Feature Channels: Stem Cells

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Released: 1-Sep-2022 12:00 PM EDT
X chromosome dosage drives statin–induced dysglycemia and mitochondrial dysfunction
Preprints

Peixiang Zhang, Joseph J Munier, Laurent Vergnes, Carrie B Wiese, Jenny C Link, Fahim Abbasi, Emilio Ronquillo, Antonio Munoz, Yu-Lin Kuang, Meng Liu, Gabriela Sanchez, Akinyemi Oni-Orisan, Carlos Iribarren, Michael J. McPhaul,

Released: 1-Sep-2022 12:00 PM EDT
Label-free imaging of 3D pluripotent stem cell differentiation dynamics on chip
Preprints

Scott Atwell, Dominik J. E. Waibel, Sayedali Shetab Boushehri, Carsten Marr, Matthias Meier

Released: 1-Sep-2022 5:00 AM EDT
Single-cell analysis of embryoids reveals lineage diversification roadmaps of early human development
Cell Stem Cell

Fu and colleagues profiled a stem cell-derived microfluidic amniotic sac embryoid (μPASE) using single-cell RNA sequencing. Molecular maps of lineage diversifications from the pluripotent human epiblast toward the amniotic ectoderm, primitive streak

Released: 1-Sep-2022 5:00 AM EDT
Modeling human multi-lineage heart field development with pluripotent stem cells
Cell Stem Cell

We describe hPSC-derived models of FHF, aSHF, and pSHF development spanning the mesoderm, progenitor, and cardiomyocyte stages. Comparison between the hPSC-derived and the corresponding mouse populations revealed conserved developmental trajectories

Released: 1-Sep-2022 5:00 AM EDT
Hepatic cytochrome P450 8B1 and cholic acid potentiate intestinal epithelial injury in colitis by suppressing intestinal stem cell renewal
Cell Stem Cell

Xie and colleagues propose a regulatory mechanism of hepatic bile acid metabolism in colitis pathogenesis. They find that the hepatic CYP8B1-cholic acid metabolic axis impairs Lgr5+ intestinal stem cell renewal by repressing PPARα, thus exacerbating

Released: 1-Sep-2022 5:00 AM EDT
Current status of cell-based interventions in Japan
Cell Stem Cell

The Act on the Safety of Regenerative Medicine regulates cell-based interventions in Japan. Recent revisions to the law require disclosure of explanatory and consent materials for interventions seeking approval. In this Forum, we present an updated a

Released: 1-Sep-2022 5:00 AM EDT
Lymphatic endothelia stakeout cryptic stem cells
Cell Stem Cell

A trio of studies in this issue of Cell Stem Cell catalogs the anatomical and functional relationship of intestinal lymphatics with epithelial stem cells, defining an important niche role for the lymphatic endothelium.

Released: 1-Sep-2022 5:00 AM EDT
Exploring the human extraembryonic mesoderm using naive pluripotent stem cells
Cell Stem Cell

In this issue of Cell Stem Cell, Pham et al. report that naive human pluripotent stem cells can be differentiated into extraembryonic mesoderm cells (EXMCs). EXMCs are maintained for up to 70 days, resemble human and monkey extraembryonic mesoderm,

Released: 1-Sep-2022 5:00 AM EDT
Fission impossible: Mitochondrial dynamics direct muscle stem cell fates
Cell Stem Cell

Muscle stem cells (MuSCs) exhibit different metabolic profiles depending on their activity, however the mechanisms by which mitochondria affect MuSC fate has been understudied. In this issue of Cell Stem Cell, Hong et al. (2022) and Baker et al. (2

Released: 1-Sep-2022 5:00 AM EDT
Uncovering the origins and lineage markers of human heart fields
Cell Stem Cell

In this issue of Cell Stem Cell, Yang et al. devise a protocol for induction and differentiation of human heart-field precursors, drawing on inspiration from in vivo development. Intricate computational analyses uncovered conserved factors governin

Released: 29-Aug-2022 12:00 PM EDT
Genetic contribution to microglial activation in schizophrenia
Preprints

Jari Koistinaho, Marja Koskuvi, Elina Pörsti, Ying Chieh Wu, Kalevi Trontti, Amanda McQuade, Ilkka Ojansuu, Tyrone Cannon, Jouko Lönnqvist, Sebastian Therman, Jaana Suvisaari, Jaakko Kaprio, Mathew Blurton-Jones, Iiris Hovatta,

