A map of the cells in the human liver has been created by University Health Network Transplant Program and University of Toronto researchers, revealing for the first time differences between individual cells at the molecular level which can have a profound impact on their behaviour in tissue, tumours and disease.
Adult patients who received liver and kidney transplants at Rush University Medical Center had better-than-expected one-year survival rates, according to the most recent transplantation on the 5-tier system report by the Scientific Registry of Transplant Recipients (SRTR), which was released on Oct. 9.
High doses of acetaminophen can damage the liver. Researchers have found a new mechanism by which an acetaminophen breakdown product can impair liver proteins. The compound activates a protein modification pathway called glutathionylation. The finding explains how the compound can damage even proteins it doesn't bind to directly.
Mayo Clinic的研究显示，相比那些在自行减肥之后接受肝脏移植的患者，同时接受挽救生命的肝脏移植以及减肥手术的肥胖患者在长期保持体重以及代谢并发症上都表现的更好。该研究成果发表在《肝病学》（Hepatology）杂志上。
Pacientes obesos submetidos simultaneamente a uma cirurgia para perda de peso e ao transplante do fígado tiveram maior sucesso para manter a redução de peso no longo prazo e tiveram menos complicações metabólicas do que pacientes que perderam peso por conta própria antes de passar por um transplante do fígado, segundo pesquisa da Mayo Clinic. As descobertas foram publicadas no periódico Hepatology.
Obese patients who underwent a life-saving liver transplant and weight-loss surgery at the same time were better able to keep the weight off long term and had fewer metabolic complications than those who lost weight on their own before undergoing a liver transplant, Mayo Clinic research shows. The findings were recently published in Hepatology.
Fixing or replacing faulty genes has emerged as a key to unlocking cures for numerous devastating diseases. But if the new, engineered genes can’t find their way into the patient’s genomic sequence, they won’t help.
Children are at a considerable disadvantage when competing with adults for livers from deceased organ donors in the U.S. allocation system for liver transplants, a University of Pittsburgh Graduate School of Public Health-led analysis reveals today in JAMA Pediatrics.
Three recent studies dig into how nonalcoholic fatty liver disease affects mitochondria in the liver: how mitochondrial energy production stutters and fails as the disease progresses, and how this affects the organ’s use of nutrients to produce energy.
Researchers at University of California San Diego School of Medicine have discovered using mice and human clinical specimens, that caspase-2, a protein-cleaving enzyme, is a critical driver of non-alcoholic steatohepatitis (NASH), a chronic and aggressive liver condition. By identifying caspase-2’s critical role, they believe an inhibitor of this enzyme could provide an effective way to stop the pathogenic progression that leads to NASH — and possibly even reverse early symptoms.
Obesity and its related ailments like type 2 diabetes and fatty liver disease pose a major global health burden, but researchers report in Nature Communications that blocking an RNA-silencing protein in the livers of mice keeps the animals from getting fat and diabetic conditions.
Doctors do the darndest things. Take the one who walked right up to Dan Thomas, MD, at a lecture, got into the ready position, and proceeded to perform several squats as Thomas watched, puzzled.
Paul Brindley, PhD, at the GW School of Medicine and Health Sciences, has received more than $1.7 million from the National Cancer Institute at the National Institutes of Health to investigate the cellular and molecular links between liver fluke infection and bile duct cancer.
Researchers from the George Washington University published an article in Trends in Parasitology outlining their lessons learned while creating vaccine candidates for hookworm and schistosomiasis.
Increasing the amount of protein in the diet may reduce the liver’s fat content and lower the risk of diabetes in people with nonalcoholic fatty liver disease (NAFLD). The study is published ahead of print in the American Journal of Physiology—Endocrinology and Metabolism.
The American College of Radiology Liver Imaging Reporting and Data System (LI-RADS®) steering committee developed and approved a new version of CT/MRI LI-RADS (v2018), thus reaching a critical milestone of integration into the American Association for the Study of Liver Diseases (AASLD) 2018 hepatocellular carcinoma (HCC) clinical practice guidance.
Mice fed a fattening diet develop new liver circadian rhythms that impact the way fat is accumulated and simultaneously burned. The team found that as liver fat production increases, surprisingly, so does the body’s ability to burn fat. These opposing physiological processes reach their peak activity each day around 5 p.m., illustrating an unexpected connection between overeating, circadian rhythms, and fat accumulation in the liver.
