Researchers at UC Davis and UC San Francisco have found a way to teach a computer to precisely detect one of the hallmarks of Alzheimer’s disease in human brain tissue, delivering a proof of concept for a machine-learning approach to distinguishing critical markers of the disease.
Memory training game may help people with fragile X and other intellectual disorders.
A major new study from the UC Davis Alzheimer’s Center has uncovered dramatic differences in the brains of Hispanics with a dementia diagnosis compared with those of non-Hispanic whites and of African Americans.
Fear of psychiatric hospitalization is one of the primary reasons that older men -- an age and gender group at high risk for suicide -- don’t talk about suicide with their physicians. Researchers discovered this finding as part of a pre-launch, stakeholder assessment of a multimedia program designed to encourage men to open up to their primary care providers about suicidal thoughts.
High-risk younger siblings of children with autism are less likely to be diagnosed with autism spectrum disorder (ASD), have significantly lower autism symptom severity, and higher cognitive scores if their mothers take maternal prenatal vitamins during their first month of pregnancy, UC Davis research has found.
Radiologists quickly learn to read 3D mammography more accurately than they read standard 2D mammograms, a first-of-its-kind study by a UC Davis researcher has found. Published today in Radiology, the study led by Diana Miglioretti, UC Davis dean’s professor of biostatistics, found that radiologists who interpret traditional mammograms, which are two-dimensional, required little start up time for transitioning to reading digital breast tomosynthesis (DBT), or 3D mammography, with improved screening accuracy
Breakthrough research demonstrating that children with autism as young as 18 months can vastly improve their language, cognition and social skills with an early intervention developed by UC Davis Professor Sally Rogers has been replicated in a major new study.
Researchers at MIND Institute at UC Davis and Rush University Medical Center have found that mavoglurant, an experimental drug known as an mGluR5 negative modulator, can positively modify a key characteristic behavior in individuals with fragile X syndrome (FXS).
Dr. Meghan Miller of the UC Davis MIND Institute talks about her paper, published in JAMA Pediatrics, about the risk of younger siblings of children with autism or ADHD for either or both disorders.
Later-born siblings of children with autism spectrum disorder (ASD) or attention-deficit/hyperactivity disorder (ADHD) are at elevated risk for both disorders, a new study led by Meghan Miller, assistant professor in the Department of Psychiatry and Behavioral Sciences and at the UC Davis MIND Institute, has concluded. The findings appear today in JAMA Pediatrics.
A groundbreaking new study by UC Davis researchers has uncovered why obesity both fuels cancer growth and allows blockbuster new immunotherapies to work better against those same tumors. The paradoxical findings, published today in Nature Medicine, give cancer doctors important new information when choosing drugs and other treatments for cancer patients.
Researchers at the UC Davis MIND Institute and the University of North Carolina have shown for the third time that an increased amount of extra-axial cerebrospinal fluid (CSF) is associated with the diagnosis of autism spectrum disorder in young children. The ability to identify ASD children early could improve both treatment and quality of life. The study was published in the journal The Lancet Psychiatry.
UC Davis Comprehensive Cancer Center has received a $6.3 million grant from the National Cancer Institute’s (NCI) Center to Reduce Cancer Health Disparities for a 5-year study to tease out why some ethnic and racial minority groups fare worse than whites when they get cancer and to find more precise treatments to improve their chances of survival.
Investigators at the UC Davis MIND Institute and NeuroPointDX, a division of Stemina Biomarker Discovery, have identified a group of blood metabolites that could help detect some children with autism spectrum disorder (ASD). Part of the Children’s Autism Metabolome Project (CAMP), the largest metabolomic ASD study ever attempted, these findings are a key step toward developing an ASD biomarker test. The research was published September 6 in the journal Biological Psychiatry.
A comprehensive analysis of eight clinical trials and four cohort studies on cervical cancer screening by researchers from UC Davis and Kaiser Permanente Northwest has found that while Pap smears are still highly effective for detecting pre-cancerous cells and cancer, testing for the virus that causes these cancers also is an excellent screening tool.
