Scientists from the Florida campus of The Scripps Research Institute have produced an approach that completely protects animal models against a type of genetic disruption that causes intellectual disability, including serious memory impairments and altered anxiety levels.
Scientists from the Florida campus of The Scripps Research Institute have identified a novel synthetic compound that sharply inhibits the activity of a protein that plays an important role in in the progression of breast and pancreatic cancers.
A team from The Scripps Research Institute has designed a more effective nicotine vaccine and proven that the structures of molecules used in vaccines is critical.
A team led by scientists at The Scripps Research Institute has identified an enzyme that produces a class of inflammatory lipid molecules in the brain. Abnormally high levels of these molecules appear to cause a rare inherited neurodegenerative disorder.
A team led by structural biologists at The Scripps Research Institute has taken a big step toward understanding the intricate molecular mechanism of a metabolic enzyme— nicotinamide nucleotide transhydrogenase—produced in most forms of life on Earth.
A new study from scientists at The Scripps Research Institute suggests therapies that change gene expression in parents could help their children. Research showed offspring of mice treated with a drug also had delayed onset and reduced symptoms of Huntington’s disease.
Scientists at The Scripps Research Institute have found that resveratrol, the red-wine ingredient once touted as an elixir of youth, powerfully activates an evolutionarily ancient stress response in human cells. The finding should dispel much of and controversy about how resveratrol really works.
Collaborating scientists from The Scripps Research Institute and the University of California San Diego have developed a powerful new system for studying how proteins and other biological molecules form and lose their natural folded structures.
Chemists at The Scripps Research Institute have invented a powerful and extraordinarily robust method for joining complex organic molecules that can be used to make pharmaceuticals, fabrics, dyes, plastics and other materials previously inaccessible to chemists.
Scientists from the Florida campus of The Scripps Research Institute (TSRI) have been awarded $2.3 million from the Department of Health and Human Services of the National Institutes of Health to better understand how memories are stored in the hopes of eventually being able to treat posttraumatic stress disorder (PTSD) by erasing traumatic memories without altering other, more benign ones.
A team led by biologists at The Scripps Research Institute has solved a long-standing mystery in neuroscience by identifying the “mechanoreceptor” protein that mediates the sense of touch in mammals.
Beginning today, anyone can download a safe and free app that will put their computer or Android-based mobile device to work to form a virtual supercomputer to help The Scripps Research Institute screen millions of chemical compounds to identify new drug leads for treating Ebola.
Researchers can now explore viruses, bacteria and components of the human body in more detail than ever before with software developed at The Scripps Research Institute. In a study published December 1 in the journal Nature Methods, the researchers demonstrated how the software, called cellPACK, can be used to model viruses such as HIV.
A team led by scientists from The Scripps Research Institute has found a simple method to convert human skin cells into the specialized neurons that detect pain, itch, touch and other bodily sensations and are affected by spinal cord injury and involved in Friedreich’s ataxia.
Scientists at The Scripps Research Institute (TSRI) have discovered how one gene is essential to hearing, uncovering a cause of deafness and suggesting new avenues for therapies.
Protein misfolding” diseases such as cystic fibrosis and Alzheimer’s may be seriously exacerbated by the body’s own response against that misfolding, according to a new study led by scientists at The Scripps Research Institute.
Scientists at The Scripps Research Institute have identified weak spots on the surface of Ebola virus that are targeted by the antibodies in ZMapp, the experimental drug cocktail administered to several patients during the recent Ebola outbreak.
Scientists at The Scripps Research Institute have found that the brain’s reward and stress systems are actually linked. Their findings show that in the core of the brain’s reward system specific neurons are active both with use of and withdrawal from nicotine.
Scientists from The Scripps Research Institute reveal that physically moving forward actually trains the brain to perceive the world normally. The findings also show that, the order in which we see things could help the brain calibrate how we perceive time, as well as the objects around us.
In a pair of related studies, scientists from the Florida campus of The Scripps Research Institute have identified a number of new therapeutic targets for memory disorders and have developed a new screening test to uncover compounds that may one day work against those disorders.
Chemists at The Scripps Research Institute (TSRI) and the Shanghai Institute of Organic Chemistry have described a method for creating and modifying organic compounds that overcomes a major limitation of previous methods.
Scripps Research Institute scientists have found that even brief workouts can reduce the risk of relapse in rats withdrawing from methamphetamine. Team found exercise affected neurons in a brain region never before associated with meth withdrawal, suggesting a new direction for drug development.
Biologists at The Scripps Research Institute have described the atomic-level workings of “microRNA” molecules, which control the expression of genes in all animals and plants. The findings add greatly to the understanding of a fundamental system of regulation in biology.
Mimicking natural evolution in a test tube, scientists at The Scripps Research Institute have devised an enzyme with a unique property that might have been crucial to the origin of life on Earth.
