Stem Cells Research News and Press Releases

Released: 28-Oct-2022 12:00 PM EDT

Extracellular vesicles promote lipid raft formation in human microglia through TLR4, P2X4R, and αVβ3/αVβ5 signaling pathways

Preprints

Augustas Pivoriūnas

Preprints MEDICINE

Released: 28-Oct-2022 12:00 PM EDT

High levels of m6A methylation and histone acetylation modification patterns contribute to the survival of LUAD patients

Preprints

Liguo Jia, Zhenzhen Gao, Jing Chen

Preprints MEDICINE

Released: 28-Oct-2022 12:00 PM EDT

Extract of Plastrum Testudinis through miR-214 mediated Wnt/β-catenin signaling stimulating bone formation

Preprints

Qing Lin, Yumei Yang, Xiaoyun Li, Haoyu Wang, Yan Cui, Panpan Wang, Xiaofeng Zhu, Li Yang, Ronghua Zhang

Preprints MEDICINE

Released: 28-Oct-2022 12:00 PM EDT

Temporary knockdown of p53 during focal limb irradiation increases the development of sarcomas

Preprints

Andrea R. Daniel, Chang-Lung Lee, Chang Su, Nerissa T. Williams, Zhiguo Li, Jianguo Huang, Omar Lopez, Lixia Luo, Yan Ma, Lorraine De Silva Campos, Sara R. Selitsky, Jennifer L. Modliszewski, Siyao Liu, Yvonne M. Mowery,

Preprints MEDICINE

Released: 28-Oct-2022 12:00 PM EDT

Induction of telomerase in p21-positive cells counteracts capillaries rarefaction in aging mice lung

Preprints

Larissa Lipskaia, Marielle Bréau, Christelle Cayrou, Dmitri Churikov, Laura Braud, Charles Fouillade, Sandra Curras-Alonso, Serge Bauwens, Frederic Jourquin, Frederic Fiore, Rémy Castellano, Emmanuelle Josselin, Carlota Sánchez-Ferrer,

Preprints MEDICINE

Released: 28-Oct-2022 12:00 PM EDT

Achieving permanent transplant tolerance via reverse chimeras in orthotopic liver transplantation

Preprints

Gaofeng Tang, Huibo Zhao, Guoyong Chen

Preprints MEDICINE

Released: 28-Oct-2022 12:00 PM EDT

Human T2D associated gene IMP2/IGF2BP2 promotes the commitment of mesenchymal stem cells into adipogenic lineage

Preprints

Laura Regue, William Wang, Fei Ji, Joseph Avruch, Hua Wang, Ning Dai

Preprints MEDICINE

Released: 28-Oct-2022 12:00 PM EDT

Advanced glycation end products inhibit the osteogenic differentiation potential of adipose‐derived stem cells in mice through autophagy

Preprints

Ting Fu, Fangzhi Lou, Qiang Zhu, Shuyu Cai, Shuanglin Peng, Jingang Xiao

Preprints MEDICINE

Released: 28-Oct-2022 12:00 PM EDT

Protein aggregation and calcium dysregulation are the earliest hallmarks of synucleinopathy in human midbrain dopaminergic neurons

Preprints

Gurvir S Virdi, Minee Liane Choi, James R Evans, Zhi Yao, Dilan Athauda, Stephanie Strohbuecker, Anna I Wernick, Haya Alrashidi, Daniela Melandri, Jimena Perez-Lloret, Plamena R Stroh, Sergiy Sylantyev, Simon Eaton, Simon Heales,

Preprints MEDICINE

Released: 28-Oct-2022 12:00 PM EDT

Transcriptional regulation profiling reveals PPARA-mediated fatty acid oxidation as a novel therapeutic target in phospholamban R14del cardiomyopathy

Preprints

Magdalena Harakalova, Jiayi Pei, Renee Maas, Karen Gaar-Humphreys, Johannes Gho, Emilia Nagyova, Christian Snijders Blok, Iris van Adrichem, René van Es, Shahrzad Sepehrkhouy, Dries Feyen, Noortje Van Den Dungen, Nico Lansu, Jorg Cal

Preprints MEDICINE

Released: 27-Oct-2022 6:00 PM EDT

Children with Resistant Leukemia Given CRISPR-Edited T Cells: Phase 1 Study Results Reported

University College London

Researchers at Great Ormond Street Hospital for Children (GOSH) and UCL Great Ormond Street Institute of Child Health (UCL GOS ICH) have used CRISPR/Cas9 technology to engineer donor T cells to try to treat seriously ill children with resistant leukemia, who had otherwise exhausted all available therapies.

