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Researchers Mimic Viral Infection in Colon Cancer Stem Cells

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Researchers targeting colorectal cancer stem cells – the root cause of disease, resistance to treatment and relapse – have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.

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UCSF Researchers Control Embryonic Stem Cells with Light

UC San Francisco researchers have for the first time developed a method to precisely control embryonic stem cell differentiation with beams of light, enabling them to be transformed into neurons in response to a precise external cue.

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Can Stem Cells Cause and Cure Cancer?

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UCI-Led Team Begins First Clinical Trial of Stem Cell-Based Retinitis Pigmentosa Treatment

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Participants are being enrolled in the first clinical trial that tests the use of retinal progenitor cells to treat retinitis pigmentosa, reported project director Dr. Henry Klassen of UCI’s Gavin Herbert Eye Institute and Sue & Bill Gross Stem Cell Research Center. The product of stem cell research at UCI, these retinal progenitors are similar to stem cells in terms of potential regenerative properties, but they’re specific to the retina.

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Source of Liver Stem Cells Identified

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Howard Hughes Medical Institute (HHMI) scientists have identified stem cells in the liver that give rise to functional liver cells. The work solves a long-standing mystery about the origin of new cells in the liver, which must constantly be replenished as cells die off, even in a healthy organ.

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Access Denied: Leukemia Thwarted by Cutting Off Link to Environmental Support

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A new study by researchers at University of California, San Diego School of Medicine reveals a protein’s critical – and previously unknown -- role in the development and progression of acute myeloid leukemia (AML), a fast-growing and extremely difficult-to-treat blood cancer. The study was published July 23 in Cell Stem Cell.

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Stem Cell Transplantation for Children with Rare Form of Leukemia Improves Outcomes

Researchers in the Division of Hematology, Oncology and Blood & Marrow Transplantation at CHLA have shown greatly improved outcomes in using stem cell transplantation to treat patients with a serious but very rare form of chronic blood cancer called juvenile myelomonocytic leukemia (JMML).

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Using Low-Dose Irradiation, Researchers Can Now Edit Human Genes

For the first time, researchers have employed a gene-editing technique involving low-dose irradiation to repair patient cells, according to a study published in the journal Stem Cells Translational Medicine. This method, developed by researchers in the Cedars-Sinai Board of Governors Regenerative Medicine Institute, is 10 times more effective than techniques currently in use.

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A Human Heart-on-a-Chip Screens Drugs for Potential Benefit, Harm

A research team funded by the National Institutes of Health has generated a novel system for growing cardiac tissue from undifferentiated stem cells on a culture plate. This heart on a chip is a miniature physiologic system that could be used to model early heart development and screen drugs prescribed during pregnancy. Researchers from the University of California (UC) Berkeley; the Gladstone Institutes, in San Francisco; and UC San Francisco, reported their work in the July 14, 2015, online issue of Nature Communications.

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A New Conductor Takes Centre Stage in the Early Embryo

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A gene called Jarid2, may play a wider role than previously thought in co-ordinating the way that stem cells change in a developing embryo to form the specialised cells that make up our bodies.