Targeting sugars that occur naturally in the body could protect the kidneys or other organs from damage associated with disease or injury, according to a Johns Hopkins study.
Johns Hopkins physicians report an extraordinarily high success rate for kidney transplants among patients traditionally considered ineligible for the surgery.
Research led by a nurse investigator at Johns Hopkins has found that a pain reliever commonly used to treat serious and painful forms of arthritis may also reduce the growth of malignant tumors after cancer surgery.
Laboratory experiments led by Hopkins scientists have revealed that so-called "jumping genes" create dramatic rearrangement in the human genome when they move from chromosome to chromosome. If the finding holds true in living organisms, it may help explain the diversity of life on Earth.
After two years of stubborn persistence, scientists at Johns Hopkins have determined the 3-D structure of part of a protein called HER3, which should speed efforts to interfere with abnormal growth and cancer.
Potentially treatable psychiatric problems are common in patients with degenerative brain diseases affecting movement and coordination, according to a study by Johns Hopkins scientists. Up to 80 percent of those with either Huntington's disease or degenerative diseases affecting the cerebellum also suffer from depression, impaired thinking and changes in personality.
One of the brain's most important chemical messengers has led Johns Hopkins School of Medicine researchers on a wild ride. Primarily interested in how and why nerve cells die in neurodegenerative diseases like Lou Gerhig's disease, the scientists now find themselves with a new rat model of epilepsy, a disease characterized not by cell death, but by rapid and uncontrolled "firing" of brain cells.
Hopkins-led researchers say they have identified in neurons a novel form of "programmed" cell death unlike those already known -- apoptosis and necrosis.
A team of Johns Hopkins researchers has identified and successfully tested in animals a potential new treatment for liver cancer, a disease for which there are few effective treatments.
The amount of oxygen-carrying hemoglobin circulating in the blood of older women could have an impact on the risk for mobility problems, Johns Hopkins physicians have found.
Learning about human stem cells requires working with them, but some Johns Hopkins researchers are turning to a clever new mouse model to learn things the human cells can't teach them.
Johns Hopkins School of Medicine researchers have what is believed to be the first solid evidence that genes in human pluripotent stem cells and their progeny work normally.
Resolving conflicting reports about the effect of hepatitis C virus infection on the progression of HIV disease, a Hopkins study of nearly 2,000 HIV patients shows that hepatitis C does not increase risk of death, accelerate the development of AIDS, or curb the value of antiretroviral HIV therapy.
A new study reverses the long held notion that birth control pills increase a women's risk for breast cancer. Breast cancer experts at Johns Hopkins say these newest results confirm that taking birth control pills, even for a long time, does not appear to increase a woman's risk for breast cancer and reduces their risk for endometrial and ovarian cancers.
It's a wonder cells make it through the day with the barrage of cues and messages they receive and transmit to direct the most basic and necessary functions of life. Such cell communication, or signal transduction, was at least thought to be an "automatic" cascade of biochemical events. Now, however, a study has found that even before a message makes it through the outer cell membrane to the inner nucleus, the cell is busy activating a molecular switch to guide how the message will be delivered in the first place.
A pioneering Johns Hopkins stem cell expert and one of the institution's leading bioethicists have won a multi-year grant from the Greenwall Foundation to develop far-reaching recommendations on a "second generation" of ethical questions about stem cell research.
Using brain cells from rats, scientists at The Johns Hopkins University School of Medicine and the University of Hamburg have manipulated a molecular "stop sign" so that the injured nerve cells regenerate.
In what may be the largest clinical trial to evaluate the effectiveness of antimicrobial agents in preventing surgical wound and hospital-based infections caused by Staphylococcus aureus, scientists at the University of Iowa and Johns Hopkins found that an antibiotic ointment, called mupirocin, smeared inside the nose cut infection rates in half or better.
Johns Hopkins interventional radiologists have demonstrated that cement can be injected into the spine without prior, potentially dangerous dye studies.
A Johns Hopkins University School of Nursing study concludes female victims of physical and/or sexual abuse have a significantly higher rate of common health problems, even after the abuse ends, compared to women who have never been abused.
A new drug blocks the impact of a cancer-causing gene mutation found in a common and lethal form of leukemia, say researchers at the Johns Hopkins Kimmel Cancer Center.
Researchers from the Johns Hopkins School of Medicine have learned that a protein that prevents the formation of cancerous tumors in animals also helps single-celled amoeba determine direction, particularly when moving toward a chemical attractant, an ability of many cell types in more complex creatures.
The Johns Hopkins researchers who first identified myostatin as a key restrictor of muscle growth in animals now report that excessive amounts of the protein in mice cause rapid and dramatic loss of both muscle and fat, without affecting appetite.