Research Results MEDICINE

Released: 27-Oct-2022 3:05 PM EDT

UCI Earns Designation as CIRM Alpha Clinic with Five-Year, $8 Million Grant

University of California, Irvine

Irvine, Calif., Oct. 27, 2022 — With a five-year, $8 million grant from the California Institute for Regenerative Medicine, the University of California, Irvine has earned designation as one of CIRM’s Alpha Clinics. The goal of the statewide network is to accelerate the development of promising stem cell and gene therapies and expand patient access to them through clinical trials approved by the U.

Announcement MEDICINE

Released: 27-Oct-2022 12:30 PM EDT

On the Trail of Missing Genes and Cancer Clues

La Jolla Institute for Immunology

La Jolla Institute for Immunology (LJI) researchers have made a major breakthrough in understanding how deletion of the genes that encode TET proteins can lead to cancer growth.

Research Results SCIENCE

Released: 27-Oct-2022 12:00 PM EDT

iPSC-derived cells lack immune tolerance to autologous NK-cells due to imbalance in ligands for activating and inhibitory NK-cell receptors

Preprints

Margarita E. Bogomiakova, Elizaveta K. Sekretova, Ksenia S. Anufrieva, Polina O. Khabarova, Anastasia N. Kazakova, Pavel A. Bobrovsky, Tatiana V. Grigoryeva, Artem V. Eremeev, Olga S. Lebedeva, Alexandra N. Bogomazova, Maria A. Lagarkova

Preprints MEDICINE

Released: 27-Oct-2022 12:00 PM EDT

3D-printed Strontium-Titanium Scaffolds Incorporated with Highly Bioactive Serum Exosomes Promotes Critical Bone Defect Repair by Enhancing Osteogenesis and Angiogenesis

Preprints

Hao Liu, Ranli Gu, Wei Li, Lijun Zeng, Yuan Zhu, Siyi Wang, Xuenan Liu, Boon Chin Heng, Yunsong Liu, Yongsheng Zhou

Preprints MEDICINE

Released: 27-Oct-2022 12:00 PM EDT

Antimicrobial peptide-loaded decellularized placental sponge as an excellent antibacterial skin substitute against XDR clinical isolates

Preprints

Hatef Ghasemi Hamidabadi, Sanaz Alizadeh, Leila Mahboobi, Zahra Khosrowpour, Maryam Nazm Bojnordi, Zahra Aliakbar Ahovan, Majid Malekzadeh Shafaroudi, Maria Zahiri, Narendra Pal Singh Chauhan, Mazaher Gholipourmalekabadi

Preprints MEDICINE

Released: 27-Oct-2022 12:00 PM EDT

Transcription factor HSFA7b controls ethylene signaling and meristem maintenance at the shoot apical meristem during thermomemory

Preprints

Sheeba John, Federico Apelt, Amit Kumar, Dominik Bents, Maria Grazia Annunziata, Franziska Fichtner, Bernd Mueller-Roeber, Justyna J. Olas

Preprints MEDICINE

Released: 27-Oct-2022 12:00 PM EDT

Tumor-educated Gr1⁺CD11b⁺cells instigate breast cancer metastasis by twisting cancer cells plasticity via OSM/IL6-JAK signaling

Preprints

Sanam Peyvandi, Manon Bulliard, Annamaria Kauzlaric, Oriana Coquoz, Yu-Ting Huang, Nathalie Duffey, Laetitia Gafner, Girieca Lorusso, Nadine Fournier, Qiang Lan, Curzio Rüegg

Preprints MEDICINE

Released: 27-Oct-2022 12:00 PM EDT

In vitro treatment of Murine splenocyte with mesenchymal stem cell derived extracellular vesicles altered the mRNA levels of master regulators gene of T cell subsets

Preprints

Alireza Yeganeh, Anwar Fathollahi, Seyed Mahmoud Hashemi, Farshid Yeganeh

Preprints MEDICINE

Released: 27-Oct-2022 12:00 PM EDT

Influential factors for optimizing and strengthening mesenchymal stem cells and hematopoietic stem cells co-culture

Preprints

Mandana Shirdarreh, Fatemeh Amiri, Mohammad Pouya Samiee, Armita Safari

Preprints MEDICINE

Released: 27-Oct-2022 12:00 PM EDT

KDM6A/UTX promotes spermatogenic gene expression across generations but is dispensable for male fertility

Preprints

Benjamin William Walters, Shannon R Rainsford, Nicolas Dias, Xiaofang Huang, Dirk G de Rooij, Bluma J Lesch

Preprints MEDICINE

Released: 27-Oct-2022 11:30 AM EDT

NIH researchers home in on a new cause of Stargardt disease

NIH, National Eye Institute (NEI)

Using a new stem-cell based model made from skin cells, scientists found the first direct evidence that Stargardt-related ABCA4 gene mutations affect a layer of cells in the eye called the retinal pigment epithelium (RPE).

