Among the 30 million U.S. adults with Type 2 diabetes, 20% have impaired kidney function. In patients like this, metformin, the recommended first-line drug therapy for Type 2 diabetes, is associated in the new study with 20 percent decreased risk of major adverse cardiovascular events when compared to a class of common diabetes drugs called sulfonylureas.
• In an analysis of published studies, a healthy dietary pattern was associated with a 30% lower incidence of chronic kidney disease. • A healthy dietary pattern was also linked with a 23% lower incidence of albuminuria, an early indicator of kidney damage
A study largely validates that immunoglobulin IgG is a crucial part of the pathogenic immunodeposits in kidneys of patients with IgA nephropathy. The routine clinical test that identifies the presence of IgA in all cases of IgA nephropathy fails to show IgG in 50 to 80 percent of biopsies.
• Kidney donation was linked with a 19% higher risk of developing hypertension, and this association did not vary by race. • Kidney function tended to improve after donation and then plateau if they developed hypertension.
• Researchers have uncovered 16 genetic regions linked to diabetic kidney disease. • The findings point to potential targets for prevention and treatment.
A UCLA-led study has found that using three-dimensional virtual reality models to prepare for kidney tumor surgeries resulted in substantial improvements, including shorter operating times, less blood loss during surgery and a shorter stay in the hospital afterward.
Kidneys from donors who were infected with the Hepatitis C virus (HCV) function just as well as uninfected kidneys throughout the first year following transplantation, according to a new Penn Medicine study.
A recent analysis reveals that kidneys from donors infected with hepatitis C virus (HCV) are now routinely used in transplants at many U.S. centers, and they are functioning well one year after transplantation.
A potential treatment for polycystic kidney disease – a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure – has shown promising results in animal testing.
UAB has successfully completed more than 14,000 transplants since doctors performed Alabama’s first kidney transplant in 1968.
On July 10, the Department of Health and Human Services (HHS) announced they were aiming to reduce the number of Americans developing end-stage renal disease by 25% by 2030. But, the results of a focus group study done by Johns Hopkins researchers of more than 30 veteran primary care physicians across the United States
A new method that automates the classification of progressive diabetic kidney disease, reducing variability and boosting precision, has been developed by researchers in the Jacobs School of Medicine and Biomedical Sciences at the University at Buffalo.
• In two different studies, researchers used machine learning algorithms to classify kidney biopsy samples and found substantial agreement with standard classification by pathologists • The methods may augment traditional diagnostics of kidney disease.
Using a novel approach and a machine designed to remove fluid from adults with heart failure, an article published in the Clinical Journal of the American Society of Nephrology (CJASN) reports higher survival rates and lower complications than previous studies.
The Kidney Health Initiative (KHI), today announced the availability of two new resources to advance the global pursuit of an artificial kidney for use in humans. The US Department of Health and Human (HHS)’s Advancing American Kidney Health initiative made developing an artificial kidney a national priority through KidneyX and its Redesign Dialysis prize competition. KHI’s Technology Roadmap for Innovative Alternatives to Renal Replacement Therapy (RRT Technology Roadmap) established the foundational strategy for KidneyX and details the basic science requirements of an artificial kidney.
Most patients who died or were removed from the kidney transplant waitlist before getting a transplant received multiple offers for a donor kidney.
Patients with advanced chronic kidney disease who died in Department of Veterans Affairs’ facilities often received intensive patterns of end-of-life care that appeared to be primarily directed at life extension.
Legend states that after the Greek army defeated the invading Persian forces near the city of Marathon in 490 B.C.E., the courier Pheidippides ran to Athens to report the victory and then immediately dropped dead.
For the first time in Southern California, surgeons at UC San Diego Health have transplanted the kidney of a deceased donor with HIV into a recipient with a pre-existing HIV infection. The procedure is part of an unprecedented multi-site national clinical trial.
French organ transplant centers are far more likely to accept “lower-rated” kidneys, like those from older organ donors, than centers in the United States, according to a study published today in JAMA Internal Medicine.
• Between 1996 and 2013, approximately 27% of adults, 21% of elderly adults, and 16% of children with kidney failure in the United States were hospitalized with a psychiatric diagnosis in the first year of kidney failure. • The prevalence of hospitalizations with psychiatric diagnoses increased over time across age groups, mostly due to secondary diagnoses.
Animal-assisted therapy has many benefits in health care settings. Yet, its biological and psychosocial effects in the military are limited, especially for injured, airlifted patients. Researchers teamed up with a not-for-profit animal organization that trains therapy dogs to see if an animal-assisted intervention is feasible and effective at reducing stress in this setting. Results showed that levels of the stress biomarkers cortisol, alpha-amylase, and immunoglobulin A, significantly decreased following a 20-minute intervention with these dogs, regardless of post-traumatic stress symptom severity.
Rutgers and other scientists have discovered how brown fat, also known as brown adipose tissue, may help protect against obesity and diabetes. Their study in the journal Nature adds to our knowledge about the role of brown fat in human health and could lead to new medications for treating obesity and type 2 diabetes.
The American Society of Nephrology (ASN) recently launched a new initiative aimed at saving lives of those who suffer from acute kidney injury (AKI). Made possible by a grant from Baxter Healthcare Corporation, the effort is called AKI!Now: Promoting Excellence in the Prevention and Treatment of Acute Kidney Injury.
Castleman Disease patients who do not respond to the only drug currently approved by the FDA may have another option that targets a specific pathway called PI3K/Akt/mTOR
AnaBios Corp. today announced it is providing validated human dorsal root ganglion (hDRG) to the National Center for Advancing Translational Sciences (NCATS), a component of the National Institutes of Health (NIH), for research collaborations to develop human cell-based screening platforms and novel drugs to treat pain and opioid use disorder.
