Latest News from: Johns Hopkins Medicine

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Released: 4-Sep-2002 12:00 AM EDT
Sugar-Based Therapies Could Prevent Damage from Kidney Failure
Johns Hopkins Medicine

Targeting sugars that occur naturally in the body could protect the kidneys or other organs from damage associated with disease or injury, according to a Johns Hopkins study.

30-Aug-2002 12:00 AM EDT
New Possibilities for Deadly Childhood Brain Cancer
Johns Hopkins Medicine

The most common brain cancer in children may have an Achilles' heel -- the signal from a protein called Hedgehog -- according to a report.

27-Aug-2002 12:00 AM EDT
Kidney Transplant Technique Prevents Rejection of Donated Organs
Johns Hopkins Medicine

Johns Hopkins physicians report an extraordinarily high success rate for kidney transplants among patients traditionally considered ineligible for the surgery.

Released: 21-Aug-2002 12:00 AM EDT
Brain Damage in Infants Not Always Tied to Delivery
Johns Hopkins Medicine

Neurological problems in newborns, including seizures, do not necessarily stem from delivery, a Johns Hopkins study demonstrates.

Released: 20-Aug-2002 12:00 AM EDT
Anti-Inflammatory Drug Reduces Growth of Cancerous Tumors in Rats
Johns Hopkins Medicine

Research led by a nurse investigator at Johns Hopkins has found that a pain reliever commonly used to treat serious and painful forms of arthritis may also reduce the growth of malignant tumors after cancer surgery.

Released: 16-Aug-2002 12:00 AM EDT
"Jumping Genes" Create Ripples in the Genome- -and Perhaps Species' Evolution
Johns Hopkins Medicine

Laboratory experiments led by Hopkins scientists have revealed that so-called "jumping genes" create dramatic rearrangement in the human genome when they move from chromosome to chromosome. If the finding holds true in living organisms, it may help explain the diversity of life on Earth.

Released: 7-Aug-2002 12:00 AM EDT
Structure of Key Receptor Unlocked
Johns Hopkins Medicine

After two years of stubborn persistence, scientists at Johns Hopkins have determined the 3-D structure of part of a protein called HER3, which should speed efforts to interfere with abnormal growth and cancer.

Released: 7-Aug-2002 12:00 AM EDT
Treatable Psychiatric Symptoms Common With Degenerative Brain Disease
Johns Hopkins Medicine

Potentially treatable psychiatric problems are common in patients with degenerative brain diseases affecting movement and coordination, according to a study by Johns Hopkins scientists. Up to 80 percent of those with either Huntington's disease or degenerative diseases affecting the cerebellum also suffer from depression, impaired thinking and changes in personality.

Released: 3-Aug-2002 12:00 AM EDT
Hopkins Scientists Unexpectedly Create Epilepsy In Rats
Johns Hopkins Medicine

One of the brain's most important chemical messengers has led Johns Hopkins School of Medicine researchers on a wild ride. Primarily interested in how and why nerve cells die in neurodegenerative diseases like Lou Gerhig's disease, the scientists now find themselves with a new rat model of epilepsy, a disease characterized not by cell death, but by rapid and uncontrolled "firing" of brain cells.

Released: 1-Aug-2002 12:00 AM EDT
Regulating Human X Chromosomes Doesn't Use Same Gene As In Mouse
Johns Hopkins Medicine

A gene thought to keep a single X chromosome turned on in mice plays no such role in humans, Johns Hopkins researchers report.

Released: 17-Jul-2002 12:00 AM EDT
Nerve Cells' Death Different from Other Cells'
Johns Hopkins Medicine

Hopkins-led researchers say they have identified in neurons a novel form of "programmed" cell death unlike those already known -- apoptosis and necrosis.

15-Jul-2002 12:00 AM EDT
Energy Blocker May Be Potential Liver Cancer Treatment
Johns Hopkins Medicine

A team of Johns Hopkins researchers has identified and successfully tested in animals a potential new treatment for liver cancer, a disease for which there are few effective treatments.

Released: 9-Jul-2002 12:00 AM EDT
Low Hemoglobin Means High Risk for Mobility Problems in Elderly Women
Johns Hopkins Medicine

The amount of oxygen-carrying hemoglobin circulating in the blood of older women could have an impact on the risk for mobility problems, Johns Hopkins physicians have found.

