Nearly 10 percent of patients who are prescribed opioid medications following heart surgery will continue to use opioids more than 90 days after the procedure, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania.
The Center of Excellence in Environmental Toxicology (CEET) at the University of Pennsylvania received an $8 million grant, to be distributed over the next five years, from the National Institute of Environmental Health Sciences, a renewal of its P30 Environmental Health Sciences Core Center (EHSCC) grant.
An experimental study from researchers in the Perelman School of Medicine at the University of Pennsylvania links a specific procedure – embryo culture – that is part of the assisted reproduction process (ART) to placental abnormalities, risk for preeclampsia, and abnormal fetal growth. The team, led by Marisa Bartolemei, PhD, a professor of Cell and Developmental Biology, published their findings today in Development.
A team at Penn Medicine, in collaboration with UnitedHealth Group, created COBALT—a digital platform that offers immediate access to mental health support for health care workers during this critical time.
Of nearly 6,500 commercially insured patients treated in EDs nationwide for an overdose or other opioid-related medical complications, only 16 percent accessed opioid use disorder (OUD) medications or another form of treatment within three months of the ED visit.
New research from the Perelman School of Medicine at the University of Pennsylvania catalogued every use documented in medical literature so far and found physicians have reported on the use of more than 100 different off-label and experimental treatments
Checkpoint inhibitors, a type of immunotherapy, that target myeloid immune cells and slow tumor growth were discovered by a team from the Perelman School of Medicine at the University of Pennsylvania and other institutions. Reporting in Nature Cancer, the researchers showed for the first time in human cells and a mouse model that inhibiting the c-Rel molecule in myeloid cells — as opposed to lymphoid cells that today’s immunotherapies target — blocked the production of immune suppressor cells and significantly shrank tumors.
“Senotherapy,” a treatment that uses small molecule drugs to target “senescent” cells, or those cells that no longer undergo cell division, blunts liver tumor progression in animal models according to new research from a team led by Celeste Simon, PhD, a professor of Cell and Developmental Biology in the Perelman School of Medicine at the University of Pennsylvania and scientific director of the Abramson Family Cancer Research Institute. The study was published in Nature Cell Biology.
PHILADELPHIA – Elizabeth Howell, MD, MPP, an accomplished researcher of health inequities and a respected women’s health leader, has been named chair of the Department of Obstetrics and Gynecology in the Perelman School of Medicine at the University of Pennsylvania. She will join Penn on Sept. 1, 2020, from her post as a professor of Obstetrics, Gynecology, and Reproductive Science at the Icahn School of Medicine at Mount Sinai.
Online forums can be used by public health officials to quickly identify topics of public interest during the COVID-19 pandemic and to quell misinformation
France and the United States have experienced a tremendous reduction in the number of organ donations and transplant procedures since the onset of the COVID-19 pandemic. By early April, transplant centers in both countries were conducting far fewer deceased donor transplants compared to just one month earlier, with the number of procedures dropping by 91 percent in France and 50 percent in the United States.
Penn researchers say they know what's going on at the cellular level when patients experience a flare
Offering $750 to emergency medicine physicians exponentially increased those trained to prescribe buprenorphine.
Activating a receptor found on the surface of many normal and cancer tissues has been shown to stop pancreatic cancer from growing, but may also make tumors more visible to the immune system and thus more susceptible to modern immunotherapy
Convalescent plasma therapy for COVID-19 patients — an experimental approach of giving a transfusion of plasma collected from a donor who has recovered from COVID-19 to a patient with an active infection — is the focus of a new two-part research initiative at Penn Medicine. Researchers will first collect plasma from people who have recovered from their infection under a donor research protocol. The second part involves conducting clinical trials to test the safety and efficacy of giving that plasma to moderately and severely ill hospitalized patients.
A new international trial will evaluate whether the use of medications to treat high blood pressure affect outcomes among patients who are prescribed the medication and hospitalized with COVID-19. Investigators will examine whether ACEI or ARBs help to mitigate complications or lead to worse outcomes.
Penn Medicine created a new meal delivery platform for frontline hospital staff called Nourished, to ensure safe and convenient access to local takeout meals during the COVID-19 pandemic. Nourished allows staff to easily order affordable meals from a curated list of local restaurants via text message.
A blood test may be able to detect the most common form of pancreatic cancer while it is still in its early stages while also helping doctors accurately stage a patient’s disease and guide them to the appropriate treatment.
Penn launched the U.S. component of a global registry that aims to help protect health care providers who intubate patients with COVID-19 and quantify their risk of developing the disease. The intubateCOVID registry tracks exposures and outcomes among providers who perform intubations, with the ultimate goal of reducing the transmission of COVID-19 to these providers.
A new trial led by the Perelman School of Medicine at the University of Pennsylvania will evaluate whether the drug hydroxychloroquine (HCQ) can benefit people infected with COVID-19, as well as whether taking the drug preventatively may help people avoid infection altogether
Penn Medicine has established a new center to help expand and accelerate research related to the novel coronavirus, SARS-CoV-2, that causes the respiratory illness known as COVID-19.The center aims to advance research to support the development of potential vaccines, diagnostic tools, and therapies
Penn Medicine research shows genetically engineering macrophages – an immune cell that eats invaders in the body – could be the key to unlocking cellular therapies that effectively target solid tumors
Daniel Yoshor, MD, has been named chair of the department of Neurosurgery in the Perelman School of Medicine at the University of Pennsylvania and vice president of Clinical Integration and Innovation for the University of Pennsylvania Health System.
Early on in each cell, a critical protein known as FoxA2 simultaneously binds to both the chromosomal proteins and the DNA, opening the flood gates for gene activation, according to a new study led by researchers in the Perelman School of Medicine at the University of Pennsylvania. The discovery, published in Nature Genetics, helps untangle mysteries of how embryonic stem cells develop into organs.
