Iowa State University engineers are developing advanced tools for cell manufacturing that could improve the cost and availability of therapeutic cells capable of fighting diseases such as cancers, heart disease, lupus and other autoimmune diseases.
Researchers at NIH’s National Eye Institute have published a detailed protocol for making three cell types that are key components to form blood vessels and capillaries.
In an effort to determine the cause behind a rare condition that causes heart failure in children, University of Maryland School of Medicine researchers have identified new gene mutations responsible for the disorder in an infant patient. They were then able to learn how the mutation works and used a drug to reverse its effects in heart muscle cells derived from stem cells from the patient.
Researchers from the University of Frieburg discovered that coordinated differentiation and changes in the metabolism of breast cancer stem cells make them invisible for the immune system.
UT Southwestern Medical Center stem cell and developmental biologists and colleagues have developed a method to produce bovine blastoids, a crucial step in replicating embryo formation in the lab that could lead to the development of new reproductive technologies for cattle breeding.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai for April 2023.
Cedars-Sinai investigators are working to develop a more effective treatment for one of the most common and hard-to-heal musculoskeletal injuries: torn tendons.
Allogeneic hematopoietic stem cell transplantation is a deterministic curative procedure for various hematologic disorders and congenital immunodeficiency. Despite its increased use, the mortality rate for patients undergoing this procedure
Different fates of neural stem/progenitor cells (NSPCs) and their progeny are determined by the gene regulatory network, where a chromatin-remodeling complex affects synergy with other regulators. Here, we review recent research progress in
Acute respiratory distress syndrome (ARDS) is a common and clinically devastating disease that causes respiratory failure. Morbidity and mortality of patients in intensive care units are stubbornly high, and various complications severely a
Mesenchymal stromal/stem cells (MSCs) are currently applied in regenerative medicine and tissue engineering. Numerous clinical studies have indicated that MSCs from different tissue sources can provide therapeutic benefits for patients. MSC
BACKGROUNDThere is no established treatment to impede the progression or restore kidney function in human chronic kidney disease (CKD). AIMTo examine the efficacy of cultured human CD34+ cells with enhanced proliferating potential in kidne
BACKGROUNDFibroblast plays a major role in tendon-bone healing. Exosomes derived from bone marrow mesenchymal stem cells (BMSCs) can activate fibroblasts and promote tendon-bone healing via the contained microRNAs (miRNAs). However, the und
Cancer stem cells (CSCs) are the main cause of tumor growth, invasion, metastasis and recurrence. Recently, CSCs have been extensively studied to identify CSC-specific surface markers as well as signaling pathways that play key roles in CSC
Osteoarthritis (OA) is the most common musculoskeletal disease, and it is a major cause of pain, disability and health burden. Pain is the most common and bothersome presentation of OA, but its treatment is still suboptimal, due to the shor
A century has passed since the Nobel Prize winning discovery of insulin, which still remains the mainstay treatment for type 1 diabetes mellitus (T1DM) to this day. True to the words of its discoverer Sir Frederick Banting, “insulin is no
Cell transplantation therapy has certain limitations including immune rejection and limited cell viability, which seriously hinder the transformation of stem cell-based tissue regeneration into clinical practice. Extracellular vesicles (EVs
Since dental pulp stem cells (DPSCs) were first reported, six types of dental SCs (DSCs) have been isolated and identified. DSCs originating from the craniofacial neural crest exhibit dental-like tissue differentiation potential and neuro-e
Obesity, the global pandemic since industrialization, is the number one lifestyle-related risk factor for premature death, which increases the incidence and mortality of various diseases and conditions, including cancer. In recent years, th
Researcher will discuss the study which involved a sleeping aid known as suvorexant that is already approved by the Food and Drug Administration (FDA) for insomnia, hints at the potential of sleep medications to slow or stop the progression of Alzheimer’s disease.
While strategies for regenerating or replacing lost neurons from stem cells are being developed, an alternative treatment option is the protection of existing neurons to prevent their degeneration, a recent study published in Stem Cell Reports suggests.
Vijay Goradia, a Houston-based businessman, philanthropist, and cancer survivor, has donated $10 million to The University of Texas MD Anderson Cancer Center to speed translational research and clinical trials.
The proposed material is chemically similar to mammalian proteins and is non-toxic, therefore contributing to fast adherence and division of human stem cell cultures. This development will help accelerate cell culture growth, which are used in medicine as a replacement for damaged tissue.
University of Pittsburgh researchers developed a novel approach that promoted bone regeneration in mice without implantation of bone tissue or biomaterials.
Cedars-Sinai investigators, in collaboration with Axiom Space of Houston, are sending stem cells to space in early May to explore whether microgravity can make it easier and more efficient to produce large batches of stem cells.
Scientists at St. Jude Children’s Research Hospital and the Broad Institute of MIT and Harvard showed how prime editing can correct mutations that cause sickle cell disease in a potentially curative approach.
An international phase 3 clinical trial led by physicians at Washington University School of Medicine in St. Louis has shown that the investigational drug motixafortide — when combined with the standard therapy for mobilizing stem cells — significantly increases the number of stem cells that can be harvested, compared with treatment with the standard agent alone.
