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Discovery Links Shift in Metabolism to Stem Cell Renewal

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Stem cells in early embryos have unlimited potential; they can become any type of cell, and researchers hope to one day harness this rejuvenating power to heal disease and injury. To do so, they must, among other things, figure out how to reliably arrest stem cells in a Peter Pan-like state of indefinite youth and potential.

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New Development in Cell Therapy: Veto Cell Technology

Overcoming graft rejection is the main obstacle when it comes to stem cell regeneration or organ transplantation. Scientists are investigating whether Veto Cell technology, which selectively tunes immune response, can change how immunologists treat blood cancers and bone marrow transplants, as well as the process of how organs are repaired and new ones are regenerated. Itamar Shimat, Cell Source’s CEO is available to talk about his company’s recent breakthroughs with Veto Cell technology.

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Not All Induced Pluripotent Stem Cells Are Made Equal

Human stem cells made from adult donor cells “remember” where they came from and that’s what they prefer to become again. This means the type of cell obtained from an individual patient to make pluripotent stem cells, determines what can be best done with them.

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Researchers Recreate Stem Cells From Deceased Patients to Study Present-Day Illnesses

Research scientists have developed a novel method to re-create brain and intestinal stem cells from patients who died decades ago, using DNA from stored blood samples to study the potential causes of debilitating illnesses such as inflammatory bowel disease.

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UCLA Researchers Unlock Protein Key to Harnessing Regenerative Power of Blood Stem Cells

UCLA scientists have discovered a protein which is integral to the regulation of human blood stem cell regeneration. Study revealed that stem cells which lack the protein have markedly increased ability to replicate in vivo and following transplantation. Discovery provides new understanding of human stem cell self-renewal and paves the way for targeted therapies to make stem cells grow.

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Signaling Molecule Crucial to Stem Cell Reprogramming

While investigating a rare genetic disorder, researchers at the University of California, San Diego School of Medicine have discovered that a ubiquitous signaling molecule is crucial to cellular reprogramming, a finding with significant implications for stem cell-based regenerative medicine, wound repair therapies and potential cancer treatments.

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Delivery of Stem Cells into Heart Muscle After Heart Attack May Enhance Cardiac Repair and Reverse Injury

Delivering stem cell factor directly into damaged heart muscle after a heart attack may help repair and regenerate injured tissue.

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UCLA Stem Cell Researcher Pioneers Gene Therapy Cure for Children with “Bubble Baby” Disease

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UCLA stem cell researchers cured 18 children born without a working immune system due to life-threatening ADA-deficient Severe Combined Immunodeficiency (SCID). Breakthrough stem cell gene therapy developed by Dr. Donald Kohn and team identifies and corrects faulty gene in children with ADA-deficient SCID using child’s own cells.

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Cardiac Stem Cell Therapy May Heal Heart Damage Caused by Duchenne Muscular Dystrophy

Researchers at the Cedars-Sinai Heart Institute have found that injections of cardiac stem cells might help reverse heart damage caused by Duchenne muscular dystrophy, potentially resulting in a longer life expectancy for patients with the chronic muscle-wasting disease.

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Morgridge Scientists Find Way to ‘Keep the Lights on’ for Cell Self-Renewal

A team from the Morgridge Institute for Research regenerative biology group, led by University of Wisconsin-Madison professor and stem cell pioneer James Thomson, discovered a way to impose an immortal-like state on mouse progenitor cells responsible for producing blood and vascular tissue. By regulating a small number of genes, the cells became “trapped” in a self-renewing state and capable of producing functional endothelial, blood and smooth muscle cells.

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