Feature Channels: Diabetes

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A multi-disciplinary team of Penn researchers, including diabetes, weight loss and bariatric surgery experts, are conducting a study funded by the National Institutes of Health (NIH) to determine if bariatric surgery, either gastric bypass or adjustable gastric banding surgery, is more effective than lifestyle modification to reduce weight and ultimately treat Type 2 diabetes.

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Bariatric surgery is a procedure designed to help patients lose weight, but what may be even more important is that it can also help resolve diabetes for patients with this disease.

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Cigarette smoking is a well-known risk factor for type 2 diabetes, but new research from Johns Hopkins suggests that quitting the habit may actually raise diabetes risk in the short term.

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In an annual supplement to the journal Diabetes Care, published Dec. 29 by the American Diabetes Association, the A1C test is given a prominent role in the 2010 guidelines for diabetes screening, diagnosis and prevention.

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Researchers at the University of North Carolina at Chapel Hill School of Medicine say a recent discovery suggests that inherited genetic variations exist between whites and blacks living in the U.S., leading to less efficient metabolism of glucose and predisposition to diabetes in blacks.

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Joslin scientists discover that high blood glucose levels damage a key enzyme that guards against oxidative stress in beta cells.

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Researchers led by specialists at the Johns Hopkins Wilmer Eye Institute have found that injecting a corticosteroid, triamcinolone, directly into the eye may slow the progression of proliferative diabetic retinopathy, a complication of diabetes that frequently leads to blindness.

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South Dakota State University researchers used the Native American spiritual concept of the Medicine Wheel to help bring positive changes for American Indian diabetics.

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New findings from the Monell Center and Kyushu University report that endocannabinoids act directly on tongue taste receptors to specifically enhance sweet taste. The findings may open doors to the development of new therapeutic compounds to combat obesity and diabetes.

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Nine weeks of education about the glycemic index in foods is enough to encourage adults with type 2 diabetes to adopt better dietary habits that result in improvements to their health, recent research suggests.

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Individuals who drink more coffee (regular or decaffeinated) or tea appear to have a lower risk of developing type 2 diabetes, according to an analysis of previous studies reported in the December 14/28 issue of Archives of Internal Medicine.

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Preparing a healthy meal loaded with fresh vegetables seems like an easy thing to do. But for some people living with diabetes, accessing nutritious food can be difficult --- and may have a detrimental effect on their health and well-being, according to a new Canadian study led by Ryerson University.

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In 1999, researchers analyzed 12 years of Los Angeles County death certificates and found that heart attack deaths rise in the balmy Los Angeles winter and peak on Christmas and New Year’s Day. Cardiologist Robert Kloner discusses his research.

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The study is designed to determine if diabetic patients exposed to insulin glargine have a higher incidence of cancer than diabetic patients exposed to other insulins or to other glucose-lowering medications.

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Pediatric researchers have found that a gene already implicated in the development of type 2 diabetes in adults also raises the risk of being overweight during childhood. The finding sheds light on the genetic origins of diabetes and may present an avenue for developing drugs to counteract type 2 diabetes, currently increasing among youths.

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New findings by UT Southwestern researchers suggest that a drug already used to treat autoimmune disorders might also help slow the destruction of insulin-producing cells in patients recently diagnosed with insulin-dependent (type 1) diabetes.

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Diabetes is one of the nation’s most prevalent chronic diseases, and Geisinger has created a “bundle” of best practice measures to improve the quality of diabetes care and outcomes.

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New Saint Louis University research finds better prognosis for patients with type 2 diabetes and coronary heart disease.

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Sinai Hospital of Baltimore takes an innovative approach to help people with diabetes mange their disease by opening the Diabetes Resource Center at Sinai. Participants in programs at this nationally recognized center learn how to achieve successful medical and lifestyle goals.

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Women who have gestational glucose intolerance (a condition less severe than gestational diabetes) exhibit multiple cardiovascular risk factors as early as three months after birth, according to a new study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).

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According to a new study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM), youth with type 1 diabetes have now been found to have abnormal insulin resistance. Having abnormal insulin resistance appears to negatively affect heart, blood vessel and exercise function in this population.

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In the next 25 years, the number of Americans living with diabetes will double and spending on diabetes will triple, rising from $113 billion to $336 billion. This will add to the existing strains on an overburdened health care system.

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Diabetics face many health challenges, and among them is the risk of developing foot ulcers.

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A first-of-its-kind consensus statement on diabetes surgery is published online today in the Annals of Surgery. The report illustrates the findings of the first international consensus conference -- Diabetes Surgery Summit (DSS) -- where an international group of more than 50 scientific and medical experts agreed on a set of evidence-based guidelines and definitions that are meant to guide the use and study of gastrointestinal surgery to treat type 2 diabetes.

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Over time, patients with type 2 diabetes lose insulin-producing cells, a difficulty that aggravates their disease. Researchers at Joslin Diabetes Center now have identified a mechanism that triggers the problem, giving a chance to find targets for drugs to protect these crucial cells.

