CRISPR-Cas13: A New Frontier in RNA-Editing with Revolutionary Therapeutic Potential
Chinese Academy of SciencesA new review highlights the potential of CRISPR–Cas13 for RNA-editing therapies. Discussing the advantages of the effector protein Cas13 over Cas9, they report that CRISPR–Cas13 facilitates RNA knockdown, RNA silencing, RNA splicing, RNA-base editing, and translation regulation. CRISPR–Cas13 has diverse applications like virus detection, antivirus vaccines, and personalized therapies. Additionally, they also discuss the role of AI in enabling the realization of the full potential of RNA-editing technologies.