Pediatric researchers who tested newborn animals with a human drug used in adults with diabetes report that this drug, when given very early in life, prevents diabetes from developing in adult animals.
DARA's DB959 Phase 1b clinical study for the treatment of type 2 diabetes - results demonstrated that DB959 is safe and well-tolerated and show support for pharmacological activity.
Sleep, hormones, weight, exercise and genetics are all related to diabetes, affecting one in three Americans. November is Diabetes Awareness Month. Experts available for radio, TV and print.
A recent study has found that a childhood behavioral intervention to lower dietary intake of total fat and saturated fat and increase consumption of foods that are good sources of dietary fiber resulted in significantly lower fasting plasma glucose levels and lower systolic blood pressure when study participants were re-evaluated in young adulthood. The study was accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology and Metabolism (JCEM).
Learn what's new in diabetes prevention and research.
In a paper published today in Diabetologia, a team at Joslin Diabetes Center, headed by Mary R. Loeken, PhD, has identified the enzyme AMP kinase (AMPK) as key to the molecular mechanism that significantly increases the risk of neural tube defects such as spina bifida and some heart defects among babies born to women with diabetes.
Researchers at the University of Pennsylvania School of Nursing encourage kids at risk for diabetes to get footloose.
Calories, not sugar, contribute to diabetes, and there is hope for people with Type 2 diabetes. Read what other diabetes myths need to be dispelled.
Diabetics who suffer from hard-to-heal open wounds may soon have help in the form of a cottony glass material developed at Missouri University of Science and Technology.
More than Half of All Americans Will Have Diabetes by 2020 – Ranks Could Swell to 135 million Half of all American adults are destined to develop diabetes or pre-diabetes by 2020 if they don't make dramatic lifestyle changes, according to a dire new prediction from the Centers for Disease Control and Prevention. If current trends continue, the ranks of American adults with excessive blood sugar levels would swell from 93.8 million this year (about 28 million diabetics and 66 million more with pre-diabetes) to 135 million in 2020 – and cost society $3.35 billion by decade’s end. In addition, diabetes is becoming one of the most common chronic diseases in children and adolescents. According to the American Diabetes Association, one in every four children is currently diagnosed with diabetes. Dr. Joel Zonszein believes that unless people improve their diet and exercise more regularly, diabetes could become an epidemic of tsunami-like proportions.
Patients with diabetes face daily challenges in managing their blood glucose levels, and it has been postulated that patients could benefit from a system providing continuous real-time glucose readings. Today, The Endocrine Society released a clinical practice guideline (CPG) providing recommendations on settings where patients are most likely to benefit from continuous glucose monitoring (CGM).
Carb counting and insulin pumps help diabetic kids sample Halloween’s sweet indulgences.
Cardium Therapeutics (CXM) has received FDA 510(k) clearance to market and sell Excellagen™ professional-use advanced wound care product for diabetic foot ulcers, pressure ulcers and other dermal wounds.
Ten years of meticulous mouse breeding, screening, and record-keeping have finally paid off for Alan Attie and his lab members.
Excessive food AGEs, through both maternal blood transmission and baby formula, could together significantly increase children’s risk for diseases such as diabetes from a very young age. A second study of AGEs in adults found that cutting back on processed, grilled, and fried foods may improve insulin resistance in people with diabetes.
Researchers at Washington University School of Medicine in St. Louis have restored normal blood sugar metabolism in diabetic mice using a compound the body makes naturally. The finding suggests that it may one day be possible for people to take the compound much like a daily vitamin as a way to treat or even prevent type 2 diabetes.
The largest-ever analysis of genetic data related to type 1 diabetes has uncovered new genes associated with the common metabolic disease, which affects 200 million people. The findings shed light on gene networks in the disorder.
In a paper published in the September 30 issue of the journal Cell, researchers at the University of California San Diego School of Medicine and colleagues offer an explanation, and a framework that could lead to dietary supplements designed to treat obesity at the molecular level.
Researchers at Washington University School of Medicine in St. Louis have identified the first genetic variant associated with severity of coronary artery disease in patients with type 2 diabetes. Though this variant is not likely the cause of more severe coronary disease, the researchers say, it implicates a gene that could be. Such a gene has promise as a future target for treating coronary artery disease in diabetic patients.
Intensive control of blood sugar levels beyond standard targets provides no additional protection against cognitive decline in older people with diabetes than standard treatment, according to a national study coordinated by researchers at Wake Forest Baptist Medical Center.
The American Association of Clinical Endocrinologists (AACE) and Takeda Pharmaceuticals North America Inc. (Takeda) have partnered to launch the Diabetes Navigator (http://DiabetesNavigator.AACE.com), a compendium capturing a selection of useful and reliable type 2 diabetes information available online for patients and caregivers.
Researchers at the Salk Institute have discovered how a hormone turns on a series of molecular switches inside the pancreas that increases production of insulin.
Visiting a primary care clinician every two weeks was associated with greater control of blood glucose, blood pressure and cholesterol levels among patients with diabetes, according to a report in the September 26 issue of Archives of Internal Medicine, one of the JAMA/Archives journals.
In an early preclinical study in mice, UCLA researchers demonstrated that an over-the-counter dietary supplement may help inhibit development of insulin resistance and glucose intolerance, conditions that are involved in the development of Type 2 diabetes and metabolic syndrome.
