Feature Channels: Autoimmune Diseases

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Awareness campaign kicking off Myositis Awareness Month aims to ensure the over 75,000 people with the disease are diagnosed and get treated

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When TET2 and TET3 proteins are genetically deleted from T-regs in mice, their suppressive function is lost over time and animals develop inflammatory disease. More importantly, because these TET2 and TET3 mutant cells had once 'experienced' being a normal T-reg, they behaved very differently.

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Researchers will receive $17.8 million in federal funding to attack a key “knowledge gap” in human immunology — how B cells and antibody-secreting cells that reside in tissues and organs differ from those found in blood. It is an exploration never undertaken in a systematic way.

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A research team at Massachusetts Eye and Ear has shown that microglia, the immune cells of the central nervous system—including the retina —serve as “gatekeepers” of neuroinflammation. Uveitis is one of the leading causes of blindness worldwide. In the study published in Proceedings of the National Academy of Sciences (PNAS), researchers describe for the first time a role for microglia in directing the initiation of autoimmune uveitis by orchestrating the inflammatory response within the retina.

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Scientists have uncovered fresh insights into how vitamin D affects the immune system and might influence susceptibility to diseases such as multiple sclerosis.

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The 2019 AARDA Champion Award will be presented to champion race car driver Kyle Marcelli at the organization's 19th annual fundraiser on May 11 at the Detroit Athletic Club.

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A recent study found that nearly 18 percent of patients diagnosed with multiple sclerosis before being referred to two major Los Angeles medical centers for treatment actually had been misdiagnosed with the autoimmune disease. The investigators found that many patients who came to the medical centers with a previous diagnosis of MS did not fulfill the criteria for that diagnosis, and spent an average of four years being treated for MS before receiving a correct diagnosis.

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Researchers using the world’s largest twin registry to study seven autoimmune diseases found the risk of developing the seven diseases is largely inherited, but that some diseases are more closely related than others. These results will be presented Sunday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.

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Drug therapy may effectively treat a potentially life-threatening condition associated with cirrhosis and other chronic liver diseases, according to a new study by Mayo Clinic researchers.

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UT Southwestern researchers used cryo-electron microscopy (cryo-EM) to determine the near-atomic structure of the smallest membrane protein solved to date.

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Researchers at University of Utah Health have developed a new approach that targets the misfunctioning immune cells while leaving normal immune cells in place.

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Autoimmune Disease Awareness Month (ADAM) takes place in March and to mark the annual event, the American Autoimmune Related Diseases Association, Inc. (AARDA) is encouraging national and local media attention through various activities.

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Examining the autoimmune disease at the molecular level led researchers to a specific molecule that could be contributing to the disease progression in patients.

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Legendary guitarist Peter Frampton announced Saturday that he has a rare, debilitating muscle disease called inclusion body myositis.

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A new and novel outcome measure is being used to determine effectiveness of new scleroderma treatments. Learn how Michigan Medicine is leading the way.

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People with two autoimmune diseases, rheumatoid arthritis (RA) and Sjögren’s syndrome, are at an increased risk for developing carpal tunnel syndrome (CTS), and should be screened for CTS and made aware of this risk.

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People who have chronic inflammation in middle-age may develop problems with thinking and memory in the decades leading up to old age, according to a new study published in the February 13, 2019, online issue of Neurology®, the medical journal of the American Academy of Neurology.

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Using sophisticated gene sequencing and computing techniques, researchers at Vanderbilt University Medical Center (VUMC) and the San Diego Supercomputer Center have achieved a first-of-its-kind glimpse into how the body’s immune system gears up to fight off infection.