9-Jul-2002 12:00 AM EDT
Return to the Mouse to Overcome Some Obstacles in Working with Human Stem Cells
Johns Hopkins Medicine

Learning about human stem cells requires working with them, but some Johns Hopkins researchers are turning to a clever new mouse model to learn things the human cells can't teach them.

9-Jul-2002 12:00 AM EDT
Normal Gene Control Increases Chances Human Stem Cells Will Be Safe
Johns Hopkins Medicine

Johns Hopkins School of Medicine researchers have what is believed to be the first solid evidence that genes in human pluripotent stem cells and their progeny work normally.

7-Jul-2002 12:00 AM EDT
Hepatitis C Infection Does Not Alter HIV Progression or Treatment
Johns Hopkins Medicine

Resolving conflicting reports about the effect of hepatitis C virus infection on the progression of HIV disease, a Hopkins study of nearly 2,000 HIV patients shows that hepatitis C does not increase risk of death, accelerate the development of AIDS, or curb the value of antiretroviral HIV therapy.

Released: 2-Jul-2002 12:00 AM EDT
Medical News Tips From the Johns Hopkins Medical Institutions
Johns Hopkins Medicine

1) Golf Okay for most heart disease patients but could be dangerous for others; 2) Tennis gets an ace for holding off heart disease.

27-Jun-2002 12:00 AM EDT
Good News About Oral Contraceptives
Johns Hopkins Medicine

A new study reverses the long held notion that birth control pills increase a women's risk for breast cancer. Breast cancer experts at Johns Hopkins say these newest results confirm that taking birth control pills, even for a long time, does not appear to increase a woman's risk for breast cancer and reduces their risk for endometrial and ovarian cancers.

Released: 26-Jun-2002 12:00 AM EDT
Decision Making at the Cellular Level
Johns Hopkins Medicine

It's a wonder cells make it through the day with the barrage of cues and messages they receive and transmit to direct the most basic and necessary functions of life. Such cell communication, or signal transduction, was at least thought to be an "automatic" cascade of biochemical events. Now, however, a study has found that even before a message makes it through the outer cell membrane to the inner nucleus, the cell is busy activating a molecular switch to guide how the message will be delivered in the first place.

Released: 25-Jun-2002 12:00 AM EDT
Independent Study of "Next Generation" Ethics Issues in Stem Cell Research
Johns Hopkins Medicine

A pioneering Johns Hopkins stem cell expert and one of the institution's leading bioethicists have won a multi-year grant from the Greenwall Foundation to develop far-reaching recommendations on a "second generation" of ethical questions about stem cell research.

Released: 20-Jun-2002 12:00 AM EDT
Molecular "Stop Signs" May Hold Secret of Nerve Regeneration
Johns Hopkins Medicine

Using brain cells from rats, scientists at The Johns Hopkins University School of Medicine and the University of Hamburg have manipulated a molecular "stop sign" so that the injured nerve cells regenerate.

Released: 15-Jun-2002 12:00 AM EDT
Hair Loss Syndrome Created in Mice
Johns Hopkins Medicine

Inactivating just one of more than two dozen similar genes can cause temporary but profound hair loss, known as alopecia, in mice.

13-Jun-2002 12:00 AM EDT
Nasal Antibiotic Ointment Reduces Infection Risk After Surgery
Johns Hopkins Medicine

In what may be the largest clinical trial to evaluate the effectiveness of antimicrobial agents in preventing surgical wound and hospital-based infections caused by Staphylococcus aureus, scientists at the University of Iowa and Johns Hopkins found that an antibiotic ointment, called mupirocin, smeared inside the nose cut infection rates in half or better.

Released: 7-Jun-2002 12:00 AM EDT
Procedure to Cement Spine Now Simpler
Johns Hopkins Medicine

Johns Hopkins interventional radiologists have demonstrated that cement can be injected into the spine without prior, potentially dangerous dye studies.

Released: 4-Jun-2002 12:00 AM EDT
Domestic Violence Cause Long-Term Health Consequences for Women
Johns Hopkins Medicine

A Johns Hopkins University School of Nursing study concludes female victims of physical and/or sexual abuse have a significantly higher rate of common health problems, even after the abuse ends, compared to women who have never been abused.

Released: 1-Jun-2002 12:00 AM EDT
New Drug Shows Promise In Common and Lethal Form of Leukemia
Johns Hopkins Medicine

A new drug blocks the impact of a cancer-causing gene mutation found in a common and lethal form of leukemia, say researchers at the Johns Hopkins Kimmel Cancer Center.

