Research sheds new light on how DNA repair occurs in the cell. Expanded repeats of the CAG/CTG trinucleotide in yeast shift to the periphery of the cell nucleus for repair. This shift is important for preventing repeat instability and genetic disease and is a previously unrecognized step for repetitive DNA to be maintained and to prevent chromosome damage.
Babson College Economics Professor Dr. Kent Jones has authored Reconstructing the World Trade Organization for the 21st Century − An Institutional Approach.
Reliable data are lacking on whether the plasticizing chemicals found in such products as cosmetics, shampoo, flooring and medical tubing, or phthalates, affect human breast cancer risk. A large new study will investigate a possible relationship with a three-year, $1.5 million grant from NIEHS.
Amherst College professor David S. Hall and a team of collaborators have experimentally identified a pointlike monopole in a quantum field for the first time. The discovery gives scientists insight into the monopole magnet, an elementary particle that they believe exists but have not yet seen.
New study shows poor nutrition for honey bee larvae leads to compromised pollination capabilities as adult bees; possible link to Colony Collapse Disorder (CCD)
Research led by Joslin Diabetes Center's Myra Lipes, MD, has identified one culprit in heart failure—an autoimmune reaction triggered by heart attacks. In a recent Current Diabetes Reports paper, Dr. Lipes and her colleague Alfonso Galderisi review progress in understanding the autoimmune mechanism and taking steps toward diagnosing and treating it.
According to the American Cancer Society, in 2015 about 17,000 new cases of esophageal cancer will be diagnosed, and about 15,600 people will die from the disease. While the 5-year survival rate in the 1960s and 1970s was only about 5%, improvements in diagnosis, treatment, and management have led to improved survival. However, information is lacking about what happens to long-term survivors of esophageal cancer. A presentation at the AATS Annual Meeting shows that while five-year survival is up to 39%, these patients still face many health risks and should be monitored for 10 years or more.
Babson College is one of the 353 most environmentally responsible colleges in the world, according to The Princeton Review. The education services company known for its test prep and tutoring services, books, and college rankings has featured Babson in the 2015 edition of its free book, The Princeton Review Guide to 353 Green Colleges.
The National Emphysema Treatment Trial (NETT) was a multicenter, randomized, controlled clinical trial comparing the efficacy of lung volume reduction surgery (LVRS) plus medical management with rehabilitation to medical management plus rehabilitation in patients with severe emphysema. In 2003, the results of NETT demonstrated that LVRS could improve lung function in patients with emphysema, and that the procedure led to improved survival. Yet, adoption of LVRS has been very slow with concerns expressed regarding safety and long-term efficacy. In this presentation, Dr. Ginsburg will present the results of ten years of’ experience with LVRS for emphysema.
The commitment of Cummings School of Veterinary Medicine at Tufts University donors has made the new vision for the 30-year-old Henry and Lois Foster Hospital for Small Animals a reality. Construction to expand and revitalize the building begins this week and the improvements will result in more exam and treatment areas for specialty services and redesigned client service areas.
Hospital readmission rates after major thoracic surgery can run as high as 10-17%. Alarmingly, readmission after pulmonary resection for lung cancer has been associated with worse outcomes, including higher mortality. Thus, reducing readmissions after thoracic surgery can both save lives and reduce healthcare costs. Studies in internal medicine and cardiology have shown that programs that improve the transition from hospital to post-discharge care can be effective in decreasing emergency room visits and re-hospitalization. This study from McMaster University describes for the first time the benefits of an active, post-discharge intervention that begins in the hospital for patients who have undergone thoracic surgery.
For patients in the early stage of non-small cell lung cancer, surgical resection yields optimal outcomes. Prior investigations have shown that different resection procedures have very different outcomes, with pneumonectomy associated with three-fold higher mortality than other resection types. While it is understandable that pathological and physiological factors influence a surgeon’s choice of surgery for a particular patient, the results presented in this study suggest that physician discomfort with the operative complexities of a procedure may lead to selection of a technique associated with less favorable outcomes.