Released: 29-Aug-2022 12:00 PM EDT
ALK signaling drives tumorigenicity and chemoresistance of pancreatic ductal adenocarcinoma cells
Preprints

Beatriz Parejo-Alonso, Alba Royo-Garcia, Pilar Espiau-Romera, Sarah Courtois, Alvaro Curiel-Garcia, Sladjana Zagorac, Isabel Villaoslada, Kenneth P. Olive, Christopher Heeschen, Patricia Sancho

Released: 29-Aug-2022 12:00 PM EDT
hBMSC-derived Exosomes Mitigate Th17/Treg Homeostasis in Periodontitis via miR-1246
Preprints

Yuxing Xia, Tianfan Cheng, Min Zhou, Feiwu Kang, Chongshan Liao

Released: 29-Aug-2022 12:00 PM EDT
Gli2 and Gli3 Regulate Horizontal Basal Cell-Mediated Regeneration of the Olfactory Epithelium
Preprints

Anna Shirazyan, Haeyoung Park, Ariell M Joiner, Justine Ra, Melissa S Kim, Archana Kumari, Nicole E Franks, Tien Peng, Robert M Bradley, Charlotte M Mistretta, Andrzej A Dlugosz, Benjamin L Allen

Released: 29-Aug-2022 12:00 PM EDT
BAIAP2L2 is activated by NFκB1 and promotes the malignancy of hepatocellular carcinoma by suppressing the ubiquitin-mediated degradation of GABPB1 to activate TRET transcription
Preprints

Wenbo Jia, Liang Yu, Bin Xu, Yanzhi Feng, Jinyi Wang, Jian Chu, Deming Zhu, Chao Xu, Yongping Zhou, Lianbao Kong, Wenzhou Ding

Released: 29-Aug-2022 12:00 PM EDT
Cancer stem-like cells of nasopharyngeal carcinoma express CXCR4 and display highly invasive activity
Preprints

Zhenwei Zhu, Jingyu Li, Jingxian Liu, Yuan He, Yan Xue, Xiangchan Hong, Zeying Jiang, Dangu Luo, Pei Guo, Kaitai Yao, Lin Chen

Released: 29-Aug-2022 12:00 PM EDT
Risk factors of primary poor graft function after allogeneic hematopoietic stem cell transplantation in patients with myeloid tumors
Preprints

Lin-Yi Zhang, Yi-Ying Xiong, Ming-Yan Liao, Xiao Qing, Xiao-Qiong Tang, Luo Xiao-Hua, Hong-Bin Zhang, Wang Li, Liu Lin

Released: 27-Aug-2022 12:00 PM EDT
SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammation
Preprints

Michael D Moore, Errin Johnson, Chloe Jacklin, Stephen Johnson, Owen Green, William S James

Released: 26-Aug-2022 12:00 PM EDT
SEC-seq: Association of molecular signatures with antibody secretion in thousands of single human plasma cells
Preprints

Rene Yu-Hong Cheng, Joseph de Rutte, Andee R Ott, Lucienne Bosler, Wei-Ying Kuo, Jesse Liang, Brian E Hall, David J Rawlings, Dino Di Carlo, Richard G James

Released: 26-Aug-2022 12:00 PM EDT
Pancreatic transplant surgery and stem cell therapy: Finding the balance between therapeutic advances and ethical principles
World Journal of Stem Cells

The latest achievements in the field of pancreas transplantation and stem cell therapy require an effort by the scientific community to clarify the ethical implications of pioneering treatments, often characterized by high complexity from a sur

Released: 26-Aug-2022 12:00 PM EDT
HepaCAM Suppresses Glioblastoma Stem Cell Invasion in the Brain
Preprints

Arpan De, John M Lattier, John E Morales, Jack R Kelly, Xiaofeng Zheng, Zhihua Chen, Sumod Sebastian, Jason T Huse, Frederick F Lang, Joseph H McCarty

Released: 26-Aug-2022 12:00 PM EDT
Changes of cell membrane fluidity for mesenchymal stem cell spheroids on biomaterial surfaces
World Journal of Stem Cells

