Long-term survival results from a breast cancer treatment study begun in 1992 at the University of North Carolina at Chapel Hill's Lineberger Comprehensive Cancer Center strongly favor chemotherapy followed by surgery for women with large, locally advanced tumors.
Dr. Larysa H. Pevny, assistant professor of genetics at the UNC-Chapel Hill School of Medicine and a member of the UNC Neuroscience Center has won a five-year federal grant to advance her laboratory's studies of a trio of genes involved in regulating neural stem cells.
Scientists for the first time have identified a protein that plays a double-agent role in the war between plants and disease-causing bacteria. The plant protein, RIN4, interacts with invading pathogen molecules and a protein in the plant's disease resistance strategy.
New research suggests a possible clue to why female recreational athletes who play basketball, soccer or volleyball tear a ligament of the knee at significantly greater rates than males. The findings offer a basis for shaping effective injury prevention training programs for female athletes.
New research that arose from a serendipitous laboratory observation could resolve a scientific mystery, the fact that some people become less able to fight HIV infection despite having a high number of "killer" immune cells circulating in the blood.
New research in yeast cells may have pinpointed a key enzyme in the molecular circuitry that silences genes. The new enzyme, Set2, could prove critical for helping regulate gene expression in the ordered cycle of growth and division common to all living cells that have a nucleus.
The Neuroscience Center at the University of North Carolina at Chapel Hill School of Medicine was awarded $1.7M from the National Institutes of Health to study factors affecting nerve growth and regeneration.
The University of North Carolina's Department of Psychiatry is expanding its multicenter national effectiveness trial of anti-psychotic medications for schizophrenia and behavioral problems in Alzheimer's disease to include a newly-approved drug.
A brain protein linked to narcolepsy, the sudden, uncontrollable and inexplicable onset of sleep, helps regulate bodily sensations.
A new cellular protein discovered by scientists at the University of North Carolina at Chapel Hill appears to be a crucial molecular component of a master switch that turns genes on and off. The new molecule may prove critical to the regulation of gene expression.
The Gene Therapy Center at the University of North Carolina at Chapel Hill School of Medicine will receive $9.2M over five years from the National Heart, Lung and Blood Institute of the National Institutes of Health.
Cardiologists from the University of North Carolina at Chapel Hill, the Duke Clinical Research Institute and other leading medical centers officially launched a 60,000-patient project aimed at encouraging physicians to follow published practice guidelines for high-risk acute cardiac patients.
Children who grow up breathing polluted air may be at increased risk of lung disease, according to a standard X-ray and CT scan study of school-age children in Mexico.
A new class of non-aspirin pain medicine now widely prescribed for arthritis symptoms may impair ligament healing associated with sprains, according to laboratory findings at the University of North Carolina at Chapel Hill.
A method for delivering an oxygen-carrying fluid to resuscitate the heart after cardiac arrest may help save trauma victims by buying valuable time to allow surgeons to repair the damage.
A new, more efficient cardiac monitoring system is helping improve the care of critically ill patients. It continuously monitors the heart's output without exposing patients to the risks of pulmonary artery catheterization to obtain crucial cardiac readings.
A new study at the University of North Carolina at Chapel Hill School of Medicine offers new hope for habitual snorers and those who must endure their nighttime cacophonies.
Scientists from the University of North Carolina schools of medicine and pharmacy have teamed up to develop a new way to calculate the stability of cellular proteins. The research could eventually have an impact on the way proteins for new drug development are designed and engineered.
Avoidance of certain foods before taking a commonly recommended screening test for colon cancer may not be necessary, according to a report from the University of North Carolina at Chapel Hill.
An experimental cancer drug's promising results in a small number of patients with the blood-borne disease multiple myeloma are prompting a larger clinical trial at major cancer centers, including the Lineberger Comprehensive Cancer Center at the University of North Carolina at Chapel Hill.
A gene discovered by scientists at the University of North Carolina at Chapel Hill appears to be crucial for female embryo survival. The study furthers the understanding of a fundamental biological process in mammals.
Richard C. Boucher, MD, Kenan Professor of Medicine at the University of North Carolina at Chapel Hill was among the top ten in federal funding among principal investigators doing basic research last year, according to the National Institutes of Health.
New findings from a large international study led by researchers at the University of North Carolina at Chapel Hill suggest that a combination treatment with a new long-acting interferon drug and an antiviral medication may be more effective than the current standard of care for hepatitis C.
Along with derailing the body's rapid disposal of dying cells, defective functioning of a gene identified at the University of North Carolina at Chapel Hill also may contribute to tissue inflammation and the development of autoimmune diseases such as systemic lupus erythematosus.
