A medication commonly used for gout holds possibilities for the treatment of heart failure, Johns Hopkins researchers report. It's a drug that works by a new principle, namely, directly decreasing heart muscle's need for energy and making it contract more efficiently.
A positive outlook may offer the strongest known protection against heart disease in adults at risk, according to a Johns Hopkins study. The report, which looked at nearly 600 adults with a family history of heart disease, will be presented Nov. 12 at the American Heart Association's annual Scientific Sessions in Anaheim, Calif.
Ischemia, or an interruption in blood flow to tissue, greatly decreases the success of transplanted kidneys. There's no specific treatment, partly because physicians don't know exactly how the injury occurs. But now, a new study shows that in mice, at least, tiny molecules within specialized immune system cells may hold some clues.
Researchers at Johns Hopkins Children's Center and 20 other hospitals report that a novel drug appears to make blood cells slip around each other and more easily through blood vessels, shortening the duration of painful crises experienced by children with sickle cell disease. The drug had a similar but less potent effect in adults.
Understanding attraction is difficult enough, but it's a little less so these days, at least in amoeba living in the lab of a Johns Hopkins scientist.
The John D. and Catherine T. MacArthur Foundation has awarded two Johns Hopkins faculty members MacArthur Fellowships. The so-called "genius awards" go to Kay Redfield Jamison, Ph.D., professor of psychiatry, and Geraldine Seydoux, Ph.D., associate professor of molecular biology and genetics, both in the School of Medicine.
The crucial job of ensuring that just one copy of a genome gets made during cell division turns out to be shared by two independent "controllers," researchers from Johns Hopkins School of Medicine report.
Patients undergoing high-risk surgeries are more likely to have post-operative complications, including difficulty breathing, if their hospital's intensive care unit (ICU) isn't sufficiently staffed by nurses, according to a Johns Hopkins study of Maryland hospitals.
Growing fat cells and nerve cells in the same dish has produced what is believed to be the first demonstration of two-way communication between the cell types, say Johns Hopkins scientists.
Fifty to 80 percent of all amputees experience pain in their stumps or what feels like the missing limbs long after surgical wounds have healed. Now new research from Johns Hopkins suggests the two pains have different sources, bringing us a step closer in understanding what types of drugs might help.
A new study identifies an important link between the two main inherited forms of Parkinson's disease, and might also connect them to non-inherited versions, Hopkins scientists report.
Using genetically engineered mice, scientists from The Johns Hopkins University School of Medicine have found that events associated with losing the function of telomeres, the repetitive ends of chromosomes, depend on the length of the shortest telomere in a cell, not the commonly measured average length.
Researchers at Johns Hopkins, Hahnemann University, and University of Maryland report sustained, treatment-free remissions in studies of a novel drug therapy approach to treating a deadly blood disorder known as aplastic anemia.
Johns Hopkins neurologists report that a rigorously high-fat, low-carbohydrate diet not only reduces the number of seizures in children with severe seizure disorders, but also keeps the frequency of attacks lower years after the diet is stopped.
Get through medical school in 12 hours for less than $150? Not quite, but a new program featuring leading physicians and researchers from Johns Hopkins Medicine and The Johns Hopkins University Bloomberg School of Public Health comes pretty close. Participants get eight 1.5-hour sessions with leading medical experts discussing everything from cancer to genetics to mysteries of the mind to human health and environmental change.
Researchers have discovered what is believed to be a novel method in yeast for governing gene expression at the end, rather than the beginning, of transcription, the process of reading DNA to make RNA.
From Moby Dick to Shamu, whales have long fascinated humans. Their remarkable status as ocean-dwelling mammals, along with dolphins and porpoises, at once makes them related to us and yet inconceivably different from us. Thus their evolution -- the developmental steps required to leave solid ground for a life in the water -- has long fascinated scientists.
A blood pressure reading taken during exercise is a more accurate test for early heart disease than one taken at rest, according to a study presented Sept. 14 at the annual meeting of the American Association of Cardiovascular and Pulmonary Rehabilitation in Minneapolis.
Gene therapy may one day be used to halt or even prevent the overgrowth of blood vessels in the eye that blinds patients with macular degeneration and diabetic retinopathy, according to two recent studies led by researchers at Johns Hopkins' Wilmer Eye Institute.
In a study of more than 200 patients with Parkinson's disease, 40 percent used at least one type of alternative therapy, such as vitamins/herbs, massage and acupuncture. Over half of the patients failed to inform their physicians about the use of alternative therapies.
An experimental drug may reverse stiffening of the cardiovascular system that occurs with aging, according to a national study led by Johns Hopkins physicians.
The Class of 2005 Arrives...Saving Voice: New Approach to Larynx Cancer...Mike Weisfeldt: New Chairman of the Department of Medicine. These stories and more now are posted on the Web in the all-new September edition of Hopkins' online magazine, @Hopkins Medicine.
Only half of people with peripheral artery disease (PAD), a condition where blood vessels in the arms and legs can become clogged with cholesterol, are appropriately diagnosed and treated, a Johns Hopkins expert says.
Modern psychiatry has become mired in a system of disease classification that defines mental disorders by the way they look and not on biological or psychological processes, according to Paul R. McHugh, M.D., Henry Phipps Professor and chair of the Department of Psychiatry and Behavioral Sciences at the Johns Hopkins University.
