Feature Channels: Stem Cells

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Newswise: Modulation of cellular recycling by calcium ion dynamics across cellular compartments
Released: 12-Mar-2024 8:05 AM EDT
Modulation of cellular recycling by calcium ion dynamics across cellular compartments
Chinese Academy of Sciences

This study discovers that upon induction of different autophagy processes, mitochondria immediately import calcium and calcium concentrations at the ER membrane start to fluctuate. The major calcium import channel in the inner mitochondrial membrane, mitochondrial calcium uniporter (MCU), is required for mitophagy-inducer-initiated mitochondrial calcium uptake. Inhibiting MCU accelerates mitophagy. In neurons derived from a Parkinson’s patient, mitophagy-inducer-triggered mitochondrial calcium influx is faster, which may slow the ensuing mitophagy.

Newswise: Iron Restriction Keeps Blood Stem Cells Young
Released: 8-Mar-2024 11:05 AM EST
Iron Restriction Keeps Blood Stem Cells Young
Albert Einstein College of Medicine

As we age, our hematopoietic (blood-forming) stem cells (HSCs) become less able to produce new red and white blood cells and other vital blood components—contributing to chronic inflammation and accelerating the onset of blood cancers and degenerative diseases.

Newswise: IU researcher developing new pediatric leukemia therapies
Released: 8-Mar-2024 10:05 AM EST
IU researcher developing new pediatric leukemia therapies
Indiana University

Reuben Kapur, director of the Herman B Wells Center for Pediatric Research at the Indiana University School of Medicine, is working to discover new treatments that will improve patient care.

Newswise: Children’s Hospital Los Angeles Awarded $6 Million from CIRM to Advance CAR T-Cell Therapies in Children with Recurring Solid Tumors
Released: 29-Feb-2024 6:05 PM EST
Children’s Hospital Los Angeles Awarded $6 Million from CIRM to Advance CAR T-Cell Therapies in Children with Recurring Solid Tumors
Children's Hospital Los Angeles

Children’s Hospital Los Angeles has received a multi-year $6 million award from the California Institute for Regenerative Medicine (CIRM) to develop innovative stem cell approaches to treat children and adolescents with recurrent solid tumors. The Cancer and Blood Disease Institute (CBDI) is a recognized leader in pediatric cancer care and research.

Newswise: ‘Gene of Prejudice’ Demystifies Autism
Released: 28-Feb-2024 4:00 PM EST
‘Gene of Prejudice’ Demystifies Autism
University of California San Diego

Individuals with Williams syndrome have a gregarious “cocktail party” personality, while those with the opposite genetic alteration, in contrast, tend to have autistic traits and are prone to struggle socially. Research from UC San Diego sheds new light on the gene responsible.

Released: 26-Feb-2024 2:05 PM EST
UC Irvine advances stem cell research with $4 million CIRM grant for shared resources lab
University of California, Irvine

Irvine, Calif., Feb. 26, 2024 — The University of California, Irvine has received a five-year, $4 million grant from the California Institute for Regenerative Medicine to establish a shared resources lab in the Sue & Bill Gross Stem Cell Research Center. The facility will offer essential technologies and training for the development of novel in vitro stem cell-based modeling that will serve researchers across the campus and the state.

Released: 26-Feb-2024 12:00 PM EST
Recent progress in hair follicle stem cell markers and their regulatory roles
World Journal of Stem Cells

Hair follicle stem cells (HFSCs) in the bulge are a multipotent adult stem cell population. They can periodically give rise to new HFs and even regenerate the epidermis and sebaceous glands during wound healing. An increasing number of biom

Released: 26-Feb-2024 12:00 PM EST
Multiple pretreatments can effectively improve the functionality of mesenchymal stem cells
World Journal of Stem Cells

In this editorial, we offer our perspective on the groundbreaking study entitled “Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cells”, recently publis

