The Cancer Center at Beth Israel Deaconess Medical Center (BIDMC) today announced the launch of a new clinical and research institute that will build on BIDMC’s long history of leadership in immunotherapy and cell therapeutics.
Bacterial toxins can wreak mass havoc within cells by shutting down multiple essential functions at once, a new study has found. The discovery could one day open the door to exploring better ways to fight life-threatening infections.
A presentation at the 2018 American Association of Neurological Surgeons Annual Scientific Meeting
With the new funding from the Gates Foundation, the Scripps Research team will expand their studies of neutralizing antibodies.
New research led by investigators at Case Western Reserve University School of Medicine and University Hospitals Cleveland Medical Center suggests that the location of immune cells in the body determines whether they help or harm the development of heart disease. The study supports the view that the immune system directly impacts heart failure—still the leading cause of death for men and women in the United States.
A presentation at the 2018 American Association of Neurological Surgeons Annual Scientific Meeting
A new study reveals the geometric underpinnings of T-cell triggering through the precise engineering of T-cell receptor geometry in all three dimensions. The researchers used nanofabrication to create a biomimetic surface that simulates the key features of the APC, presenting T-cell receptor ligands in different geometric arrangements, with different inter-ligand spacings arranged in clusters of varying size. The results could have a significant impact on adoptive immunotherapy and the design of CAR T cells.
Doctors could be a step closer to finding the most effective way to treat cancer with a double whammy of a virus combined with boosting the natural immune system, according to a pioneering study by researchers at The University of Texas Health Science Center at Houston (UTHealth) and The Ohio State University.
Wistar and Ben Franklin Technology Partners of Southeastern Pennsylvania (Ben Franklin), a nonprofit conglomerate of partners providing direct/seed funding, mentorship and networks to strengthen enterprise development, have signed a Memorandum of Understanding (MoU) to accelerate the advancement of early-stage life sciences start-ups coming out of Wistar.
CU researchers mine data of 583 patient samples of advanced differentiated thyroid cancer and 196 anaplastic thyroid cancers, showing genetic alterations, and "high mutation burden" that is an FDA-approved marker for immunotherapy.
The bacteria that reside on and within our bodies are known to have a significant influence on our health. New research suggests wiping out the gut microbiota could improve heart functioning and potentially slow the cardiac damage that occurs with heart failure.
One of the most frustrating and debilitating complications of diabetes is the development of wounds on the foot or lower leg. Once they form, they can persist for months, leading to painful and dangerous infections.
Cancer immune cell therapy has made headlines with astounding successes like saving former U.S. President Jimmy Carter from brain cancer. But immunotherapy has also had many tragic flops. Georgia Tech researchers working to optimize the innovative treatment have implanted a genetic switch that activates T-cells when they are inside of tumors. Remote-control light waves resembling those used in a TV remote combine with gold nanorods to flip the switch.
Researchers at the University of Michigan Rogel Cancer Center designed this new delivery system – a drug hidden in a nanodisc – to increase the number of patients who can be treated successfully with cancer immunotherapy drugs.
A compound from the body's own immune cells can treat psoriasis in mice and holds promise for other autoimmune diseases such as multiple sclerosis, according to a new study at Washington University School of Medicine in St. Louis.
Researchers at the UC Davis MIND Institute have found that children with autism spectrum disorder (ASD) have reduced immune system regulation, as well as shifts in their gut microbiota. The immune deregulation appears to facilitate increased inflammation and may be linked to the gastrointestinal issues so often experienced by children with ASD. The research was published in the journal Brain, Behavior, and Immunity.
The Emily Whitehead Foundation today presented a check totaling $250,000 to Stephan A. Grupp, MD, PhD, Director of the Cancer Immunotherapy Frontier Program, and Section Chief of the Cellular Therapy and Transplant Program at Children’s Hospital of Philadelphia (CHOP), benefitting cellular immunotherapy research at CHOP.
This new insight may allow researchers to design drugs that improve immune responses to vaccines.
As immunotherapies continue to make up a larger share of new cancer drugs, researchers are looking for the most effective ways to use these cutting edge treatments in combination with each or with other pre-existing options. New studies from the Abramson Cancer Center of the University of Pennsylvania are providing fresh clues on potentially effective combinations with CAR T therapy in brain cancer as well as a novel therapeutic target in head and neck cancer, and also providing greater understanding of the mechanisms of resistance in pancreatic cancer.
Using chemotherapy along with aptamers -- lab-made molecules that function like antibodies -- Duke Health researchers showed that they can zero in on and kill prostate cancer tumors in mice while leaving healthy tissue unscathed.
CU Cancer Center study presented at AACR18 shows that TIM3 and/or increased regulatory T cells (Tregs) within a tumor may help cancers inactivate immune system killer T cells that would otherwise identify and attack the cancer.
The immunotherapy drug pembrolizumab, when combined with chemotherapy, doubles survival in patients with non-squamous non-small cell lung cancer (NSNSCLC) lacking genetic changes in the EGFR or ALK genes, when compared to chemotherapy alone, according to an international, Phase III clinical trial.
