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15-Jan-2020 10:50 AM EST
Pathogenic Alzheimer’s disease cascade is activated by faulty norepinephrine signaling
University of Alabama at Birmingham

Preclinical research has revealed a key missing piece of the Alzheimer’s disease puzzle. That allowed proof-of-concept experiments — using an existing drug — that dramatically reduced Alzheimer’s pathology and symptoms in mouse models, potentially offering an immediate treatment for this disease.

Released: 8-Jan-2020 3:30 PM EST
Persistence of gut microbial strains in twins, living apart after cohabitating for decades
University of Alabama at Birmingham

Using a genomics strain-tracking bioinformatics tool, analyzed two metagenomic sequencing databases from pairs of twins — one for children who were still living together and the other from adult twins, ages 36 to 80, who then lived apart for periods from one to 59 years.

Released: 2-Jan-2020 3:05 PM EST
Extra benefit from epilepsy neurostimulators — reducing comorbid neuropsychiatric symptoms
University of Alabama at Birmingham

Researchers report cases of five epilepsy patients who found better treatments for deleterious neuropsychiatric symptoms like anxiety and depression using data collected — while the patients were at home — from implanted neurostimulators placed in their brains to control their epileptic seizures.

Released: 2-Jan-2020 12:35 PM EST
How to stay healthy while avoiding the dirtiest places at the gym
University of Alabama at Birmingham

During the colder months, many exercise routines transition indoors, especially in gyms. However, the gym may be one of the dirtiest places you walk into. Numerous studies have shown that gyms can be covered in cold and flu viruses, as well as E. coli, MRSA and other bacteria and virus strains that can make you sick. Learn how to avoid illnesses while staying leading a healthy lifestyle.

Released: 18-Dec-2019 2:25 PM EST
Cancer therapy may be aided by induced macropinocytosis, a rarely reported form of cell death
University of Alabama at Birmingham

A metabolic inhibitor was able to kill human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route — catastrophic macropinocytosis. The inhibitor acted synergistically with the chemotherapy drug, cyclophosphamide, in mouse xenografts to reduce tumor growth.

Released: 18-Dec-2019 11:25 AM EST
75 Million-Year-Old Sea Turtle Fossil Discovery Is a New Genus and Species That Sheds Light on the Evolution of Its Modern Relatives
University of Alabama at Birmingham

Scientists are racing to determine which genealogy most accurately represents the evolutionary history of sea turtles — a challenging proposition.

Released: 17-Dec-2019 10:10 AM EST
5 ways to be a healthy holiday party pro
University of Alabama at Birmingham

Lavish get-togethers with delicious treats by the sleigh-full will abound, but will that cause your waistline to bulge as well?

Released: 13-Dec-2019 10:20 AM EST
The smart-dumb question, a key to writing about — and understanding — immunology
University of Alabama at Birmingham

A New York Times journalist shared his key to reporting with a UAB honors seminar class. Both the reporter and the class want to understand how — for good or for bad — the human immune system works. UAB has one of the few in-depth undergraduate immunology programs in the nation.

Released: 5-Dec-2019 4:55 PM EST
Novel bioprinter shows potential to speed tissue engineering
University of Alabama at Birmingham

Researchers have found a way to speed engineered-tissue creation using a novel bioprinter built for $2,000, they report in the journal Micromachines. Building blocks for the tissue are pre-grown spheroids of human induced-pluripotent stem cells that contain 200,000 cells per spheroid.

Released: 5-Dec-2019 3:05 PM EST
Nearly one-third of participants drop out of psychosocial substance use disorder treatments
University of Alabama at Birmingham

People who abuse cigarettes, alcohol and/or heroin are less likely to drop out of a substance use disorder treatment than those who are addicted to cocaine, according to a new study led by a researcher at the University of Alabama at Birmingham. The study found that approximately 30 percent of participants in psychosocial substance use disorder treatments do not finish the programs. This is the first time a study of this kind has been published.

Released: 5-Dec-2019 2:05 AM EST
Can the state of Alabama conquer its biggest health challenges? It's a Grand Challenge, and one state university is determined to prevail
University of Alabama at Birmingham

For far too long, Alabama’s residents have seen their health statuses languish when compared to those of other states. Often, Alabama is a punchline when it comes to obesity, diabetes and the overall health of its people. But the consequences, unfortunately, are counted in decreased quality of life, increased health costs and lives lost — hardly a laughing matter.

Released: 4-Dec-2019 10:50 AM EST
UAB tops $600 million in research funding for first time
University of Alabama at Birmingham

One year after surpassing $500 million in research grant and award funding, University of Alabama at Birmingham faculty, staff and administration have hit another institutional milestone for the first time in its 50-year history — exceeding more than $600 million in research funding awards.

Released: 2-Dec-2019 3:40 PM EST
Model probes possible treatments for neonatal infection, a common cause of infant death
University of Alabama at Birmingham

In a new model for neonatal late-onset sepsis, or LOS, researchers show that disrupting the normal maturation of gut microbes can make newborn mouse pups highly susceptible to LOS. Giving the pups specific protective bacteria before a challenge with invasive bacteria prevented the deadly infection.

Released: 25-Nov-2019 12:15 PM EST
Tips for healthy living during the holidays
University of Alabama at Birmingham

UAB provides tips for healthy eating and staying active during the upcoming holidays.

   
Released: 21-Nov-2019 4:55 PM EST
Being aware of your surroundings — five helpful tips to reduce the chances of abduction
University of Alabama at Birmingham

UAB social work professor Stacy Moak provides best practices on avoiding abduction during the holiday season and every day of your life.

Released: 21-Nov-2019 3:15 PM EST
Germ-free lungs of newborn mice are partially protected against hyperoxia
University of Alabama at Birmingham

A novel newborn mouse model probes the effect of high oxygen concentration, or hyperoxia, on lung development of pups that are germ-free — with no microbes in their lungs. The model will show how different types of microbes that colonize human lungs at birth protect or make an infant more susceptible to life-threatening bronchopulmonary dysplasia.

Released: 20-Nov-2019 1:25 PM EST
Probing the role of an inflammation resolution sensor in obesity and heart failure
University of Alabama at Birmingham

After heart attack, ALX/FPR2 is activated by resolvin D1 in immune cells in the spleen and at the heart attack site. This speeds resolution of the heart injury. Research with mice that completely lack ALX/FPR2 reveals more about the pathways this resolution sensor uses to target inflammation.

Released: 12-Nov-2019 3:40 PM EST
Research points to possible target to treat idiopathic pulmonary fibrosis, or IPF
University of Alabama at Birmingham

In a study of idiopathic pulmonary fibrosis, or IPF, recruited macrophages with increased mevalonate-pathway flux were able induce lung fibrosis in mice without any prior lung injury. In humans, three hallmarks of the fibrosis mechanism were also found in bronchoalveolar cells from IPF patients.

Released: 11-Nov-2019 12:20 PM EST
Here’s a playbook for stopping deadly cytokine storm syndrome
University of Alabama at Birmingham

UAB pediatric rheumatologist Randy Cron gets calls from doctors around the globe asking if their patients have cytokine storm syndrome. Now he has co-authored the first textbook on this mysterious and deadly condition with his former trainee.



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