The study, conducted in mice, is the first to show that creatine uptake is critical to the anti-tumor activities of killer T cells, the foot soldiers of the immune system.
A team at the Morgridge Institute for Research has characterized a natural chemical that paralyzes the parasite that causes schistosomiasis, offering a new pathway to fight the catastrophic neglected disease.
Fatty liver disease is contributing to an increase in liver cancer and basic scientists at The University of Texas Health Science at Houston (UTHealth) have new insight as to why.
Without fat, nothing works in the body: These substances serve as energy suppliers and important building blocks
NUS researchers from the Cancer Science Institute of Singapore and the N.1 Institute for Health have shown the potential use of small molecule inhibitors to treat advanced liver cancer.
UC San Diego researchers investigated how a type of immune cell called a macrophage becomes specialized to the liver. Their study, published October 3, 2019 in Immunity, sets the stage for understanding how macrophage specialization gets disrupted by — or contributes to — liver disease.
BOSTON – (October 1, 2019) – Researchers at Joslin Diabetes Center have found that high levels of fructose in the diet inhibit the liver’s ability to properly metabolize fat. This effect is specific to fructose. Indeed, equally high levels of glucose in the diet actually improve the fat-burning function of the liver. This explains why high dietary fructose has more negative health impacts than glucose does, even though they have the same caloric content.
Disrupting a metabolic pathway in the liver in a way that creates a more “cancer-like” metabolism actually reduces tumor formation in a mouse model of liver cancer. This surprising finding from a Univ. of Iowa study identifies the mitochondrial pyruvate carrier as a potential target for preventing liver cancer.
Toxins produced during harmful algal blooms may be more harmful to people than previously known.
The Hackensack Meridian Health Jersey Shore University Medical Center Foundation is pleased to announce a gift of $1.25 million from Charles Adell to create The Charles & Jackie Adell Endowed Chair in Surgical Oncology at Jersey Shore University Medical Center.
By comparing needles and syringes to disease-carrying mosquitoes, an innovative mathematical model of how the Hepatitis C virus spreads is offering scientists new perspectives on how best to prevent its proliferation.
Castleman Disease patients who do not respond to the only drug currently approved by the FDA may have another option that targets a specific pathway called PI3K/Akt/mTOR
A new study from the UT Southwestern Simmons Comprehensive Cancer Center demonstrates that antiviral drugs for hepatitis C reduce liver-related deaths by nearly 50% in patients with a history of liver cancer.
A research team has been awarded a five-year, $1.8 million grant from the NIH to study chronic inflammation of the liver, a major factor in the development of liver cancer.
Fluoride exposure may lead to a reduction in kidney and liver function among adolescents, according to a study published by Mount Sinai researchers in Environment International in August.
In a proof-of-concept paper, Pitt researchers chronicle how they transformed genetically engineered human cells into functional, 3D liver tissue that mimics non-alcoholic fatty liver disease (NAFLD) – a condition involving fat buildup in the liver, which can lead to cirrhosis or even liver failure.
Jefferson researchers unveil first demonstration of heritable mutations behind non-alcoholic fatty liver disease
A UCLA-led research team has found that giving mice antibiotics for 10 days prior to a liver transplant leads to better liver function after the surgery -- then they came across data that it also works in humans. It's all linked to the antibiotics' effect on the microbiome.
A study at The University of Texas MD Anderson Cancer Center discovered a cellular pathway tied to cancer that may be beneficial in reducing side effects and extending duration of immunotherapy in some patients with hepatocellular carcinoma, the most common form of liver cancer.
New research from UPMC and Pitt shows that living-donor liver transplant offers numerous advantages over deceased-donor transplant, including superior outcomes and less resource utilization.
Cardiologists at Beth Israel Deaconess Medical Center (BIDMC), scientists found that increasing exercise can lower levels of dimethylguanidino valeric acid (DMVG), a molecule in the blood linked to poor health outcomes.
The males of one species of butterfly are more attracted to females that are active, not necessarily what they look like, according to a recent research conducted at Augustana University.The paper, “Behaviour before beauty: Signal weighting during mate selection in the butterfly Papilio polytes,” found that males of the species noticed the activity levels of potential female mates, not their markings.
Papers on current concepts in natural killer cell biology; the role of copper in Alzheimer’s disease; how sulfane sulfur may act as a defense against electrophilic stress, assessing the proarrhythmic potential of drugs, and more are featured in latest issue of Toxicological Sciences.
The American Association for the Study of Liver Diseases Foundation, the largest private supporter of liver disease research and training in the United States, today announced its investment of $3.42 million in Research and Career Development Awards granted to 29 researchers and clinicians to conduct innovative liver disease research and seek advanced hepatology training.
Scientists at Cincinnati Children’s Hospital Medical Center have identified an expression pattern of 14 genes at the time of diagnosis that predicts two year, transplant-free survival in children with biliary atresia – the most common diagnosis leading to liver transplants in children. The researchers also found that the antioxidant N-acetyl-cysteine (NAC) reduced liver injury and fibrosis (excess fibrous connective tissue) in mice with biliary atresia and increased survival times.
A statewide bipartisan initiative is transforming health care from a focus on treating disease to one of tapping the body's ability to heal itself. Regenerative Medicine Minnesota is a legislative initiative aimed at improving health by advancing regenerative medicine in research, technology, education and patient care across the state.
