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A reporter's PressPass is required to access this story until the embargo expires on 30-Jun-2016 12:00 AM EDT

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New Findings Challenge Current View on Origins of Parkinson's Disease

The neurodegeneration that occurs in Parkinson's disease is a result of stress on the endoplasmic reticulum in the cell rather than failure of the mitochondria as previously thought, according to a study in fruit flies. It was found that the death of neurons associated with the disease was prevented when chemicals that block the effects of endoplasmic reticulum stress were used.

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TSRI Scientists Reveal Single-Neuron Gene Landscape of the Human Brain

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A team of scientists at The Scripps Research Institute (TSRI), University of California, San Diego (UC San Diego) and Illumina, Inc., has completed the first large-scale assessment of single neuronal “transcriptomes.”

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UCI, Queensland Scientists Identify New Switch to Boost Memory

New insight into the process that converts experiences into stable long-term memories has been uncovered by neurobiologists from the University of California, Irvine and the University of Queensland.

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Understanding How Chemical Changes in the Brain Affect Alzheimer's Disease

A new study from Western University is helping to explain why the long-term use of common anticholinergic drugs used to treat conditions like allergies and overactive bladder lead to an increased risk of developing dementia later in life. The findings show that long-term suppression of the neurotransmitter acetylcholine - a target for anticholinergic drugs - results in dementia-like changes in the brain.

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Case Western Reserve University Receives NIH Funding to Participate in Launch of Genomics Center on Alzheimer's Disease

Case Western Reserve University School of Medicine is one of six recipients of a five-year, $10.8 million award from the National Institute on Aging, part of the National Institutes of Health, to establish the Coordinating Center for Genetics and Genomics of Alzheimer’s disease.

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Penn Medicine Team and Collaborators Receive NIH Award to Launch Genomics Center on Alzheimer's Disease

A five-year, projected $10.8 million award from the National Institute on Aging will establish the Coordinating Center for Genetics and Genomics of Alzheimer’s Disease, a joint venture of researchers from the Perelman School of Medicine at the University of Pennsylvania and five other institutions.

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Leading FAU Neuroscientist Available as Expert on Younger Onset Alzheimer’s Disease

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Pre and Post Testing Show Reversal of Memory Loss From Alzheimer’s Disease in Ten Patients

Small trial from the Buck Institute and UCLA succeeds using systems approach to memory disorders.

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Alzheimer's Researchers Find Clues to Toxic Forms of Amyloid Beta

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A subtle change to the amyloid beta protein affects its aggregation behavior and stabilizes an intermediate form with enhanced toxicity.

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Rowan Researchers Develop Blood Test That Detects Early Alzheimer’s Disease

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Researchers from Rowan University School of Osteopathic Medicine have announced the development of a blood test that leverages the body’s immune response system to detect early stage of Alzheimer’s disease with unparalleled accuracy. In a “proof of concept” study involving 236 subjects, the test demonstrated an overall accuracy, sensitivity and specificity rate of 100 percent in identifying subjects whose mild cognitive impairment (MCI) was actually caused by an early stage of Alzheimer’s disease.

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Videoconferencing Between Hospital Clinicians and Nursing Home Staff Lowers Use of Physical Restraint, Antipsychotics in Patients with Dementia

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Nursing homes care for increasing numbers of people with dementia, yet many lack access to geriatric psychiatrists, behavioral neurologists and other specialists who can help manage dementia care. Consequently, nursing home staff may resort to physical restraints or antipsychotic medications to manage behavioral challenges. A new study led by BIDMC has found that use of video consultations between nursing home staff and hospital clinical experts was associated with significant reductions in the use of physical restraints and antipsychotic medication among dementia patients.

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Study Reveals Insights Into Protein Linked to Cancer and Alzheimer’s Disease

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Cancer and Alzheimer's disease drugs target specific proteins, blocking or inhibiting their natural interactions, which may be in overdrive. The traditional drug design process typically assumes the protein shapes are static. But tradition turns out to be too limiting, according to new research from the University of Notre Dame.

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Scripps Florida Scientists Discover a New Protein Crucial to Normal Forgetting

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A study by scientists at The Scripps Research Institute Florida campus uncovers a new aspect of how the process of forgetting works, indicating a protein called “Scribble” orchestrates the intracellular signaling processes for forgetting, joining several molecules to forge a pathway.

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Lack of Diagnosis Creates Added Risks for Those with Dementia

A Johns Hopkins study on data from more than 7,000 older Americans has found that those who show signs of probable dementia but are not yet formally diagnosed are nearly twice as likely as those with such a diagnosis to engage in potentially unsafe activities, such as driving, cooking, and managing finances and medications.

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Exploring the Link Between Infection and Alzheimer’s

Brian Balin, PhD, has studied the link between infection and Alzheimer's disease for more than 20 years and offers his thoughts on this growing area of research.

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Is Beer Good for the Brain?

While most people will agree that excessive consumption of alcohol can have a detrimental effect on the brain, there is less agreement regarding the effects of light or moderate drinking. This includes concern and controversy surrounding the effects of drinking on the development of neurodegenerative diseases such as Alzheimer’s (AD). This study investigated the association between consumption of different alcoholic beverages – beer, wine, and spirits – and one of the neuropathological signs of Alzheimer’s disease, β-amyloid (Aβ) aggregation in the brain.

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Study Investigates Why Blacks Have Higher Risk of Cognitive Impairment

Social and economic disadvantages play a significant role in why blacks face a much higher risk than whites of developing cognitive impairment later in life, indicates a national study led by a Michigan State University (MSU) sociologist.

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Sea Urchins Defy Aging, Study Identifies How Brain Connects Memories Across Time, Regular Exercise at Any Age Might Stave Off Alzheimer’s, and more in the Aging News Source

Click to visit the Aging Channel

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Current Screening Methods Miss Worrisome Number of Persons with Mild Cognitive Impairment

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In a paper published in the current Journal of Alzheimer’s Disease, researchers at University of California San Diego School of Medicine and Veterans Affairs San Diego Healthcare System say existing screening tools for mild cognitive impairment (MCI) result in a false-negative error rate of more than 7 percent. These persons are misclassified as not having MCI based on standard screening instruments but actually do have MCI when more extensive testing is conducted.