Un nuevo estudio de los investigadores de Mayo Clinic identificó que un gen de inestabilidad cromosómica, el USP24, está a menudo ausente en los pacientes pediátricos con neuroblastoma (tipo agresivo de cáncer cerebral en niños). El resultado ofrece una perspectiva importante sobre el desarrollo de esta enfermedad.
A new study by Mayo Clinic researchers has identified that a chromosome instability gene, USP24, is frequently missing in pediatric patients with neuroblastoma, an aggressive form of childhood cancer. The finding provides important insight into the development of this disease. The study is published in Cancer Research, the journal of the American Association for Cancer Research.
في دراسة جديدة نُشرت في مجلة سيركوليشن، قدَّم باحثو مايو كلينك أول دراسة ما قبل المراحل السريرية لإثبات مفهوم العلاج الجيني الهجين في علاج متلازمة فترة كيو تي الطويلة، وهي حالة تؤثر على إيقاع القلب ويُحتمل أن تكون مميتة.
En un estudio publicado en la revista Circulation, los investigadores de Mayo Clinic presentan el primer estudio preclínico y tipo prueba de conceptos para aplicar la terapia genética con método híbrido en el síndrome del QT largo, que es una afección potencialmente mortal del ritmo cardíaco.
Em um novo estudo publicado no periódico Circulation, os pesquisadores da Mayo Clinic forneceram o primeiro estudo pré-clínico de validação de conceito para terapia genética híbrida para síndrome do QT longo, uma doença ritmo-cardíaca potencialmente fatal.
Um novo estudo multi-institucional liderado pelo Fergus Couch, Ph.D, um patologista da Mayo Clinic, fornece estimativas mais precisas do risco de câncer de mama para mulheres dos EUA que têm mutações herdadas nos genes de predisposição do câncer de mama.
There is no coat colour that distinguishes dingoes from dingo-dog hybrids, a study involving UNSW Sydney has found.
DALLAS – Feb. 16, 2021 – A study that identifies how a coronavirus protein called Nsp1 blocks the activity of genes that promote viral replication provides hope for new COVID-19 treatments.
In a recent study, published in The Journal of Clinical Investigation, University Hospitals (UH) Cleveland Medical Center and Case Western Reserve University School of Medicine researchers have found that skeletal muscle significantly affects how the body stores and metabolizes fat.
Five genes may play a key part in influencing if a person will contract Lewy body dementia, and possibly dementia from Parkinson's and Alzheimer’s diseases, according to a study published in Nature Genetics Feb. 15. The genes, BIN1, TMEM175, SNCA, APOE, and GBA, were identified by a team of scientists at the National Institute of Neurological Disorders and Stroke and the National Institute on Aging, National Institutes of Health, and sequenced by The American Genome Center (TAGC), a series of state-of-the-art laboratories at the Uniformed Services University of the Health Sciences.
An international team of scientists has sequenced the genome of a capuchin monkey for the first time, uncovering new genetic clues about the evolution of their long lifespan and large brains.
Biologists at Washington University in St. Louis lead a team awarded $1.7 million from the National Science Foundation to streamline the genome of a cyanobacterium with the goal of developing a green cellular factory for sustainable production of food, feed and fuels.
Researchers at the Southwest National Primate Research Center (SNPRC) at Texas Biomedical Research Institute (Texas Biomed) may have found a new pathway to treat and control tuberculosis (TB), the disease caused by Mycobacterium tuberculosis (Mtb). Using single-cell RNA sequencing (scRNAseq), a next-generation sequencing technology, scientists were able to further define the mechanisms that lead to TB infection and latency.
A new study from Washington University School of Medicine in St. Louis demonstrates that a liquid biopsy examining blood or urine can help gauge the effectiveness of therapy for colorectal cancer that has just begun to spread beyond the original tumor. Such a biopsy can detect lingering disease and could serve as a guide for deciding whether a patient should undergo further treatments.
Researchers have produced a groundbreaking new reference genome for the Asian malaria vector mosquito Anopheles stephensi. The achievement will help scientists engineer advanced forms of defense against malaria transmission, including targeted CRISPR and gene drive-based strategies.
An international team of scientists has determined how harmless E. coli gut bacteria in chickens can easily pick up the genes required to evolve to cause a life-threatening infection.
An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the “guardian of the genome” for its ability to repair DNA damage or destroy cancerous cells.
The largest and most detailed molecular analysis yet of an aggressive brain cancer, called glioblastoma, reveals fundamental details that drive its growth. The
UC San Diego researchers discovered a single gene alteration that may help explain cognitive differences between modern humans and our predecessor, and used that information to develop Neanderthal-like brain organoids in the lab.
Working with fish, birds and mice, Johns Hopkins Medicine researchers report new evidence that some animals’ natural capacity to regrow neurons is not missing, but is instead inactivated in mammals. Specifically, the researchers found that some genetic pathways that allow many fish and other cold-blooded animals to repair specialized eye neurons after injury remain present in mammals as well, but are turned off, blocking regeneration and healing.
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