Feature Channels: Biotech

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Released: 23-Sep-2022 12:00 PM EDT
IRF7 impacts on prostate cancer cell survival in response to radiation
Preprints

Adam Pickard, Francesca Amoroso, Kelsey McCulloch, Andrew Erickson, Ashwin Sachdeva, Rebecca Steele, Debayan Mukherjee, Margaret Dellett, Jonathan McComb, Laura McCaffrey, Claire Hart, Michael Brown, Simon S McDade, David Waugh,

Released: 22-Sep-2022 12:00 PM EDT
ESDR573 - Marine and Bovine-Derived Collagen Peptides Inhibit Catagen Development and Generate Diverse Effects on Stem Cells and Progeny in Human Scalp Hair Follicles Ex Vivo
Preprints

Karin Pappelbaum, Nicolina Virgilio, Francisco Jiménez, Wolfgang Funk, Janne Prawitt, Bastian van der Steen, Marta Bertolini

Released: 22-Sep-2022 12:00 PM EDT
The impact of pretransplant use of tyrosine kinase inhibitors on allogeneic stem cell transplantation in patients with chronic myeloid leukemia - A single-institution retrospective study
Preprints

Shinya Fujita, Masatoshi Sakurai, Hidenori Kasahara, Jun Kato, Yuya Koda, Kentaro Yamaguchi, Kohei Shiroshita, Mikio Okayama, Ryohei Abe, Taku Kikuchi, Takayuki Shimizu, Takehiko Mori, Keisuke Kataoka, Shinichiro Okamoto

Released: 22-Sep-2022 12:00 PM EDT
Three-dimensional nanofibrous sponges with aligned architecture and controlled hierarchy regulating neural stem cell fate for spinal cord regeneration
Preprints

Shilei Ni, Zhiwei Li, Ye Qi, Lei Sun, Zheng Li, Shaojun Chen, Yuqi Zhang, Yuan Ma, Jinming Han, Zide Wang, Yulin Zhang, Huimin Geng, Bin Huang, Jian Wang, Gang Li,

Released: 22-Sep-2022 12:00 PM EDT
ESDR572 - Olfactory Receptor 2A4/7 Activation by the Fragrance, Cyclohexyl Salicylate, Promotes Human Hair Follicle Growth and Stem Cell Progeny Expansion
Preprints

Janin Edelkamp, Daniela Pinto, Hanieh Erdmann, Talveen Purba, Francisco Jiménez, Ralf Paus, Marta Bertolini

Released: 22-Sep-2022 12:00 PM EDT
ESDR559 - Induction of tissue-specific premature stem cell aging promotes senescence-like phenotypes in remote multiple organs
Preprints

Yasuaki Ikuno, Koichiro Watanabe, Yumi Kakeya, Toshimasa Nakabo, Dai Ihara, Noriki Fujimoto, Hayato Naka-Kaneda

Released: 22-Sep-2022 12:00 PM EDT
Carcinoma associated mesenchymal stem cells promote ovarian cancer metastasis by increasing tumor heterogeneity through direct mitochondrial transfer
Preprints

Catherine Pressimone, Leonard G Frisbie, Emma Dyer, Roja Baruwal, Grace Gorecki, Zaineb Javed, Claudette St. Croix, Simon C Watkins, Michael Calderon, Huda I Atiua, Nadine Hempel, Alexander T. Pearson, Lan Coffman

Released: 22-Sep-2022 12:00 PM EDT
The relationship between PD-L1 and quiescence in melanocyte stem cell aging.
Preprints

Joseph W. Palmer, Kyrene M. Villavicencio, Misgana Idris, Dominique Weddle, Fabian V. Filipp, William J. Pavan, Melissa L. Harris, Nisc Comparative Sequencing Program - Nhgri

Released: 21-Sep-2022 12:00 PM EDT
The effects of adipose-derived stem cell transplantation on tendon-bone healing in a model of chronic rotator cuff tear with suprascapular nerve injury
Preprints

Kenichiro Eshima, Hiroki Ohzono, Masafumi Gotoh, Hidehiro Nakamura, Takahiro Okawa, Naoto Shiba

Released: 21-Sep-2022 12:00 PM EDT
ESDR556 - Functional and proliferative melanocyte-derived pluripotent stem cells: from developmental studies to clinical perspectives
Preprints

Manoubia Saidani, Annabelle Darle, Margot Jarrige, Hélène Polveche, Sévenine Julie, Sandrine Bessou Touya, Lemaitre Gilles, Cécile Martinat, Christine Baldeschi, Jennifer Allouche

Released: 21-Sep-2022 12:00 PM EDT
Genome instability underlies an augmented DNA damage response in familial and sporadic ALS human iPSC-derived motor neurons
Preprints

Oliver Ziff, Jacob Neeves, Jamie Mitchell, Guilia Tyzack, Carlos Ruiz, Nicholas McGranahan, Raphaelle Luisier, Anob Chakrabarti, Simon Boulton, Gavin Kelly, Jack Humphrey, Rickie Patani

