Diagnosing Mononucleosis, Need for Health Interventions for Single Parent Households in Urban Subsidized Housing Programs, Inadequate Financial Savings Tied to Increased Childhood Health Risks, and more in the Public Health News Source
Synthetic peptides called minihepcidins may potentially treat two serious genetic blood diseases: beta-thalassemia and polycythemia vera. The compounds restored red blood cell levels of red blood cells and controlled iron absorption in animal models.
University of Vermont blood-clotting expert Mary Cushman, M.D., M.Sc., talks about the reasons why sometimes fatal blood clots occur in elite athletes like the Portland Trail Blazers' Jerome Kersey, tennis great Serena Williams and most recently, the Miami Heat's Chris Bosh.
Atrial fibrillation patients taking warfarin, a popular anticoagulation drug, are at higher risk of developing kidney failure if anticoagulation levels are not properly managed, according to a new study from researchers at the Intermountain Medical Center Heart Institute.
Northwestern Medicine researchers are co-investigators in a breakthrough clinical trial that found transplanted human islets prevent hypoglycemic events and provide excellent glycemic control for patients with Type 1 diabetes with severe hypoglycemia. The results of the multi-center, single arm, phase III study are published in Diabetes Care on Monday, April 18.
Pinellas County a Model for Mosquito-Borne Disease Surveillance, Scientists Unravel the Genetic Evolution of Zika Virus, Worm Infection Counters Inflammatory Bowel Disease and more in the Infectious Diseases News Source
Discovery provides a serious advantage in determining how to maximize blood stem cells in therapeutics and could help ease current stem cell shortages.
Cancer researchers at the University of Cincinnati (UC) have found a particular signaling route in microRNA (miR-22) that could lead to targets for acute myeloid leukemia, the most common type of fast-growing cancer of the blood and bone marrow.
Early results suggest novel gene therapy is safe and effective for treatment of inherited immune disease, according to St. Jude Children’s Research Hospital and the National Institute of Allergy and Infectious Diseases.
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Colorectal cancers heavily bedecked with tumor-related proteins called neoantigens are likely to be permeated with disease-fighting white blood cells, researchers at Dana-Farber Cancer Institute and the Broad Institute of MIT and Harvard report in a new study.
A new generation of blood thinners can reduce the risk of stroke in patients with atrial fibrillation, without requiring frequent monitoring and dietary restrictions.
People with type 2 diabetes are at greater risk of serious liver disease than those without the condition, research has shown.
Implementation of a multifaceted quality improvement intervention with daily checklists, goal setting, and clinician prompting did not reduce in-hospital mortality compared with routine care among critically ill patients treated in intensive care units (ICUs) in Brazil, according to a study appearing in the April 12 issue of JAMA.
The American College of Radiology (ACR) — as a member of a coalition of leading medical societies — provided peripheral arterial disease (PAD) treatment recommendations to the Medicare Evidence Development Coverage Advisory Committee (MEDCAC). In addition, the coalition called for continued research in how to provide the best care for U.S. seniors with lower extremity PAD.
Protective role for SHARPIN, a protein involved in regulating inflammation, according to report in The American Journal of Pathology.
While controlling blood pressure, blood sugar and LDL-cholesterol levels reduces the risk of cardiovascular disease in people with diabetes, only 7 percent of diabetic participants in three major heart studies had recommended levels of these three factors, according to research from the Heart Disease Prevention Program at the University of California, Irvine School of Medicine.
The investigational drug abaloparatide-SC (subcutaneous) may help increase bone mineral density in postmenopausal women and reduce their risk of fracture, new industry-sponsored research suggests. The results of the subgroup analysis within the ACTIVE clinical trial will be presented Friday, April 1, at ENDO 2016, the annual meeting of the Endocrine Society in Boston
People with high levels of good cholesterol, or high-density lipoprotein, are not as safe from heart disease when high levels of a newly identified biomarker of inflammation in the arteries are also found in their bloodstream, according to a new study.
Doctors have devised a test which could help them predict which women going through menopause will lose bone faster than average, new research reports. The results of the study will be presented Friday, April 1, at ENDO 2016, the annual meeting of the Endocrine Society, in Boston.
Researchers have identified a common variant in a non-coding RNA that may contribute to the intestinal inflammation that occurs in people with celiac disease. The findings point to a possible new risk factor for developing celiac disease in people with celiac disease risk genes.
Patients are often instructed not to take ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) before or after surgery because of increased bleeding risk. But available evidence suggests that ibuprofen does not increase the risk of bleeding after plastic surgery procedures, according to a research review in the April issue of Plastic and Reconstructive Surgery®, the official medical journal of the American Society of Plastic Surgeons (ASPS).
Intermountain Healthcare is one of eight health systems and hospitals nationwide that were recognized Tuesday by the U.S. Centers for Disease Control and Prevention for implementing protocols that have helped to reduce the rate of venous thromboembolism (VTE), or blood clots, among hospital patients.
A study led by researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) has uncovered a new clue that may help fight acute myeloid leukaemia (AML), the most common form of cancer of the blood and bone marrow, and an aggressive type of cancer. The findings open a new door to treating the disease more effectively.
Researchers are using 3-D printers to develop a low cost, point-of-care device that can quickly detect anemia.
A study led by scientists from the Cancer Science Institute of Singapore at the National University of Singapore has uncovered a key player contributing to the maintenance of hematopoietic stem cells, blood cell precursors which have the ability to become any type of blood cell in the body. The research findings could contribute towards better understanding of the underlying causes of blood diseases.