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Researchers from the University of California, San Diego recently offered the sharpest-yet picture of how core biochemical pathways in skeletal muscle cells and fat cells are altered in people who suffer from insulin resistance—a primary defect in type 2 diabetes and obesity. Taking a systems biology approach, the bioengineers and medical researchers also determined how a common class of drugs for treating insulin resistance—TZDs—alter these same core pathways. This led the team to uncover previously unknown effects of TZDs and insights that could lead to improved drug therapies for insulin resistance.

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One out of five Type 2 diabetics is morbidly obese -- approximately 100 pounds overweight -- a Loyola University Health System study has found.

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A new survey from the American Diabetes Association asked participants to rank which disease: diabetes, breast cancer or AIDS, was responsible for the largest number of deaths annually.

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Columbia University Medical Center will present the 2009 Naomi Berrie Awards to a nationally recognized diabetes researcher, and a promising young investigator, for their outstanding achievements in diabetes research.

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Postmenopausal women who have higher testosterone levels may be at greater risk of heart disease, insulin resistance and the metabolic syndrome compared to women with lower testosterone levels, according to a new study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM). This new information is an important step, say researchers, in understanding the role that hormones play in women’s health.

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Researchers at the University of Maryland are using the fruit fly, Drosophila melanogaster, as a model system to unravel what genes and gene pathways are involved in the metabolic changes that lead to insulin resistance and full-blown diabetes in humans.

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Sustaining modest weight loss for 10 years, or taking an anti-diabetic drug over that time, can prevent or lower the incidence of type 2 diabetes in people at high risk for developing the disease, according to the Diabetes Prevention Program Outcomes Study (DPPOS), a long-term follow-up to a landmark 2001 diabetes prevention study.

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Joslin Diabetes Center scientists discover new route by which high blood glucose levels damage eyes.

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Cellular phones have taken on many new roles in recent years. Now researchers at Saint Louis University and Old Dominion University say smartphones can be used to help elderly diabetics manage their health and learn more about their condition.

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Intensive lifestyle changes aimed at modest weight loss reduced the rate of developing type 2 diabetes by 34 percent over 10 years in people at high risk for the disease.

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Researchers from the University of Manitoba report that whole yellow pea flour can be used as an ingredient to produce low-glycemic foods that may help those with diabetes, according to a new study from the Journal of Food Science, published by the Institute of Food Technologists.

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Mayo Clinic clinicians and designers, along with colleagues from other institutions, have developed and tested a tool to involve patients more in their diabetes treatment and medication choices. The tool, a set of decision aid cards, could help patients make decisions involving their disease and perhaps lead to better outcomes.

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A study, published online in the journal Current Medical Research and Opinion, showed that a greater percentage of patients with type 2 diabetes treated with the fixed-dose combination ACTOplus met (pioglitazone HCl and metformin HCl) as initial therapy reached the study goal of hemoglobin A1c (HbA1c) of ≤7 percent compared to either component alone. Safety and tolerability of ACTOplus met therapy were evaluated by rate of drug discontinuation and treatment-emergent adverse events.

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A naturally produced molecule called resveratrol, found in the skin of red grapes, has been shown to lower insulin levels in mice when injected directly into the brain, even when the animals ate a high-fat diet.

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Surgeons from St. Michael’s Hospital, Toronto, and the University of Toronto have observed that sepsis and sepsis-related mortality are linked to a naturally occurring hormone found in visceral adipose tissue. The implications of the study results may assist in developing methods of both predicting and decreasing sepsis and sepsis-related complications.

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Individuals living in neighborhoods conducive to physical activity and providing access to healthy foods may have a lower risk of developing type 2 diabetes in a five-year period, according to a report in the October 12 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.

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MedTagger.com – a new online community that combines social networking and search technology to provide trusted, relevant information to the global diabetes community – is hosting an exclusive webcast presentation on Wednesday, October 14 at 12:00 noon ET (9:00 am PT).

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St. Jude Children’s Research Hospital investigators have discovered how destructive immune cells gain access to insulin-producing cells and help cause diabetes. The finding points to possible new strategies to halt or prevent type I diabetes.

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A new study accepted for publication in Endocrinology, a journal of The Endocrine Society, shows that the brain plays a key role in mediating resveratrol’s anti-diabetic actions, potentially paving the way for future orally-delivered diabetes medications that target the brain.

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Fat and muscle mass, as potentially determined by a person’s ethnic background, may contribute to diabetes risk, according to a new study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM).

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Mathematicians Have Developed Powerful New Tools for Winnowing Out the Genes Associated with Diabetes.

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When Sonia Sotomayor was named Supreme Court nominee, the type 1 diabetes community seized the news as proof that diabetes is no longer a life-limiting condition.

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Nutrition scientists at UMass Amherst have identified the molecular pathway by which foods rich in soy bioactive compounds, or isoflavones, to lower diabetes and heart disease risk. Soy foods can lower cholesterol, decrease blood glucose levels and improve glucose tolerance in people with diabetes.

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Mayo Clinic has repeatedly been ranked #1 in endocrinology by annual U.S. News and Report medical surveys. An excellent story is our work toward finding a means of regenerating insulin-producing tissue through iPSC or induced pluripotent stem cells.

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Weight management underlies a successful new approach to type 2 diabetes care at Joslin Diabetes Center.