Released: 21-Sep-2022 12:00 PM EDT
A bipartite function of ESRRB can integrate signaling over time to balance self-renewal and differentiation
Preprints

Teresa Emmilie Knudsen, William Hamilton, Martin Proks, Maria Lykkegaard, Alexander Valentin Nielsen, Ala Trusina, Joshua M Brickman

Released: 20-Sep-2022 12:00 PM EDT
Presence of cells in the polyaneuploid cancer cell (PACC) state predicts risk of recurrence in prostate cancer
Preprints

Levent Trabzonlu, Kenneth J Pienta, Bruce J Trock, Angelo Michael De Marzo, Sarah R Amend

Released: 20-Sep-2022 12:00 PM EDT
Autophagy inhibits inflammation via down-regulation of p38 MAPK/mTOR signaling cascade in endothelial cells
Preprints

Ling Zhou, Juanjuan Wang, Hui Hou, Jiao Li, Juan Li, Jiannan Liang, Junqin Li, Xuping Niu, Ruixia Hou, Kai-Ming Zhang

Released: 20-Sep-2022 12:00 PM EDT
Integrated analysis of next generation sequencing minimal residual disease (MRD) and PET scan in transplant eligible myeloma patients
Preprints

Rodrigo Fonseca, Mariano Arribas, Julia E. Wiedmeier-Nutor, Yael N. Kusne, Miguel Gonzalez-Velez, Heidi Kosiorek, Richard J. Butterfield, Ilan Kirsch, Joseph Mikhael, A. Keith Stewart, Craig Reeder, Jeremy Larsen, P. Bergsagel, Rafael Fonseca

Released: 20-Sep-2022 12:00 PM EDT
mRNA-based generation of marmoset PGCLCs capable of differentiation into gonocyte-like cells
Preprints

Musashi Kubiura-Ichimaru, Christopher Penfold, Kazuaki Kojima, Constance Dollet, Haruka Yabukami, Katsunori Semi, Yasuhiro Takashima, Thorsten Boroviak, Hideya Kawaji, Knut Woltjen, Aki Minoda, Erika Sasaki, Toshiaki Watanabe

Released: 20-Sep-2022 12:00 PM EDT
Intensity of Induction Regimen and Outcomes Among Adults with Ph+ ALL Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Preprints

Marlise Luskin, Hari Raman, Se Eun Kim, Daniel DeAngelo, Kristen Stevenson, Donna Neuberg, Eric Winer, Martha Wadleigh, Jacqueline Garcia, Annette Kim, Richard Stone, Vincent Ho

Released: 20-Sep-2022 12:00 PM EDT
Differential elasticity in lineage segregation of embryonic stem cells
Preprints

Christine M. Ritter, Natascha Leijnse, Younes Farhangi Barooji, Joshua M. Brickman, Amin Doostmohammadi, Lene B. Oddershede

Released: 19-Sep-2022 12:00 PM EDT
Inositol pyrophosphate profiling reveals regulatory roles of IP6K2-dependent enhanced IP7 metabolism in enteric nervous system
Preprints

Masatoshi Ito, Natsuko Fujii, Saori Kohara, Shuho Hori, Masayuki Tanaka, Christopher Wittwer, Kenta Kikuchi, Takatoshi Iijima, Yu Kakimoto, Kenichi Hirabayashi, Daisuke Kurotaki, Henning Jacob Jessen, Adolfo Saiardi, Eiichiro Nagata

Released: 19-Sep-2022 12:00 PM EDT
Lung remodeling regions in long-term Covid-19 feature basal epithelial cell reprogramming
Preprints

Kangyun Wu, Yong Zhang, Stephen R Austin, Huqing Yin Declue, Derek E Byers, Erika C Crouch, Michael J Holtzman

Released: 19-Sep-2022 12:00 PM EDT
Weight Loss Post Allogeneic Stem Cell Transplant is Associated with Increased Transplant Related Mortality
Preprints

Kayla Madsen, Katherine Lee, Shiyi Chen, Carol Chen, Arjun Law, Armin Gerbitz, Rajat Kumar, Dennis Kim, Wilson Lam, Ivan Pasic, Auro Viswabandya, Fotios Michelis, Ram Vasudevan Nampoothiri, Jeffrey Lipton,

Newswise: University of Oklahoma Biomedical Engineering Researcher Ready to Transform TBI Surgery
Released: 19-Sep-2022 11:05 AM EDT
University of Oklahoma Biomedical Engineering Researcher Ready to Transform TBI Surgery
University of Oklahoma, Gallogly College of Engineering

Patients who suffer a severe traumatic brain injury must undergo two surgeries: one to remove a part of the skull to allow the brain to swell and another surgery to replace the missing bone after brain swelling subsides. University of Oklahoma biomedical engineering researcher Michael Detamore and his team may have found a way to reduce the number of surgeries to just one.