Released: 31-May-2002 12:00 AM EDT
Cancer-Suppressing Protein is Part of Amoeba's Compass
Johns Hopkins Medicine

Researchers from the Johns Hopkins School of Medicine have learned that a protein that prevents the formation of cancerous tumors in animals also helps single-celled amoeba determine direction, particularly when moving toward a chemical attractant, an ability of many cell types in more complex creatures.

Released: 29-May-2002 12:00 AM EDT
Protein Causes Muscle Wasting Syndrome in Mice
Johns Hopkins Medicine

The Johns Hopkins researchers who first identified myostatin as a key restrictor of muscle growth in animals now report that excessive amounts of the protein in mice cause rapid and dramatic loss of both muscle and fat, without affecting appetite.

28-May-2002 12:00 AM EDT
Dietary Component Kills Bacterial Cause of Ulcers and Stomach Cancer
Johns Hopkins Medicine

A bacterium responsible for the vast majority of stomach cancers, a leading cause of cancer death worldwide, and ulcers may have met its match, scientists from Johns Hopkins and the French National Scientific Research Center report.

28-May-2002 12:00 AM EDT
Siliciano Named a Howard Hughes Medical Institute Investigator
Johns Hopkins Medicine

Johns Hopkins AIDS researcher and immunologist Robert F. Siliciano, M.D., Ph.D., has been named a Howard Hughes Medical Institute (HHMI) investigator. He is one of 12 physician- scientists recently selected by HHMI for their achievements in patient-oriented research.

Released: 22-May-2002 12:00 AM EDT
Henderson Commencement Speaker for Hopkins School of Medicine
Johns Hopkins Medicine

The Johns Hopkins University School of Medicine will award doctor of medicine degrees to 114 women and men from 25 states and six foreign countries at the commencement exercises May 23, 2002. The class is the 107th to graduate since the school opened in 1893. Johns Hopkins is among the most selective medical schools in the nation, with 4,654 applicants for 120 places for the freshman class this fall.

22-May-2002 12:00 AM EDT
Implantable Pain Pumps Improve Cancer Patients' Quality of Life
Johns Hopkins Medicine

An implantable pump that delivers pain medication in a slow-release fashion directly into the spinal fluid could greatly improve the pain relief, overall quality of life and survival for cancer patients living in pain, according to an international study completed at Johns Hopkins, the Medical College of Virginia and 25 other medical centers.

19-May-2002 12:00 AM EDT
Radiation Alone After Surgery Still the Standard for Head and Neck Cancer
Johns Hopkins Medicine

A preliminary study has found no advantage to adding chemotherapy to radiation after surgery for treating advanced head and neck cancer patients. The findings of the research, to be presented at the American Society of Clinical Oncology meeting May 18, appear to set aside earlier data suggesting that a combination of chemotherapy and radiation would improve the odds of staying cancer-free after surgery.

Released: 14-May-2002 12:00 AM EDT
Potential Therapy Reported For Children, Adults With End-Stage Liver Disease
Johns Hopkins Medicine

A Johns Hopkins Children's Center scientist reports success in animal studies in preventing a cascade of brain pathology that appears to both cause and signal the final and fatal stages of acute and chronic liver disease in children and adults.

14-May-2002 12:00 AM EDT
Key Powerhouse Enzyme Linked to Cancer Development
Johns Hopkins Medicine

Scientists at the Johns Hopkins Kimmel Cancer Center have discovered that an enzyme found in a tumor cell's energy center has a special relationship with a gene that controls cancer cell growth and death. Their findings may offer a road map to anti-cancer therapies designed to manipulate the genetic pathway that switches the enzyme on and off.

Released: 3-May-2002 12:00 AM EDT
Hopkins Scientists Reveal How Sound Becomes Electric
Johns Hopkins Medicine

Scientists from The Center for Hearing and Balance at Johns Hopkins have discovered how tiny cells in the inner ear change sound into an electrical signal the brain can understand.

1-May-2002 12:00 AM EDT
Filtering Patient's Blood Before Kidney Transplant Allows Transplant From Any Donor
Johns Hopkins Medicine

By filtering kidney patients' blood of antibodies that normally would reject a donor kidney, transplant surgeons at Johns Hopkins have been 93 percent successful in transplanting the organs between any two people regardless of blood type or prior exposure to their tissue type.