Researchers at UC Davis, Genentech and Foundation Medicine are the first to show that a blood-based test to assess tumor mutational burden (TMB) accurately identifies non-small cell lung cancer (NSCLC) patients who could benefit from immunotherapies called checkpoint inhibitors. The blood test offers a much less invasive and more repeatable alternative to tissue testing. The study was published online today in Nature Medicine.
Humanpapilloma virus (HPV) is now the leading cause of certain types of throat cancer. Dr. Michael Moore, director of head and neck surgery at UC Davis and an HPV-related cancer expert, answers some tough questions about the trend and what can be done about it.
Can a new mouse model provide essential insights into one type of autism spectrum disorder? UC Davis researchers hope their work yields new therapies for children.
Migraine headaches can strike any time and be debilitating, making it impossible to work or enjoy even life’s simple pleasures. They affect approximately 12 percent of the population living in the U.S. and are three times more prevalent in women than men. The neurology team at UC Davis provides excellent care and outcomes for migraine sufferers. In this Q&A Marc Lenaerts, director of outpatient neurology and a headache medicine specialist, discusses the condition and how to manage it.
Researchers at UC Davis have confirmed that autologous hematopoietic stem cell transplant improves survival for people suffering from multiple myeloma, yet many potentially eligible patients never undergo the procedure.
What You Can Do, launched today by the UC Davis Violence Prevention Research Program, offers information and support for providers looking for ways to reduce firearm injury and death, particularly among patients at elevated risk.
Researchers at the UC Davis MIND Institute have found that children with autism spectrum disorder (ASD) have reduced immune system regulation, as well as shifts in their gut microbiota. The immune deregulation appears to facilitate increased inflammation and may be linked to the gastrointestinal issues so often experienced by children with ASD. The research was published in the journal Brain, Behavior, and Immunity.
In a striking new finding, researchers at the UC Davis MIND Institute found that typically-developing children gain more neurons in a region of the brain that governs social and emotional behavior, the amygdala, as they become adults. This phenomenon does not happen in people with autism spectrum disorder (ASD). Instead, children with ASD have too many neurons early on and then appear to lose those neurons as they become adults. The findings were published today in the journal Proceedings of the National Academy of Sciences (PNAS).
Researchers at UC Davis have shown that patients with acute myeloid leukemia (AML) who received their care at a National Cancer Institute (NCI) cancer center in California had a dramatically reduced risk of early mortality. Using data from the California Cancer Registry and the Patient Discharge Dataset, the team determined that the risk was reduced by 53 percent. These findings were reported in February in the journal Cancer.
UC Davis pathologist Hooman Rashidi is an expert in blood disorders but also a computer programmer. He has married the two disciplines and created must-have learning tools for medical students and residents. His latest is HemeQuiz1, a medical student training app.
In a commentary published in the Jan. 4 issue of the New England Journal of Medicine, UC Davis researcher William Murphy expressed cautious optimism about efforts to genetically engineer hematopoietic stem cells (HSCs) to temporarily resist cell death during transplantation. While these gene therapy approaches could dramatically improve patient outcomes, Murphy argues that their risks must be carefully studied in diverse models.
For many, breast cancer is more than just a disease – it’s personal. One in eight women will be diagnosed with breast cancer at some point in their lives.
Researchers at UC Davis and other institutions have shown that mothers who take recommended amounts of folic acid around conception might reduce their children’s pesticide-related autism risk.
The UC Davis MND Institute has been awarded a 5-year, $12 million Autism Centers of Excellence (ACE) grant, one of five in the nation, to create a “Center for the Development of Phenotype-based Treatments of Autism Spectrum Disorder.”
In two papers published in the Journal of the National Cancer Institute researchers from UC Davis, UCLA and other institutions have found that peripheral neuropathy, which causes pain, numbness, and tingling in hands and/or feet, can bother early-stage breast cancer patients years after completing chemotherapy. In addition, a systematic literature review found only a handful of studies that tracked long-term peripheral neuropathy, leaving little data for patients and clinicians to make informed decisions.
Breast Cancer Surveillance Consortium (BCSC) investigators have received a $17 million program project grant renewal from the National Cancer Institute to study the effectiveness of different breast cancer screening and surveillance strategies using digital mammography, digital breast tomosynthesis (3D mammography), and breast MRI. Co-led by UC Davis researcher Diana Miglioretti, the consortium seeks to ensure that women get personalized care based on their individual risk and preferences.