The Perelman School of Medicine at the University of Pennsylvania has been ranked #3 among the nation’s medical schools, marking 23 consecutive years the school garnered honors among the top 10 research-oriented medical schools.
Now, as part of an effort to reduce the rate of patients with diabetic kidney disease who develop kidney failure, researchers at Penn Medicine are spearheading a collaboration to better understand the progression of DKD and advance research aimed at preserving kidney function in these patients.
The language in Facebook posts becomes less formal and invokes family more often in the lead-up to an emergency room visit.
Delivering the medication dantrolene through the nose rather than the mouth may help the medication penetrate the brain more effectively, potentially maximizing its therapeutic benefits in the treatment of neurodegenerative diseases, like Alzheimer’s disease.
New research shows brain imaging may be able to predict when a blood test known as a liquid biopsy would or would not produce clinically actionable information
The deadly brain cancer glioblastoma (GBM) is often resistant to chemotherapy and radiation, but new research shows targeting stromal cells – the cells that serve as the connective tissue of the organs – may be an effective way of overcoming that resistance
Non-small cell lung cancer (NSCLC) patients with higher measures of tumor mutations that show up in a blood test generally have a better clinical response to PD-1-based immunotherapy treatments than patients with a lower measure of mutations.
Testing of small molecules in mouse models of Duchenne muscular dystrophy shows promise for restoration of muscle structure and function.
Machine learning is helping Penn Medicine researchers identify the size and shape of brain networks in individual children, which may be useful for understanding psychiatric disorders. In a new study published in Neuron, a multidisciplinary team showed how brain networks unique to each child can predict cognition. The study is the first to show that functional neuroanatomy can vary greatly among kids, and is refined during development.
The insights from the PEXIVAS Trial, a 10-year study, shows treatment for ANCA-associated vasculitis can become much more patient-friendly by using half the typical dose of steroids and no blood plasma exchanges
A new CRISPR gene-editing technique prevented a genetic liver disease known to be driven by hundreds of different mutations and improved clinical symptoms in mice
Researchers found, in mice, that changes in DNA sequence can trigger the chromosomes to misfold in a way that puts one at a heightened risk for Type 1 diabetes. The study revealed that differences in DNA sequences dramatically changed how the DNA was folded inside the nucleus, ultimately affecting the regulation of genes linked to the development Type 1 diabetes.
Six months after discharge, smartphone users were 32 percent more likely to continue sending health data to researchers than those using wearables
Genetically-edited immune cells can persist, thrive, and function months after a cancer patient receives them
Every dollar spent on patients receiving support from Penn Medicine’s community health worker (CHW) program resulted in an annual return on investment (ROI) of $2.47 for every dollar invested annually by Medicaid, according to a new study published online today in Health Affairs. The savings are generated by reducing hospitalizations.
Some cancer cells refuse to die, even in the face of powerful cellular immunotherapies like CAR T cell therapy, and new research is shedding light on why.
While it’s known that weight “self-stigma” is associated with poor mental and physical health, little is known about how to help people combat it. Researchers show that people who received a new stigma-reduction intervention, along with standard behavioral weight loss treatment, devalued themselves less due to their weight compared to participants who only received the treatment.
The findings may inform care in other parts of the hospital to improve end-of-life experiences.
Cancer patients may one day be able to get their entire course of radiation therapy in less than a second rather than coming in for treatment over the course of several weeks, and researchers in the Abramson Cancer Center of the University of Pennsylvania have taken the first steps toward making it a reality
A new Penn Medicine study puts researchers within closer reach of vaccines that can protect infants against infections by overcoming a mother’s antibodies, which are known to shut down immune defenses initiated by conventional vaccines. That hurdle largely explains why vaccinations for infectious diseases like influenza and measles not given until six to 12 months of age. Findings from the preclinical study were published online today in Science Translational Medicine.
Researchers from the Perelman School of Medicine at the University of Pennsylvania applied tools from network science to identify how anatomical connections in the brain develop to support neural activity underlying executive function.
People living in predominately Hispanic neighborhoods are less likely to receive CPR from a bystander following an out-of-hospital cardiac arrest compared to people living in non-Hispanic neighborhoods, researchers from Penn Medicine and the Duke University of School of Medicine reported in the journal Circulation. This same group also had a lower likelihood of survival.
Direct-to-consumer hormone-based “fertility testing” for women is viewed by consumers as both an alternative, empowering tool for family planning, and a confusing and misleading one, according to the results of a new study from Penn Medicine. Findings from the small, first-of-its-kind ethnographic study reinforce the need for consumer education around the purpose and accuracy of the tests, which have seen increasing interest in recent years due to the low cost and widespread availability. The study was published in the journal of Social Science and Medicine.
Closing of local automotive assembly plants may lead to increases in deaths from opioid overdose, according to a study led by researchers at the Perelman School of Medicine at the University of Pennsylvania and the Massachusetts General Hospital. The findings highlight fading economic opportunity as a driving factor in the ongoing national opioid epidemic, and build on previous research that links declining participation in the labor force to increased opioid use in the U.S. The findings are published today in JAMA Internal Medicine.
Lab-grown brain organoids developed from a patient’s own glioblastoma, the most aggressive and common form of brain cancer, may hold the answers on how to best treat it. A new study in Cell from researchers at Penn Medicine showed how glioblastoma organoids could serve as effective models to rapidly test personalized treatment strategies.
Proton therapy leads to significantly lower risk of side effects severe enough to lead to unplanned hospitalizations for cancer patients when compared with traditional radiation, while cure rates between the two groups are almost identical
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