A new software tool developed by Texas Biomedical Research Institute and collaborators can help scientists and vaccine developers quickly edit genetic blueprints of pathogens to make them less harmful. The tool, called CoDe – short for Codon Deoptimization – enables users to make precise edits to a genetic code to make genes less functional – in other words, to deoptimize the genes.
In reviewing data from previous studies, a team lead by researchers at the University of Chicago and the French National Institute of Health and Medical Research (Inserm) found that individuals who had fewer than six hours of sleep per night in the days surrounding vaccination had a blunted antibody response. That indicates efforts to promote heathy sleep duration ahead of an immunization could be an easy way to improve vaccine effectiveness.
Sleeping fewer than six hours per night around the time of vaccination was associated with a robust decrease in antibody response, researchers found.
So far mRNA vaccines, like those targeting COVID-19, have been effective against viruses but not against bacteria.
Reducing the methylation of a key messenger RNA can promote migration of macrophages into the brain and ameliorate symptoms of Alzheimer’s disease in a mouse model, according to a new study publishing March 7th in the open access journal PLOS Biology by Rui Zhang of Air Force Medical University in Xian, Shaanxi, China. The results illuminate one pathway for entrance of peripheral immune cells into the brain, and may provide a new target for treatment of Alzheimer’s disease.
To evaluate best strategies for increasing vaccination rates, researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, collaborated with Danish researchers to develop and implement a nationwide trial in Denmark testing nine different electronic messaging tactics among adults over age 65.
A clinical trial testing a freeze-dried, temperature-stable experimental tuberculosis (TB) vaccine in healthy adults found that it was safe and stimulated both antibodies and responses from the cellular arm of the immune system.
The recent public health emergency declarations in New York and London due to polio infections and detection of the virus in these cities’ wastewater strongly indicate that polio is no longer close to being eradicated. Now, four members of the Global Virus Network (GVN) proposed changes in global polio eradication strategy to get the world back on track to one day eliminating polio’s threat.
The recent public health emergency declarations in New York and London due to polio infections and detection of the virus in these cities’ wastewater strongly indicate that polio is no longer close to being eradicated.
Public and private sector health officials and public policymakers should team up immediately with community leaders to more effectively disseminate accurate narratives regarding the life-saving benefits of vaccines to counter widespread, harmful misinformation from anti-vaccine activists in the United States.
Public and private sector health officials and public policymakers should team up immediately with community leaders to more effectively disseminate accurate narratives regarding the life-saving benefits of vaccines to counter widespread, harmful misinformation from anti-vaccine activists.
What promoted citizens to favour a fair distribution of vaccines during the COVID-19 pandemic? This is the focus topic in the current study of Konstanz researchers, political scientists Dirk Leuffen, Pascal Mounchid and Max Heermann as well as sociologist Sebastian Koos, published in npj Vaccines.
After more than two years since its discovery, six million deaths, and half a billion reported cases, there is still no effective cure for COVID-19. Even though vaccines have lowered the impact of outbreaks, patients that contract the disease can only receive supportive care while they wait for their own body to clear the infection.
A new Australian study led by SAHMRI and Flinders University has uncovered fundamental differences in how the AstraZeneca and Pfizer COVID-19 vaccines impact the immune system.
For parents, the decision to vaccinate their kids against SARS-CoV-2 is complex, influenced by scientific evidence, political and social pressures, and views about individual versus collective benefits of vaccination.
Below are some of the latest articles that have been added to the Chemistry news channel on Newswise.
A new study has found that people with a university degree were less likely to believe in COVID-19 misinformation and more likely to trust preventive measures than those without a degree.
Analyzing the most extensive datasets in the U.S., researchers from the Icahn School of Medicine at Mount Sinai have revealed that vaccination against COVID-19 is associated with fewer heart attacks, strokes, and other cardiovascular issues among people who were infected with SARS-CoV-2, the virus that causes COVID-19. The research letter, “Impact of Vaccination on Major Adverse Cardiovascular Events in Patients with COVID-19 Infection,” was published in the Journal of the American College of Cardiology on February 20. The research will also be presented on March 5, 2023 in a poster session in New Orleans, LA, at the American College of Cardiology’s 72nd Annual Scientific Session Together With World Heart Federation’s World Congress of Cardiology.
Although the public had been alerted that this winter could be a potentially bad flu season, barely half of Americans said in January that they had received a flu shot, a vaccination level unchanged in a representative national panel from the comparable period last year.
The Covid-19 pandemic has highlighted the vital role of vaccination in preventing life-threatening diseases and the collapse of health care systems.
Largest review and meta-analysis assessing the extent of protection following COVID-19 infection by variant and how durable that protection is against different variants, including 65 studies from 19 countries.
In an article published in Frontiers in Public Health, researchers Carlos Alós-Ferrer of the Center for Neuroeconomics at the University of Zurich and Jaume García-Segarra and Miguel Ginés Vilar of the Department of Economics at the Universitat Jaume I in Castelló have questioned the distribution of vaccines against COVID-19 and propose an algorithm to satisfy the properties that experts in medical ethics consider fundamental.
This study shows vaccination against COVID-19 is an essential strategy to improve outcomes in this high-risk population. The results support guidelines that patients with cancer should receive at least 3 COVID-19 vaccine doses.
A biomedical researcher at the Lankenau Institute for Medical Research, part of Main Line Health, has created a groundbreaking resource for scientists seeking to develop new and better vaccines in the fight against COVID-19.
