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Down Syndrome Helps Researchers Understand Alzheimer’s Disease

The link between a protein typically associated with Alzheimer’s disease and its impact on memory and cognition may not be as clear as once thought, according to a new study from the University of Wisconsin-Madison’s Waisman Center. The researchers looked at the role of the brain protein amyloid-β in adults living with Down syndrome, a genetic condition that leaves people more susceptible to developing Alzheimer’s.

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EMBARGOED

A reporter's PressPass is required to access this story until the embargo expires on 24-Sep-2014 4:00 PM EDT

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Novel Mechanism Involved in Memory Discovered by UAB Researchers

Researchers at UAB report in Nature the discovery of a novel mechanism in the brain involved in the formation of memory and learning. The discovery could have therapeutic ramifications for conditions including dementia, age-related memory loss or even post-traumatic stress disorder.

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Neuroscientists Get Busy in the CRISPR Kitchen—What Will They Cook Up?

Molecular biologists are wielding a hot new gene editing tool called CRISPR to mutate, slice, and hopefully repair virtually any spot in the genome of any animal. Neuroscientists are finally taking advantage of the new technique, with an eye toward potential therapies for genetic diseases.

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Protein Variant May Boost Cardiovascular Risk by Hindering Blood Vessel Repair

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Researchers at UT Southwestern Medical Center have found that the most common variant of the circulating protein apolipoprotein E, called apoE3, helps repair the lining of blood vessels.

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Scientists Identify the Master Regulator of Cells' Heat Shock Response, Pointing to New Potential Targets for Neurodegenerative Diseases and Cancer

Heat shock proteins protect the molecules in all human and animal cells with factors that regulate their production and work as thermostats. In new research published Sept. 16 in the journal eLife, scientists at NYU Langone Medical Center and elsewhere report for the first time that a protein called translation elongation factor eEF1A1 orchestrates the entire process of the heart shock response.

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Can Your Blood Type Affect Your Memory?

People with blood type AB may be more likely to develop memory loss in later years than people with other blood types, according to a study published in the September 10, 2014, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Targeted Immune System Booster Removes Toxic Proteins in Mouse Model of Alzheimer's Disease

Alzheimer’s disease experts at NYU Langone Medical Center and elsewhere are reporting success in specifically harnessing a mouse’s immune system to attack and remove the buildup of toxic proteins in the brain that are markers of the deadly neurodegenerative disease.

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Some Anti-Inflammatory Drugs Affect More Than Their Targets

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Researchers have discovered that three commonly used nonsteroidal anti-inflammatory drugs, or NSAIDs, alter the activity of enzymes within cell membranes. Their finding suggests that, if taken at higher-than-approved doses and/or for long periods of time, these prescription-level NSAIDs and other drugs that affect the membrane may produce wide-ranging and unwanted side effects.

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Investigational Therapy Focuses on Slowing Progression in Mild to Moderate Alzheimer’s

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Patients with mild to moderate Alzheimer’s disease currently have no treatment options to slow brain cell deterioration. Researchers at Houston Methodist’s Nantz National Alzheimer Center are studying an investigational drug that proposes to do just that.

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