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Released: 23-Aug-2022 12:00 PM EDT
Golgi-dependent Reactivation and Regeneration of Quiescent Neural Stem Cells
Preprints

Mahekta Rajeshkumar Gujar, Yang Gao, Xiang Teng, Qiannan Deng, Ye Sing Tan, Yusuke Toyama, Hongyan Wang

Newswise: Untapped potential of stem cells could aid repair of spinal cord damage
Released: 22-Aug-2022 3:15 PM EDT
Untapped potential of stem cells could aid repair of spinal cord damage
Francis Crick Institute

Scientists at the Francis Crick Institute have identified a group of latent stem cells that respond to injury in the central nervous system of mice.

Released: 22-Aug-2022 12:00 PM EDT
Human Embryonic Stem Cell-derived Cerebral Organoids for Treatment of Mild Traumatic Brain Injury in a Mouse Model
Preprints

Jong-Tae Kim, Sung Min Cho, Dong Hyuk Youn, Tae Yeon Kim, Sung Woo Han, Chan Hum Park, Younghyurk Lee, Eun Pyo Hong, Harry Jung, Jae Jun Lee, Jong Kook Rhim, Jeong Jin Park, Jun Hyong Ahn, Heung Cheol Kim,

Released: 22-Aug-2022 12:00 PM EDT
Transplantation of human umbilical cord mesenchymal stem cells induces angiogenesis and promotes repair of uterine scars in rats
Preprints

Xiuyin Shen, Xin Luo, Shuzhen Wu, Yingchun Wan, Huiting Ma, Shaoxin Ye, Zhuoling Zhang, Min Lu, Hai Tang, Xiaoyan Gou, Xiaoling Guo, ZhengPing Liu

Released: 22-Aug-2022 12:00 PM EDT
Cortical interneuron development is affected in leukodystrophy 4H
Preprints

Stephanie Dooves, Liza M.L. Kok, Dwayne B. Holmes, Nicole Breeuwsma, Marjolein Breur, Marianna Bugiani, Nicole Wolf, Vivi M Heine

Released: 22-Aug-2022 12:00 PM EDT
A nationwide survey of late effects in survivors of juvenile myelomonocytic leukemia in Japan
Preprints

Shuichi Ozono, Kazuo Sakashita, Nao Yoshida, Harumi Kakuda, Kenichiro Watanabe, Miho Maeda, Yasushi Ishida, Atsushi Manabe, Takashi Taga, Hideki Muramatsu

Released: 22-Aug-2022 12:00 PM EDT
Differentiation of human induced pluripotent stem cells into cortical neural stem cells
Preprints

Alexandra Neaverson, Malin H.L. Andersson, Osama A. Arshad, Luke Foulser, Mary Goodwin-Trotman, Adam Hunter, Ben Newman, Minal Patel, Charlotte Roth, Tristan Thwaites, Helena Kilpinen, Matthew E. Hurles, Andrew Day, Sebastian S. Gerety

Released: 22-Aug-2022 12:00 PM EDT
Induced pluripotent stem cell-derived dendritic cell vaccine therapy genetically modified on the ubiquitin-proteasome system
Preprints

Shinta Tominaga, Toshiyasu Ojima, Motoki Miyazawa, Hiromitsu Iwamoto, Junya Kitadani, Shimpei Maruoka, Keiji Hayata, Hiroki Yamaue

17-Aug-2022 4:35 PM EDT
The Locked Library: Disease Causes Cells to Reorder Their DNA Incorrectly
Perelman School of Medicine at the University of Pennsylvania

With super-resolution imaging, Penn Medicine researchers discovered that cells change the physical structure of their genome when they’re affected by disease

Released: 20-Aug-2022 12:00 PM EDT
Molecular evolution and inheritance pattern of Sox gene family among Bovidae
Preprints

Mabel O Akinyemi, Muyiwa S Adegbaju, Anastasia Grytsay, Osamede H Osaiyuwu, Jessica Finucan, Ibukun M Ogunade, Sunday O Peters, Bolaji N Thomas, Olanrewaju B Morenikeji

Released: 19-Aug-2022 12:00 PM EDT
Lipidomic profiling reveals age-dependent changes in complex plasma membrane lipids that regulate neural stem cell aging
Preprints

Xiaoai Zhao, Xin Yan, Kévin Contrepois, Francesco Vallania, Mathew Ellenberger, Chloe M. Kashiwagi, Stephanie D. Gagnon, Cynthia J. Siebrand, Matias Cabruja, Gavin M. Traber, Andrew McKay, Daniel Hornburg, Purvesh Khatri, Michael P.

