Feature Channels: Clinical Trials

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Studies to be presented at the ASCO meeting are co-authored by research oncologists Eric Whitman, MD; Missak Haigentz, MD; and Angela Alistar, MD. Their ASCO studies include: two separate studies looking at TILS therapy and Keytruda for advanced melanoma; immunotherapy for metastatic head and neck cancer; treatment for recurrent Epstein-Barr virus (EBV)-positive nasopharyngeal carcinoma; and a combination of CPI-613 -- a new type of medication, pioneered by Dr. Alistar, known as an altered energy metabolism drug -- with 5-FU in treating metastatic colorectal cancer.

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UNMC is the only institution in the central plains region participating in the research. Globally, 880 patients will be enrolled at 130 sites in 20 countries. Researchers will follow patients for up to five years.

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Clinical Research Pathways, a non-profit that advocates for increasing diversity in clinical research and expanding access to experimental drugs, biologics and medical devices, has added a new member to its board of directors.

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Findings from Rutgers Cancer Institute of New Jersey focused on immunotherapy will be featured at the 2019 American Society of Clinical Oncology Annual Meeting being held in Chicago tomorrow through Tuesday.

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Cancer patients previously excluded and underrepresented in immunotherapy clinical trials, such as African Americans and patients with HIV or viral hepatitis, actually benefit at the same rate as patients tested in the clinical trials, according to a Georgetown-led study to be presented at the 2019 ASCO Annual Meeting in Chicago.

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A survey conducted by Georgetown investigators found a significant knowledge and practice gap among community oncologists in the understanding and usage of genetic testing in determining patients' treatment plans and potential clinical trial outcomes.

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Something as simple as a phone call could be a way to alert health care providers and caregivers that an elderly person suffering from dementia may be spiraling down to dangerous self-neglect, according to researchers at The University of Texas Health Science Center at Houston (UTHealth).

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Fred Hutchinson Cancer Research Center’s latest findings in immunotherapy, prevention of cancer-linked viruses, health care disparities and more will be showcased at the annual meeting of the American Society of Clinical Oncology. The conference, “Caring for Every Patient, Learning from Every Patient,” will be held May 31-June 4 in Chicago. See highlights below.

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Today, the Journal of the American College of Radiology (JACR®) published a report detailing real-world artificial intelligence (AI) challenges and summarizing the priorities for translational research in AI for medical imaging to help accelerate the safe and effective use of AI in clinical practice.

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The Cancer Research Institute announced today a series of public education and awareness offerings during its seventh annual Cancer Immunotherapy Month™ in June.

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A new method of assessing the actions of medicines by matching them to their unique protein receptors has the potential to greatly accelerate drug development and diminish the number of drug trials that fail during clinical trials.

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Case Comprehensive Cancer Center has been selected, once again, as a Lead Academic Participating Site by the National Cancer Institute. The renewal comes with a six-year, $8.9 million grant that will enable the center to provide patients with additional access to clinical trials through the National Clinical Trials Network. In this renewal, NCI is committed to improving the resources provided for each patient to cover research costs at levels linked to the complexity of the clinical trial.

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As many as 90 percent of individuals who have a parent with Huntington’s disease (HD) choose not to take a gene test that reveals if they will also develop the fatal disorder — and a new study details the reasons why. Understanding the “why” matters as new clinical trials testing therapies for people who haven’t yet developed symptoms of Huntington disease requires participants to be tested for the HD gene to be included in the trials.

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A new clinical trial at The Ohio State University Wexner Medical Center and two other sites is testing an innovative procedure that may provide hope in the fight against Alzheimer’s disease. The non-invasive procedure uses low-intensity focused ultrasound to open the blood-brain barrier.

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The University of Illinois at Chicago will lead a $14.6 million, multi-center research project to determine which of two drugs — azithromycin, an antibiotic, or roflumilast, an anti-inflammatory medication — is the most effective at treating chronic obstructive pulmonary disease, which is also known as COPD.