Released: 26-Feb-2024 12:00 PM EST
Advances in the differentiation of pluripotent stem cells into vascular cells
World Journal of Stem Cells

Blood vessels constitute a closed pipe system distributed throughout the body, transporting blood from the heart to other organs and delivering metabolic waste products back to the lungs and kidneys. Changes in blood vessels are related to

Released: 26-Feb-2024 12:00 PM EST
VX-509 attenuates the stemness characteristics of colorectal cancer stem-like cells by regulating the epithelial-mesenchymal transition through Nodal/Smad2/3 signaling
World Journal of Stem Cells

BACKGROUNDColorectal cancer stem cells (CCSCs) are heterogeneous cells that can self-renew and undergo multidirectional differentiation in colorectal cancer (CRC) patients. CCSCs are generally accepted to be important sources of CRC and are

Released: 26-Feb-2024 12:00 PM EST
Crosstalk between Wnt and bone morphogenetic protein signaling during osteogenic differentiation
World Journal of Stem Cells

Mesenchymal stem cells (MSCs) originate from many sources, including the bone marrow and adipose tissue, and differentiate into various cell types, such as osteoblasts and adipocytes. Recent studies on MSCs have revealed that many transcrip

Released: 26-Feb-2024 12:00 PM EST
Silencing of Jumonji domain-containing 1C inhibits the osteogenic differentiation of bone marrow mesenchymal stem cells via nuclear factor-κB signaling
World Journal of Stem Cells

BACKGROUNDOsteoporosis is a common metabolic bone disorder induced by an imbalance between osteoclastic activity and osteogenic activity. During osteoporosis, bone mesenchymal stem cells (BMSCs) exhibit an increased ability to differentiate

Released: 26-Feb-2024 12:00 PM EST
Therapeutic utility of human umbilical cord-derived mesenchymal stem cells-based approaches in pulmonary diseases: Recent advancements and prospects
World Journal of Stem Cells

Pulmonary diseases across all ages threaten millions of people and have emerged as one of the major public health issues worldwide. For diverse disease conditions, the currently available approaches are focused on alleviating clinical sympt

Released: 26-Feb-2024 12:00 PM EST
Cellular preconditioning and mesenchymal stem cell ferroptosis
World Journal of Stem Cells

In this editorial, we comment on the article published in the recent issue of the World Journal of Stem Cells. They focus on stem cell preconditioning to prevent ferroptosis by modulating the cystathionine γ-lyase/hydrogen sulfide (H2S) pa

Released: 26-Feb-2024 12:00 PM EST
Human dental pulp stem/stromal cells in clinical practice
World Journal of Stem Cells

Dental pulp stem/stromal cells (DPSCs) are fibroblast-like, neural crest-derived, and multipotent cells that can differentiate into several lineages. They are relatively easy to isolate from healthy and inflamed pulps, with little ethical c

Released: 26-Feb-2024 12:00 PM EST
Human pluripotent stem cell-derived kidney organoids: Current progress and challenges
World Journal of Stem Cells

Human pluripotent stem cell (hPSC)-derived kidney organoids share similarities with the fetal kidney. However, the current hPSC-derived kidney organoids have some limitations, including the inability to perform nephrogenesis and lack of a c

Released: 26-Feb-2024 12:00 PM EST
High quality repair of osteochondral defects in rats using the extracellular matrix of antler stem cells
World Journal of Stem Cells

BACKGROUNDCartilage defects are some of the most common causes of arthritis. Cartilage lesions caused by inflammation, trauma or degenerative disease normally result in osteochondral defects. Previous studies have shown that decellularized

Released: 26-Feb-2024 12:00 PM EST
Extracellular vesicles derived from mesenchymal stem cells mediate extracellular matrix remodeling in osteoarthritis through the transport of microRNA-29a
World Journal of Stem Cells