Released: 19-Aug-2022 12:00 PM EDT
NANOGP1, a tandem duplicate of NANOG, exhibits partial functional conservation in human naive pluripotent stem cells
Preprints

Katsiaryna Maskalenka, Gokberk Alagoz, Felix Krueger, Joshua Wright, Maria Rostovskaya, Asif Nakhuda, Adam Bendall, Christel Krueger, Simon Walker, Aylwyn Scally, Peter Rugg-Gunn

Released: 19-Aug-2022 12:00 PM EDT
Hematopoietic Stem Cell Gene Therapy Alleviates Disease Phenotypes in a Murine Model of Danon Disease
Preprints

Chao Chen, Sherin Hashem, Jay Sharma, Ana Maria Manso, Paul Bushway, Jason Duran, Emily Gault, Yusu Gu, Jose Cano Nigenda, Angel Soto-Hermida, Kirk Peterson, Paul Saftig, Stephanie Cherqui, Sylvia Evans,

Released: 18-Aug-2022 12:00 PM EDT
Gilteritinib-induced severe immune-related enteritis: a possible case report
Preprints

Pan Luo, Huiyin Qiu, Yushan Yang, Jiaqi Wu, Xianmin Song, Guorong Fan, Gaolin Liu, Junwei Gao

Released: 18-Aug-2022 12:00 PM EDT
Mesenchymal stromal cell encapsulation in uniform chitosan beads using microchannel emulsification
Preprints

Dongjin S Shin, Francesco K Touani, Damon G.K Aboud, Anne Kietzig, Sophie Lerouge, Corinne A Hoesli

Released: 18-Aug-2022 12:00 PM EDT
Loss of LRP1 in adult neural stem cells impairs migration to ischemic lesions
Preprints

Kristi Dietert, Swetha Mahesula, Sheetal Hegde, John Verschelde, Pamela Reed, Shane Sprague, Erzsebet Kokovay, Naomi L Sayre

Newswise: CRISPR-based Technology Targets Global Crop Pest
15-Aug-2022 6:05 PM EDT
CRISPR-based Technology Targets Global Crop Pest
University of California San Diego

UC San Diego scientists have developed a technology that uses CRISPR genetic editing in Drosophila suzukii, the invasive fruit fly responsible for millions of dollars in fruit crop damage.

Newswise: Why We Fit A Mini Brain with a Mini Cap
14-Aug-2022 2:05 PM EDT
Why We Fit A Mini Brain with a Mini Cap
 Johns Hopkins University

It could be the world’s tiniest EEG electrode cap, created to measure activity in a brain model the size of a pen dot. Its designers expect the device to lead to better understanding of neural disorders and how potentially dangerous chemicals affect the brain. This engineering feat, led by Johns Hopkins University researchers and detailed today in Science Advances, expands what researchers can accomplish with organoids, including mini brains—the lab-grown balls of human cells that mimic some of a brain’s structure and functionality.

Released: 17-Aug-2022 12:00 PM EDT
Media for culturing cells v1
Preprints

Rebecca Berrens

Released: 17-Aug-2022 12:00 PM EDT
Deriving Schwann Cells from hPSCs Enables Disease Modeling and Drug Discovery for Diabetic Peripheral Neuropathy
Preprints

Homa Majd, Sadaf Amin, Zaniar Ghazizadeh, Andrius Cesiulis, Edgardo Arroyo, Karen Lankford, Sina Farahvashi, Angeline K Chemel, Mesomachukwu Okoye, Megan D Scantlen, Jason Tchieu, Elizabeth L Calder, Valerie LeRouzic, Abolfazl Arab,

Newswise: Hackensack University Medical Center Becomes Second Hospital in the World to Implant New Heart Pump to Treat Chronic Heart Failure
Released: 17-Aug-2022 10:50 AM EDT
Hackensack University Medical Center Becomes Second Hospital in the World to Implant New Heart Pump to Treat Chronic Heart Failure
Hackensack Meridian Health

