Whereas ATM signaling is well known to be activated by DNA doubles-strand breaks, this study provides new evidence that ATM signaling is directly activated by DNA single-strand breaks and activated and regulated by APE1 in eukaryotic systems.
A new study reviews how cancer-associated fibroblasts (CAFs) influence lymph node metastasis. Researchers identified various CAF subsets that interact with the tumor microenvironment, promoting cancer spread. By targeting these specific subsets, new therapeutic strategies can be developed to inhibit metastasis, potentially improving patient outcomes. This breakthrough offers a deeper understanding of CAF heterogeneity and its role in cancer progression, paving the way for more effective cancer treatments.
Progenitor exhausted CD8+ T (Tpex) cells have emerged as a pivotal component in tumor immunotherapy due to their unique ability to self-renew and rapidly proliferate. These cells have shown promise in expanding and differentiating into functional exhausted CD8+ T cells, significantly enhancing clinical outcomes. Understanding and leveraging Tpex cells can revolutionize immunotherapeutic strategies against cancer.
Scientists developed a new method to improve resolution and reduce noise in fluorescence microscopy images. This technique utilizes mathematical tools to analyze and enhance image details, specifically addressing the fidelity of computational resolution extension. It outperforms existing methods by boosting signal-to-noise ratio and achieving higher resolution without introducing artifacts. This paves the way for more precise and informative imaging in various microscopy applications.
Targeting a protein called ZFP574 suppressed leukemia in a mouse model of the disease, UT Southwestern Medical Center researchers showed in a new study. Their findings, published in PNAS (Proceedings of the National Academy of Sciences), could lead to new treatments for leukemias and lymphomas in cancer patients.
Using powerful new visualization technologies, researchers have captured the first 3-D images of the structure of a key muscle receptor, providing new insights on how muscles develop across the animal kingdom and setting the stage for possible future treatments for muscular disorders.
The University of Texas MD Anderson Cancer Center and collaborators are initiating a research project that will send T cells to the International Space Station (ISS) to study the effects of prolonged microgravity on cell differentiation, activation, memory and exhaustion.
They’re colorful. They’re fluorescent. And they wouldn’t look out of place hanging in a modern art museum.They are the photos captured by the Cellular Imaging Core, one of 10 research cores at The Saban Research Institute of Children’s Hospital Los Angeles.
As an HHMI Investigator, David Pagliarini, PhD, the Hugo F. & Ina C. Urbauer Professor and a BJC Investigator in the Department of Cell Biology & Physiology will receive approximately $11 million in HHMI funding over a seven-year term.
Scientists use a multimodal approach that combines hard X-ray computed tomography and X-ray fluorescence imaging to see the structure and chemical processes inside of a single cell.
Cell biologist embraces new tools to study human development on the smallest scale
Relapsed B-cell ALL is the leading cause of cancer-related deaths in children and young adults. UniSA research has shown the potential of new microfluidic technology, to improve the CAR T-cell manufacturing process by efficiently removing contaminating cancerous cells and other large white blood cells - potentially leading to greater access and lower costs of treatment.
Cancer cells salvage purine nucleotides to fuel tumor growth, including purines in foods we eat, an important discovery with implications for cancer therapies from research by Children’s Medical Center Research Institute at UT Southwestern published in Cell.
he EveryLife Foundation for Rare Diseases commends the Food and Drug Administration (FDA) on today's announcement of its intention to create a Rare Disease Innovation Hub. Co-chaired by CDER Director, Dr. Peter Marks, and CBER Director, Dr. Patrizia Cavazzoni, the Hub will directly engage patients and the public to inform its strategic agenda.
A protein receptor called PAQR4 found within fat cells appears to act as a sensor for ceramides, waxy lipids whose overabundance has been linked to a variety of metabolic disorders and cancers, a study led by UT Southwestern Medical Center researchers suggests. Their findings, published in Nature Metabolism, could eventually lead to drugs that reduce cellular ceramide levels, much like statins reduce cholesterol levels.
Researchers at the UNC School of Medicine have connected the dots between a small protein, the brain’s lymphatic system, and migraine pain.
Discover research from UC San Diego showing how stem cell-derived therapy, targeting treatment-resistant liver cancer through genetically modified NK cells, offers promising new avenues for immunotherapy.
NanoCellect Biomedical, a leader in microfluidic cell sorting technology, proudly announces the launch of VERLO™ Image-Guided Cell Sorter, a groundbreaking cell sorter poised to redefine the landscape of single-cell visualization and gentle flow cytometry analysis and cell sorting.
In a recent study, researchers at Johns Hopkins Medicine suggest the cell’s messenger RNA (mRNA) — the major translator and regulator of genetic material — along with a critical protein called ZAK, spur the cell’s initial response to UV radiation damage and play a critical role in whether the cell lives or dies.
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