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Researchers Resolve Longstanding Issue of Components Needed to Regenerate Muscle

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Findings clear path to devise new treatments for muscular injuries and dystrophies

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Coriell Institute Licenses PluriTest, a Novel Stem Cell Technology

The Coriell Institute for Medical Research today announces the in-licensing of PluriTest, a cost-effective, accurate, animal-free bioinformatics assay for determining the pluripotency of human induced pluripotent stem cells (hiPSC).

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CRISPR Used to Repair Blindness-Causing Genetic Defect in Patient-Derived Stem Cells

Scientists have used a new gene-editing technology called CRISPR, to repair a genetic mutation responsible for retinitis pigmentosa (RP), an inherited condition that causes the retina to degrade and leads to blindness in at least 1.5 million cases worldwide.

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Signals That Make Early Stem Cells Identified

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Where and when do stem cells first appear during development? Researchers investigated this question by examining how cells organize as the hair follicle first appears in mouse embryos. They uncovered signaling pathways that may provide insights into some skin cancers.

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Insulin-Producing Pancreatic Cells Created from Human Skin Cells

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Scientists at the Gladstone Institutes and the University of California, San Francisco (UCSF) have successfully converted human skin cells into fully-functional pancreatic cells. The new cells produced insulin in response to changes in glucose levels, and, when transplanted into mice, the cells protected the animals from developing diabetes in a mouse model of the disease.

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Genetic Traffic Signal Orchestrates Early Embryonic Development

New research by UC San Francisco stem cell biologists has revealed that a DNA-binding protein called Foxd3 acts like a genetic traffic signal, holding that ball of undifferentiated cells in a state of readiness for its great transformation in the third week of development.

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Mayo Clinic Researchers Reduce Stem Cell Dysfunction and Metabolic Disease in Aged Mice

Mayo Clinic researchers have taken what they hope will be the first step toward preventing and reversing age-related stem cell dysfunction and metabolic disease, including diabetes. The researchers discovered methods for reducing these conditions in naturally aged mice.

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The Leonard C. Goodman Institute for Investigative Reporting Is Now Accepting Submissions

The deadline for this round of proposals is January 15, 2016. Candidates will be notified of decisions by the end of February 2016. The Institute pays a competitive rate--and covers expenses--for investigative reporting that advances social and economic justice. All stories are published in In These Times magazine and on InTheseTimes.com.

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First Serotonin Neurons Made From Human Stem Cells

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Su-Chun Zhang, a pioneer in developing neurons from stem cells at the University of Wisconsin-Madison, has created a specialized nerve cell that makes serotonin, a signaling chemical with a broad role in the brain.

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Top Stories 11 Dec 2015; New Forensic Science Breakthroughs, Breast Cancer Treatment Difference by Age, Racial Disparities in Dialysis, and More...

Click to view today's top stories.

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‘Ghost Fibers’ Left Behind by Injured Muscle Cells Guide Stem Cells Into Position for Regeneration

Ghosts are not your typical cell biology research subjects but scientists at the Carnegie Institution for Science and the National Institute of Child Health and Human Development (NICHD) who developed a technique to observe muscle stem/progenitor cells migrating within injury sites in live mice, report that “ghost fibers,” remnants of the old extracellular matrix left by dying muscle fibers, guide the cells into position for healing to begin.

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Memory Loss Enables the Production of Stem Cells

In a study published in this week’s edition of NATURE, scientists from the Research Institutes of Molecular Biotechnology (IMBA) and Molecular Pathology (IMP) in Vienna and from the Harvard Medical School in Boston have identified a long-sought “roadblock factor” in stem cell engineering that prevents the conversion of adult cells into induced pluripotent stem cells. By suppressing this factor, the team discovered a way to

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Discovery of an Embryonic Switch for Cancer Stem Cell Generation

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An international team of scientists, headed by researchers at UC San Diego School of Medicine and UC San Diego Moores Cancer Center, report that decreases in a specific group of proteins trigger changes in the cancer microenvironment that accelerate growth and development of therapy-resistant cancer stem cells (CSCs). The findings are published in the November 30 online issue of Proceedings of the National Academy of Sciences.

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UofL Scientists Identify a Critical Pathway to Improve Muscle Repair

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Researchers at the University of Louisville have identified the role of TNF receptor-associated factor 6 (TRAF6), an adaptor protein and E3 ubiquitin ligase, in ensuring the vitality of stem cells that regenerate muscle tissue.

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Researchers Grow Retinal Nerve Cells in the Lab

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Johns Hopkins researchers have developed a method to efficiently turn human stem cells into retinal ganglion cells, the type of nerve cells located within the retina that transmit visual signals from the eye to the brain.

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How a Genetic Locus Protects Adult Blood-Forming Stem Cells

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A particular location in DNA, called the Dlk1-Gtl2 locus, plays a critical role in protecting hematopoietic, or blood-forming, stem cells—a discovery revealing a critical role of metabolic control in adult stem cells, and providing insight for potentially diagnosing and treating cancer, according to researchers from the Stowers Institute for Medical Research.

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Stem Cell Treatment Mediates Harmful Immune Response Following Spinal Cord Injury in Pre-Clinical Trials

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Scientists at Case Western Reserve University School of Medicine have demonstrated in lab animals that a family of therapeutic stem cells lessen consequences of a damaging immune response and preserve function that would otherwise be lost. Their findings appear in the Nov. 19 Scientific Reports.

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Stem Cell–Derived Kidneys Connect to Blood Vessels When Transplanted Into Mice

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• After researchers transplanted kidney tissue generated from human induced pluripotent stem cells into a mouse kidney, the animal’s blood vessels readily connected to the human tissue.

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Amphibian Approach to Help Bones Heal Faster and Better

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Researchers from the University of Southampton are developing a new type of drug that may help bones heal faster and better.

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UNC Researchers Find New Way to Force Stem Cells to Become Bone Cells

Imagine you have a bone injury but you heal slowly. Instead of forming bone, you could form fat. UNC researchers may have found a way to tip the scale in favor of bone. They used cytochalasin D, a naturally occurring substance, to alter gene expression in stem cells to force them to become bone.