Study Identifies Which Bipolar Patients Will Respond to Ketamine Therapy for Depression, Pain

Article ID: 608612

Released: 7-Oct-2013 2:00 PM EDT

Source Newsroom: American Society of Anesthesiologists (ASA)

EMBARGOED FOR RELEASE:October 13, 201310 a.m. PDT

Newswise — SAN FRANCISCO – October 13, 2013 – Researchers have discovered how to determine which bipolar patients will benefit from Ketamine, a treatment commonly used for depression and pain relief, according to a study presented at the ANESTHESIOLOGY™ 2013 annual meeting.

Two-thirds of patients benefit from Ketamine and using a blood test, researchers can predict which patients will respond favorably.

“Doctors know that very small doses of Ketamine help relieve depression and pain,” said Michael Goldberg, M.D., professor and chairman of anesthesiology, and associate dean for education at Cooper Medical School of Rowan University and chief of the Department of Anesthesiology for Cooper University Health Care, Camden, N.J. “But one in three patients do not respond to this treatment. This research will help as we seek ways to provide these patients relief.”

Researchers identified the compound that Ketamine breaks down into, which they named HNK (2S, 6S hydroxynorketamine). Additionally, researchers discovered the pattern or ‘fingerprint’ in the fatty acids of the blood that indicates which patients will respond to HNK.

In the study, 22 patients with bipolar disorder were given intravenous doses of Ketamine. Blood was collected from each patient. Responders and non-responders were identified using a standardized depression rating scale. A positive response was defined as a 50 percent or greater improvement. Additionally, researchers examined metabolic patterns in blood samples.

Researchers discovered there was a difference in how responders and nonresponders metabolized fatty acids, based on the variability in levels of 18 different metabolites.

“These are significant discoveries which should eventually help in the treatment of patients suffering from depression and chronic pain,” said Irving Wainer, Ph.D., senior investigator with the Intramural Research Program at the National Institute on Aging, Baltimore. “The next step is to look for the genetic or environmental factors that determine whether a person develops the metabolic pattern that responds to the treatment. We hope this leads to the development of customized or individualized treatment for each patient.”

The American Society of AnesthesiologistsFounded in 1905, the American Society of Anesthesiologists (ASA) is an educational, research and scientific society with more than 50,000 members organized to raise and maintain the standards of the medical practice of anesthesiology. ASA is committed to ensuring physician anesthesiologists evaluate and supervise the medical care of patients before, during and after surgery to provide the highest quality and safest care every patient deserves. For more information on the field of anesthesiology, visit the American Society of Anesthesiologists online at To learn more about the role physician anesthesiologists play in ensuring patient safety, visit Join the ANESTHESIOLOGY™ 2013 social conversation today. Like ASA on Facebook, follow ASALifeline on Twitter and use the hashtag #ANES2013.

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