Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers has been shown to be safe, resulting in durable remissions, in a study of acute myeloid leukemia (AML) with relapsed or refractory disease.
Matching targeted therapies to tumor-specific gene mutations across tumor types improved progression-free survival (PFS) and overall survival (OS) in patients with advanced disease relative to those receiving non-matched treatment (NMT), according to research from The University of Texas MD Anderson Cancer Center. The researchers also found that receiving matched targeted therapy (MTT) was an independent factor for predicting longer OS.
In a small Phase II study of early-stage breast cancer patients with BRCA1/2 mutations, researchers at The University of Texas MD Anderson Cancer Center found that more than half of the women who took the PARP inhibitor talazoparib once daily prior to surgery had no evidence of disease at the time of surgery. If further validated in larger, confirmatory trials, the oral medication could replace chemotherapy for these patients.
The University of Texas MD Anderson Cancer Center and Amgen today announced two multi-year collaboration agreements aimed at accelerating development of a variety of Amgen’s early-stage oncology therapies for patients with leukemia, myelodysplastic syndromes, multiple myeloma, small-cell lung cancer, and other non-lung cancers with small-cell histologies.
The WorldFest-Houston International Film Festival has honored a 56-minute film produced by Cizik School of Nursing at The University of Texas Health Science Center at Houston (UTHealth) with a Platinum Remi Award given for a documentary under 60 minutes. The original documentary film, Caring Corrupted: the Killing Nurses of the Third Reich, is a grim cautionary story about nurses who participated in the Holocaust and abandoned their professional ethics during the Nazi era.
Glucose is the energy that fuels cells, and the body likes to store glucose for later use. But too much glucose can contribute to obesity, and scientists have long wanted to understand what happens within a cell to tip the balance.
Building on two decades of research, investigators at UT Southwestern have determined that “cellular housekeeping” can extend the lifespan and healthspan of mammals.
UT Southwestern Medical Center geneticist Dr. Helen Hobbs is the 2018 recipient of the Institut de France Grand Prix Scientifique.
UT Southwestern biochemist Dr. Benjamin Tu has been selected as one of 31 finalists for the 2018 Blavatnik National Awards for Young Scientists for his innovative studies of molecules that could help improve treatments for cancer and conditions associated with aging.
An “alcopop” is a bottled alcoholic beverage that masks the taste of alcohol with flavors such as soda or lemonade. Originally marketed in Australia during the mid-1990s, alcopop brands such as Smirnoff Ice and Mike’s Hard Lemonade soon became popular in the U.S. Supersized alcopops, such as Four Loko, contain large quantities of alcohol and are reportedly popular among underage drinkers. This study examined the extent to which young adults recognize how intoxicated they would become from drinking supersized alcopops.
When scientists at The University of Texas Health Science Center at Houston (UTHealth) applied a chemical found in soybeans to a non-steroidal anti-inflammatory drug (NSAID), they increased its anticancer properties and reduced its side effects. Findings of the preclinical study of phosphatidylcholine, also called lecithin, appear in the journal Oncology Letters.
Betty Ozen has a spring in her step again, thanks to her quick-acting daughter, the wonders of telemedicine and a helping paw from Jojo.
The University of Texas MD Anderson and Ipsen, a global biopharmaceutical group, today announced a global licensing and joint development agreement for a pre-clinical oncology drug candidate discovered by researchers in MD Anderson’s Institute for Applied Cancer Science (IACS).
“Our research suggests it might be a good idea for potential close relationship partners to have compatible attitudes towards pets,” Marshall said.
Effort leads to new Exploration Green nature park that will detain floodwater, clean runoff
Effort leads to new Exploration Green nature park that will detain floodwater, clean runoff
Researchers asked 60 adult participants (31 men, 29 women) – recruited through newspaper advertisements – to record their daily social interactions for 20 days. Specifically, for each interaction, participants reported their perception of their interacting partner’s quarrelsome behavior, their own anger and quarrelsome behavior, and the number of alcoholic drinks consumed up to three hours prior to the event.
Obese children who consume at least two servings of any type of cow’s milk daily are more likely to have lower fasting insulin, indicating better blood sugar control, according to researchers at The University of Texas Health Science Center at Houston (UTHealth).
The nationally recognized Kidney Cancer Program at UT Southwestern Medical Center’s Harold C. Simmons Comprehensive Cancer Center led a team of investigators who identified a new way to help doctors determine the prognosis for patients with stage 3 kidney cancer, which has important implications for decisions about surgery and inclusion in clinical trials.
General Data Protection Regulation (GDPR) will require more consumer control and creative digital marketing. To clear up some of the confusion, Venky Shankar, Professor & Coleman Chair in Marketing and Director of Research at the Center for Retailing Studies, answers some questions about it.
Addressing a critical issue for people with a genetic disorder called tuberous sclerosis complex (TSC), doctors at The University of Texas Health Science Center at Houston (UTHealth) reported that a skin cream containing rapamycin significantly reduced the disfiguring facial tumors affecting more than 90 percent of people with the condition.
Dr. Ralph DeBerardinis, Professor at the Children’s Medical Center Research Institute at UT Southwestern (CRI), today became the University’s newest Howard Hughes Medical Institute (HHMI) Investigator.
James Isbon was the second patient in the United States and the seventh in the world to have an aneurysm, or bulge, in the aortic arch above his heart repaired in a novel and minimally invasive way.
