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World Breakthrough: A New Molecule Allows for an Increase in Stem Cell Transplants

A new molecule, the first of its kind, allows for the multiplication of stem cells in a unit of cord blood. Umbilical cord stem cells are used for transplants aimed at curing a number of blood-related diseases, including leukemia, myeloma and lymphoma. For many patients this therapy comprises a treatment of last resort.

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NYU Langone Scientists Report Reliable and Highly Efficient Method for Making Stem Cells

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NYU Langone Medical Center scientists have found a way to boost dramatically the efficiency of the process for turning adult cells into so-called pluripotent stem cells by combining three well-known compounds, including vitamin C.

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Simple Method Turns Human Skin Cells Into Immune-Fighting White Blood Cells

The fast and safe technique developed at the Salk Institute circumvents problems that have hindered regenerative medicine.

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Combining Antibodies, Iron Nanoparticles and Magnets Steers Stem Cells to Injured Organs

Researchers at the Cedars-Sinai Heart Institute infused antibody-studded iron nanoparticles into the bloodstream to treat heart attack damage. The combined nanoparticle enabled precise localization of the body’s own stem cells to the injured heart muscle. The study addresses a central challenge in stem cell therapeutics: how to achieve targeted interactions between stem cells and injured cells.

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In Directing Stem Cells, Study Shows Context Matters

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In a new study published today, Sept. 8, in the Proceedings of the National Academy of Sciences, a team of researchers from the University of Wisconsin-Madison has added a new wrinkle to the cell differentiation equation, showing that the stiffness of the surfaces on which stem cells are grown can exert a profound influence on cell fate.

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Researchers Discover a Key to Making New Muscles

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A new study finds that cyclic bursts of a STAT3 inhibitor can replenish muscle stem cells and promote their differentiation into muscle fibers. The findings are an important step toward developing and maintaining new muscle to treat muscle diseases.

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UT Southwestern Scientists Identify Rare Stem Cells in Testis That Hold Potential for Infertility Treatments

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Rare stem cells in testis that produce a biomarker protein called PAX7 help give rise to new sperm cells — and may hold a key to restoring fertility, research by scientists at UT Southwestern Medical Center suggests.

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New Reprogramming Factor Cocktail Produces Therapy-Grade Induced Pluripotent Stem Cells

Induced pluripotent stem cells (iPSCs) can acquire serious genetic and epigenetic abnormalities that lower the cells’ quality and limit their therapeutic usefulness. Now Whitehead Institute researchers have identified a cocktail of reprogramming factors that produces very high quality iPSCs.

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Skin Cells Can Be Engineered Into Pulmonary Valves for Pediatric Patients

Researchers have found a way to take a pediatric patient’s skin cells, reprogram the skin cells to function as heart valvular cells, and then use the cells as part of a tissue-engineered pulmonary valve

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New Tool Aids Stem Cell Engineering for Medical Research

A Mayo Clinic researcher and his collaborators have developed an online analytic tool that will speed up and enhance the process of re-engineering cells for biomedical investigation. CellNet is a free-use Internet platform that uses network biology methods to aid stem cell engineering. Details of CellNet and its application to stem cell engineering are described in two back-to-back papers in the journal Cell.

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