Mice With Lou Gehrig’s Disease Not Quite What the Doctors Ordered

Released: 10/5/2012 1:00 PM EDT
Source Newsroom: Alzheimer Research Forum Foundation
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Newswise — The mice in which scientists expected to test treatments for Lou Gehrig’s disease turn out to have problems that could slow research, reported Alzforum, a research news site specializing in Alzheimer’s and related diseases. To the researchers’ surprise, the mice didn’t die of the spinal nerve disease. Instead, they succumbed to intestinal blockage.

“There were high expectations,” said Robert Baloh of the Cedars-Sinai Medical Center in Los Angeles, who made the new mice. “The problem is, they are still mice. Humans and mice, even if they have the same genetic mutation, get different diseases.”

Between 20,000 and 30,000 people in the U.S. have Lou Gehrig’s disease, or amyotrophic lateral sclerosis, which kills nerve cells in the spine. It causes paralysis and death, typically within a few years. There is only one treatment, riluzole, which extends live by a couple of months.

Difficulties in transferring treatments from mice to people have long plagued scientists trying to treat Lou Gehrig’s and Alzheimer’s. That’s why researchers were excited when, five years ago, it was discovered that some people with Lou Gehrig’s have mutations in a gene called TDP-43. They rushed to make mice with the same mutations, thinking the animals would be an excellent new testing ground.

But problems, such as the intestinal blockage, are arising as scientists work to fully understand the new mice. Nonetheless, the mice could still be useful in testing drugs and should also help researchers understand just how Lou Gehrig’s kills nerve cells, experts say. And in the process, scientists are learning just how rigorously they have to characterize a given mouse model, and design treatment studies in those mice, to then have a fair shot at success in the clinic.

Alzforum’s “Are TDP-43 Mice Living Up to Expectations?” published on September 20, 2012, is freely available on the ARF website.

About Alzforum: The Alzheimer Research Forum (www.alzforum.org), founded in 1996, is the web's most dynamic scientific community dedicated to understanding Alzheimer disease and related disorders. Access to the web site is free to all. The Forum’s editorial priorities are as diverse as the needs of the research community. The web site reports on the latest scientific findings, from basic research to clinical trials; creates and maintains public databases of essential research data and reagents; and produces discussion forums to promote debate, speed the dissemination of new ideas, and break down barriers across the numerous disciplines that can contribute to the global effort to cure Alzheimer's disease.

The ARF team of professional science writers and editors, information technology experts, web developers and producers all work closely with its distinguished and diverse Advisory Board to ensure a high quality of information and services. The Alzheimer Research Forum is an independent nonprofit organization supported by grants and individual donations. The web site does not endorse any specific product or scientific approach.


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