Dr. Craig A. Peters, Professor of Urology and Chief of Pediatric Urology at UT Southwestern Medical Center, received the John W. Duckett, Jr., MD Pediatric Urology Research Excellence Award, which honors a physician-scientist or researcher for outstanding work in pediatric urology.
SivaTeja Pati, a biology major at Texas Tech University, presented Toby with a custom-made, Spider-Man-patterned prosthetic hand he designed and 3D printed for the boy, using the Makerspace in the University Library.
A national retrospective study led by researchers at The University of Texas MD Anderson Cancer Center found no association between intensity of post-treatment surveillance and detection of recurrence or overall survival (OS) in patients with stage I, II or III colorectal cancer (CRC). Published in the Journal of the American Medical Association, the study is the largest of surveillance intensity in CRC ever conducted.
Despite the pervasive use of social media by young adults, little is known about whether, and how, social-media engagement influences their drinking patterns and risk of alcohol-related problems. Reviews thus far have looked at drinking relative to risky behaviors and advertising. This review examined associations between young adults’ alcohol-related social-media activity – defined as posting, liking, commenting on, and viewing of alcohol-related content on social media – and their drinking behaviors and alcohol-related problems.
Recent research from Houston Methodist Hospital showed that a new immunotherapy was safe for patients with ALS and also revealed surprising results that could bring hope to patients who have this relentlessly progressive and fatal disease.
Dr. Hae-Kwon Jeong has developed a novel method to separate light olefins – such as ethylene and propylene that are used in packaging, plastic processing and textile manufacturing – from paraffins – such as ethane and propane. This is one of the most significant seperations in chemical and petrochemical industries, with propylene production amounting to around $90 billion annually worldwide, yet one of the most challenging due to the similarity of their physical and chemical properties.
In a landmark study, researchers found that patients treated with paramedic oxygen delivery using a newer, more flexible laryngeal breathing tube may have a greater survival rate after sudden cardiac arrest than the traditional intubation breathing tube.
Everyone enjoys spending the summer months in the great outdoors but you have to do it responsibly or injury can occur, say doctors with UT Physicians, the clinical practice of McGovern Medical School at The University of Texas Health Science Center at Houston (UTHealth.)
The impacts of potential trade tariffs on crops such as soybeans would send ripple effects through other agricultural commodities, according to a Texas A&M AgriLife Extension Service economist.
The impacts of potential trade tariffs on crops such as soybeans would send ripple effects through other agricultural commodities, according to a Texas A&M AgriLife Extension Service economist.
Texas A&M AgriLife research will collaborate with the Texas Department of Agriculture and the University of California at Davis on a project to help agricultural producers and consumers through improving nitrogen use efficiency and food safety in spinach
The study – to be published in the June edition of the Journal of the American Medical Association Psychiatry – found that measuring electrical activity in the brain can help predict a patient’s response to an antidepressant.
Drug-resistant staph infections continue to be deadlier than those that are not resistant and treatable with traditional antibiotics, but treatment costs surprisingly are the same or slightly less, a new national analysis shows.
A new model for improving how clinical trials are developed and conducted by bringing together academic cancer experts and pharmaceutical companies is being tested by research experts at The University of Texas MD Anderson Cancer Center.
Anesthesiologist Vivian Porche, M.D., could be considered the Texas Medical Center’s very own Mary Poppins and now her daughter Bobbi is following in her high-flying footsteps.
In today’s retail climate, where stores struggle to keep up with online competition and customers can compare prices with the ease of their smartphones, the price tag is just a starting point for negotiations, said a negotiation expert at Baylor University.
Funny thing about restaurant menus. They often are among the best gauges of telling us how tastes have changed – quite literally – and how economic good times come and go.
Red Raiders have arrived in Costa Rica, ready to cut the ribbon on the university’s first international campus, Texas Tech University at Costa Rica (TTU-CR), located in the capital city of San Jose. The ribbon cutting is one more step in the university’s efforts to increase its global presence.
Houston Methodist researchers developed a new lab-on-a-chip technology that could quickly screen possible drugs to repair damaged neuron and retinal connections, like what is seen in people with macular degeneration or who’ve had too much exposure to the glare of electronic screens.
Becoming a mother was her greatest joy, but just days after giving birth to her daughter, Jessica Hitt’s mental state was severely affected by a rare genetic disorder. She became delirious, agitated, and hysterical. UT Southwestern researchers and physicians were able to quickly diagnose and treat the disease, and now she’s looking forward to expanding her family.
Alcohol use during pregnancy can lead to Fetal Alcohol Spectrum Disorders (FASDs), a range of effects that include lowered intelligence and developmental delays. Over 30 percent of the pregnancies in the United States are unplanned, with most women unaware of being pregnant until after the fourth week, and many not recognizing that they are pregnant until after that. However, the early weeks of pregnancy are critical for fetal development and susceptibility to the damaging effects of alcohol. While face-to-face interventions can significantly reduce risk for an alcohol-exposed pregnancy (AEP), this study, the Contraception and Alcohol Risk Reduction Internet Intervention (CARRII), examined an Internet-delivered intervention designed to reach more women at risk.
A child obesity expert from the Michael & Susan Dell Center for Healthy Living at The University of Texas Health Science Center at Houston (UTHealth) School of Public Health in Austin was called upon to help lead a groundbreaking project to involve and empower adolescents in the fight against obesity in Europe.
Low-income individuals are often reluctant or too embarrassed to discuss their financial hardships and constraints with caregivers during office visits. As a result, physicians and caregivers frequently misinterpret that choice as noncompliance with medical care.
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