PAGER-CoV is a database packed with nearly 12,000 (so far) pieces of genetic information on the SARS-CoV-2 virus, information that researchers and physicians can use to tailor treatments against the disease.
Researchers inactivated the gene for CHD7 — whose mutation causes congenital birth defects — in mouse embryos, and then rigorously probed how this change in developing cardiac neural crest cells caused severe defects in the outflow tract and great arteries, leading to perinatal lethality.
Maryland-based Altimmune Inc., a clinical stage biopharmaceutical company, has submitted an Investigational New Drug, or IND, application to the United States Food and Drug Administration to commence a Phase 1 clinical study of its single-dose intranasal COVID-19 vaccine candidate, AdCOVID.
Mask orders. Constant cleaning. Quarantine. The COVID-19 pandemic has completely changed how many people live. This can be especially true for older adults. As one of the most at-risk populations for COVID-related complications, many older adults have been forced to isolate themselves, causing decreased physical and mental activity.
Researchers have discovered a previously undescribed set of neurons called saccade-vergence burst neurons that help control our eyes as they view in three-dimensional space. Models had predicted the existence of such neurons, which are in the mid-brain’s central mesencephalic reticular formation.
During the COVID-19 pandemic, the sickest patients at the University of Alabama at Birmingham Hospital have had their troubles eased, however briefly, thanks to an innovative musical project. Helping those patients recover — and keeping their spirits up amid the isolation the virus requires — is the motivation for the project, an effort between UAB health care staff and the Alabama Symphony Orchestra.
People with multiple depressive symptoms have an increased risk for stroke, with new findings showing that individuals who scored higher on a test designed to measure depressive symptoms had a higher stroke risk than those with lower scores.
Transplanting cadaver pancreatic islets is a promising therapy for Type 1 diabetes, but a reactivated autoimmunity means low graft viability after five years. Research now shows that a protective coating of two biopolymers can delay allograft and autoimmune-mediated rejection in mouse models of T1D.
A new study published in the Mayo Clinic Proceedings: Innovations, Quality & Outcomes by University of Alabama at Birmingham researchers showed that Black individuals have a disproportionately higher COVID-19 mortality burden across all of the United States, which is driven by a high incidence of COVID-19 infection. They found that there are key geographic differences in the distribution of health determinants and COVID-19 mortality patterns.
For many rural Americans, especially those in the South or Southeastern areas of the country, it is taking longer to get to a hospital. Delays in reaching appropriate health care facilities could have a profound negative effect in cases of medical emergency.
UAB’s uterus transplant program is the first in the Southeast and fourth in the United States.
An inhaled monoclonal antibody treatment against the SARS-CoV-2 virus may lead to self-administered therapy for COVID-19, according to preclinical tests. It was discovered at UAB and the Texas Biomedical Research Institute, and it has been licensed for development to Aridis Pharmaceuticals.
A COVID-19 vaccine candidate that underwent extensive preclinical testing this spring and summer shows potent preclinical immune responses — including several that distinguish it from other COVID-19 vaccine approaches — according to a preprint deposited in the BioRxiv repository.
Reports that some young athletes testing positive for COVID-19 also had increased rates of heart swelling have concerned sports medicine physicians around the country, concerned about the possible impact of myocarditis, a potentially fatal heart condition.
Research in pigs shows that using the exosomes naturally produced from a mix of heart muscle, endothelial and smooth muscle cells — all derived from human induced pluripotent stem cells — yields regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells.
Researchers combined a lung-epithelial cell host interactome with a SARS-CoV-2 interactome. Network biology analysis of this human/SARS-CoV-2 interactome revealed potential molecular mechanisms of pathogenesis for SARS-CoV-2, the virus responsible for the COVID-19 pandemic.
A new study published in Circulation by University of Alabama at Birmingham researchers showed that Black heart failure patients have worse prognoses even after achieving biomarker-based treatment goals.
Inflammatory lipid signaling may provoke the autoimmune disease Type 1 diabetes. Researchers have identified a proinflammatory lipid profile that precedes development of T1D in a mouse model and in children under age 15 who are at high risk for T1D. These lipids may be therapeutic targets.
After nearly 15 years on an upward trend, awareness among Americans about their high blood pressure and rates of blood pressure control are now on the decline. many groups, including older adults and Black adults, are less likely than they were in earlier years to control their blood pressure.
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