BACKGROUNDKnee osteoarthritis (KOA) is a common orthopedic condition with an uncertain etiology, possibly involving genetics and biomechanics. Factors like changes in chondrocyte microenvironment, oxidative stress, inflammation, and immune

Released: 26-Feb-2024 12:00 PM EST
Effects of different concentrations of nicotinamide on hematopoietic stem cells cultured in vitro
World Journal of Stem Cells

BACKGROUNDIn vitro expansion to increase numbers of hematopoietic stem cells (HSCs) in cord blood could improve clinical efficacy of this vital resource. Nicotinamide (NAM) can promote HSC expansion ex vivo, but its effect on hematopoietic

Released: 26-Feb-2024 12:00 PM EST
Unlocking the versatile potential: Adipose-derived mesenchymal stem cells in ocular surface reconstruction and oculoplastics
World Journal of Stem Cells

This review comprehensively explores the versatile potential of mesenchymal stem cells (MSCs) with a specific focus on adipose-derived MSCs. Ophthalmic and oculoplastic surgery, encompassing diverse procedures for ocular and periocular enha

Newswise: Healing Diabetes Wounds with a New Superhero: Stem Cell Magic
Released: 20-Feb-2024 10:10 AM EST
Healing Diabetes Wounds with a New Superhero: Stem Cell Magic
Chinese Academy of Sciences

Researchers unveiled a novel therapy for diabetic wound healing. This research highlights the use of exosomal miR-4645-5p from hypoxic bone marrow mesenchymal stem cells (BMSCs) to significantly enhance wound healing by promoting keratinocyte autophagy.

   
Newswise: Drug used for cocaine addiction may pave way for new treatment of advanced colon cancer
Released: 13-Feb-2024 10:05 PM EST
Drug used for cocaine addiction may pave way for new treatment of advanced colon cancer
University of Ottawa

New research from the University of Ottawa proposes using vanoxerine as a safe method for potentially eliminating cancer stem cells in colorectal tumors.

Newswise: Nutrients direct intestinal stem cell function and affect ageing
Released: 12-Feb-2024 10:05 PM EST
Nutrients direct intestinal stem cell function and affect ageing
University of Helsinki

The capacity of intestinal stem cells to maintain cellular balance in the gut decreases upon ageing.

Released: 31-Jan-2024 10:05 AM EST
UGA stroke treatment headed to clinical trial
University of Georgia

A new therapeutic for stroke based on University of Georgia research will soon enter clinical trials.

Released: 30-Jan-2024 2:05 PM EST
Our winter of discontent: Get the latest news on the flu in the Influenza channel
Newswise

The latest research and expertise on the flue can be found in the Influenza channel on Newswise.

Newswise: Re-energizing mitochondria to treat Alzheimer’s disease
Released: 29-Jan-2024 4:05 PM EST
Re-energizing mitochondria to treat Alzheimer’s disease
Scripps Research Institute

Nerve cells in the brain demand an enormous amount of energy to survive and maintain their connections for communicating with other nerve cells.

Newswise: 3rd Space Launch of Cedars-Sinai Stem Cells Slated for Jan. 29
Released: 29-Jan-2024 11:05 AM EST
3rd Space Launch of Cedars-Sinai Stem Cells Slated for Jan. 29
Cedars-Sinai

Cedars-Sinai and Space Tango are planning their third launch of pilot-scale systems for the automated in-space production of stem cells to the International Space Station.