Church-based nutrition and exercise programs can move African-American women to adopt healthier habits, according to a study led by Johns Hopkins researchers.
Parents, add this to your back-to-school to-do list: meet with teachers to discuss food allergies. According to a recent Hopkins study, published in the Archives of Pediatrics and Adolescent Medicine, roughly one in five food-allergic children will have an allergic reaction while in school, and teachers may not know how to handle an attack properly.
A Johns Hopkins scientist and a team of collaborators have discovered how precancerous moles may progress to melanomas, the most deadly type of skin cancer. The report describes a link between two genes that trigger skin cancers and could serve as early diagnostic markers for the disease.
The 10th edition of the Hopkins guide to AIDS care, Medical Management of HIV Infection mirrors a decade's history of medical successes and challenges. The internationally renowned publication began in 1991 as a 28-page booklet with 10 pages devoted to anti-HIV therapy as well as treatment of opportunistic infections and complications. It is now a 356-page book.
Researchers at the Johns Hopkins Oncology Center have developed a new gene-based therapy that they hope will transform one of the most lethal types of adult leukemia to one of the most treatable.
Cholesterol is instrumental in HIV's ability to infiltrate cells, and removing this fatty material from a cell's membrane blocks infection, according to a Johns Hopkins study.
Acting on a scientific hunch, Hopkins medical sleuths set out to find individuals with an extremely rare disorder affecting their ability to internally process water. Using international blood banks, the investigators identified two such persons, confirming their belief that the absence of a certain protein interferes with the body's ability to regulate its water levels.
The Johns Hopkins scientists who first created "mighty mice" by genetically engineering animals with a missing growth regulator called myostatin have now created a second group of mice whose genetic makeup shows it's possible to get the same effect by blocking the gene for myostatin, rather than entirely knocking it out.
A team of scientists from Johns Hopkins Children's Center and two other institutions have found that low levels of HIV-1 virus in the blood of children and adults undergoing a common combination drug therapy does not necessarily indicate the virus is becoming resistant to these life-prolonging medications.
The care of asthmatic African Americans falls short of many recommendations contained in national guidelines, compared to whites, according to a new study by Johns Hopkins researchers.
1) Faulty bee tests make for stinging surprises; 2) Mexican-Americans at high risk for diabetic retinopathy; 3) Novel measure of blood cholesterol better predicts death from heart disease; 4) Women facing cancer treatment may still have fertility options.
Researchers from Johns Hopkins and Toshiba Corporation Medical Systems Company have formed a joint research program at Hopkins to develop new, minimally invasive procedures using combinations of CT scans and fluoroscopy.
The Johns Hopkins Medicine Department of Radiology has been selected to take part in the first major study assessing the value of digital mammography versus standard mammography. The study, called the American College of Radiology Imaging Network (ACRIN) study, is funded with a $25 million grant from the National Cancer Institute.
Researchers at Johns Hopkins Children's Center report success in treating sickle cell disease in mice with a modified bone marrow transplant. The finding adds further support to human trials now under way at the Children's Center.
Armed with evidence from a recent study of latex allergy skin reactions in patients' scientists at Johns Hopkins encourage the Food and Drug Administration and drug makers to label all current vials as "containing natural rubber" where appropriate and convert to using synthetic rubber for all medicine bottle stoppers.
On July 13, an 18-wheeler will leave Maryland, bound for the Navajo Indian Reservation in Arizona. On board will be an astonishing array of the latest in digital breast mammography equipment and sophisticated satellite systems for relaying the mammography images back to expert radiologists at the U.S. Army's Walter Reed Medical Center in Maryland and to Johns Hopkins in Baltimore.
Resistance training burns calories for more than an hour after a workout and may be as important as aerobic exercise for women in the fight against fat, according to researchers at Johns Hopkins and Arizona State universities.
For the first time, Hopkins is the top earner of AIDS research funding from the National Institutes of Health for fiscal year 2000.
Older people who are more fit and have less body fat may also have a better outlook on life than their less active, less lean counterparts, according to a Johns Hopkins study.
The furry- or feathered-costumed mascots at professional ball games may have more in common than entertaining the crowd: a high propensity for heat illness and other assorted injuries, according to a Johns Hopkins study.
Spending more time and money up front to keep injection drug users with latent tuberculosis (TB) on strict, anti-TB regimens will improve patient outcomes and save money in the long run, according to a new study by Johns Hopkins researchers.
A Johns Hopkins study of elderly persons found that many have either moderate or severe asthma that has been underdiagnosed or undertreated.
Approximately one in five older people -- even those with good health insurance -- misuse their asthma drugs, and doctors fail an even greater proportion by not managing their care aggressively or giving them enough information to manage symptoms on their own, according to a report from Johns Hopkins researchers.
Investigators at Johns Hopkins have proven that distracting patients during and after bronchoscopy with the gurgle of a brook and a colorful panorama of tranquil meadow improves pain control by approximately 43 percent.
Doctors who do not periodically reevaluate their patients' asthma severity are failing to provide good care to asthma sufferers, report Johns Hopkins physicians May 20 at the American Thoracic Society's annual meeting.
Researchers at Johns Hopkins and the University of Pittsburgh report promising results in tests of a new prostate cancer drug known as ABT-627 made by Abbott Laboratories (Abbott Park, IL).
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