ONC201, an anti-cancer drug that triggers cell death in various tumor types, may have clinical potential for some blood cancers including mantel cell lymphoma (MCL) and acute myeloid leukemia (AML), according to a recent clinical study.
UAB researchers have found a marker on blood cells that may help the most pressing problem in chronic myelogenous leukemia today — an inability to get patients off treatment. This marker shows heterogeneity among the leukemia stem cells and correlates with leukemic potential.
There are many things you can do to lower your heart disease risks. This article from cardiologist Dr. Mauro Moscucci of LifeBridge Health looks at the seven modifiable risk factors (according the the American Heart Association) and the one most of us struggle with.
Most clinical studies have shown that renal denervation—a procedure that disrupts the nerves in the kidneys and prevents them from relaying signals—can treat drug-resistant hypertension, although a number have shown the procedure to be ineffective. A new study in American Journal of Physiology—Regulatory, Integrative and Comparative Physiology supports that renal denervation can treat hypertension and suggests that failures may be due to incomplete procedure. This research is highlighted as one of this month’s “best of the best” as part of the American Physiological Society’s APSselect program.
Using a model blood vessel system built on a polymer microchip, researchers have shown that the relative softness of white blood cells determines whether they remain in a dormant state along vessel walls or enter blood circulation to fight infection.
A research team from the Department of Pharmacology and Therapeutics at Roswell Park Cancer Institute (RPCI) has discovered a new class of small-molecule compounds that are good candidates for development of novel targeted therapies in the treatment of leukemia and lymphoma. This new class of compounds drives cancer cells to suicide, the researchers report in the peer-reviewed journal Cell Death and Disease.
A single injection. That’s all someone with a factor VII deficiency would need for a life-long cure, thanks to a new gene therapy treatment developed in a collaboration of researchers at the University of North Carolina (UNC) and The Children’s Hospital of Philadelphia (CHOP).
Based on new evidence, the age of introduction of gluten into the infant diet—or the practice of introducing gluten during breast-feeding—does not reduce the risk of celiac disease in infants at risk, according to a Position Paper of the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN). The statement appears in the Journal of Pediatric Gastroenterology and Nutrition (JPGN), official journal of ESPGHAN and the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, published by Wolters Kluwer.
Researchers at Wake Forest Baptist Medical Center have found an association between obesity and the formation of blood clots in the veins of children and adolescents.
UAB researchers have discovered a new mechanism of differentiation, as studied in megakaryocytes, the blood cells responsible for platelet production. The ultimate effect of this new pathway is an alternative splicing of messenger RNAs.
Researchers detail how they have been able to fingerprint myelodysplastic syndromes (MDS), a state for blood cells that turns into acute myeloid leukemia (AML) cancer in approximately 30% of patients
Research conducted by members of the Colorado School of Mines Department of Chemical and Biological Engineering demonstrates microscale biomedical devices shaped like wheels can be injected into the body and effectively “roll” to treat areas in need – such as arterial blockages.
Tel Aviv University researchers develop unique system to deliver therapy at site of Mantle Cell Lymphoma.
A new $8.5M (CAD) grant award by the European commission via its Horizon 2020 program will be used for the treatment of hemophilia A, also called factor VIII (FVIII) deficiency, the most common form of hemophilia A. The genetic disorder is caused by missing or defective factor VIII, a blood clotting protein. The grant was awarded to the HemAcure consortium consisting of Canadian- based Sernova Corp and five European academic and private partners to advance development of a GMP clinical grade Factor VIII releasing therapeutic cell product in combination with Sernova's Cell Pouch™ for the treatment of severe hemophilia A.
Vitamin D2 supplements taken for 6 months did not reduce dialysis patients’ need for anemia drugs that stimulate red blood cell production.
The Angelo Bianchi Bonomi Foundation is pleased to announce that the SIPPET (Survey of Inhibitors in Plasma-Products Exposed Toddlers), the first randomized and controlled study on hemophilia and inhibitors designed to answer a key clinical question regarding the role that the product source plays in the development of inhibitors, has been completed.
A team of researchers from the National University of Singapore has found a new significant correlation between the protein nucleophosmin and the development of an aggressive form of blood cancer called acute myeloid leukemia (AML). The team, led by Professor Lim Tit Meng from the Department of Biological Sciences at the NUS Faculty of Science, explained the puzzling phenomenon of AML cells appearing like normal cells even though they are cancerous. The team discovered that the mutated form of the protein which is found in about one-third of AML cases, is associated with a novel cellular mechanism that develops AML cells containing normal chromosomes.
Montefiore Einstein Center for Cancer Care, Albert Einstein Cancer Center and The Children’s Hospital at Montefiore present research at the American Society of Hematology’s annual meeting. Presentations include the first report on a genetic risk factor for avascular necrosis associated with treatment of acute lymphoblastic leukemia (ALL) in children.
A brain protein called SNTF, which rises in the blood after some concussions, signals the type of brain damage that is thought to be the source of these cognitive impairments.
• After 6 months of treatment with hydroxyurea, sickle cell disease patients’ kidney function, as measured by the urinary albumin/creatine ratio, improved significantly.
Researchers from the Duke-NUS Graduate Medical School Singapore (Duke-NUS) and Duke Medicine have identified a potential treatment strategy for an often-fatal inherited glycogen storage disease.
Researchers from the University of Birmingham have, for the first time, identified how Salmonella infections that have spread to our blood and organs can lead to life-threatening thrombosis.
Scientists at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have determined how the body responds during times of emergency when it needs more blood cells. In a study published in Nature, researchers report that when tissue damage occurs, in times of excessive bleeding, or during pregnancy, a secondary, emergency blood-formation system is activated in the spleen.
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