BACKGROUNDThe therapeutic potential of mesenchymal stem cells (MSCs) in the form of three-dimensional spheroids has been extensively demonstrated. The underlying mechanisms for the altered cellular behavior of spheroids have also been investiga

Released: 26-Aug-2022 12:00 PM EDT
Sinomenine promotes differentiation of induced pluripotent stem cells into immature dendritic cells with high induction of immune tolerance
World Journal of Stem Cells

BACKGROUNDImmature dendritic cells (imDCs) play an important role in the induction of donor-specific transplant immunotolerance. However, these cells have limitations, such as rapid maturation and a short lifespan in vivo. In previous studies,

Released: 26-Aug-2022 12:00 PM EDT
Cell type-specific role of CBX2-cPRC1 at the onset of spermatogonial differentiation
Preprints

Jongmin J Kim, Emma R Steinson, Mei Sheng Lau, David C Page, Robert E Kingston

Released: 26-Aug-2022 12:00 PM EDT
Enhancer deregulation in TET2 Mutant Clonal Hematopoiesis is associated with increased COVID-19 related inflammation severity and mortality
Preprints

Moritz Binder, Terra L. Lasho, Wazim Mohammed Ismail, Nana A. Ben-Crentsil, Jenna A. Fernandez, Minsuk Kim, Susan M. Geyer, Amelia Mazzone, Christy M. Finke, Abhishek A. Mangaonkar, Jeong-Heon Lee, Kwan Hyun Kim, Vernadette A. Simon,

Released: 26-Aug-2022 12:00 PM EDT
Molecular analyses of chorionic-type intermediate trophoblastic lesions: Atypical placental site nodules are closer to placental site nodules than epithelioid trophoblastic tumors
Preprints

Gaspard Jeremie, Fabienne Allias, Alexis Trecourt, Lucie Gaillot-Durand, Pierre-Adrian Bolze, Françoise Descotes, Garance Tondeur, Jimmy Perrot, Touria Hajri, Benoit You, François Golfier, Jonathan Lopez, Mojgan Devouassoux-Shisheboran

Released: 26-Aug-2022 12:00 PM EDT
Reprogramming of fish somatic cells for nuclear transfer is primed by Xenopus egg extract
Preprints

Nathalie Chenais, Aurelie LE Cam, Brigitte Guillet, Jean-Jacques Lareyre, Catherine Labbe

Released: 26-Aug-2022 12:00 PM EDT
Bone marrow mesenchymal stem cell treatment improves post-stroke cerebral function recovery by regulating gut microbiota in rats
World Journal of Stem Cells

Early intervention with bone marrow mesenchymal stem cells to change the form and function of the gut microbiota may help rats regain neurological function after a stroke. Key Words: Ischemic stroke, Bone marrow mesenchymal ste

Released: 25-Aug-2022 12:00 PM EDT
A cell therapy approach to prevent muscle atrophy and paralysis in an aggressive mouse model of ALS
Preprints

Barney Bryson, Alexandra Kourgiantaki, Dai Jiang, Andreas Demosthenous, Linda Greensmith

Released: 25-Aug-2022 12:00 PM EDT
p16High senescence restricts totipotent potential during somatic cell reprogramming
Preprints

Bogdan B Grigorash, Dominic van Essen, Laurent Grosse, Alexander Emelyanov, Benoit Kanzler, Clement Molina, Elsa Lopez, Oleg N Demidov, Carmen Garrido, Simona Saccani, Dmitry Bulavin

Released: 24-Aug-2022 12:00 PM EDT
XIST Regulates Breast Cancer Stem Cells by Activating Proinflammatory IL-6 Signaling
Preprints

Yuxi Ma, Yongyou Zhu, Li Shang, Yan Qiu, Na Shen, Qingxuan Song, Jun Li, Max S. Wicha, Ming Luo

Released: 24-Aug-2022 12:00 PM EDT
JNK signalling regulates self-renewal of proliferative urine-derived renal progenitor cells via inhibition of ferroptosis
Preprints

Lisa Nguyen, Michelle Westerhoff, Leonie Thewes, Wasco Wruck, Andreas S Reichert, Carsten Berndt, James Adjaye

Released: 24-Aug-2022 12:00 PM EDT
Sorafenib alleviates inflammatory signaling of tumor microenvironment in lung cancer
Preprints