   
Released: 26-Jan-2024 12:00 PM EST
Effects of exosomes from mesenchymal stem cells on functional recovery of a patient with total radial nerve injury: A pilot study
World Journal of Stem Cells

BACKGROUNDPeripheral nerve injury can result in significant clinical complications that have uncertain prognoses. Currently, there is a lack of effective pharmacological interventions for nerve damage, despite the existence of several small

Released: 26-Jan-2024 12:00 PM EST
Use of priming strategies to advance the clinical application of mesenchymal stromal/stem cell-based therapy
World Journal of Stem Cells

Mesenchymal stromal/stem cells (MSCs) have garnered significant attention in the field of regenerative medicine due to their remarkable therapeutic potential. MSCs play a pivotal role in maintaining tissue homeostasis and possess diverse fu

Released: 26-Jan-2024 12:00 PM EST
Research progress and challenges in stem cell therapy for diabetic foot: Bibliometric analysis and perspectives
World Journal of Stem Cells

BACKGROUNDStem cell therapy has shown great potential for treating diabetic foot (DF). AIMTo conduct a bibliometric analysis of studies on the use of stem cell therapy for DF over the past two decades, with the aim of depicting the current

Released: 26-Jan-2024 12:00 PM EST
Application of mesenchymal stem cell therapy for premature ovarian insufficiency: Recent advances from mechanisms to therapeutics
World Journal of Stem Cells

The incidence of premature ovarian insufficiency (POI) is increasing worldwide, particularly among younger women, posing a significant challenge to fertility. In addition to menopausal symptoms, POI leads to several complications that profo

Released: 4-Jan-2024 2:00 PM EST
Starting a family with the help of science: The latest research in Fertility
Newswise

Find the latest research and features on fertility in the Fertility News Source on Newswise.

       
Released: 26-Dec-2023 12:00 PM EST
Mid-term outcomes of microfragmented adipose tissue plus arthroscopic surgery for knee osteoarthritis: A randomized, active-control, multicenter clinical trial
World Journal of Stem Cells

BACKGROUNDOsteoarthritis (OA) is the most prevalent form of degenerative whole-joint disease. Before the final option of knee replacement, arthroscopic surgery was the most widely used joint-preserving surgical treatment. Emerging regenerat

Released: 26-Dec-2023 12:00 PM EST
Human mesenchymal stem cells exhibit altered mitochondrial dynamics and poor survival in high glucose microenvironment
World Journal of Stem Cells

BACKGROUNDMesenchymal stem cells (MSCs) are a type of stem cells that possess relevant regenerative abilities and can be used to treat many chronic diseases. Diabetes mellitus (DM) is a frequently diagnosed chronic disease characterized by

Released: 26-Dec-2023 12:00 PM EST
ADSC-Exos outperform BMSC-Exos in alleviating hydrostatic pressure-induced injury to retinal ganglion cells by upregulating nerve growth factors
World Journal of Stem Cells

BACKGROUNDMesenchymal stem cells (MSCs) have protective effects on the cornea, lacrimal gland, retina, and photoreceptor cell damage, which may be mediated by exosomes (exos) released by MSCs. AIMTo investigate the ameliorating effect of e

Released: 13-Dec-2023 1:05 PM EST
‘Tis the season to get vaccinated: How to stay healthy through the holidays
Michigan Medicine - University of Michigan

With virus cases rising and the holidays nigh, three expert from University of Michigan Health give their top 12 tips for avoiding or reducing the impact of COVID-19, flu, RSV, pneumonia and whooping cough in adults and kids.

Newswise: Clinical trial finds cell therapy improves quality of life in advanced heart failure
Released: 12-Dec-2023 10:05 AM EST
Clinical trial finds cell therapy improves quality of life in advanced heart failure
Mayo Clinic

Stem cell-based therapy improved quality of life for patients with advanced heart failure, Mayo Clinic researchers and international collaborators discovered in a late-stage multinational clinical trial.

Newswise: UC Irvine researchers discover a mechanism that controls the identity of stem cells
Released: 7-Dec-2023 7:05 PM EST
UC Irvine researchers discover a mechanism that controls the identity of stem cells
University of California, Irvine

University of California, Irvine, researchers discovered a mechanism that controls the identity of stem cells. When this mechanism fails, embryonic stem cells revert back in time and become totipotent.