Hospital is one of only five in the U.S. selected to participate in early clinical trial for the minimally invasive Impella BTR technology

Newswise: Building better biomedical research avenues
Released: 16-Aug-2022 4:35 PM EDT
Building better biomedical research avenues
Case Western Reserve University

Leading researchers will gather this week at a Case Western Reserve University-led symposium highlighting progress and opportunities in biomedical research and human-performance sciences. The event takes place this Thursday and Friday, Aug. 18-19, at the Wolstein Research Center on the Case Western Reserve campus, and features researchers and clinicians from the university, area hospital affiliates and the Wright-Patterson Air Force Base in Dayton.

Released: 16-Aug-2022 12:00 PM EDT
Mass spectrometry imaging reveals early metabolic priming of cell lineage in differentiating human induced pluripotent stem cells
Preprints

Arina A. Nikitina, Alexandria Van Grouw, Tanya Roysam, Danning Huang, Facundo M. Fernandez, Melissa L. Kemp

Released: 16-Aug-2022 12:00 PM EDT
Bone Regeneration by Hydroxyapatite-Gelatinnanocomposites
Preprints

Sahar I Mostafa, Nesma M Abdelfattah, Sayed M Ghorab, Manal F Osman, Noha A Elwassefy

Released: 16-Aug-2022 12:00 PM EDT
Collagen Ⅰ-DDR1 signaling promotes hepatocellular carcinoma cell stemness via Hippo signaling repression.
Preprints

Yi-Xiao Xiong, Xiaochao Zhang, Jing-Han Zhu, Yuxin Zhang, Yonglong Pan, Yu Wu, Jian-Ping Zhao, Junjie Liu, Yuan-Xiang Lu, Huifang Liang, Zhanguo Zhang, Wanguang Zhang

Released: 16-Aug-2022 12:00 PM EDT
Fludarabine/TBI 8 Gy versus fludarabine/treosulfan conditioning in patients with AML in first complete remission: A Study from the Acute Leukemia Working Party of the EBMT
Preprints

Gesine Bug, Myriam Labopin, Riitta Niittyvuopio, Matthias Stelljes, Christian Reinhardt, Inken Hilgendorf, Nicolaus Kroeger, Ain Kaare, Wolfgang Bethge, Kerstin Schaefer-Eckart, Mareike Verbeek, Stephan Mielke, Kristina Carlson, Ali

Released: 15-Aug-2022 3:05 PM EDT
Scientists develop gel made from spider silk proteins for biomedical applications
Karolinska Institute

Researchers at Karolinska Institutet in Sweden and the Swedish University of Agricultural Sciences have discovered that spider silk proteins can be fused to biologically active proteins and be converted into a gel at body temperature.

Newswise: New Chip Could Make Treating Metastatic Cancer Easier and Faster
Released: 15-Aug-2022 2:55 PM EDT
New Chip Could Make Treating Metastatic Cancer Easier and Faster
Georgia Institute of Technology

Researchers at the Georgia Institute of Technology have found a detection method that could revolutionize cancer treatment by showing how cancers metastasize and what stage they are.

   
Released: 15-Aug-2022 12:00 PM EDT
Directed differentiation of mouse pluripotent stem cells into functional lung-specific mesenchyme
Preprints

The successful generation of endodermal, ectodermal, and most mesodermal lineages from pluripotent stem cells has resulted in basic discoveries and regenerative medicine clinical trials of cell-based therapies.

Released: 15-Aug-2022 12:00 PM EDT
Alcam-a and Pdgfr-α are essential for the development of sclerotome derived stromal cells that support hematopoiesis in vivo.
Preprints

: Mesenchymal stromal cells are essential components of hematopoietic stem and progenitor cell (HSPC) niches, regulating HSPC proliferation and fate decisions.