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Participants in a phase I/II clinical trial of a new enzyme-based treatment for severe dry eye disease experienced reduced signs of disease and discomfort, according to a paper in Translational Vision Science and Technology.The trial compared eye drops containing a biosynthetic form of an enzyme called DNase with eye drops without the enzyme.

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A new clinical trial finds transcatheter aortic valve replacement (TAVR) to be equivalent or potentially preferable to surgical aortic valve replacement (SAVR) for low risk patients.

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A new study shows that a potential treatment for ischemia- reperfusion injury is safe for humans. Building upon three decades of preclinical animal studies, this NIH-funded trial demonstrated, for the first time, the safety of Regadenoson (an adenosine 2A receptor agonist) in human lung transplant patients.

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The American Association for Thoracic Surgery 99th Annual Meeting takes place at the Metro Toronto Convention Center, Toronto, Canada, May 4 - 7, 2019.

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Scientists at Seattle Children’s Research Institute are paving the way to use gene-edited B cells – a type of white blood cell in the immune system – to treat a wide range of potential diseases that affect children, including hemophilia and other protein deficiency disorders, autoimmune diseases, and infectious diseases.

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The early-stage prostate cancer treatment, approved for use in 31 European countries, is now being marketed in Germany, Italy, Israel, and Mexico

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A diabetes drug is being enlisted in the war against smoking by UTHealth researchers.

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Taking a pharmaceutical formulation of cannabidiol, a cannabis-based medicine, cut seizures nearly in half for children with a rare and severe type of epilepsy called Dravet syndrome, according to a phase 3 study released today that will be presented at the American Academy of Neurology’s 71st Annual Meeting in Philadelphia, May 4 to 10, 2019. Dravet syndrome, which starts in infancy, can lead to intellectual disability and frequent, prolonged seizures. Cannabidiol is derived from marijuana that does not include the psychoactive part of the plant that creates a “high.”

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Ablacon, Inc. (www.ablacon.com), a Wheat Ridge, CO-based company developing an advanced mapping system to guide the treatment of atrial fibrillation (AFib)

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Scientists at the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have been awarded a $4.6 million grant from the California Institute for Regenerative Medicine – also known as CIRM – to support a phase I clinical trial of a novel treatment for advanced sarcomas and other cancers with a specific tumor marker called NY-ESO-1.

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A USC Norris study aims to increase clinical trial enrollment among low-income patients and racial and ethnic minorities by offering financial assistance for out-of-pocket costs associated with the trial. Because patients from low-income and racial minorities enroll in clinical trials at much lower rates, researchers are not capturing accurate data about personalized cancer care within these groups.

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Penn Nursing’s Rosemary Polomano, PhD, RN, FAAN, Associate Dean for Practice Professor of Pain Practice, and M. Kit Delgado, MD, MS, Assistant Professor of Emergency Medicine and Epidemiology at Penn’s Perleman School of Medicine, have been appointed members of the National Academies of Sciences, Engineering, and Medicine’s (the Academies) Committee on Evidence-based Clinical Practice Guidelines to Prescribing Opioids for Acute Pain.

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An investigational drug that may block harmful antibodies from passing through the placenta of an expectant mother to the fetus is the focus of a new clinical trial led by Kenneth Moise, MD, a maternal-fetal medicine specialist at UTHealth.

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Researchers at University of California San Diego School of Medicine found using blood thinners in patients with worsening heart failure, coronary artery disease and irregular heart rhythms was associated with a reduced risk of thromboembolic events, such as stroke and heart attack.

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Fire ecologists and wildlife specialists at La Trobe University have made key discoveries in how wildlife restores itself after bushfires

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University of California San Diego School of Medicine researchers found that treating patients with personalized precision medicine that combined therapies to target multiple alterations improved outcomes in patients with therapy resistant cancers.

