chapel Hill offers the first molecular explanation of how the body metabolizes and detoxifies cocaine and heroin. Implications for cocaine overdose therapy and detoxifying chemical weapons,including nerve agents.
A new bio-artificial technology in clinical tests at the University of North Carolina at Chapel Hill and several other centers nationally may help extend the lives of acute liver failure patients and may even allow the damaged liver to heal itself completely.
Researchers at the University of North Carolina at Chapel Hill School of Medicine have helped identify a large, undetected epidemic of the sexually transmitted disease chlamydia in China.
New research at the University of North Carolina at Chapel Hill offers an important contribution to a new wave of thinking in genetics: the idea that not all human disease states are due to alterations in DNA sequence.
For the first time, scientists have identified a specific molecular pathway within cells that becomes mutated by ultraviolet light exposure, thereby speeding up melanoma development.
Researchers at the University of North Carolina at Chapel Hill School of Medicine have found that people with gene mutations associated with abnormally high iron levels are 40 percent more likely than others to develop colon cancer.
In three separate studies, scientists at the University of North Carolina at Chapel Hill School of Medicine have shown that it is possible to correct defective molecular splicing pathways that would otherwise contribute to cancer, genetic diseases and possibly other disorders.
Genetically altered adult liver stem cells cloned from a male rat can turn into functional adult bone marrow cells in female mice. The accomplishment may prove useful for tapping potential for tissue repair using human adult stem cells.
University of North Carolina at Chapel Hill researchers report a 50 percent reduction in the number of deaths among kidney hemodialysis patients who are given a new drug that helps prevent excess phosphorus from accumulating in the bloodstream.
New research at the University of North Carolina sheds light on the process that silences a group of genes in the developing embryo. Down regulation of gene expression or "gene silencing" is considered crucial for normal development, including limb formation.
The NIH has designated the University of North Carolina at Chapel Hill one of 10 medical centers nationwide to participate in the Adult to Adult Living Donor Liver Transplant Cohort Study focusing on factors influencing outcomes for donors and recipients.
For the first time, scientists at the University of North Carolina at Chapel Hill have discovered similar gene activity profiles between a herpes virus that affects rhesus macaque monkeys and a human herpes virus linked to Kaposi's sarcoma.
A combination treatment with peginterferon alfa-2a (Pegasys) - a new long-acting interferon drug - and an antiviral medication is more beneficial than the standard combination therapy for people with the most-difficult-to-treat and most common strain of hepatitis C.
Scientists for the first time have engineered a harmless virus to correct, rather than replace, the genetic defect causing the most common single gene disorder.The new research presents a novel approach to gene therapy in treating the most common inherited anemias: the thalassemias.
Scientists at the University of North Carolina at Chapel Hill have found evidence indicating that the standard vaccine against smallpox confers long-term immunity.
The collaboration between cardiologist and orthopedist may at first seem novel, if not odd. But just such an interdisciplinary connection at the University of North Carolina at Chapel Hill has yielded potentially useful fruit: a bioengineered, rhythmically beating experimental model of a heart muscle.
New research at the University of North Carolina at Chapel Hill has found that a fatty molecule on the surface of platelet cells is a regulator of blood coagulation.
Scientists at the University of North Carolina have successfully treated mice with hemophilia A using a new approach to gene therapy - RNA trans-splicing. The experimental procedure repairs a mutated section of the gene responsible for hemophilia A, a hereditary bleeding disorder.
Scientists at the University of North Carolina at Chapel Hill have discovered another facet to the molecular engine that targets cell proteins for elimination.
The number of people living with Alzheimer's disease will at least double by 2050 even if major treatment breakthroughs should occur over the coming decades, according to a report from the University of North Carolina.
The University of North Carolina at Chapel Hill School of Medicine has been granted $1.5M to join seven other medical centers around the country to determine if African-Americans respond less well to anti-viral drug therapy for hepatitis C infection than Caucasians.
Dr. Richard V. Wolfenden, Alumni Distinguished Professor of Chemistry, Biochemistry & Biophysics at the University of North Carolina at Chapel Hill was elected to the National Academy of Sciences and the American Academy of Arts and Sciences, April 30th.
A software grant from SAS to the UNC Center for AIDS Research for data warehousing is also yielding valuable patient care benefits.
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