Colon polyps from patients with Lynch syndrome, a hereditary condition that raises colorectal cancer risk, display immune system activation well before cancer development, according to research from The University of Texas MD Anderson Cancer Center. The preclinical research challenges traditional models of cancer immune activation and suggests immunotherapy may be useful for colorectal cancer prevention in certain high-risk groups.
Roswell Park Comprehensive Cancer Center researchers have found that the effect of a key gene driving an aggressive, recurrent and often incurable form of prostate cancer is dose-dependent, opening new avenues for therapies that overcome resistance to treatment of advanced disease.
University of North Carolina at Chapel Hill Lineberger Comprehensive Cancer Center experts are available to provide expert commentary and feedback on research presented at the AACR Annual Meeting 2018.
Baylor University Medical Center is the first in North Texas to offer the only FDA approved CAR-T cellular therapy to treat diffuse large B-cell lymphoma. (DLBCL)
Cornell University researchers have developed a “lymphoma micro-reactor” device that exposes human lymphomas to fluid flow similar to that in the lymphatics and parts of the lymph node. It is designed to explore how fluid forces may relate to a tumors’ drug resistance.
Atlantic Health System’s new Atlantic HPV Center is one of a small number of research centers in the nation to begin a study to determine whether an innovative combination of immuno-oncology treatments is safe, shows preliminary efficacy and provokes an anticancer immune system response in patients with recurrent or metastatic human papilloma virus (HPV) associated head and neck squamous cancer.
The American College of Rheumatology (ACR) today expressed concern that the 2019 Benefit and Payment Parameters final rule allowing states to select their own Essential Health Benefits (EHB) benchmark plans on federal health exchanges could jeopardize care access for patients with complex rheumatologic conditions.
Scientists have developed novel ways to study how and why cells move in their search for treatments of bacterial infection and diseases such as cancer.
Researchers from Mount Sinai and Sema4, a health information company and Mount Sinai venture, have discovered that giving metastatic bladder cancer patients simultaneous chemotherapy and immunotherapy is safe and that patients whose tumors have certain genetic mutations may respond particularly well to this combination approach, according to the results of a clinical trial published in European Urology.
A vaccine may successfully turn off peanut allergy in mice, a new study shows.
Some of what you think are allergy symptoms could be signs of asthma.
Researchers at Université de Montréal and the research centres of the CHUM and CHU Sainte-Justine are banding together to conquer this rare orphan pediatric disease. They have recently proven what scientists had already suspected: the disease is autoimmune, which means that it attacks patients using their own immune system.
Sandia National Laboratories computer scientists Pat Finley and Drew Levin have been working to improve the U.S. biosurveillance system that alerts authorities to disease outbreaks by mimicking the human immune system.
By April, nearly one-third of the U.S. is already experiencing high pollen levels while the weather and temperatures continue to fluctuate, aggravating sinus symptoms. A patient’s mucus may predict the type of his or her chronic sinusitis, which could help doctors determine whether surgery or medical treatments can produce the best outcomes, according to a recently published Vanderbilt study.
We are the first to demonstrate that pTregs are important in autoimmune diabetes, and we hypothesize that microbes in the gut, where most of this pTreg cell population is switched on, may be responsible for generating these protective cells and thus protecting against the autoimmune attack on pancreatic beta cells that cause type 1 diabetes.
By combining data on pathology images of 13 types of cancer and correlating that with clinical and genomic data, researchers are able to identify tumor-infiltrating lymphocytes (TILs), called TIL maps, which will enable specialists to generate tumor-immune information from pathology slides.
Cancer Research Institute iAtlas now online -- a comprehensive web-based tool that allows oncologists and researchers to study and analyze interactions between tumors and the immune microenvironment.
Studying mice and cells from patients, vision researchers at Washington University School of Medicine in St. Louis found that as immune cells called macrophages get older, they are more likely to contribute to inflammation and abnormal blood vessel growth in the back of the eye. This can damage vision in patients with age-related macular degeneration.
The Ted Rogers Centre for Heart Research today announces that Dr. Slava Epelman has accepted the brand new role of Loretta Rogers Chair in Immunobioengineering.
T Southwestern Medical Center Professor Dr. Zhijian “James” Chen today became the recipient of the 2018 Lurie Prize in Biomedical Sciences for his discovery of the cGAS enzyme, a sensor of innate immunity. The enzyme patrols the cell’s interior and sounds the alarm to trigger the immune system in response to DNA.
Scientists at The Scripps Research Institute have discovered a new aspect of the flu virus and how it interacts with antibodies in the lungs.
One way to fight diseases including HIV infection and autoimmune disorders could involve changing how a naturally occurring enzyme called SAMHD1 works to influence the immune system, new research suggests.
Exposing infants to antacids or antibiotics in their first six months of life could increase their risk of developing allergies in childhood.
E. John Wherry, PhD, co-leader of the Abramson Cancer Center’s Immunobiology Program and director of the Institute for Immunology at the University of Pennsylvania, has received a Phillip A. Sharp Innovation in Collaboration Award from Stand Up To Cancer.
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