The Loyola Center for Cancer Care & Research at Palos Health South Campus in Orland Park is the first center in Illinois – and only the fifth in the country – to offer a groundbreaking MRI-guided radiation therapy that targets tumors with millimeter precision.
Nonalcoholic fatty liver disease, or NAFLD, which affects roughly 100 million Americans, costs the United States healthcare system $32 billion annually, according to a first-of-its-kind study by Intermountain Healthcare researchers on the economic impact of the disease.
A new review published online on Monday, July 2, in Nature Medicine highlights cutting-edge research associated with non-alcoholic fatty liver disease (NAFLD) and its more advanced, and worrisome, form, non-alcoholic steatohepatitis (NASH).
BIDMC researchers led a retrospective analysis of four randomized clinical trials focused on the effects of DAA therapies in patients with HCV-associated liver failure and developed a new means of predicting improvement in liver function in response to DAA treatment.
For patients who live in rural areas, driving to see a specialist in a large city or at a university hospital can be challenging, if not impossible. But providing their physicians with virtual access to specialists can be lifesaving to liver disease patients.
Normal cells located next to kidney cancer cells provide new clues about prognosis and survival rates, researchers from UT Southwestern Medical Center’s Kidney Cancer Program report.
The number of insurance denials for life-saving hepatitis C drugs among patients with both private and public insurers remains high across the United States. Private insurers had the highest denial rates, with 52.4 percent of patients denied coverage, while Medicaid denied 34.5 percent of patients and Medicare denied 14.7 percent.
Researchers at University of California San Diego School of Medicine discovered that they can block inflammation in mice with a naturally occurring antibody that binds oxidized phospholipids (OxPL), molecules on cell surfaces that get modified by inflammation. Even while on a high-fat diet, the antibody protected the mice from arterial plaque formation, hardening of the arteries and liver disease, and prolonged their lives.
On Tuesday, June 5, Virginia Governor Ralph Northam visited the Focused Ultrasound Foundation and met with the Foundation’s staff as well as with members of the Foundation’s Board and Council, and donors. Virginia House of Delegates Leader David Toscano, representatives from the University of Virginia, and members of the local media were also in attendance.
Un grupo de investigadores de Mayo Clinic y Exact Sciences Corporation terminaron un estudio de fase II para comparar un conjunto de marcadores del ADN frente a la alfafetoproteína, como método para analizar el cáncer de hígado.
Um grupo de pesquisadores da Mayo Clinic e da Exact Sciences Corporation concluiu um estudo de fase II que realizou uma comparação entre um conjunto de marcadores de DNA e a alfafetoproteína como método para testar o câncer de fígado. Os pesquisadores apresentaram suas conclusões na conferência Digestive Disease Week (Semana das doenças digestivas) de 2018, em Washington, D.C.
来自Mayo Clinic和Exact Sciences Corporation的一组研究人员已经完成了一项II期研究，将一组DNA标记物作为一种检测肝癌（liver cancer）的方法与甲胎蛋白进行了比较。 研究人员在华盛顿特区举行的2018年消化疾病周（Digestive Disease Week）会议上介绍了他们的发现。
Since 1968, UAB Medicine has performed more than 14,000 life-saving organ transplants.
A new review by Michigan Medicine finds that women drinkers are disproportionately affected in alcohol-related cirrhosis cases. Why — and what's next.
By studying a rare liver disease called Alagille syndrome, scientists discovered the mechanism behind a form of tissue regeneration that may someday reduce the need for organ transplants. Researchers report in Nature that when disease or injury causes a shortage in one type of liver cell, the organ can instruct another type of liver cell to change identities to provide replacement supplies. The findings one day may lead to a viable treatment for human disease.
Mayo Clinic的研究显示，移植的肝脏改变了受体的血液细胞的状况，减少了器官排斥反应的可能性。 这些发现发表在Kidney International杂志上。
A new study by Sanford Burnham Prebys Medical Discovery Institute (SBP) researchers helps explain the connection between a tumor suppressor called protein kinase C zeta (PKC zeta) and metastatic colorectal cancer.
Increased awareness of the importance of the microbes that live in our gut has spurred a great deal of research on the microbiome and fueled a booming probiotics industry. A new study suggests probiotics can improve not only the health of our gut but liver health, as well.
A treatment gap remains for many conditions involving damage to the liver, the body’s main organ for removing toxins, among other functions. The Experimental Biology 2018 meeting (EB 2018) will feature important research announcements related to the causes of liver degradation and possible treatments.