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Fight CRC’s Clinical Trial Finder App aims to make the web-based resource more accessible to Late-State, MSS colorectal cancer patients

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• The Time to Reduce Mortality in ESRD (TiME) trial was a large pragmatic trial demonstration project designed to determine the benefits of hemodialysis sessions that are longer than many patients currently receive. • The trial was conducted through a partnership between academic investigators and 2 large dialysis provider organizations using a highly centralized implementation approach. • Although the trial accomplished most of its demonstration project objectives, uptake of the intervention was insufficient to determine whether longer sessions improve outcomes.

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The University of Chicago will lead the NRG Oncology Statistics and Data Management Center, which is receiving six more years of funding from the National Cancer Institute.

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New research suggests that the microbial communities associated with chronic wounds common in diabetic patients affect whether those wounds heal or lead to amputations.

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Small children may one day avoid invasive, painful and often traumatic oesophageal tube-testing for gut damage and coeliac disease with a new method of simply blowing into a glass tube to provide effective diagnoses. Research published in international journal Scientific Reports describes an exciting new breath test that could have global implications on how to detect gastrointestinal damage.

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“Magic mouthwash,” an oral rinse containing diphenhydramine, lidocaine and antacids, significantly reduced pain from oral mucositis, mouth sores, in patients receiving radiation therapy for cancers of the head and neck when compared to plaecbo. These were the findings of a multi-institution, randomized, double-blind, placebo-controlled, phase III clinical trial, led by Robert Miller, M.D., an emeritus Mayo Clinic radiation oncologist. Dr. Miller and his colleagues published their findings on Tuesday, April 16, in JAMA.

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Patient-reported outcomes (PROs) are an important target for efforts to improve healthcare – focusing on the most important problems and outcomes identified by patients themselves. A special supplement to Medical Care presents a toolkit of methods to help personalize care for patients with cancer using a 'PRO cision Medicine' approach. The journal is published in the Lippincott portfolio by Wolters Kluwer.

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UC San Francisco is collaborating with the nonprofit Lazarex Cancer Foundation on a three-year study to identify ways to improve cancer clinical trial participation among medically underserved populations, including low-income individuals and racial and ethnic minorities.

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Doctors promote prevention during Oral and Head and Neck Cancer Awareness Month

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Hematology researchers have further refined how a treatment currently used urgently to control bleeding in hemophilia patients holds promise for prevention as well. A study in animals may lead to a new therapy for patients who now develop antibodies to the standard maintenance treatment.

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Through partnerships with Sanofi Argentina, Sanofi Chile, Sanofi Colombia, Sanofi Pacific and Caribbean, Sanofi Peru and Sanofi Uruguay, the Endocrine Society hosted its first Latin American (LATAM) Leadership Academy. Sixty-two clinicians from over 15 countries across South America, Central America and the Caribbean took part in a one-day leadership training program and attended ENDO 2019, the annual meeting of the Endocrine Society, in New Orleans, La.

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Georgetown University faculty offer expertise for journalists seeking interviews in a variety of subjects related to Ebola. Topics include WHO, Public Health Emergency of International Concern (PHEIC), International Health Regulations, infectious disease control and treatment, vaccine development, clinical trials, and global health security and law.

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Dr. Leena Pattarkine and Dr. Shailaja Agrawal are partnering with students to design and fabricate a tool that will aid in the growth of cell cultures via a 3D platform. Launched this spring, the “Biopolymer Sponge Microfluidics for Continuous 3D Cell Culture and Drug Screening Project” aims to transform the field of drug screening and make it much more cost effective.

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Southern Research and Japan’s Ina Research announced today they have formed a partnership that calls for Ina to help connect Southern Research with potential new customers for drug development services in the country with the world’s third largest pharmaceutical industry.

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Below are summaries of recent Fred Hutch research, with links for additional background and media contacts.

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ASCO, ASH, and NCCN receive letter clarifying CDC Guideline for Prescribing Opioids for Chronic Pain not meant to limit access to appropriate pain management for individuals with cancer, sickle cell disease

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A glimpse into the future of global public health: a credit-card sized piece of paper is dunked into a liquid sample at a health clinic in a developing nation, quickly telling a doctor or nurse whether a malnourished child with diarrhea is infected with a virus, a bacteria, or a parasitic protozoan.