A group of international cancer researchers led by investigators from Mayo Clinic and University of New South Wales Sydney has found that the level of a type of white blood cell, called tumor-infiltrating lymphocytes, present in the tumors of patients with high-grade ovarian cancer may predict a patient’s survival.
African American women were found to be twice as likely to be diagnosed with peripartum cardiomyopathy as compared to women of Caucasian, Hispanic/Latina, Asian, and other ethnic backgrounds, according to a new study—the largest of its kind—published today in JAMA Cardiology by researchers from the Perelman school of Medicine at the University of Pennsylvania.
Johns Hopkins researchers report that the level, or “copy number,” of mitochondrial DNA—genetic information stored not in a cell’s nucleus but in the body’s energy-creating mitochondria—is a novel and distinct biomarker that is able to predict the risk of heart attacks and sudden cardiac deaths a decade or more before they happen. In the future, testing blood for this genetic information could not only help physicians more accurately predict a risk for life-threatening cardiac events, but also inform decisions to begin—or avoid—treatment with statins and other drugs.
A commentary in JAMA Internal Medicine calls for improved oversight and transparency for compounded bioidentical hormone therapies.
Researchers report in JAMA Dermatology that surgical treatment delays – defined as surgery that occurred more than six weeks after diagnosis – were common. Medicaid patients were 36 percent more likely than private insurance patients to experience delays.
New research shows families who used activity trackers with specially designed gaming elements increased daily step counts by nearly one mile per day and achieved daily fitness goals 27 percent more than families who did not.
An analysis reveals that the branded form of a synthetic progestin for the prevention of recurrent preterm births costs 5,000 percent more than the compounded, made-to-order version of the medication despite having the same active ingredients and being clinically interchangeable.
A new study finds that genetic testing can help determine the safest dose of the blood thinner warfarin, with fewer side effects, in patients undergoing joint replacement surgery.
Do you really need that MRI? Your doctor may order an MRI based on factors other than your actual medical need for imaging, researchers in UT Southwestern’s Center for Patient-Centered Outcomes Research found. Their study in JAMA Internal Medicine showed that a physician’s prior image-ordering habits, as well as ownership of the equipment, were strong indicators of unnecessary imaging orders.
Largest study to date identifies gender-specific patterns of autism and related disorders occurrence among sibling pairs.
Findings of a new and comprehensive study from FSU College of Medicine Associate Professor Antonio Terracciano and colleagues, published today in the journal JAMA Psychiatry, has found no evidence to support the idea that personality changes begin before the clinical onset of mild cognitive impairment (MCI) or dementia.
Victims of gunshots and stabbings are significantly less likely to die if they’re taken to the trauma center by a private vehicle than ground emergency medical services (EMS), according to results of a new analysis.
In addition to caring for U.S. troops and coalition forces during conflicts in the Middle East, U.S. military surgeons also provided humanitarian surgical care to nearly 6,000 local national Afghan adult patients over the course of a decade, according to a study published Sept. 13 in JAMA Surgery.
A woman’s choice of surgeon plays a significant role in whether she’s likely to receive contralateral prophylactic mastectomy, an increasingly popular aggressive breast cancer surgery.
Cost savings fell below expectations for generic versions of an orally administered cancer treatment in an analysis by University of North Carolina Lineberger Comprehensive Cancer Center researchers. The findings raise questions about the extent to which generic drugs can help control care costs for cancer treatments.
Sending a letter and, in some cases, a simple mail-in kit tripled colon cancer screening completion among low-income adults, researchers at UT Southwestern’s Simmons Cancer Center report this week in JAMA.
Brain imaging study shows white matter structural changes in children correspond to severity of autistic traits.
High levels of a protein known as suPAR, which has been shown to be a marker and likely cause of kidney damage, is as reliably predictive in children as in adults, according to results of a study published online today in JAMA Pediatrics, a clinical publication of the American Medical Association.