New evidence suggests that lung cancer surgery patients are at higher risk of developing venous thromboembolism, including deep vein thrombosis (DVT) and pulmonary embolism (PE), than previously thought, with elevated risks of complications or death. When thromboemboli occur, they may be asymptomatic or attributed to post-surgical pain or complications, and may reflect both the lung cancer itself as well as compromised lung function after surgery. These incidents may also be ascribed to an inconsistent approach to prevention that currently exists among thoracic surgeons and hematologists who care for these patients. Three presentations at the 95th Annual Meeting of the American Association for Thoracic Surgery explore the problem of venous thromboembolism (VTE) after surgery for lung cancer.
When educating medical students or residents to perform highly technical procedures, there is always a challenge to balance the educational mission with maintaining quality results and optimal patient care. This report compared outcomes of cardiac surgery residents to those of attending physicians in performing coronary artery bypass grafting. It found no differences in patient outcomes or graft patency between the residents and attending surgeons.
Over the last 15 years, survival of children with congenital heart disease (CHD) has greatly improved, so that currently there are more adults than children living with CHD. Consequently, people with CHD of all ages are undergoing pulmonary valve replacement (PVR) with bioprosthetic valves. In this retrospective review of all patients with CHD who underwent bioprosthetic PVR over an 18-year period at Boston Children’s Hospital, investigators found that young age and small body weight predisposed patients toward re-intervention, as did the type of valve used.
As a fast-moving virus forces U.S. poultry producers to kill millions of chickens and turkeys, Dr. Richard French of Becker College explains why this strain of avian influenza is different from others—and says food producers should brace for an even greater impact and loss.
Morningside College Professor Geoff Harkness looks at diverse communities in the U.S. and abroad. His work has taken him to the streets, clubs and recording studios of Chicago to learn about the connections between rap music and gang culture.
The drive to tame gnawing hunger can sabotage even the best-intentioned dieter. Now, investigators have identified the brain circuit that underlies this powerful physiological state, providing a promising new target for the development of weight-loss drugs.
Meeting at a glance
BOSTON – Air pollution, even at moderate levels, has long been recognized as a factor in raising the risk of stroke. A new study led by scientists from Beth Israel Deaconess Medical Center and Boston University School of Medicine suggests that long-term exposure can cause damage to brain structures and impair cognitive function in middle-aged and older adults.
The Tufts University Police Department has added an electric motorcycle to its fleet of vehicles, demonstrating that being green and business-savvy go hand-in-hand.
More than 100 drugs have been approved to treat cancer, but predicting which ones will help a particular patient is an inexact science at best. A new implantable device developed at MIT may change that.
Babson College Professor of History and Foodways Frederick Douglass Opie has authored the new book, Zora Neale Hurston on Florida Food: Recipes, Remedies & Simple Pleasures.
A novel approach that allows real-time imaging of the immune system’s response to the presence of tumors—without the need for blood draws or invasive biopsies—offers a potential breakthrough both in diagnostics and in the ability to monitor efficacy of cancer therapies.
The Centers for Medicare & Medicaid Services has given the nod to an 18,500-patient study to see whether amyloid scans prove their worth in the clinic. Researchers hope the study will eventually convince CMS and private insurance companies to cover the technology.
A remedy for Boston's parking woes and a therapy for a treatment-resistant cancer were among the winners of the 11th New Ventures business competition organized by the Entrepreneurial Leadership Program of Tufts Gordon Institute. Finalists vied for $100,000 in cash and in-kind awards in general/high tech ventures, life sciences and social impact.
As researchers are discovering that placebo responses are modified by a person's genetics, investigators from Beth Israel Deaconess Medical Center are raising questions as to how "the placebome" will impact both patient care and drug development.
Cancerous tumors have the ability to evade targeted therapies by activating alternative pathways. Tumors also contain cancer stem cells, believed responsible for metastasis and drug resistance. Now scientists in the Cancer Research Institute at Beth Israel Deaconess Medical Center have identified a drug target that addresses both of these challenges.
Renowned novelist Chimamanda Ngozi Adichie will address the members of the Wellesley College Class of 2015, and an international audience of their family and friends, at Wellesley’s 137th Commencement Exercises on Friday, May 29, at 10:30 a.m.
Small changes to the types of protein- and carbohydrate-rich foods that we eat may have a large impact on preventing long-term weight gain. The study also suggests that changes in refined carbohydrates can enhance – or offset – the weight-gain or weight-loss effects of certain protein-rich foods.