Released: 15-Aug-2022 12:00 PM EDT
Lipids Maintain Genomic Stability and Developmental Potency of Murine Pluripotent Stem Cells
Preprints

Liangwen Zhong, Miriam Gordillo, Xingyi Wang, Yiren Qin, Yuanyuan Huang, Alexey Soshnev, Ritu Kumar, Gouri Nanjangud, Daylon James, C. David Allis, Todd Evans, Bryce Carey, Duancheng Wen

Released: 15-Aug-2022 12:00 PM EDT
Mechanical force sensing drives extrusion of Enterovirus A71-infected cells from colonic epithelial organoids
Preprints

Jasmine Moshiri, Ailsa Craven, Sara Mixon, Manuel Amieva, Karla Kirkegaard

Released: 15-Aug-2022 12:00 PM EDT
Mesenchymal stem cells transplantation combined with IronQ attenuates ICH-induced inflammation response via Mincle/Syk signaling pathway
Preprints

Guoqiang Yang, Jiraporn Kantapan, Maryam Mazhar, Xue Bai, Yuanxia Zou, Honglian Wang, Bingfeng Huang, Sijing Yang, Nathupakorn Dechsupa, Li Wang

Released: 15-Aug-2022 10:05 AM EDT
Mayo Clinic announces a strategic collaboration for a new era of biomanufacturing
Mayo Clinic

Mayo Clinic today announced a strategic collaboration in biomanufacturing to deliver novel biotherapeutics for rare and complex conditions. The collaboration brings together science, engineering and manufacturing to advance Mayo Clinic's vision of bringing new cures to clinical care. The focus will be on therapies derived from human sources known as biologics — cells, blood, enzymes, tissues, genes or genetically engineered cells — for use in medicines. Therapeutics based on biologics have the potential to target exact tissues needing repair.

Released: 12-Aug-2022 1:05 PM EDT
Smart contact lenses for cancer diagnostics and screening
Terasaki Institute for Biomedical Innovation

Scientists from the Terasaki Institute for Biomedical Innovation (TIBI) have developed a contact lens that can capture and detect exosomes, nanometer-sized vesicles found in bodily secretions which have the potential for being diagnostic cancer biomarkers.

Released: 12-Aug-2022 12:00 PM EDT
Effect of human breast milk-derived exosomes on the migration and inflammatory response of lipopolysaccharide-exposed dental pulp stem cells
Preprints

Ehsaneh Azaryan, Samira Karbasi, Mansoore Saharkhiz, Mohammad Yahya Hanafi-Bojd, Asghar Zarban, Fariba Emadian Razavi, Mohsen Naseri

Released: 12-Aug-2022 12:00 PM EDT
Peripherally Inserted Central Venous Catheter for Pediatric Hematologic Diseases; A Retrospective 11-year Single-center Experience.
Preprints

Silvio Ligia, Salvatore Giacomo Morano, Francesca Kaiser, Alessandra Micozzi, Maria Luisa Moleti, Walter Barberi, Fiorina Giona, Antonio Chistolini, Valentina Arena, Alfonso Piciocchi, Maurizio Forgione, Giulia Gasperini, Marco Fabbri, Anna Maria Testi

Newswise: Safer imaging technology for complex aortic repairs uses light instead of X-rays
Released: 12-Aug-2022 11:05 AM EDT
Safer imaging technology for complex aortic repairs uses light instead of X-rays
UT Southwestern Medical Center

A new imaging device at UT Southwestern is making complex aortic repairs safer for patients and operating room staff by dramatically reducing their exposure to radiation. The device, known as Fiber Optic RealShape (FORS) and manufactured by Philips, uses light to visualize blood vessels, nearly eliminating the need for X-rays typically used during minimally invasive vascular procedures.

Newswise: Two Monumental Milestones Achieved in CT Imaging
Released: 12-Aug-2022 10:05 AM EDT
Two Monumental Milestones Achieved in CT Imaging
National Institute of Biomedical Imaging and Bioengineering

Two biomedical imaging technologies developed with support from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) have been cleared for clinical use by the Food and Drug Administration (FDA). Both technologies offer advances in computed tomography (CT).

   
Newswise: Mount Sinai Launches Large-Scale Genetic Sequencing Project with the Regeneron Genetics Center
Released: 12-Aug-2022 9:50 AM EDT
Mount Sinai Launches Large-Scale Genetic Sequencing Project with the Regeneron Genetics Center
Mount Sinai Health System

Mount Sinai Health System and the Icahn School of Medicine at Mount Sinai have launched a new human genome sequencing research project called the Mount Sinai Million Health Discoveries Program with the Regeneron Genetics Center (RGC), part of the industry-leading, New York-based biotechnology company Regeneron.



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