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Stem Cells

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Medicine

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Fertility, sex-linked conditions, Urogenital System, Sperm, Stem Cells, Genetics, Cell Biology, Male Infertility

Researchers Find Fertility Genes Required for Sperm Stem Cells

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The underlying cause of male infertility is unknown for 30 percent of cases. In a pair of new studies, researchers at University of California San Diego School of Medicine determined that the reproductive homeobox (RHOX) family of transcription factors — regulatory proteins that activate some genes and inactivate others — drive the development of stem cells in the testes in mice. The investigators also linked RHOX gene mutations to male infertility in humans.

Medicine

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Cirm, California Institute For Regenerative Medicine, University of California at San Diego, UCSD, Stem Cell, Stem Cell Research, C. Randal Mills, Ph.D., Cystonisis, Blood Stem Cells, Stephanie Cherqui, FDA, Food And Drug Administration, Cysteine

Rare, Life-Threatening Childhood Disease is the Focus of CIRM’s Most Recent Investment

Cystinosis is a rare disease that usually strikes children before they are two years old and can lead to end stage kidney failure before their tenth birthday. Current treatments are limited, which is why the CIRM Board today approved $5.2 million for research that holds the possibility of a safe, effective, one-time life-long treatment.

Medicine

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Heart Attack, Heart Failure, Heart Disease, Biomedical Engineering, Stem Cells, Progenitor Cells

$8 Million Grant to Support Research to Repair Hearts with Bioengineered Patch

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To prevent heart failure and restore heart function, researchers will work to create a bioengineered, human heart-tissue patch that is large, standardized and highly functional. This preclinical work will be supported by a seven-year grant just awarded by the NHLBI.

Medicine

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Stem Cells, Animal Research, Animal Studies, Heart, Heart Cells, Medicine

Stem Cell ‘Heart Patch’ Moves Closer to Clinic

The promise of stem cells to treat cardiovascular disease may soon be a step closer to clinical application as scientists from three institutions seek to perfect and test three-dimensional “heart patches” in a large animal model — the last big hurdle before trials in human patients.

Medicine

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induced pluripotent stem (iPS) cells, Reprogramming, Bromodomains, BET bromodomains, JQ1, Stem Cells

Removing Cellular Bookmarks Smooths the Path to Stem Cells

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Cells use specific proteins that help the cell remember what collection of genes needs to be turned on again after cell division. Removing these transcriptional bookmarks may be a key to better reprogramming of human fibroblasts to create induced pluripotent stem cells, or iPSCs.

Medicine

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antonio jimeno, University Of Colorado Cancer Center, Head And Neck Cancer, PI3K, Cancer Stem Cells, cancer stem cell

Seven-Year Study Pays Off with ‘Most Detailed’ Picture of Head and Neck Cancer Stem Cells to Date

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"After chemo, PI3K helps the cell shut down and weather the storm. Then when the chemo is gone, PI3K helps cancer stem cells start back up again," says University of Colorado Cancer Center investigator, Antonio Jimeno, MD, PhD.

Medicine

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Chimera, Pluripotency, Bioethics, Human Embryonic Stem Cells

In Nature Opinion Piece, Case Western Reserve Researcher Calls for Animal-Human Embryo Research to Proceed – but with Strong Animal Protections

In a World View opinion column published in Nature, a Case Western Reserve University School of Medicine researcher calls for animal-human embryo research to proceed – but only with strong animal protections in place.

Medicine

Science

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Stem Cell, Bioenginerring, Neural Stem Cells, Tissue Engineering, hiNSC, Human Brain

New Technique Generates Human Neural Stem Cells for Tissue Engineering, 3D Brain Models

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Tufts University researchers have discovered a new technique for generating rapidly-differentiating human neural stem cells for use in a variety of tissue engineering applications, including a three-dimensional model of the human brain, according to a paper published today in Stem Cell Reports.

Medicine

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McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth), Charles Cox, M.D., Stem Cell Therapy, autologous stem cells, traumatic brain injury (TBI), Department Of Defense

UTHealth Receives $6.8 Million From DOD to Study Stem Cell Therapy for TBI

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A research team led by Charles S. Cox, Jr., M.D., at McGovern Medical School at UTHealth has been awarded $6.8 million from the U.S. Department of Defense (DOD) to assess the safety and efficacy of using autologous stem cell therapy in adults with emergent traumatic brain injury.