Researchers have identified a genetic mutation that caused an 11-year-old girl to suffer a fatal reaction to infection with the Hepatitis A virus (HAV). The study, which will be published June 18 in the Journal of Experimental Medicine, reveals that mutations in the IL18BP gene causes the body’s immune system to attack and kill healthy liver cells, and suggests that targeting this pathway could prevent the deaths of patients suffering rapid liver failure in response to viral infection.
If you're looking for health and fitness story ideas, view these research highlights from the June 2019 issue of Medicine & Science in Sports & Exercise®, ACSM’s flagship journal. ACSM is the largest sports medicine and exercise science organization in the world.
The confluence of two major health crises—the opioid epidemic and organ shortage—has moved surgeons to consider transplanting organs deemed as less than “perfect” in an effort to expand the donor pool and save more lives.
A new targeted therapy using non-thermal radio waves has been shown to block the growth of liver cancer cells anywhere in the body without damaging healthy cells, according to a study conducted by scientists at Wake Forest School of Medicine, part of Wake Forest Baptist Health.
Scientists successfully bioengineered human liver organoids that faithfully mimic key features of fatal liver disease in the laboratory. This allowed them to uncover underlying disease biology in the organoids and test a potential therapy that in preclinical lab tests reversed an often-fatal childhood condition called Wolman disease.
Bioengineers have developed a 3D printing technique that creates the interacting networks for transport of air, blood, and other bodily fluids—a major step toward 3D printed replacement organs.
Exposure to glyphosate, the primary ingredient in the popular weed killer Roundup, correlates to more severe cases of nonalcoholic fatty liver disease.
Alcohol Relapse Rate Among Liver Transplant Recipients Identical Whether or Not There is A 6-Month Wait Before Transplant 04/25/2019 AddThis Sharing Buttons Share to Facebook Share to TwitterShare to EmailShare to PrintShare to More Credit: Getty Images For decades, patients with liver disease related to alcohol use have been told they must be sober for six months before they can get a liver transplant. Many die before that six-month wait period is up. Now, a growing number of researchers are questioning that six-month waiting period.
It was in the Boy Scouts, decades before he came to Cedars-Sinai, that Dr. Nicholas Nissen, surgical director of Liver Transplantation, learned about going above and beyond the call of duty. On Thursday, April 25, he will receive one of the highest honors bestowed by Scouts USA: The rank of Distinguished Eagle Scout.
An anonymous living liver donor helped the UHN Transplant Program achieve a North American first with an innovative living liver donor exchange, or “swap,” that saved the lives of two failing liver patients, with the potential to save many more.
UT Southwestern researchers have found that a protein in the body’s innate immune system that responds to gut microbes can suppress the most common type of liver cancer.
If you're looking for health and fitness story ideas, here is research from the October 2018 issue of Medicine & Science in Sports & Exercise, ACSM’s flagship journal. ACSM is the largest sports medicine and exercise science organization in the world.
New research points to a potential way to prevent acute liver damage, or even treat it -- as well as a possible way to better monitor the health of patients who have suffered from it. It's based on the discovery that a protein involved in one of the liver’s most basic functions also sounds the alarm when liver cells get hurt.
New research has uncovered important differences in the biological pathways that lead to cancer for alcoholic fatty liver disease compared to non-alcoholic fatty liver disease.
Mayo Clinic 研究人员的一项新研究显示，药物疗法能有效治疗一种可能危及生命的与肝硬化和其他慢性肝病有关的疾病。这项研究发表于 3 月份的美国胃肠病学协会的在线期刊《肠胃病学 (Gastroenterology)》上。印刷出版物定于 7 月份出版。
Researchers at the Children’s Medical Center Research Institute at UT Southwestern (CRI) have identified genetic mutations that accumulate in the adult liver that can promote regeneration in the context of chronic liver damage.
University at Buffalo researchers have developed a new method to more accurately predict tumor growth rates, a crucial statistic used to schedule screenings and set dosing regimens in cancer treatment.
Embargoed press materials are now available for the Experimental Biology (EB) 2019 meeting, to be held in Orlando April 6–9. EB is the annual meeting of five scientific societies bringing together more than 12,000 scientists and 25 guest societies in one interdisciplinary community.
In a study of people with nonalcoholic fatty liver disease and their twins and other close relatives, UC San Diego researchers were able to diagnose liver cirrhosis simply by analyzing a person’s stool microbes.
Researchers in Spain have discovered that a hormone secreted by fat cells that is present at higher levels in women can stop liver cells from becoming cancerous. The study, which will be published April 3 in the ournal of Experimental Medicine, helps explain why hepatocellular carcinoma (HCC) is more common in men, and could lead to new treatments for the disease, which is the fourth leading cause of cancer-related death worldwide.
Según un reciente estudio realizado por investigadores de la Mayo Clinic, la terapia con medicamentos puede tratar de manera efectiva una enfermedad que pone en riesgo la vida relacionada con la cirrosis y otras enfermedades hepáticas crónicas.
Billions worldwide are infected with tropical worms. Unsurprisingly, most of these people live in poor countries, kept poor by the effects of worm-related malnourishment.
Scientists have discovered a novel molecular pathway for an enzyme inhibitor in humans that plays a direct role in the development of high cholesterol and nonalcoholic fatty liver disease, which they then were able to reverse in mice with an investigational drug. The study results will be presented Monday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La., by researchers from Northwestern University Feinberg School of Medicine in Chicago, Ill.
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