UAB’s Diabetes Bridge Clinic helps patients keep symptoms under control during the vulnerable period as they go from hospital to home.
Researchers at the Joslin Diabetes Center have identified for the first time two molecular pathways that are critical to activating a type of “good” fat found in the body, called brown fat, which actually burns energy rather than storing it, which the more common white fat does. This discovery could play an important role in the fight against obesity and diabetes.
Obese teenagers who don’t get the proper amount of sleep may have disruptions in insulin secretion and blood sugar levels, say researchers. Optimal sleep duration may lower these teens' risk of developing type 2 diabetes.
People with diabetes appear to be at a significantly increased risk of developing dementia, according to a study published in the September 20, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.
Two newer drugs used to treat Type 2 diabetes could be linked to a significantly increased risk of developing pancreatitis and pancreatic cancer, and one could also be linked to an increased risk of thyroid cancer.
A survey of federally funded diabetes prevention and control programs in 57 U.S. states and territories has highlighted the need for better diabetes treatment guidelines that are specifically adapted to different populations. Such guidelines do not currently exist.
Researchers from Dana-Farber and the Scripps Research Institute in Jupiter, Fla., have created prototype drugs that have powerful anti-diabetic effects and are free of dangerous side effects plaguing some current diabetes medications.
A somewhat mysterious soft tissue found in the fetus during early development in the womb plays a pivotal role in the formation of mature beta cells the sole source of the body’s insulin. This discovery, made by scientists at University of California, San Francisco (UCSF) and Texas A&M University, may lead to new ways of addressing Type 1 and Type 2 diabetes.
Researchers at the Joslin Diabetes Center have shown that an enzyme found in the mitochondria of cells is decreased in the skeletal muscle of those with type 2 diabetes, a finding that could lead to the development of drugs to boost the activity of this enzyme in an effort to fight the disease.
Until more studies are available, physicians should continue to use BMI to identify high risk children, U-M researchers say.
Many Americans suffer from diabetes and hypertension and, according to a study by researchers at the University of Michigan Kellogg Eye Center, these individuals may have an increased risk of developing open-angle glaucoma (OAG).
Researchers at the Johns Hopkins University School of Medicine have found a protein normally involved in blood pressure regulation in a surprising place: tucked within the little “power plants” of cells, the mitochondria. The quantity of this protein appears to decrease with age, but treating older mice with the blood pressure medication losartan can increase protein numbers to youthful levels, decreasing both blood pressure and cellular energy usage. The researchers say these findings, published online during the week of August 15, 2011, in the Proceedings of the National Academy of Sciences, may lead to new treatments for mitochondrial–specific, age-related diseases, such as diabetes, hearing loss, frailty and Parkinson’s disease.
Researchers at Joslin Diabetes Center and Children’s Hospital Boston have shown that a type of “good” fat known as brown fat occurs in varying amounts in children – increasing until puberty and then declining -- and is most active in leaner children.
Type 2 diabetes patients, who face higher risk of cardiovascular disease, often take a combination of medications designed to lower their LDL or “bad” cholesterol and triglyceride levels while raising their HDL or “good” cholesterol because doctors long have thought that taken together, the drugs offer protection from heart attacks and improve survival.
Joslin scientists have uncovered a new way in which obesity wreaks its havoc, by altering the production of proteins that affect how other proteins are spliced together. Their finding may point toward novel targets for diabetes drugs.
A new study suggests smoking, high blood pressure, diabetes and being overweight in middle age may cause brain shrinkage and lead to cognitive problems up to a decade later. The study is published in the August 2, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology.
The University of Maryland School of Medicine has found that mobile phone software is effective for the self-management of diabetes. The study published in September in Diabetes Care is one of the first to examine the new field of mobile health.
Patients with diabetes who also suffer from depression are more likely to develop a serious complication known as diabetic retinopathy, a disease that damages the eye’s retina, a five-year study finds.
A recent study accepted for publication in The Endocrine Society’s Journal of Clinical Endocrinology & Metabolism (JCEM) found that the greater an individual’s total muscle mass, the lower the person’s risk of having insulin resistance, the major precursor of type 2 diabetes.
Menopause has little to no impact on whether women become more susceptible to diabetes, according to a one-of-a-kind study that provides good news for older women.
Summer time awareness story that covers foot care and diabetes.
Though rats, fish oil and beetroot juice read like ingredients in a witch's brew, to a Kansas State University research team, information from this combination could lead to health breakthroughs for aging populations and people suffering from heart failure and diabetes.
Researchers at Mount Sinai School of Medicine have identified how a gene for a protein that can cause Type 2 diabetes, also possibly kills nerve cells in the brain, thereby contributing to Alzheimer’s disease.
Surgeons at NewYork-Presbyterian Hospital/Columbia University Medical Center are innovating new ways to treat diabetes using techniques from weight-loss surgery, including experimental procedures to improve blood glucose levels and address a major complication of the disease.
Dental visits represent a chance to intervene in the diabetes epidemic by identifying individuals with diabetes or pre-diabetes who are unaware of their condition, according to a study in the July 2011 issue of the Journal of Dental Research.
DARA BioSciences' diabetes medication DB959 achieves positive results in first clinical trial; drug is well-tolerated with possibility for once-daily oral dosing; results presented at ADA.
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