Released: 26-Apr-2002 12:00 AM EDT
Manganese Blocks HIV Replication; Potential New Class of HIV Treatments
Johns Hopkins Medicine

Johns Hopkins scientists have found that simply increasing manganese in cells can halt HIV's unusual ability to process its genetic information backwards, providing a new way to target the process's key driver, an enzyme called reverse transcriptase.

26-Apr-2002 12:00 AM EDT
Need, Potential for Hepatitis C Vaccine Highlighted By Hopkins Study
Johns Hopkins Medicine

Humans may be able to develop immunity to hepatitis C virus, according to a study by Hopkins researchers, findings that add to a growing body of evidence that immunity to the virus can be acquired. The findings are important because no vaccines exist for preventing hepatitis C in humans although preliminary vaccine research in primates appears promising.

26-Apr-2002 12:00 AM EDT
Search for Schizophrenia Genes Takes an Unplanned Turn
Johns Hopkins Medicine

Despite promising evidence that a gene closely linked to schizophrenia would be found on human chromosome number 1, an international team of scientists who scoured the chromosome in more than 1,900 patients concludes it isn't there.

22-Apr-2002 12:00 AM EDT
Angry Young Men Prone to Premature Heart Disease
Johns Hopkins Medicine

Young men who quickly react to stress with anger are at three times the normal risk of developing premature heart disease, according to a Johns Hopkins study of more than 1,000 physicians.

Released: 20-Apr-2002 12:00 AM EDT
One Site for International Study on Noninvasive Treatment of Uterine Fibroids
Johns Hopkins Medicine

The Johns Hopkins Hospital is one of eight worldwide sites chosen to conduct a Phase 3 clinical trial on the treatment of uterine fibroids using magnetic resonance imaging (MRI)-guided high intensity focused ultrasound.

Released: 18-Apr-2002 12:00 AM EDT
Symposium Features Pulitzer Prize-Winning Author, World-Renowned Neurosurgeon
Johns Hopkins Medicine

Author William Styron and pediatric neurosurgeon Benjamin Carson, M.D., will be featured speakers at the annual symposium sponsored by the Johns Hopkins Affective Disorders Clinic and DRADA, the Depression and Related Affective Disorders Association. Noted Hopkins psychiatrist, writer and MacArthur Prize winner Kay Redfield Jamison will also speak.

Released: 17-Apr-2002 12:00 AM EDT
New Molecular Marker for Prostate Cancer Tested
Johns Hopkins Medicine

Hopkins cancer researchers have identified a new genetic culprit-with dietary links-in the initiation of prostate cancer.

17-Apr-2002 12:00 AM EDT
Angioplasty Beats Clot-Busting Drugs For Most Heart Attack Patients
Johns Hopkins Medicine

Heart attack patients may be better off with balloon angioplasty to open blocked blood vessels than with clot-busting drugs, even if their hospital lacks a cardiac surgery program, according to a Johns Hopkins-led study.

Released: 16-Apr-2002 12:00 AM EDT
Scientists Close in on Trigger of Insulin Resistance
Johns Hopkins Medicine

In experiments with fat cells, Johns Hopkins scientists have discovered direct evidence that a build-up of sugar on proteins triggers insulin resistance, a key feature of most cases of diabetes.

15-Apr-2002 12:00 AM EDT
Complicated Genetic Disease Unraveled in One Fell Swoop
Johns Hopkins Medicine

For what is believed to be the first time, scientists have unraveled the complicated genetics of an inherited intestinal disease, opening the door to revealing complete genetic pictures of other complex diseases. The findings underscore non-coding genetic regions' importance in disease.

Released: 10-Apr-2002 12:00 AM EDT
Next Generation of Scientists Recognized at Johns Hopkins
Johns Hopkins Medicine

The best of the best. The cream of the crop. Cliches may accurately describe the winners of this year's 25th annual Young Investigators' Day awards at The Johns Hopkins University School of Medicine, but their work is anything but run of the mill.

Released: 10-Apr-2002 12:00 AM EDT
Recognizing Hopkins Researchers-In-Training for 25 Years
Johns Hopkins Medicine

A lot has happened since 1978. Kings have fallen, conventional wisdoms have been squashed, villains slain and heroes brought to light. And that's just in laboratory dishes. April 11 marks the twenty-fifth annual Young Investigators' Day at Johns Hopkins.

10-Apr-2002 12:00 AM EDT
Cancer Research Tip Sheet
Johns Hopkins Medicine

This information tip sheet highlights research news from the Kimmel Cancer Center at Johns Hopkins that are the subject of presentations at the annual meeting of the American Association of Cancer Research.



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