Compared to people who live in predominantly white neighborhoods, those who live in predominantly black areas are much less likely to receive CPR or defibrillation from a bystander when their heart suddenly stops beating while they are at home or out in the community.
When Tim Anegon became an eye tissue donor after his death in 2014, it wasn’t just one person he would touch with his eyes — it was millions as University of Michigan researchers use donated tissue in the fight against diabetic eye disease.
The “involuntary treatment” of unwilling psychiatric patients has long been accepted as necessary in some cases, for the sake of patients and society, though it can raise serious ethical concerns as well as legal barriers. In a Viewpoint essay published online today in JAMA, Dominic Sisti, PhD, an assistant professor of Medical Ethics & Health Policy at the Perelman School of Medicine at the University of Pennsylvania, argues that some of the concerns about treating patients without their consent would be alleviated if the mental health profession recognized an important distinction among these cases.
Mitochondria, the tiny structures inside our cells that generate energy, may play a key role in autism spectrum disorders (ASD). A provocative new study by Children’s Hospital of Philadelphia’s pioneering mitochondrial medicine team suggests that variations in mitochondrial DNA originating during ancient human migrations may play an important role in predisposition to ASD.
Researchers at the Johns Hopkins University School of Medicine and the Mayo Clinic have compiled peer-reviewed evidence and crafted a guideline designed to help physicians and medical centers stop the use of a widely ordered blood test that adds no value in evaluating patients with suspected heart attack.
A third of insured people with cancer end up paying more out-of-pocket than they expected, despite having health coverage, researchers at the Duke Cancer Institute have found.
UNC Lineberger scientists led a multi-institution research team to identify key features linked to amelanotic melanoma, a form of skin cancer that lacks the brown or black color that stems from the pigment melanin.
A recent study out of San Diego State University has found an increase of internet searches for suicide immediately following the release of the popular Netflix show “13 Reasons Why.” Researchers used data from Google Trends and found that suicide-related queries were 19 percent higher than expected following the show’s release in March.
In a review of half a dozen published studies in which patients self-reported use of opioids prescribed to them after surgery, researchers at Johns Hopkins report that a substantial majority of patients used only some or none of the pills, and more than 90 percent failed to dispose of the leftovers in recommended ways.
A study published in JAMA Pediatrics supports the use of genetic testing, especially with sequencing, as first-line diagnostic method for young children with seizures. Specific genetic factors were found to be the cause of epilepsy in 40 percent of patients evaluated for first presentation with seizures. Genetic testing also yielded a diagnosis in 25 percent of children who had epilepsy with an otherwise unknown cause.
After more than 20 years of research on the best treatment for full-term infants affected by oxygen deprivation during the birthing process, Seetha Shankaran, M.D., neonatologist at DMC Children's Hospital of Michigan and DMC Hutzel Women's Hospital, served as the lead investigator in a definitive Journal of the American Medical Association study that documented the safest depth and duration of body-cooling to minimize injury from hypoxic ischemic encephalopathy (HIE) in newborns.
The struggle to escape obesity is pointing more Americans toward bariatric surgery. But a new study shows that only one in three patients who have an operation succeed in getting their body-mass index below 30, the cutoff for obesity, in the first year. The odds were better for those who had surgery while they were still below a “morbid obesity” BMI of 40.
Does a previous suicide attempt in a soldier’s unit increase the risk of additional suicide attempts? According to a study, “Risk of Suicide Attempt Associated with Previous Attempts in One’s Army Unit,” published July 26, 2017 in JAMA Psychiatry, the answer is yes.
Stem cell centers claim to offer effective treatment to patients with heart failure, despite the fact that the treatment is not approved for such use by the U.S. Food and Drug Administration (FDA), says the author of research letter in the current issue of JAMA Internal Medicine.
In a first-of its kind study, researchers from the Icahn School of Medicine at Mount Sinai found an elevated risk of intellectual disability (ID) in children born to mothers treated with antidepressants, but the risk was not statistically significant and is likely due to other factors, including parental age and the parents’ psychiatric history.