Research Results MEDICINE

Released: 27-Oct-2022 6:00 AM EDT

Profiling of Fatty Sweet Molecules on Cell Surfaces

University of Vienna

Glycolipids, basically "fatty sweet" molecules, are a relatively unknown group of lipids. A new method developed by an Austrian team led by chemist Evelyn Rampler of the University of Vienna has now provided deeper insights into the functioning of certain glycolipids located on the surfaces of stem cells.

Research Results MEDICINE SCIENCE

Released: 26-Oct-2022 12:00 PM EDT

Exosomes from circ-Astn1-modified adipose-derived mesenchymal stem cells enhance wound healing through miR-138-5p/SIRT1/FOXO1 axis regulation

World Journal of Stem Cells

BACKGROUNDWound healing impairment is a dysfunction induced by hyperglycemia and its effect on endothelial precursor cells (EPCs) in type 2 diabetes mellitus. There is increasing evidence showing that exosomes (Exos) derived from adipose-derive

Research Alert MEDICINE

Released: 26-Oct-2022 12:00 PM EDT

Maternal inappropriate calcium intake aggravates dietary-induced obesity in male offspring by affecting the differentiation potential of mesenchymal stem cells

World Journal of Stem Cells

BACKGROUNDThe effects of inappropriate dietary calcium intake in early life on later obesity have not been fully elucidated. AIMTo raise the mechanism of maternal calcium intake on the multi-differentiation potential of mesenchymal stem cells

Research Alert MEDICINE

Released: 24-Oct-2022 7:15 PM EDT

Even Good Gene Edits Can Go Bad

Rice University

A Rice University lab is leading the effort to reveal potential threats to the efficacy and safety of therapies based on CRISPR-Cas9, the Nobel Prize-winning gene editing technique, even when it appears to be working as planned.

Research Results SCIENCE

Released: 24-Oct-2022 5:15 PM EDT

The New York Stem Cell Foundation Names Dr. Derrick Rossi as Interim CEO

New York Stem Cell Foundation (NYSCF)

The New York Stem Cell Foundation (NYSCF) announced Dr. Derrick Rossi, a member of the NYSCF Board of Directors and co-founder of Moderna, as Interim CEO of NYSCF.

Announcement MEDICINE

Released: 24-Oct-2022 2:55 PM EDT

University Hospitals Seidman Cancer Center Researchers Slash Time Needed to Produce CAR T-Cells

University Hospitals Cleveland Medical Center

Researchers at University Hospitals (UH) Seidman Cancer Center in Cleveland, Ohio and a biotech start-up company have developed a streamlined way to manufacture CAR T-cells for immunotherapy treatment in just 24 hours – an improvement over the team’s previous benchmark of eight days and commercial suppliers that typically take three weeks. The team is one of the first in the country to test this manufacturing approach.

Feature MEDICINE

Released: 21-Oct-2022 12:00 PM EDT

Short-term exposure of human minor salivary gland stem cells to hypergravity enhances stemness

Preprints

Jeong-Seok Choi, Tri Ho Minh, Jeong Mi Kim, Mi Eun Choi, Eun Jeong Jeon, Jin-Mi Park, Sungryeal Kim, Young Mo Kim

Preprints MEDICINE

Released: 21-Oct-2022 12:00 PM EDT

Differential expression of HEPH in amyotrophic lateral sclerosis.

Preprints

Shahan Mamoor

Preprints MEDICINE

Released: 21-Oct-2022 12:00 PM EDT

Differential expression of DNAI2 in amyotrophic lateral sclerosis.

Preprints

Shahan Mamoor

Preprints MEDICINE

19-Oct-2022 5:05 PM EDT

Researchers find that different stem cells are responsible for the repair of different kinds of bone injuries

UT Southwestern Medical Center

The discovery that different bone-forming stem cells are responsible for different aspects of bone maintenance and repair will allow us to focus future bone regeneration efforts

Research Results MEDICINE SCIENCE