Fluoride exposure may lead to a reduction in kidney and liver function among adolescents, according to a study published by Mount Sinai researchers in Environment International in August.
The internet can serve as a pathway to diagnosis and care for people who suspect they have a rare condition that has not been identified by their physicians, according to a study by researchers at Wake Forest School of Medicine, part of Wake Forest Baptist Health.
Mount Sinai researchers describe striking racial and ethnic disparities exist in the use of palliative care by hospitalized patients with end-stage kidney disease (ESKD) on dialysis, based on a a retrospective cohort study.
For transplant patients, organ rejection can be a serious complication. A new clinical trial at the UK Transplant Center seeks to change how the body reacts to a new organ by inducing tolerance to it through a special process prior to transplant.
• Brain aneurysms were detected by pre-symptomatic screening in 9% of patients with autosomal dominant polycystic kidney disease, more frequently in those with a history of hypertension and smoking. • Very few patients experienced aneurysmal ruptures, but the overall rupture rate was approximately 5 times higher than in the general population.
• The number of U.S. patients with kidney failure undergoing weight loss surgery increased 9-fold between 2006 and 2016. • The proportional use of sleeve gastrectomy in patients with kidney failure increased from less than 1% of weight loss surgeries in 2006 to 84% in 2016. • Complication rates for sleeve gastrectomy were similar between patients with and without kidney failure; however, patients with kidney failure had more hospital readmissions and slightly longer hospitals stays.
The American Society of Nephrology (ASN) is pleased to announce the launch of the Diabetic Kidney Disease Collaborative (DKD-C) in response to the recent development of new therapies for people with diabetic kidney disease (DKD). The Diabetic Kidney Disease Collaborative will work to increase coordination among primary care physicians, nephrologists, and other specialists to deliver appropriate therapies to people living with DKD.
• In an analysis of information on children with kidney failure who began dialysis in the United States between 1995 and 2015, the risk of death was 1.36 times higher among children with higher kidney function at dialysis initiation. • The risk of death was even greater for children with higher kidney function who initiated treatment with hemodialysis rather than peritoneal dialysis. • In more recent years, children have been started on dialysis with higher kidney function.
Among U.S. patients who started dialysis in 2005 to 2013, racial/ethnic differences in initiating home dialysis decreased over time, although in the most recent era, Blacks were still less likely to use home dialysis as the initial modality than other groups.
Washington, D.C. – July 11, 2019 – Today, the U.S. Department of Health and Human Services (HHS), American Society of Nephrology (ASN) and National Kidney Foundation (NKF) announced a new prize competition that seeks to identify ideas and solutions patients and care partners have developed to improve their daily life with kidney disease. The KidneyX Patient Innovator Challenge, funded by the National Kidney Foundation (NKF) invites individuals, communities, businesses, institutions, and not-for-profit organizations, among others, to submit ideas on how to improve therapeutic options and quality of life for people living with kidney disease.
•From 2006 to 2014, patients with chronic kidney disease (CKD) had a high prevalence of uncontrolled hypertension that did not decrease over time.
Nearly a fifth of the respondents in a recent study said they would reverse their opposition to compensating kidney donors if a form of non-cash payment led to a substantial increase in the supply of available organs for transplant.
President Donald J. Trump and Department of Health and Human Services Secretary Alex Azar, II, today unveiled the Advancing American Kidney Health initiative.
The exclusion of patients with kidney diseases from clinical trials remains an unsolved problem that hinders optimal care of these patients. Over 850 million people suffer from kidney diseases worldwide, a number which signifies epidemic proportions, yet these patients are still ignored by investigators and initiators of clinical trials in all medical fields – and are thus excluded from clinical trials. ASN, ERA-EDTA and ISN, collaboratively aim to bring about a paradigm change in medical research and have launched an information campaign to that end.
The males of one species of butterfly are more attracted to females that are active, not necessarily what they look like, according to a recent research conducted at Augustana University.The paper, “Behaviour before beauty: Signal weighting during mate selection in the butterfly Papilio polytes,” found that males of the species noticed the activity levels of potential female mates, not their markings.
• In older adults initiating dialysis at 17 centers in Netherlands, 40% experienced a decline in functional status, 34% remained stable, 18% improved, and 8% died within 6 months. • The risk of functional decline or death was higher in participants who were older and those who were frail. • The percentage of caregivers reporting a high burden of care increased from 23% to 38% after dialysis initiation.
• Among older living kidney donors, those with hypertension had higher risk of developing kidney failure through 15 years after donation; however, the absolute risk was small. • Hypertension was not linked with a higher risk of early death among older donors.
A common metric for monitoring kidney health may not accurately represent that of Indian patients. Research into an improved method for this population is presented today at the American Physiological Society/American Society of Nephrology Conference, Control of Renal Function in Health and Disease.
Researchers found a low dose of endotoxin prior to induction of acute kidney injury improved outcomes for male rats. Their study will be presented today at the American Physiological Society (APS)/American Society of Nephrology (ASN) Conference: Control of Renal Function in Health and Disease.
Metabolomics, the study of small molecules the body produces during metabolism (metabolites) may be a future key to identifying diabetes-related kidney disease. The finding will be presented today at the American Physiological Society (APS)/American Society of Nephrology (ASN) conference, Control of Renal Function in Health and Disease, in Charlottesville, Va.
Early research suggests that the common pantry staple baking soda affects inflammation and insulin handling in type 2 diabetes. The findings will be presented today at the American Physiological Society (APS)/American Society of Nephrology (ASN) conference, Control of Renal Function in Health and Disease in Charlottesville, Va.
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