Scientists from the Florida campus of The Scripps Research Institute have uncovered a major contributor to Huntington’s disease, a devastating progressive neurological condition that produces involuntary movements, emotional disturbance and cognitive impairment.
Positive new clinical data were released today on a drug candidate for ulcerative colitis that was first discovered and synthesized at The Scripps Research Institute.
A team from The Scripps Research Institute has established a new C-H activation technique that opens the door to creating a broader range of pure molecules of one-handedness or “chirality” by eliminating previous starting-material limitations.
Scientists at The Scripps Research Institute have discovered a way to decrease deadly protein deposits in the heart, kidney and other organs associated with a group of human diseases called the systemic amyloid diseases.
Scientists at The Scripps Research Institute have identified the long-sought activating molecules for a rare but crucial subset of immune system cells that help rally other white blood cells to fight infection.
Scientists from The Scripps Research Institute have been awarded $6.6 million from the National Institutes of Health to lead an investigation of Lassa fever virus, the most prevalent virus-induced hemorrhagic fever disease in Africa.
A new study by scientists from The Scripps Research Institute, Lawrence Berkeley National Laboratory and other institutions suggests a cause of amyotrophic lateral sclerosis, also known as Lou Gehrig’s disease.
Scientists at The Scripps Research Institute have created a synthetic molecule that mimics “good” cholesterol and have shown it can reduce plaque buildup in the arteries of animal models. The molecule, taken orally, improved cholesterol in just two weeks.
San Diego researchers at The Scripps Research Institute and Scripps Translational Science Institute will receive more than $4.4 million as part of a National Institutes of Health initiative called “Big Data to Knowledge.”
Scripps Research Institute scientists have found an enzyme best known for its fundamental role in building proteins has a second major function: to protect DNA during times of cellular stress. The finding, remarkable on a basic science level, also points the way to possible therapeutic applications.
Scientists at The Scripps Research Institute (TSRI) have discovered that a gene mutation linked to hereditary spastic paraplegia, a disabling neurological disorder, interferes with the normal breakdown of triglyceride fat molecules in the brain. The TSRI researchers found large droplets of triglycerides within the neurons of mice modeling the disease.
Scientists at The Scripps Research Institute (TSRI) have described how a single family of antibodies that broadly neutralizes different strains of HIV has evolved remarkably diverse structures to attack a vulnerable site on the virus. The findings provide clues for the design of a future HIV vaccine.
Scientists from both campuses of The Scripps Research Institute (TSRI) have been awarded a total of $7.9 million from the Defense Advanced Research Projects Agency (DARPA) of the U.S. Department of Defense. The two teams will build what is, in essence, an artificial immune system.
Positive new data have been released on a drug candidate, RPC1063, for relapsing multiple sclerosis that was first discovered and synthesized at The Scripps Research Institute (TSRI).
Scientists at The Scripps Research Institute (TSRI) have devised a new antibiotic based on vancomycin that is powerfully effective against vancomycin-resistant strains of MRSA and other disease-causing bacteria.
Scientists from the Florida campus of The Scripps Research Institute and the La Jolla Institute for Allergy and Immunology have developed a more effective method to determine how T cells differentiate into specialized cell types.
In a new study that could lead to many new medicines, scientists from the Florida campus of The Scripps Research Institute have adapted a chemical approach to turn diseased cells into unique manufacturing sites for molecules that can treat a form of muscular dystrophy.
Scientists at The Scripps Research Institute solved the mystery of why a specific signaling pathway can be associated with alcohol dependence. The new research shows the gene, Nf1, regulates gamma-aminobutyric acid (GABA), a neurotransmitter that lowers anxiety and increases relaxation feelings.
Chemists led by Nobel laureate K. Barry Sharpless at The Scripps Research Institute have used his click chemistry to uncover unprecedented, powerful reactivity for making new drugs, diagnostics, plastics, smart materials and many other products.
A team led by scientists from the Florida campuses of The Scripps Research Institute and the Mayo Clinic have designed a therapeutic strategy targeting a specific genetic mutation that causes a common form of amyotrophic lateral sclerosis and a type of frontotemporal dementia.
A study from The Scripps Research Institute’s Florida campus and Columbia University shows the huntingtin gene plays a critical role in long-term memory.
The Scripps Research Institute (TSRI) Board of Trustees today announced that James Paulson, chair of TSRI’s Department of Cell and Molecular Biology, has been appointed acting president and CEO as Michael Marletta’s presidency comes to a close.
Scientists at The Scripps Research Institute have disrupted the function of MYC, a cancer regulator thought to be “undruggable.” The researchers found that a credit card-like molecule they developed moves in and disrupts critical interactions between MYC and its binding partner.
Laboratories at The Scripps Research Institute are investigating antibodies to fight Ebola virus, including the three antibodies recently used to treat two American health care workers infected with the Ebola virus.
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