Chemists at The Scripps Research Institute have invented the first practical, scalable method for synthesizing jiadifenolide, a plant-derived molecule that may have powerful brain-protecting properties.
Scientists from the Florida campus of The Scripps Research Institute have identified a new therapeutic approach that, while still preliminary, could promote the development of new bone-forming cells in patients suffering from bone loss.
A new study from The Scripps Research Institute, Florida campus, integrates neuroscience and psychological research to reveal how sleep suppresses certain nerve cell activity that promotes forgetting, insuring that at least some memories will last.
While it is well-known that weight gain results from an imbalance between what we eat and our energy expenditure, not so obvious is the role the nervous system plays in controlling energy balance. Scientists from the Florida campus of The Scripps Research Institute have shed light on the question.
Scientists from the Florida campus of The Scripps Research Institute have been awarded $2.1 million from the National Institute of Neurological Disorders and Stroke to study a protein that has been closely linked in animal models to Parkinson’s disease and Huntington’s disease.
Scientists from the Florida campus of The Scripps Research Institute have found that a drug candidate with anticancer potential can be activated by one of the body’s natural responses to cellular stress. Once activated, the agent can kill prostate cancer cells.
Scientists at The Scripps Research Institute have found that state-specific odor “blindness” exists in female mice, who cannot sense the odor of male mice when in diestrus, the period of sexual inactivity during the reproductive cycle, pointing to new avenues for studying senses and behavior.
Scientists from The Scripps Research Institute Florida campus have been awarded nearly $2.2 million by the National Institute of Diabetes and Digestive and Kidney Diseases to advance an innovative approach to the treatment of obesity.
Chemists at The Scripps Research Institute have discovered a broad, strikingly inexpensive method for synthesizing “amines,” a class of organic compounds prominent in drugs and other modern products. The new reaction is particularly useful for synthesizing complex amines valuable in pharmaceuticals, but impractical—or impossible—to make with standard methods.
Interferon proteins are normally considered virus-fighters, but scientists at The Scripps Research Institute have found evidence that one of them, interferon beta, has an immune-suppressing effect that can help some viruses establish persistent infections.
Scientists from The Scripps Research Institute, working closely with researchers at the National Institutes of Health, have mapped out the structure of an important protein involved in cellular function and nervous system development.
Scientists at The Scripps Research Institute have discovered that a brain protein has a key role in controlling binge drinking in animal models.
Scientists at The Scripps Research Institute have found using animal models that the new recreational drug alpha-PVP (“flakka”) seems equivalently potent as a stimulant, and therefore as addictive, as its chemical cousin MDPV (“bath salts”).
team led by scientists at The Scripps Research Institute and Johns Hopkins University School of Medicine has uncovered a big clue to how bacteria may promote some colon cancers.
A new study led by scientists at The Scripps Research Institute sheds light on the cause of some cancers, including breast cancer and leukemia.
Scientists from the Florida campus of The Scripps Research Institute have been awarded $2.4 million from the National Institute on Drug Abuse of The National Institutes of Health to expand development of new pain medications with fewer side effects than those currently available.
Scientists from the Florida campus of The Scripps Research Institute have uncovered some surprising details of a group of compounds that have shown significant potential in stimulating the growth of brain cells and memory restoration in animal models that mimic Alzheimer’s disease.
A new study from scientists at The Scripps Research Institute (TSRI) shows that nerve cells and blood vessels in the eye constantly “talk” to each other to maintain healthy blood flow and prevent disease.
Scientists at The Scripps Research Institute have been awarded two grants to study brain mechanisms that actively suppress relapse associated with cocaine and alcohol addiction.
Scientists from the Florida campus of The Scripps Research Institute have found how a widely known but little-studied enzyme protects brain cells in models of Parkinson’s disease.
A study led by scientists at The Scripps Research Institute reveals that, in rat models, nicotine exposure actually promotes alcohol dependence.
Scientists from the Florida campus of The Scripps Research Institute have been awarded $1.2 million from the National Cancer Institute of the National Institutes of Health to accelerate development of drug candidates to curb one of the most important drivers of human cancer.
Scientists at The Scripps Research Institute (TSRI) have identified a molecule in the brain that triggers schizophrenia-like behaviors, brain changes and global gene expression in an animal model. The research gives scientists new tools for someday preventing or treating psychiatric disorders such as schizophrenia, bipolar disorder and autism.
Scientists from the Florida campus of The Scripps Research Institute have been awarded $3.3 million by the National Institutes of Health to identify biomarkers to accelerate drug development for disorders including autism spectrum disorder, epilepsy and some types of intellectual disability.
Scientists from The Scripps Research Institute have uncovered the unique mechanism of a powerful natural product with wide-ranging antifungal, antibacterial, anti-malaria and anti-cancer effects. The new study sheds light on the natural small molecule known as borrelidin.
