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Neurophage Discovers GAIM-Changing Molecules to Combat Alzheimer’s Disease and Other Neurodegenerative Disorders

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Researchers from NeuroPhage Pharmaceuticals, Inc. have engineered a series of molecules with the potential to treat most neurodegenerative diseases that are characterized by misfolded proteins, such as Alzheimer’s, Parkinson’s and Huntington’s diseases.

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LBD, Underrecognized Yet Common, Says Whoopi Goldberg

Today, if you hear, “Knock, knock,” on your cyber door, be sure to answer, “Who’s there?” You’ll hear Whoopi Goldberg say, “Lewy.“ To which you respond, of course, “Lewy who?” Glad you asked. The Lewy Body Dementia Association (LBDA) launched this month an awareness campaign – “Lewy Who?” – to educate the public about Lewy body dementia (LBD), the most misdiagnosed form of dementia and, following Alzheimer’s disease, the second most common cause of progressive dementia.

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Experts Propose New Approach to Manage the Most Troubling Symptoms of Dementia, Lessen Use of Drugs

A new approach to handling agitation, aggression and other unwanted behaviors by people with dementia may help reduce the use of antipsychotics and other psychiatric drugs in this population, and make life easier for them and their caregivers.

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“Chaperone” Compounds Offer New Approach to Alzheimer's Treatment

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A team of researchers from Columbia University Medical Center (CUMC), Weill Cornell Medical College, and Brandeis University has devised a wholly new approach to the treatment of Alzheimer's disease involving the so-called retromer protein complex. Retromer plays a vital role in neurons, steering amyloid precursor protein (APP) away from a region of the cell where APP is cleaved, creating the potentially toxic byproduct amyloid-beta, which is thought to contribute to the development of Alzheimer's.

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In Old Age, Lack of Emotion and Interest May Signal Your Brain Is Shrinking

Older people who have apathy but not depression may have smaller brain volumes than those without apathy, according to a new study published in the April 16, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology. Apathy is a lack of interest or emotion.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 4/23/2014 4:00 PM EDT

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Community-Living Seniors with Dementia Are More Likely to Be Hospitalized Than Those Without Dementia; Little Difference Found Among Nursing Home Residents

Seniors living in the community who have dementia are more likely to be hospitalized and visit the emergency department than those who do not have dementia, according to a new study by researchers at RTI International.

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Alzheimer’s Disease May Be More Prevalent and Manifests Itself Differently Among African Americans

A new study by researchers at Rush University Medical Center reviews research that suggests that the risk for developing Alzheimer’s disease among older African Americans may be two to three times greater than in the non-Hispanic white population and that they differ from the non-Hispanic white population in risk factors and disease manifestation. The study results will be published in the April 7 issue of Health Affairs.

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Cognitive Impairment Common Among Community-Dwelling and Nursing-Home Resident Elderly Nearing End-of-Life

More than 70% of elderly Medicare beneficiaries experience cognitive impairment or severe dementia near the end-of-life and may need surrogate decision makers for healthcare decisions. Advance care planning for older adults with dementia may be particularly important for individuals who do not reside in a nursing home or a long-term care facility, according to an article published in the April issue of Health Affairs.

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Policy Changes Urgently Needed as Millions of Americans to Start Receiving Early Label of Alzheimer's Disease

How will we, as individuals, and a society, live with brains at risk for Alzheimer's disease dementia? As part of Health Affairs’ April issue, a theme issue focusing on Alzheimer’s, a neurodegenerative disease ethicist and clinician with the Perelman School of Medicine at the University of Pennsylvania offers keen observations to help navigate ethically-charged points on the course of the disease progression.

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