Betul Cicek, Serhat Hayme, Mehmet Kuzucu, Ahmet Cetin, Yesim Yeni, Sidika Genc, Serkan Yildirim, Ismail Bolat, Mecit Kantarci, Mustafa Gul, Ahmet Hacimuftuoglu

Released: 24-Aug-2022 12:00 PM EDT
Adipose transplantation improves olfactory function and neurogenesis via PKCα-involved lipid metabolism in Seipin Knockout mice
Preprints

Jing Yang, Na Yang, Huifang Zhao, Yan Qiao, Yanqiu Li, Chunfang Wang, Kah-Leong Lim, Chengwu Zhang, Wulin Yang, Li Lu

Released: 23-Aug-2022 12:00 PM EDT
Non-canonical Telomerase Reverse Transcriptase Controls Osteogenic Differentiation of Aortic Valve Cells Through STAT5
Preprints

Rolando A Cuevas, Luis Hortells, Claire Chu, Ryan Wong, Alex Crane, Camille Boufford, Caylin Regan, William Moorhead, Michael Bashline, Aneesha Parwal, Angeline Parise, Aditi Gurkar, Dennis Bruemmer, John Sembrat,

Released: 23-Aug-2022 12:00 PM EDT
Effects of miR-629-5p on odontoblast differentiation and target gene TEAD4 expression of dental pulp stem cells
Preprints

Jianpeng Han, Xin Zhao, Rongrong Jiang, Chengfeng Jiang, Lei Li, Zhiliang Xu, Yihua Song, Xingmei Feng

Released: 23-Aug-2022 12:00 PM EDT
High intensity interval training protects the heart against acute myocardial infarction through SDF-1a, CXCR4 receptors and c-kit levels
Preprints

Mohsen Bapiran, Hamid Rajabi, Farinaz Nasirinezhad, Fatemeh Ramezani, Reza Ghanimati, Maral Ramez

Released: 23-Aug-2022 12:00 PM EDT
Mesenchymal stem cells polarize macrophages to an anti-inflammatory phenotype to ameliorate diabetic nephropathy
Preprints

Linxi Zhang, Songyan Yu, Yu Cheng, Zhengyuan Gong, Jing Xue, Bing Li, Yaqi Yin, Junyan Zou, Rui Wei, Tianpei Hong, Yiming Mu

Released: 23-Aug-2022 12:00 PM EDT
Metabolic enhancement of mammalian developmental pausing
Preprints

Vera A van der Weijden, Maximilian Stoetzel, Beatrix Fauler, Dhanur P Iyer, Mohammed Shahraz, David Meierhofer, Steffen Rulands, Theodore Alexandrov, Thorsten Mielke, Aydan Bulut-Karslioglu

Released: 23-Aug-2022 12:00 PM EDT
The PIP4K2 inhibitor THZ-P1-2 exhibits antileukemia activity by disruption of mitochondrial homeostasis and autophagy
Preprints

Keli Lima, Diego Antonio Pereira-Martins, Livia Bassani Lins de Miranda, Juan Luiz Coelho-Silva, Giovana Da Silva Leandro, Isabel Weinhauser, Rita De Cassia Cavaglieri, Aline Medeiros de Leal, Wellington Fernandes da Silva, Ana Paula Alencar De Lima Lange, Elvira Deolinda Rodrigues Pereira Velloso, Emmanuel Griessinger,

Released: 23-Aug-2022 12:00 PM EDT
The preceding hyponatremia is a useful hallmark for the diagnosis of HHV-6 encephalitis after allogeneic hematopoietic stem cell transplantation
Preprints

Takahide Ara, Shota Yoshida, Kohei Okada, Yuto Mori, Shihori Tsukamoto, Naoki Miyashita, Kohei Kasahara, Ko Ebata, Junko Iwasaki, Shojiro Takahashi, Akio Shigematsu, Koichiro Minauchi, Naoki Kobayashi, Masahiro Ogasawra,

Released: 23-Aug-2022 12:00 PM EDT
Frataxin deficiency disrupts mitochondrial respiration and pulmonary endothelial cell function
Preprints

Miranda K Culley, Monica Mehta, Jingsi Zhao, Dror Perk, Yi Yin Tai, Ying Tang, Sruti Shiva, Marlene Rabinovitch, Mingxia Gu, Thomas Bertero, Stephen Y Chan



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