An estimated 5.3 million people in the U.S. suffer from Alzheimer’s disease (AD). The five current FDA-approved AD medications only help mask the disease symptoms instead of treating the underlying disease. In a new study, researchers used IRL-1620, a chemical that binds to endothelin B receptors, to treat AD in rats.
No cures exist for amyotrophic lateral sclerosis (ALS), and the only approved therapy slows the progression by only a few months. A new study identifies a promising unexplored avenue of treatment for ALS, the endothelin system.
Endothelin (ET) plays a role in many functions throughout the body, including blood vessel constriction and blood pressure regulation, and insights gained through the study of ET have great therapeutic potential for health and disease. As ET experts convene for the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics, the translational aspect of ET research will take center stage during the “Endothelin Therapeutics—Where Are We?” symposium.
Endothelin is a peptide produced by cells in the blood vessels and has powerful vessel-constricting effects. Although mainly associated with its role in blood pressure control and cardiovascular diseases, it continues to appear in other physiological functions and diseases. This symposium will discuss its roles in diabetes, cognitive decline, sickle cell disease and skin pigmentation.
CPAP machines are a common treatment for obstructive sleep apnea, but some people have a hard time adjusting and do not continue the treatment or are reluctant to start. A new study shows that CPAP is an effective sleep apnea treatment, finding that it reverses health changes that result in cardiovascular disease if the disorder is left untreated.
Babies born through assisted reproductive technologies (ART) are at increased risk of cardiovascular disease later in life. In new research published ahead-of-print in AJP-Heart, researchers find that the solution used to culture ART embryos may play a role and that adding melatonin to the culture solution could help improve cardiovascular outcomes.
Mostly associated with male reproduction, advances in genomic sequencing have revealed a new set of roles for the Y chromosome. In a new review article in Physiological Genomics, researchers summarize the influence of the Y chromosome in male disease risk.
A new study in Journal of Neurophysiology uses a novel approach to identify potential drug targets for treating fibromyalgia, This study is published ahead-of-print.
A protein found in dairy is discovered to be a prebiotic that holds promise for treating gastrointestinal conditions and obesity. This study is published ahead-of-print in the American Journal of Physiology—Gastrointestinal and Liver Physiology.
Statins have significant cardiovascular benefits, but also serious side effects. A new study finds that statin use impairs stem cell function, which helps in slowing atherosclerosis but hinders other body processes. Because of these effects, the study supports weighing individual risk when considering statins as a preventive measure.
APS will host the 14th International Conference on Endothelin: Physiology, Pathophysiology and Therapeutics on September 2–5 in Savannah, Ga. The meeting will convene leading global researchers who study endothelin—a type of powerful peptide that constricts blood vessels, raises blood pressure and controls many other cellular functions throughout the body.
Many lifestyle factors cause heart disease, and exercise may not be enough to prevent heart attacks. A new study shows that regular exercise can still benefit the heart after a heart attack occurs. This research is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program.
A new review article published in the American Journal of Physiology–Endocrinology and Metabolism explores the effects of the “ingredients” of Mediterranean lifestyle as a whole on post-meal blood triglyceride levels (PPL). Consistently elevated PPL is a cardiovascular disease risk factor. This article is published ahead of print.
A clinical study finds that regular consumption of beet juice had positive cardiovascular effects on subjects during exercise and led to increased endurance. The study is published ahead of print in the American Journal of Physiology - Regulatory, Integrative and Comparative Physiology.
A new review article finds that post-traumatic stress disorder (PTSD) leads to overactive nerve activity, dysfunctional immune response and activation of the hormone system that controls blood pressure. These changes can ultimately increase risk of cardiovascular disease.
New research reports that diabetes drug metformin can treat portal hypertension--high blood pressure in the liver resulting from cirrhosis. This study adds to the growing body of evidence showing that use of metformin goes beyond treating type 2 diabetes.
Omega-3 fish oil is a popular supplement because of its perceived cardiovascular benefits, but the scientific evidence has been conflicting. New research in Physiological Reports supports the claims for seniors, finding that healthy seniors who took omega-3 supplements every day had better cardiovascular health after 12 weeks of use.
New research shows that cardiovascular disease conditions trigger pathways that protect the blood vessels. The response may be a new therapeutic strategy for cardiovascular disease. This research is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program.
Vanderbilt University researchers have found embryonic brown fat transplants reversed type 1 diabetes and restored glucose tolerance to normal in non-obese diabetic mice. The research is published in the American Journal of Physiology–Endocrinology and Metabolism and was selected as an APSselect article for July.
Researchers find that nerve stimulation can improve the function of peripheral nerves damaged by spinal cord injury (SCI). This technique may be a new approach to preventing long-term changes in nerve and muscle function after SCI and improving SCI rehabilitation outcomes.This research is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program.
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