With its internationally renowned school of veterinary medicine and its NCI-designated comprehensive cancer center, UC Davis is uniquely positioned to harness the power of each to tackle one of life’s greatest challenges: cancer.
Second cancers in children and adolescents and young adults (AYA) are far deadlier than they are in older adults and may partially account for the relatively poor outcomes of cancer patients ages 15-39 overall, a new study by UC Davis researchers has found."Second Primary Malignant Neoplasms and Survival in Adolescent and Adult Cancer Survivors" is published today in JAMA Oncology.
In a new study published today in JCI Insight, UC Davis researchers have shown that combining high-intensity focused ultrasound with two immunotherapies (a PD-1 checkpoint inhibitor and TLR9 agonist) can produce excellent response rates in mouse models of epithelial cancer. They also found that, for the combination to be effective, immunotherapies must come first.
Researchers from the UC Davis MIND Institute, University of North Carolina (UNC) and other institutions have found that altered distribution of cerebrospinal fluid (CSF) in high-risk infants can predict whether they will develop autism spectrum disorder (ASD). The study appears today in the journal Biological Psychiatry.
In two recent studies, researchers at UC Davis have shown that placental tissue can provide critical information about the epigenetic landscape that influences fetal development.
Recognizing a critical need to improve national vaccination rates for the human papillomavirus (HPV), UC Davis Comprehensive Cancer Center has again united with each of the 69 National Cancer Institute (NCI)-designated cancer centers in issuing a joint statement in support of recently revised recommendations from the U.S. Centers for Disease Control and Prevention (CDC)
For the first time, researchers have found higher levels of Gram-negative bacteria antigens in brain samples from late-onset Alzheimer’s disease patients. Compared to controls, patients with Alzheimer's had much higher levels of lipopolysaccharide (LPS) and E coli K99 pili protein. In addition, The UC Davis team also found LPS molecules congregated with amyloid plaques, which have been linked to Alzheimer’s pathology and progression. The research was published today in the print edition of the journal Neurology.
Patients with disseminated advanced cancer who undergo surgery are far more likely to endure long hospital stays and readmissions, referrals to extended care facilities and death, UC Davis researchers have found.
Painful sex in women after cancer treatment is relatively common, often treatable and needs to be addressed by medical providers, a UC Davis oncologist and researcher suggests.
Researchers at the UC Davis MIND Institute have found that a battery of tests appears to have strong potential for measuring cognitive changes over time for people with intellectual disabilities. The work could open new doors to research into whether drugs and specialized educational programs or treatments can improve function in people with Down syndrome, fragile X syndrome and other causes of intellectual disabilities.
Treatment with sertraline may provide nominal but important improvements in cognition and social participation in very young children with fragile X syndrome, the most common genetic cause of intellectual disability and the leading single-gene cause of autism, a study by researchers with the UC Davis MIND Institute has found.
Hmong Americans are more likely to understand the importance of colorectal cancer screening and to get screened when they’re provided information by specially trained Hmong lay health educators, new research from UC Davis has found.
Researchers at UC Davis and Ionis Pharmaceuticals have developed a hybrid treatment that harnesses a monoclonal antibody to deliver antisense DNA to acute lymphoblastic leukemia (ALL) cells and that may lead to less toxic treatments for the disease.
A UC Davis researcher has created a video game for children who experience cognitive impairments from genetic disorders with the hope that that it will improve their ability to mentally process information about space and time.
Diana Miglioretti, UC Davis dean’s professor of biostatistics and an internationally recognized breast cancer screening expert, has received $7.5 million to determine the effectiveness of two supplemental breast screening and diagnostic workup strategies -- digital breast tomosynthesis (3D mammography) and magnetic resonance imaging (MRI) -- used with mammography for cancer detection. Miglioretti’s team also will work to determine whether effectiveness of the screening strategies depends on a woman’s breast density.
Researchers at UC Davis have shown that docosahexaenoic acid (DHA), a fatty acid commonly found in fish and fish oil supplements, reduces renal cell carcinoma invasiveness, growth rate, and blood vessel growth when combined with the anti-cancer therapy regorafenib. The study was published in the May issue of the journal Molecular Cancer Therapeutics.
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