Preclinical research has revealed a key missing piece of the Alzheimer’s disease puzzle. That allowed proof-of-concept experiments — using an existing drug — that dramatically reduced Alzheimer’s pathology and symptoms in mouse models, potentially offering an immediate treatment for this disease.
Using a genomics strain-tracking bioinformatics tool, analyzed two metagenomic sequencing databases from pairs of twins — one for children who were still living together and the other from adult twins, ages 36 to 80, who then lived apart for periods from one to 59 years.
Researchers report cases of five epilepsy patients who found better treatments for deleterious neuropsychiatric symptoms like anxiety and depression using data collected — while the patients were at home — from implanted neurostimulators placed in their brains to control their epileptic seizures.
During the colder months, many exercise routines transition indoors, especially in gyms. However, the gym may be one of the dirtiest places you walk into. Numerous studies have shown that gyms can be covered in cold and flu viruses, as well as E. coli, MRSA and other bacteria and virus strains that can make you sick. Learn how to avoid illnesses while staying leading a healthy lifestyle.
A metabolic inhibitor was able to kill human cancer cells of the skin, breast, lung, cervix and soft tissues through a non-apoptotic route — catastrophic macropinocytosis. The inhibitor acted synergistically with the chemotherapy drug, cyclophosphamide, in mouse xenografts to reduce tumor growth.
Scientists are racing to determine which genealogy most accurately represents the evolutionary history of sea turtles — a challenging proposition.
Lavish get-togethers with delicious treats by the sleigh-full will abound, but will that cause your waistline to bulge as well?
A New York Times journalist shared his key to reporting with a UAB honors seminar class. Both the reporter and the class want to understand how — for good or for bad — the human immune system works. UAB has one of the few in-depth undergraduate immunology programs in the nation.
Researchers have found a way to speed engineered-tissue creation using a novel bioprinter built for $2,000, they report in the journal Micromachines. Building blocks for the tissue are pre-grown spheroids of human induced-pluripotent stem cells that contain 200,000 cells per spheroid.
People who abuse cigarettes, alcohol and/or heroin are less likely to drop out of a substance use disorder treatment than those who are addicted to cocaine, according to a new study led by a researcher at the University of Alabama at Birmingham. The study found that approximately 30 percent of participants in psychosocial substance use disorder treatments do not finish the programs. This is the first time a study of this kind has been published.
For far too long, Alabama’s residents have seen their health statuses languish when compared to those of other states. Often, Alabama is a punchline when it comes to obesity, diabetes and the overall health of its people. But the consequences, unfortunately, are counted in decreased quality of life, increased health costs and lives lost — hardly a laughing matter.
One year after surpassing $500 million in research grant and award funding, University of Alabama at Birmingham faculty, staff and administration have hit another institutional milestone for the first time in its 50-year history — exceeding more than $600 million in research funding awards.
In a new model for neonatal late-onset sepsis, or LOS, researchers show that disrupting the normal maturation of gut microbes can make newborn mouse pups highly susceptible to LOS. Giving the pups specific protective bacteria before a challenge with invasive bacteria prevented the deadly infection.
UAB provides tips for healthy eating and staying active during the upcoming holidays.
UAB social work professor Stacy Moak provides best practices on avoiding abduction during the holiday season and every day of your life.
A novel newborn mouse model probes the effect of high oxygen concentration, or hyperoxia, on lung development of pups that are germ-free — with no microbes in their lungs. The model will show how different types of microbes that colonize human lungs at birth protect or make an infant more susceptible to life-threatening bronchopulmonary dysplasia.
After heart attack, ALX/FPR2 is activated by resolvin D1 in immune cells in the spleen and at the heart attack site. This speeds resolution of the heart injury. Research with mice that completely lack ALX/FPR2 reveals more about the pathways this resolution sensor uses to target inflammation.
In a study of idiopathic pulmonary fibrosis, or IPF, recruited macrophages with increased mevalonate-pathway flux were able induce lung fibrosis in mice without any prior lung injury. In humans, three hallmarks of the fibrosis mechanism were also found in bronchoalveolar cells from IPF patients.
UAB pediatric rheumatologist Randy Cron gets calls from doctors around the globe asking if their patients have cytokine storm syndrome. Now he has co-authored the first textbook on this mysterious and deadly condition with his former trainee.
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