A study led by MIT researchers found that a subset of glioblastoma tumor cells is dependent on a particular enzyme that breaks down the amino acid glycine. Without this enzyme, toxic metabolic byproducts build up inside the tumor cells, and they die. Blocking this enzyme could offer a new way to combat such tumors.
A new study from the Liver Center at Beth Israel Deaconess Medical Center (BIDMC) suggests that standard assessments that nurses already use to care for patients can be mined for data that significantly improve the ability to predict survival following liver transplantation and may help improve patient outcomes.
A two-year epidemiological study found that people on insulin living next to roads with heavy traffic had markedly increased concentration of C-reactive protein, a marker of inflammation, compared to those living in lower traffic areas. Individuals taking oral diabetes medications did not experience increases in CRP concentration.
The Babson College B.E.T.A. (Babson Entrepreneurial Thought and Action®) Challenge kicks off on April 8th, 2015, recognizing major milestones that Babson businesses have achieved by taking action.
The search to discover and validate the first-ever clinical biomarker to diagnose and treat pancreatic cancer is at the foundation of a new, cross-sector collaboration. Berg, a biopharmaceutical company committed to uncovering health solutions through a data-driven, biological research approach; the Cancer Center at Beth Israel Deaconess Medical Center (BIDMC), a Harvard Medical School teaching hospital, and the Pancreatic Cancer Research Team (PCRT) managed by Cancer Research And Biostatistics (CRAB) announced today they will work together to eradicate the disease.
The Lewis Institute at Babson College will award five global social entrepreneurs with the 2015 Social Innovator Awards at an honorary on-campus event on April 8, 2015. The two teams from Partners in Health and Channels of Hope are being acknowledged and celebrated for their tireless efforts in creating extraordinary social ripples that change lives, transform communities, and, in many cases, impact an entire country.
Steven Keating's curiosity led to the detection of a baseball-sized brain tumor and sparked an interest into the potential of open health data to help himself and others.
Babson College students have launched 33 new businesses as part of the Foundations of Management and Entrepreneurship (FME) course, a 7-credit immersion into the world of business. All first-year Babson students are given the assignment to develop and run a business during the spring semester.
Candida albicans causes potentially lethal infections in immunocompromised individuals. Now, using a modified CRISPR-Cas system, Whitehead researchers can edit the fungus’s genome systematically—an approach that could help identify potential drug targets.
A team of Whitehead Institute scientists has discovered that during division, stem cells distinguish between old and young mitochondria and allocate them disproportionately between daughter cells.
Because pseudogenes have lost the ability to code for proteins they have have long been considered nothing more than "genomic junk." Now, a team from the Cancer Research Institute at Beth Israel Deaconess Medical Center has discovered that one of these evolutionary relics caused an aggressive cancer, suggesting this "junk" may play a key role in disease.
Babson College and Boston Mayor Marty Walsh have announced exciting new plans for Lemonade Day Boston 2015, now in its 5th consecutive year supporting children in the Greater Boston area. The growing initiative, championed by Babson to help empower youth through entrepreneurship, college-readiness, financial literacy, and life-skills programming, will see upwards of 4,000 local participants during a mix of new and traditional Lemonade Day Boston activities.
What if a better and more accurate approach to financial modeling existed, one that could anticipate, understand and minimize risk? Through his research, Professor Kevin Jacques says he has developed a new model to predict market fluctuations with great accuracy.
Babson’s Energy and Environmental Club (BEEC) will convene a host of leading environmental enthusiasts for its 9th annual Energy and Environmental Conference on April 9, 2015.
A new study out of Wellesley College sheds light on the role of beliefs about the value of diversity in fostering attitudinally diverse friendships. Led by professor and social psychologist Angela Bahns, the study demonstrates that people who place a higher value on diversity are more likely to have friends of different races, religions, and/or classes, as well as friends with different sociopolitical views.
Babson College’s F.W. Olin Graduate School of Business and the Babson Latin American Club have announced the list of confirmed speakers for the 7th annual Babson Latin American Entrepreneurship Forum on April 10, 2015.
Babson’s MBA and MS programs have been ranked among the top 4,000 in 30 fields of study, across 154 countries, by Eduniversal.
Wellesley College has announced participation in the “Let Everyone Dream” Coalition, a national initiative announced Monday during the White House Science Fair that introduces new multi-sector partnerships in support of STEM education for underserved students.
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