Scientists at the University of North Carolina at Chapel Hill are using a new way to study how heart muscle cells communicate electrical and chemical messages.
Hospitals can significantly improve the care of people 65 years and older who are admitted for a heart attack by adopting specific treatment guidelines shown by research to be highly effective, according to findings at UNC-Chapel Hill School of Medicine.
Scientists have developed a new working model of cell membrane fusion. The model, which mimics the biochemical machinery of fusion in mammalian nerve membranes, offers researchers guidance for studying the biophysics of a process fundamental to all life.
Hormone replacement therapy may be most effective in lowering the risk of hypertensive heart disease if begun in the first five years after menopause, according to a new study. The heart condition is tied to high blood pressure.
The University of North Carolina at Chapel Hill School is one of nine centers nationally trying to determine if injections of a genetically modified common cold virus may be an effective treatment for recurrent head and neck cancer.
A new use for magnetic resonance imaging may reduce brain damage from stroke and save lives, according to a study led by a scientist at the University of North Carolina at Chapel Hill.
New research on the tick-borne bacteria responsible for Lyme disease likely will make scientists think differently about how to develop a more effective vaccine. (Proceedings of the National Academy of Sciences, 1-16-01)
New research at the University of North Carolina at Chapel Hill points to a key role played by a molecular protein in the way body cells maintain quality control when under stress. The findings add new insights into molecular changes involved in heart attack, heart failure, stroke and some common neurological disorders. (Nature Cell Biology, 1-01)
People diagnosed with first-episode schizophrenia may fare much better when treated with newer anti-psychotic drugs than with traditional medications that were first introduced over forty years ago.
Scientists at the University of North Carolina at Chapel Hill for the first time have identified the three dimensional crystal structure of two cellular proteins that when bound together play a key role in triggering the spread of cancer cells. (Nature, 12-7-00)
For the first time, scientists at the University of North Carolina at Chapel Hill have used a gene-therapy technique in animals to continually produce very high amounts of a clotting protein similar to that lacking in people with hemophilia. (Molecular Therapy, 12-4-00)
New laboratory research at the University of North Carolina at Chapel Hill appears to kindle prospects of finding ways to treat head and neck cancer with gene therapy. (Human Gene Therapy, 11-20-00)
After studies spanning more than a decade, scientists at the University of North Carolina at Chapel Hill have become the first to identify and purify hepatic stem cells, progenitor cells capable of regenerating liver and bile duct tissue. (National Academy of Sciences, 10-24-00)
Cancer tumors with cells low in oxygen often survive despite treatment. A novel method of identifying these hypoxic tumors may lead to a greater understanding of treatment resistance and more effective prediction of treatment outcome.
A California researcher became the first winner of an annual national prize endowed by a distinguished scientist at the University of North Carolina. The prize is for an outstanding scientific contribution to the field of neuroscience.
A groundbreaking $5M federal grant to the University of North Carolina at Chapel Hill School of Medicine could help researchers find the cause of an often debilitating blood vessel inflammation of the kidneys, lungs, skin, heart, and other organs.
The Center for Alcohol Studies at the University of North Carolina at Chapel Hill is developing an educational program for middle-school students about alcohol-related birth defects.
A husband-wife scientist team from Duke University and the University of North Carolina at Chapel Hill have developed a computerized interactive learning tool that simulates laboratory experiments on nerve cells.
Children who survive a condition at birth in which their lungs are too stiff to saturate their blood with enough oxygen may be at increased risk for progressive hearing loss and need periodic hearing tests, according to a University of North Carolina at Chapel Hill physician (Archives of Otolaryngology, 8-00).
A protein discovered at the University of North Carolina at Chapel Hill appears to play a key role in determining the shape of cells and allowing them to move. It may influence cancer spread, wound healing, brain development, and embryo implantation in the uterus (Journal of Cell Biology, 8-7-00).
The University of North Carolina at Chapel Hill School of Medicine won a highly competitive federal grant for helping young faculty build research careers in women's health.
New research at the University of North Carolina at Chapel Hill shows that men infected with HIV will more rapidly develop AIDS if they use strategies of denial to cope with the disease threat.
Proteins missing from cells lining the wombs of women with endometriosis may help explain their infertility, according to findings from a study headed by a University of North Carolina at Chapel Hill scientist.
Doctors at the University of North Carolina have opened their first clinical trial of a vaccine treatment for advanced breast cancer.
HIV, the virus that causes AIDS, may be adapted for use in gene therapy to treat genetic diseases and disorders of the immune system, even including AIDS, according to a scientist at the University of North Carolina at Chapel Hill.
In research carrying implications for human disease development, University of North Carolina scientists and others have linked gene defects to the inability of cells to repair damaged DNA (Cell, 4-13-00).
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