People afflicted with autoimmune diseases may someday receive help through treatments now under development by a Lawrence Livermore National Laboratory (LLNL) licensee and its’ collaborations with two major pharmaceutical companies.
When designing strategies to create lasting impact in a particular community, there is no better resource than the strength and intelligence of the community members themselves, and in this case, girls and women. Using crowdsourcing as a framework, a Saint Louis University researcher aims to increase HPV vaccination and HPV screening to lower incidents of cervical cancer among girls and women in Nigeria.
The National Institutes of Health has awarded $3.8 million to Texas Biomedical Research Institute to further develop a promising HIV vaccine candidate that stops the virus upon entry, before it begins rapidly spreading throughout the body.
Investigators in the Smidt Heart Institute at Cedars-Sinai have confirmed that people who have had COVID-19 have an increased risk for new-onset diabetes—the most significant contributor to cardiovascular disease.
COVID-19 vaccines did not cause an increased risk of adverse events such as heart attack, stroke, cardiac arrest, myocarditis, pericarditis, and deep vein thrombosis.
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Researchers tested lambda’s effectiveness using a randomized placebo-controlled trial involving adults with COVID-19 from both Canada and Brazil, who freely volunteered for the study. A total of 931 people received lambda and 1,018 received a placebo. Eighty-three per cent of the trial participants were vaccinated. Researchers ran the lambda trial from June 2021 to March 2022.
A single-dose of the antiviral drug peginterferon lambda reduced by half the risk of hospitalization or a visit to the Emergency Department due to COVID-19, according to a study published today in the New England Journal of Medicine.
Cleveland Clinic researchers have launched the next step in their novel study of a vaccine aimed at preventing triple-negative breast cancer, the most aggressive and lethal form of the disease.
An analysis led by Brown University researchers showed that work shift is an important factor to consider when designing workplace health interventions.
People who know someone who became ill with COVID-19 or died from the disease are twice as likely to receive a COVID-19 vaccine, according to a study led by Rutgers and Penn State University.
Few studies have evaluated the waning of vaccine effectiveness against severe outcomes caused by SARS-CoV-2 Omicron infection. Hong Kong is providing inactivated and mRNA vaccines, but the population had limited protection from natural infections before the Omicron variant emerged.
Breakthrough COVID-19 infections after vaccination occurred in 7.5% of Texans surveyed and higher odds were associated with Hispanic ethnicity, larger household size, rural versus urban living, type of vaccination, and multiple comorbidities, according to findings from UTHealth Houston School of Public Health published today in the Journal of Infectious Diseases.
The tuberculosis vaccine (or BCG vaccine) does not protect elderly with co-morbidities against disease symptoms caused by a coronavirus infection.
Pia Pannaraj, MD, MPH, an infectious disease specialist at Children's Hospital Los Angeles, was awarded $4.2 million from the National Institutes of Health to study COVID-19 immunity in children.
Implementing financial coaching for parents of infants in a pediatric primary care setting reduced missed well-child care visit rates by half and significantly improved receipt of vaccinations at a timely age, according to a new community-partnered pilot study led by UCLA researchers.
Below are some of the latest articles that have been added to the Surgery and the Transplantation channels on Newswise, a free source for journalists.
The Cotswold Foundation Postdoctoral Fellowship is a new fellowship totaling $500,000 over the course of five years to support a postdoctoral researcher studying immunology, cancer research, or vaccine biology at The Wistar Institute.
A booster (third) dose of a SARS-CoV-2 vaccine was associated with a 90% reduction in death in people with multiple health conditions compared to 2 doses, according to a new study from Hong Kong published in CMAJ (Canadian Medical Association Journal).
The main point of the study, which was completed before other variants came on the scene, is for pregnant women to get vaccinated and receive all their boosters, including the bivalent booster.
Three years ago this month, the first case of COVID was diagnosed in the United States. Here are the latest figures on the pandemic, collected by UCLA Health hospitals and clinics.
Las vacunas han protegido a las personas de enfermedades mortales durante generaciones. ¿También podrían ayudar a combatir el cáncer? Los investigadores de Mayo Clinic están trabajando en el desarrollo de vacunas terapéuticas personalizadas contra el cáncer que podrían atacar las características distintivas de los tumores en cada persona.
As vacinas protegem as pessoas contra doenças mortais ao longo de gerações, mas será que elas também poderiam ajudar a combater o câncer? Os pesquisadores da Mayo Clinic estão trabalhando para desenvolver vacinas terapêuticas personalizadas contra o câncer.
As its 11th-anniversary approaches, the National Primate Research Center of Thailand Chulalongkorn University (NPRCT-CU) and the Primates Enterprise Co., Ltd. are pleased to announce two events in February 2023:
جاكسونفيل، فلوريدا — لطالما حمت اللقاحات الناس من الأمراض الفتاكة لأجيال. فهل يمكنها أيضًا المساعدة في محاربة السرطان؟ يعمل باحثو مايو كلينك على تطوير لقاحات علاجية مخصصة للسرطان يمكنها استهداف خصائص الورم المميزة لكل شخص. إن هذا النهج الجديد، المبني على التقدم في الأبحاث الجينومية وتحليلات البيانات، يحمل إمكانات تحويلية لتعزيز قوة الجهاز المناعي للتعرف على الخلايا السرطانية ومهاجمتها.
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