Released: 18-Sep-2022 12:00 PM EDT
Within-host virus evolution during the extended treatment of RSV infection with mutagenic drugs
Preprints

Christopher Jr Illingworth, Alexandra Y Kreins, Adriana Margarit Soler, Tim Best, Patricia Dyal, Giovanna Lucchini, Kanchan Rao, Rachel Williams, Austen Jj Worth, Judith Breuer

Released: 18-Sep-2022 12:00 PM EDT
Reserpine maintains photoreceptor survival in retinal ciliopathy by resolving proteostasis imbalance and ciliogenesis defects
Preprints

Holly Y Chen, Manju Swaroop, Samantha Papal, Anupam Mondal, Gregory Tawa, Florian Regent, Hiroko Shimada, Kunio Nagashima, Natalia de Val, Samuel G Jacobson, Wei Zheng, Anand Swaroop

Released: 17-Sep-2022 12:00 PM EDT
Oncogenic Kras induces spatiotemporally specific tissue deformation through converting pulsatile into sustained ERK activation
Preprints

Tianchi Xin, Sara Gallini, David Gonzalez, Lauren E. Gonzalez, Sergi Regot, Valentina Greco

Newswise: Improved mineralized material can restore tooth enamel
Released: 16-Sep-2022 2:05 PM EDT
Improved mineralized material can restore tooth enamel
Ural Federal University

Scientists have perfected hydroxyapatite, a material for mineralizing bones and teeth.

   
Newswise: Lab experiments support COVID-19 bradykinin storm theory
Released: 16-Sep-2022 11:05 AM EDT
Lab experiments support COVID-19 bradykinin storm theory
Oak Ridge National Laboratory

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.

   
Released: 15-Sep-2022 12:00 PM EDT
The downstream PPARγ target LRRC1 participates in early-stage adipocytic differentiation
Preprints

Xinping Wang, Jianyun Liu, Ting Wang, Baicheng Ma, Ping Wu, Xiaoyuan Xu, Jianjun Xiong

Newswise: A Cut Above — Two Devices Are Teamed to Simplify, Quicken and Improve Ear Reconstruction
Released: 15-Sep-2022 10:00 AM EDT
A Cut Above — Two Devices Are Teamed to Simplify, Quicken and Improve Ear Reconstruction
Johns Hopkins Medicine

Thanks to two novel tools developed by a Johns Hopkins Medicine resident and a former resident, the traditionally difficult surgery to create a replacement ear from a patient’s rib cartilage may soon be done faster, more simply and accurately.

Released: 14-Sep-2022 12:00 PM EDT
Trans-synaptic dwelling of SARS-CoV-2 particles perturbs neural synapse organization and function
Preprints

Emma Partiot, Aurelie Hirschler, Sophie Colomb, Willy Lutz, Tine Claeys, Francois Delalande, Maika S Deffieu, Judith Roels, Joanna Bons, Domitille Callon, Laurent Andreoletti, Marc Labrousse, Frank Mj Jacobs, Valerie Rigau,

Released: 14-Sep-2022 12:00 PM EDT
NOTCH-pathway inactivation reprograms oral-stem-like cancer cells to JAK-STAT dependent state and provides the opportunity of synthetic lethality
Preprints

Subhashis Ghosh, Paromita Mitra, Uday Saha, Arnab Ghosh, Nidhan Kumar Biswas, Shantanu Saha Roy, Moulinath Acharya, Sandeep Singh

Released: 14-Sep-2022 4:05 AM EDT
Bacteria from the sewer can become producers of hydrogen fuel
Scientific Project Lomonosov

Scientists from the Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences studied bacterium discovered in a wastewater treatment bioreactor. This microorganism has adapted to life in an acidic environment and breaks down carbohydrate-rich organic waste to form hydrogen.

Released: 14-Sep-2022 4:05 AM EDT
Fungi, destroyers of tempera, can be used in pharmacy
Scientific Project Lomonosov

The ability of microfungi to destruct organic compounds can be the object of envy for any processing plant. However, they sometimes destroy things that people prefer to keep safe – for example, paints of the masterpieces. The good news is that some of their biochemical reactions can be used in pharmacy.

Released: 13-Sep-2022 4:55 PM EDT
DOE Announces $178 Million to Advance Bioenergy Technology
Department of Energy, Office of Science

The U.S. Department of Energy (DOE) today announced $178 million for bioenergy research to advance sustainable technology breakthroughs that can improve public, health, help address climate change, improve food and agricultural production, and create more resilient supply chains. This funding will support cutting-edge biotechnology R&D of bioenergy crops, industrial microorganisms, and microbiomes. Alternative clean energy sources like bioenergy are playing a key role in reaching President Biden’s goal of a net-zero carbon economy by 2050.

Newswise:Video Embedded johns-hopkins-team-finalist-in-collegiate-inventors-competition
VIDEO
Released: 13-Sep-2022 4:05 PM EDT
Johns Hopkins Team Finalist in Collegiate Inventors Competition
 Johns Hopkins University

The team developed a simpler and more comfortable brace to treat kids born with clubfoot.



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