For decades, transplant experts have observed that liver transplant recipients often need less anti-rejection medication, known as immunosuppressive drugs, than recipients of other solid organs. Similarly, when patients receive a multiple-organ transplant that includes the liver along with any other organ, they need less immunosuppressive medication and have less incidence of rejection even if they are highly sensitive to cellular bad actors, known as antigens, from the donor organs.
In preclinical studies using cell models that mimicked liver cells of patients with the rare disease Friedreich’s ataxia (FA), a widely used cholesterol-lowering drug increased a precursor of HDL (high-density lipoprotein), the “good cholesterol.” Decreased HDL and ApoA-l levels in the general population are associated with an increased risk of death from cardiomyopathy and heart failure. Researchers found the FA patients had serum ApoA-I levels lower than healthy control subjects.
Dr. Janardan K. Reddy, Professor Emeritus of Pathology at Northwestern University, is this year’s recipient of the American Society for Investigative Pathology (ASIP) Gold-Headed Cane Award.
Patients with cholangiocarcinoma, a form of liver cancer, were never candidates for liver transplant in the past. However, a new study looking at treating these patients with chemotherapy treatment first.
Hackensack Meridian Health Bayshore Medical Center is proud to announce that it has expanded services to offer transcatheter arterial chemoembolization, also known as transarterial chemoembolization, or TACE. TACE is an image-guided, non-surgical procedure used to treat malignant lesions in the liver. Performed in the Interventional Radiology department, an X-ray guided catheter delivers chemotherapy medication and embolization materials into the blood vessels in the liver that lead to the tumor.
A new study found that weight gain, obesity can increase the risk of a serious liver disease in children as young as 8.
Gary Shapiro, President and CEO of the Consumer Technology Association (CTA)™, which annually produces CES®, the largest technology and innovation show in the world, will deliver a keynote address at the 6th International Symposium on Focused Ultrasound on Tuesday, October 23, 2018, in Reston, Virginia.
This week, a 40-year-old patient was treated at UNC’s Clinical and Translational Research Center (CTRC) with SB-913, an investigational genome editing therapy for individuals with mucopolysaccharidosis type II (MPS II), a rare lysosomal storage disorder also known as Hunter syndrome.
In people with type 2 diabetes, nonalcoholic fatty liver disease (NAFLD) is common and can progress to a severe liver disease known as nonalcoholic steatohepatitis (NASH). Now a study has found that empagliflozin, a newer treatment for type 2 diabetes, reduces liver fat in patients with NAFLD and diabetes. Results of the randomized controlled study, called the E-LIFT Trial, will be presented Monday at the Endocrine Society’s 100th annual meeting in Chicago, Ill., during a late-breaking abstracts session.
Using e-cigarettes may lead to an accumulation of fat in the liver, a study of mice exposed to the devices suggests. The research will be presented Sunday, March 18, at ENDO 2018, the Endocrine Society’s 100th annual meeting in Chicago, Ill.
Through a randomized, double-blind, placebo-controlled phase II clinical trial, researchers at University of California San Diego School of Medicine report that small doses of NGM282, a non-tumorigenic variant of an endocrine gastrointestinal hormone, can significantly and rapidly decrease liver fat content in patients with non-alcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH). The findings, they say, represent an important proof-of-concept for the compound as there are currently no Food and Drug Administration-approved treatments for NAFLD and NASH.
Each year in the U.S., more than 40,000 patients need a liver transplant because of complications associated with cirrhosis and liver failure. Alcohol-related liver disease (ALD) alone accounts for nearly 30 percent of all liver transplants, yet up to 50 percent of patients with alcoholism return to drinking within five years of undergoing a liver transplant. Many transplant centers now require a minimum of six months of alcohol abstinence prior to placing candidates on the United Organ Network Sharing waiting list. This pilot study examined the use of text messaging as an alcohol relapse-prevention intervention for patients with ALD scheduled to undergo a liver transplant.
A heating and freezing process known as dual thermal ablation can kill pancreatic cancer cells, according to new research from Binghamton University, State University at New York.
RSS
Medicine keyboard_arrow_right
Sciencekeyboard_arrow_right
Life keyboard_arrow_right
Business keyboard_arrow_right
Journal News keyboard_arrow_right
By Location keyboard_arrow_right
Meetings, Grants, and Events keyboard_arrow_right