Medicine

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Stem Cells, Chronic Kidney Disease, atheroscleroisis, Cardiovascular Disease, osteoblasts

Scientists Find Culprit Responsible for Calcified Blood Vessels in Kidney Disease

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Scientists have implicated a type of stem cell in the calcification of blood vessels that is common in patients with chronic kidney disease. The research will guide future studies into ways to block minerals from building up inside blood vessels and exacerbating atherosclerosis, the hardening of the arteries.

Medicine

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Cancer Research, Leukemia, Stem Cell Transplant, Umbilical Cord Blood Transplant, Cord Blood

For High-Risk Leukemia Patients, Umbilical Cord Blood Transplant Associated with Lower Risk of Relapse

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Umbilical cord blood transplants may have advantages beyond offering an alternative stem cell source for leukemia patients without a traditional donor match, according to a study published today in The New England Journal of Medicine.

Medicine

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Stem Cell, Neurorestoration, Regeneration, Regenerative Medicine, clinicial trials, Neurology, Movement, AST-OPC1, Spinal Cord Injury

Paralyzed Man Regains Use of Arms and Hands After Experimental Stem Cell Therapy at Keck Hospital of USC

After receiving a stem cell injection into his spine, Kris Boesen, who was paralyzed from his neck to his toes after a car accident, is regaining movement in his extremities and hope for increased independence.

Medicine

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Embryology, Chimera, Embryo Donation

Case Western Reserve Researcher Outlines Road Map for Addressing Ethical Concerns Tied to Research on Combination Human-Animal Embryos

Insoo Hyun has proposed a framework for addressing ethical questions surrounding potentially revolutionary research on part-human, part-animal embryos, which can be produced when human stem cells are transplanted into animal embryos.

Science

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Cirm, California Institute For Regenerative Medicine, Asteroid, Stem Cells, Embryonic Stem Cell, Spinal Cord Injury, Clincal Trial, Dr. Edith Perez, C. Randal Mills, Dr. Randy Mills, Jake Javier

Stem Cell Agency Spinal Cord Injury Clinical Trial Passes Safety Hurdles

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A clinical trial using stem cells to treat people with recent spinal cord injuries has cleared two key safety hurdles, and been given approval to expand the therapy to a larger group of patients with a much higher dose of cells.

Medicine

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Drug Discovery, Mood Disorder, Schizophrenia, Bipolar Disorder, induced pluripotent stem (iPS) cells

Sanford Burnham Prebys Medical Discovery Institute Included in Consortium Awarded $15 Million to Unravel Bipolar Disorder and Schizophrenia

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Sanford Burnham Prebys Medical Discovery Institute (SBP), the Johns Hopkins University School of Medicine, the Salk Institute for Biological Studies, and the University of Michigan will embark on a $15.4 million effort to develop new systems for quickly screening libraries of drugs for potential effectiveness against schizophrenia and bipolar disorder, the National Institute of Mental Health (NIMH) has announced.

Medicine

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Mount Sinai Health System, Icahn School of Medicine at Mount Sinai

Stem Cell Breakthrough Unlocks Mysteries Associated with Inherited and Sometimes Lethal Heart Conditions

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Scientists have created a model of a heart condition called hypertrophic cardiomyopathy (HCM).

Medicine

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tissue-engineered liver, Progenitor Cells

Functional Human Tissue-Engineered Liver Generated From Stem and Progenitor Cells

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A research team at Children’s Hospital Los Angeles has generated functional human and mouse tissue-engineered liver from adult stem and progenitor cells. Tissue-engineered Liver (TELi) was found to contain normal structural components such as hepatocytes, bile ducts and blood vessels.

Medicine

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Cancer, Leukemia, Stem Cells, Hematology, Aging, Secondary Acute Myeloid Leukemia, sAML

Researchers Find a New Way to Identify and Target Malignant Aging in Leukemia

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Researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified RNA-based biomarkers that distinguish between normal, aging hematopoietic stem cells and leukemia stem cells associated with secondary acute myeloid leukemia (sAML), a particularly problematic disease that typically afflicts older patients who have often already experienced a bout with cancer.

Medicine

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Altering Stem Cell Perception of Tissue Stiffness May Help Treat Musculoskeletal Disorders

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A new biomaterial can be used to study how and when stem cells sense the mechanics of their surrounding environment. With further development, this biomaterial could be used to control when immature stem cells differentiate into more specialized cells for regenerative and tissue-engineering-based therapies.

Medicine

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Cancer, Cell Biology

New Research Reveals Cancers Need a 'Perfect Storm' of Conditions to Develop

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SCIENTISTS have demonstrated for the first time the 'perfect storm' of conditions that cells need to start forming cancer, helping to explain why some organs are more susceptible to developing the disease, according to a new study published in Cell today (Thursday).







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