The CD70-targeting allogeneic chimeric antigen receptor (CAR) T cell therapy, ALLO-316, demonstrated encouraging response rates and disease control rates in patients with metastatic clear cell renal cell carcinoma (ccRCC), according to results of a Phase I trial led by researchers at The University of Texas MD Anderson Cancer Center and presented today at the American Association for Cancer Research (AACR) Annual Meeting 2023.
An international coalition of biomedical researchers co-led by Alexander Bick, MD, PhD, at Vanderbilt University Medical Center has determined a new way to measure the growth rate of precancerous clones of blood stem cells that one day could help doctors lower their patients’ risk of blood cancer. The technique, called PACER, led to the identification of a gene that, when activated, drives clonal expansion.
A team of scientists led by those in Trinity College Dublin has discovered new mechanisms involved in establishing cellular identity, a process that ensures the billions of different cells in our bodies do the correct job.
Human embryo development and early organ formation remain largely unexplored due to ethical issues surrounding the use of embryos for research as well as limited availability of materials to study.
Zhang et al. show that the mechanical properties of a three-dimensional (3D) hydrogel can enhance the secretion of niche factors from bone marrow stromal cells, which in turn promotes the maintenance of hematopoietic stem cells (HSCs) and reverses a
Li et al. report on the generation of cynomolgus monkey models of blastocyst-stage embryos (called “blastoids”) using naive cynomolgus embryonic stem cells. These blastoids recapitulate gastrulation in vitro and induce early pregnancy responses
Shivdasani et al. assign niche functions to specific mesenchymal cell types near stem cells at the base of intestinal crypts. They identify PDGFRAlo fibroblasts as a substantial source of requisite Wnt ligands and show that BMP signaling from crypt
Stem cell-based embryo models provide a useful system for studying early embryonic development. Li and colleagues reported the generation of cynomolgus monkey blastoids with similar characteristics to natural blastocysts. These blastoids possess the
The existence of adult beta cell neogenesis has been controversial, with numerous papers published arguing for and against over the years, and many conclusions in the field are thus based on studies that were performed years and sometimes decades ago
Marchiano and colleagues interrogate the underlying causes of ventricular arrhythmias occurring after human pluripotent stem cell-cardiomyocyte transplantation. Through stepwise analysis and gene editing of ion channel expression, they mitigate pace-
Alzheimer’s disease (AD) is associated with reduced adult hippocampal neurogenesis and impaired hippocampal-dependent behaviors. Li et al. report that stimulating adult neurogenesis combined with new-born neuron activation ameliorates behavioral s
Engraftment arrhythmia (EA) compromises the safety of hPSC-CM cell therapy. We hypothesized that spontaneous graft depolarizations are the source of EAs. We used a CRISPR screen to demonstrate that targeting excitatory channels HCN4, CACNA1H, and SLC
The process of generating adult-born neurons (ABNs) in the hippocampus is impaired in AD. Song and colleagues report a circuit-based strategy by stimulating SuM to enhance hippocampal neurogenesis in AD mice. Activation of SuM-modified ABNs restores
The paucity of hematopoietic stem cells (HSCs) presents a challenge for both transplantation and the study of HSCs.1 Sakurai et al.2 now present a cytokine-free culture system for robust ex vivo expansion of functional human HSCs that may lead to e
Magenheim et al. challenge a recent study claiming that pancreatic beta cells are generated at a physiologically important rate from progenitor cells within ducts. They show that the lineage-tracing systems used in that study do in fact pulse label
Small molecule-induced cell fate transitions are characterized by low efficiency and slow kinetics. An optimized chemical reprogramming approach now facilitates the robust and rapid conversion of somatic cells to pluripotent stem cells, unlocking exc
Yue and colleagues demonstrate that matrix stiffness negatively regulates the HSC niche factor expression by BMSCs. They successfully engineer a soft bone marrow niche that not only promotes HSC maintenance and lymphopoiesis but also rejuvenates midd
Banjac et al. review the mechanisms behind homeostasis and regeneration in the epidermis, hematopoietic system, and intestinal epithelium with an emphasis on tissue stem cells. They highlight key challenges facing the field with reference to underst
Chemical reprogramming provides a robust approach for cell fate manipulation. Here, Deng and colleagues developed a highly reproducible and efficient chemical reprogramming method for the induction of human pluripotent stem cells and revealed increas
The Federation of American Societies for Experimental Biology (FASEB) awarded Paola Arlotta, PhD, Professor of Stem Cell and Regenerative Biology at Harvard University, with its Excellence in Science Mid-career Investigator Award.
A National Eye Institute-led team has identified a compound already approved by the U.S. Food and Drug Administration that keeps light-sensitive photoreceptors alive in three models of Leber congenital amaurosis type 10 (LCA 10), an inherited retinal ciliopathy disease that often results in severe visual impairment or blindness in early childhood.
The Departments of Neurology and Neurosurgery at Cedars-Sinai highlighted progress against Alzheimer’s disease, Parkinson’s disease, ALS, multiple sclerosis, brain cancer and stroke in their 2023 Annual Report, which also details advancements in spine surgery.
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