The late adolescent years are an important period for gaining bone mineral, even after a teenager attains his or her adult height. Scientists analyzing a racially diverse, multicenter sample from a large, federally funded national study say their findings reinforce the importance of diet and physical activities during the late teen years, as a foundation for lifelong health.
Surgeons at Johns Hopkins Medicine report that their first series of a minimally invasive procedure to treat chronic pancreas disease, known as severe pancreatitis, resulted in shorter hospital stays, less need for opioids and fewer complications, compared with standard surgical approaches.
Acupuncture, alone or with the medication clomiphene, does not appear to be effective in treating infertility in women with polycystic ovary syndrome (PCOS), according to a new international study including Penn State College of Medicine.
A systematic review of zolpidem for noninsomnia neurological disorders, including movement disorders and disorders of consciousness, finds reason for additional research.
Women who receive human papillomavirus (HPV) testing, in addition to a pap smear, receive a faster, more complete diagnosis of possible cervical precancer, according to a study of over 450,000 women by Queen Mary University of London (QMUL) and the University of New Mexico (UNM) Comprehensive Cancer Center.
Parents of prematurely born babies often fear their children may go on to struggle in school, but findings from a new large-scale study from the Institute for Policy Research at Northwestern University and Northwestern Medicine should reassure parents.
A study examining the impact of antibiotics prescribed for nearly 1500 adult patients admitted to The Johns Hopkins Hospital found that adverse side effects occurred in a fifth of them, and that nearly a fifth of those side effects occurred in patients who didn't need antibiotics in the first place.
Adolescent drivers with attention-deficit hyperactivity disorder (ADHD) have a 36 percent higher crash risk than other newly licensed teens. Although elevated, this risk is far lower than previous reports of being four times higher. This is the first large-scale study to provide detailed information on crash risk of adolescents with ADHD compared to other newly licensed young drivers.
In a landmark study, UNC School of Medicine researchers have shown that blood glucose testing does not offer a significant advantage in blood sugar control or quality of life for type 2 diabetes patients who are not treated with insulin.
In a dramatic shift since the publication of margin guidelines for breast cancer surgery, lumpectomy rates have substantially increased and more-aggressive surgical options have been used less often, according to research findings from a new study being presented at the 2017 annual meeting of the American Society of Clinical Oncology (ASCO) in Chicago. The study will also be published in a corresponding issue of JAMA Oncology.
A new study conducted by researchers from Tulane University finds reducing target systolic blood pressure below current recommendations significantly reduces the risk of cardiovascular disease and preventable death.
Efforts to reduce hospital readmissions are working, but they’re not always saving money, according to a new Cedars-Sinai study. The study, published today in the Journal of the American Medical Association Internal Medicine, evaluated the effectiveness and financial benefit of quality improvement programs at medical centers in the U.S. and elsewhere.
One-third of American children are overweight or obese. Family-based treatment (FBT) has been considered the best model for the treatment of obese children as it provides both parents and children with education and behavior therapy techniques but is provided mainly in a hospital setting. Researchers at University of California San Diego School of Medicine have found that parent-based therapy (PBT) has similar outcomes to FBT and could be more cost-effective.
An analysis of billing records for more than 12,000 emergency medicine doctors across the United States shows that charges varied widely, but that on average, adult patients are charged 340 percent more than what Medicare pays for services ranging from suturing a wound to interpreting a head CT scan.
Every year, nearly 200,000 Americans turn to surgeons for help with their obesity, seeking bariatric surgery to lose weight and prevent life-threatening health problems. But after more than two decades of steadily increasing numbers of operations, American bariatric surgery centers still vary greatly in the quality of care they provide.
Adherence to care improves when youth with HIV receive education and help navigating the system, according to study out of UAB.
A study from NYU Langone Medical Center researchers published in JAMA Internal Medicine finds that initiating statins in heart-healthy older adults may not extend lifespan.
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