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A reporter's PressPass is required to access this story until the embargo expires on 30-Mar-2015 11:00 AM EDT

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Mayo Clinic Study of Thousands of Brains Reveals Tau as Driver of Alzheimer’s Disease

By examining more than 3,600 postmortem brains, researchers at Mayo Clinic’s campuses in Jacksonville, Florida, and Rochester, Minnesota, have found that the progression of dysfunctional tau protein drives the cognitive decline and memory loss seen in Alzheimer’s disease.

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Pre-Clinical Research Validates Potential for Focused Ultrasound in Alzheimer's

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A pre-clinical study published this week in Science Translational Medicine suggests that focused ultrasound may hold a key to providing a non-invasive, non-pharmaceutical approach to treating Alzheimer’s disease.

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Penn Medicine Researchers Pinpoint Potential New Drug Target for Protection against Certain Neurodegenerative Diseases

Penn Medicine researchers have discovered that hypermethylation - the epigenetic ability to turn down or turn off a bad gene implicated in 10 to 30 percent of patients with Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Degeneration (FTD) - serves as a protective barrier inhibiting the development of these diseases. Their work, published this month in Neurology, may suggest a neuroprotective target for drug discovery efforts.

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Changes in a Blood-Based Molecular Pathway Identified in Alzheimer’s Disease

New research identifies a bridge between the mechanisms that spur the destruction of neurons in Alzheimer’s disease - accumulation of the amyloid-β peptide (the main component of plaques found in Alzheimer’s patient brains) and chronic inflammation..

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Neuroinflammation Emerges as a Key Player in Neurodegenerative Disease at Keystone Meeting

At the Keystone symposium “Neuroinflammation in Diseases of the Central Nervous System,” researchers bridged the gap between inflammation and neurobiology to uncover how the two influence neurodegenerative disease. Read Alzforum’s seven-part series for the highlights.

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New MIND Diet May Significantly Protect Against Alzheimer’s Disease

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A new diet, appropriately known by the acronym MIND, could significantly lower a person’s risk of developing Alzheimer’s disease, even if the diet is not meticulously followed, according to a paper published online for subscribers in March in the journal Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association.

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Who Will Develop Memory Problems? New Tool May Help Predict

Researchers have developed a new scoring system to help determine which elderly people may be at a higher risk of developing the memory and thinking problems that can lead to dementia, according to a new study published in the March 18, 2015, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Is it Dementia, or Just Normal Aging? New Tool May Help Triage

Researchers at Mayo Clinic developed a new scoring system to help determine which elderly people may be at a higher risk of developing the memory and thinking problems that can lead to dementia. The study is published in the March 18, 2015, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Boosting A Natural Protection Against Alzheimer’s Disease

Researchers at the University of California, San Diego School of Medicine have identified a gene variant that may be used to predict people most likely to respond to an investigational therapy under development for Alzheimer’s disease (AD). The study, published March 12 in Cell Stem Cell, is based on experiments with cultured neurons derived from adult stem cells.