Newswise: Discovery fuels insights into early developmental disorders
Released: 5-Dec-2023 2:05 PM EST
Discovery fuels insights into early developmental disorders
UT Southwestern Medical Center

A new study led by UT Southwestern Medical Center molecular biologists presents a novel culture system to grow both embryonic and extraembryonic stem cells, potentially providing important insights into the genesis of congenital malformations and early developmental disorders.

Released: 26-Nov-2023 12:00 PM EST
Dissecting molecular mechanisms underlying ferroptosis in human umbilical cord mesenchymal stem cells: Role of cystathionine γ-lyase/hydrogen sulfide pathway
World Journal of Stem Cells

BACKGROUNDFerroptosis can induce low retention and engraftment after mesenchymal stem cell (MSC) delivery, which is considered a major challenge to the effectiveness of MSC-based pulmonary arterial hypertension (PAH) therapy. Interestingly,

Released: 26-Nov-2023 12:00 PM EST
How to enhance the ability of mesenchymal stem cells to alleviate intervertebral disc degeneration
World Journal of Stem Cells

Intervertebral disc (ID) degeneration (IDD) is one of the main causes of chronic low back pain, and degenerative lesions are usually caused by an imbalance between catabolic and anabolic processes in the ID. The environment in which the ID

Released: 26-Nov-2023 12:00 PM EST
Hypoxia and inflammatory factor preconditioning enhances the immunosuppressive properties of human umbilical cord mesenchymal stem cells
World Journal of Stem Cells

BACKGROUNDMesenchymal stem cells (MSCs) have great potential for the treatment of various immune diseases due to their unique immunomodulatory properties. However, MSCs exposed to the harsh inflammatory environment of damaged tissue after i

Newswise: Stem Cells: Progress in Treating Degenerative Eye Disease
Released: 15-Nov-2023 2:05 AM EST
Stem Cells: Progress in Treating Degenerative Eye Disease
Cedars-Sinai

Investigators from the Board of Governors Regenerative Medicine Institute at Cedars-Sinai are advancing stem cell technology to treat degenerative diseases of the eye.

Released: 26-Oct-2023 12:00 PM EDT
Potential of dental pulp stem cells and their products in promoting peripheral nerve regeneration and their future applications
World Journal of Stem Cells

Peripheral nerve injury (PNI) seriously affects people’s quality of life. Stem cell therapy is considered a promising new option for the clinical treatment of PNI. Dental stem cells, particularly dental pulp stem cells (DPSCs), are adult

Released: 26-Oct-2023 12:00 PM EDT
MicroRNA-584-5p/RUNX family transcription factor 2 axis mediates hypoxia-induced osteogenic differentiation of periosteal stem cells
World Journal of Stem Cells

BACKGROUNDThe hypoxic environment during bone healing is important in regulating the differentiation of periosteal stem cells (PSCs) into osteoblasts or chondrocytes; however, the underlying mechanisms remain unclear. AIMTo determine the e

Released: 26-Oct-2023 11:05 AM EDT
UC Irvine study exposes risks of direct-to-consumer stem cell, exosome COVID-19 therapy ads
University of California, Irvine

Irvine, Calif., Oct. 26, 2023 — A study from the University of California, Irvine has revealed that in 2022, 38 North American businesses used direct-to-consumer advertising to promote unproven stem cell interventions and exosome products as purported treatments and preventatives for COVID-19. Collectively, these organizations operated or facilitated access to 60 clinics – with 24 in the U.

Released: 24-Oct-2023 6:05 PM EDT
New clues to early development of schizophrenia
Elsevier

Schizophrenia is a severe neuropsychiatric disease that remains poorly understood and treated. Schizophrenia onset is typically in adolescence or early adulthood, but its underlying causes are thought to involve neurodevelopmental abnormalities.

Released: 20-Oct-2023 5:00 PM EDT
Potato starch supplements could be solution to bone marrow transplant complications
Michigan Medicine - University of Michigan

Research shows it could potentially prevent Graft versus Host Disease from occurring.



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