A bacterium responsible for the vast majority of stomach cancers, a leading cause of cancer death worldwide, and ulcers may have met its match, scientists from Johns Hopkins and the French National Scientific Research Center report.
Johns Hopkins AIDS researcher and immunologist Robert F. Siliciano, M.D., Ph.D., has been named a Howard Hughes Medical Institute (HHMI) investigator. He is one of 12 physician- scientists recently selected by HHMI for their achievements in patient-oriented research.
The Johns Hopkins University School of Medicine will award doctor of medicine degrees to 114 women and men from 25 states and six foreign countries at the commencement exercises May 23, 2002. The class is the 107th to graduate since the school opened in 1893. Johns Hopkins is among the most selective medical schools in the nation, with 4,654 applicants for 120 places for the freshman class this fall.
An implantable pump that delivers pain medication in a slow-release fashion directly into the spinal fluid could greatly improve the pain relief, overall quality of life and survival for cancer patients living in pain, according to an international study completed at Johns Hopkins, the Medical College of Virginia and 25 other medical centers.
A preliminary study has found no advantage to adding chemotherapy to radiation after surgery for treating advanced head and neck cancer patients. The findings of the research, to be presented at the American Society of Clinical Oncology meeting May 18, appear to set aside earlier data suggesting that a combination of chemotherapy and radiation would improve the odds of staying cancer-free after surgery.
A Johns Hopkins Children's Center scientist reports success in animal studies in preventing a cascade of brain pathology that appears to both cause and signal the final and fatal stages of acute and chronic liver disease in children and adults.
Scientists at the Johns Hopkins Kimmel Cancer Center have discovered that an enzyme found in a tumor cell's energy center has a special relationship with a gene that controls cancer cell growth and death. Their findings may offer a road map to anti-cancer therapies designed to manipulate the genetic pathway that switches the enzyme on and off.
Scientists from The Center for Hearing and Balance at Johns Hopkins have discovered how tiny cells in the inner ear change sound into an electrical signal the brain can understand.
By filtering kidney patients' blood of antibodies that normally would reject a donor kidney, transplant surgeons at Johns Hopkins have been 93 percent successful in transplanting the organs between any two people regardless of blood type or prior exposure to their tissue type.
Johns Hopkins scientists have found that simply increasing manganese in cells can halt HIV's unusual ability to process its genetic information backwards, providing a new way to target the process's key driver, an enzyme called reverse transcriptase.
Humans may be able to develop immunity to hepatitis C virus, according to a study by Hopkins researchers, findings that add to a growing body of evidence that immunity to the virus can be acquired. The findings are important because no vaccines exist for preventing hepatitis C in humans although preliminary vaccine research in primates appears promising.
Despite promising evidence that a gene closely linked to schizophrenia would be found on human chromosome number 1, an international team of scientists who scoured the chromosome in more than 1,900 patients concludes it isn't there.
Young men who quickly react to stress with anger are at three times the normal risk of developing premature heart disease, according to a Johns Hopkins study of more than 1,000 physicians.
The Johns Hopkins Hospital is one of eight worldwide sites chosen to conduct a Phase 3 clinical trial on the treatment of uterine fibroids using magnetic resonance imaging (MRI)-guided high intensity focused ultrasound.
Author William Styron and pediatric neurosurgeon Benjamin Carson, M.D., will be featured speakers at the annual symposium sponsored by the Johns Hopkins Affective Disorders Clinic and DRADA, the Depression and Related Affective Disorders Association. Noted Hopkins psychiatrist, writer and MacArthur Prize winner Kay Redfield Jamison will also speak.
Heart attack patients may be better off with balloon angioplasty to open blocked blood vessels than with clot-busting drugs, even if their hospital lacks a cardiac surgery program, according to a Johns Hopkins-led study.
In experiments with fat cells, Johns Hopkins scientists have discovered direct evidence that a build-up of sugar on proteins triggers insulin resistance, a key feature of most cases of diabetes.
For what is believed to be the first time, scientists have unraveled the complicated genetics of an inherited intestinal disease, opening the door to revealing complete genetic pictures of other complex diseases. The findings underscore non-coding genetic regions' importance in disease.
The best of the best. The cream of the crop. Cliches may accurately describe the winners of this year's 25th annual Young Investigators' Day awards at The Johns Hopkins University School of Medicine, but their work is anything but run of the mill.
A lot has happened since 1978. Kings have fallen, conventional wisdoms have been squashed, villains slain and heroes brought to light. And that's just in laboratory dishes. April 11 marks the twenty-fifth annual Young Investigators' Day at Johns Hopkins.
This information tip sheet highlights research news from the Kimmel Cancer Center at Johns Hopkins that are the subject of presentations at the annual meeting of the American Association of Cancer Research.