The Scripps Research Institute has named Christopher A. Lee, formerly of PCI (Project Concern International), as director of philanthropy on the institute’s La Jolla, California campus.
Scientists at The Scripps Research Institute have found a particular enzyme in blood stem cells that is key to maintaining healthy periods of cell inactivity; if these cells become too active and divide too often, they risk acquiring cell damage and mutations.
Scientists from the Florida campus of The Scripps Research Institute have been awarded a $1.5 million grant from the National Institutes of Health to develop drug candidates that could treat cancer and neurodegenerative disease.
Scientists from the Florida campus of The Scripps Research Institute have successfully tested a potent synthetic compound that prevents type 1 diabetes in animal models of the disease.
Scientists from the Florida campus of The Scripps Research Institute have confirmed the ribosome assembly process as a potentially fertile new target for anti-cancer drugs by detailing the essential function of a key component in the assembly process.
Scientists at The Scripps Research Institute have analyzed a key protein from two influenza strains that recently began causing sporadic infections among people in China and Taiwan. The analyses suggest the flu viruses have not acquired changes allowing them to infect people easily.
New research from The Scripps Research Institute shows that two proteins critical for maintaining healthy day-night cycles also protect against mutations that could lead to cancer.
A team led by scientists at The Scripps Research Institute has determined the basic structural organization of a molecular motor that hauls cargoes and performs other critical functions within cells.
A research team from The Scripps Research Institute, Mayo Clinic and other institutions has identified a new class of drugs that in animal models dramatically slows the aging process—alleviating symptoms of frailty, improving cardiac function and extending a healthy lifespan.
Chemists at The Scripps Research Institute (TSRI) have developed a broadly useful technique for building new drug molecules and other chemical products.
Scientists from the Florida campus of The Scripps Research Institute have discovered a mechanism that causes long-term memory loss due to age in Drosophila, the common fruit fly, a widely recognized substitute for human memory studies.
Scientists at The Scripps Research Institute have published a pair of studies showing how the primary protein responsible for multidrug chemotherapy resistance changes shape and reacts to therapeutic drugs.
The Scripps Research Institute scientists have captured the first images showing how immune molecules bind to a site on the surface of Marburg virus and have described an antibody that binds to both Marburg and Ebola viruses, pointing to new antibody treatments to fight an entire family of viruses.
A new study led by researchers at The Scripps Research Institute (TSRI) and the University of California (UC), San Diego School of Medicine shows that certain stem cell culture methods are associated with increased DNA mutations.
Much speculation has occurred in the media over possible heightened aggression in those diagnosed with autism spectrum disorder. A study by scientists from The Scripps Research Institute found no evidence of increased aggressive behavior toward strangers in an animal model of the condition.
In a remarkable new advance against the virus that causes AIDS, scientists from The Scripps Research Institute have announced the creation of a novel drug candidate so potent and universally effective, it might work as part of an unconventional vaccine.
A study by scientists from the Florida campus of The Scripps Research Institute sheds significant new light on a surprising and critical role that microbes may play in nutritional disorders such as protein malnutrition.
Scientists from the Florida campus of The Scripps Research Institute have for the first time discovered a killing mechanism that could underpin a range of the most intractable neurodegenerative diseases such as Alzheimer’s, Parkinson’s and ALS.
Scientists at The Scripps Research Institute have identified a new cellular pathway affected in cystinosis, a rare genetic disorder that can result in eye and kidney damage. The findings could eventually lead to new drug treatments for reducing or preventing the onset of renal failure in patients.
To help people with hormone deficiencies, scientists at The Scripps Research Institute have developed a potential new therapy based on an unlikely model: immune molecules from cows. Their research shows that human hormones and antibodies can be fused together—mimicking long, stalk-like cow antibodies.
Scientists at The Scripps Research Institute have found diverse genomic changes in single neurons from the brains of Alzheimer’s patients, pointing to an unexpected factor that may underpin the most common form of the disease.
Scientists from the Florida campus of The Scripps Research Institute have uncovered the workings of cell-protection device, one that may play a major role in a number of age-related diseases, including diabetes and Parkinson’s, Alzheimer’s and Huntington’s diseases.
A new study from scientists at The Scripps Research Institute (TSRI) helps explain how booster shots prompt immune “memory” to improve, an important step toward the development of more effective, longer-lasting vaccines.
A team at The Scripps Research Institute (TSRI) has won a $1,784,000 grant from the California Institute for Regenerative Medicine (CIRM) to support the development of a new method for detecting DNA damage in stem cells to ensure that only the highest quality cells are used in transplantation or therapy.
In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have shown their drug candidates can target biological pathways involved in the destruction of brain cells in Parkinson's disease.
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