In a recent study, scientists led by Professor Stefan Müller from Goethe University’s Institute of Biochemistry II investigated a specific form of blood cancer known as acute myeloid leukemia, or AML. The disease mainly occurs in adulthood and often ends up being fatal for older patients.
Many of the most potent human oncoproteins belong to a class of proteins called transcription factors, but designing small molecule drugs that target transcription factors is a major challenge.
Gene expression is often regulated by chemical modifications, a process known as epigenetics for DNA and epitranscriptomics for RNA. Among these, N6-methyladenosine (m6A) is a significant internal modification of mRNA that plays crucial roles in gene expression and various biological and pathological processes, including cancer development.
A comprehensive analysis of the soybean genome can help develop improved varieties of soybean by identifying crucial genes linked to desirable traits.
A roundup of the latest medical discoveries and faculty news at Cedars-Sinai.
A massive genetic study involving almost 800,000 participants has uncovered genetic factors that contribute to the use of sleep medications, shedding new light on the intricate relationship between sleep problems and psychiatric conditions.
Venoms have developed in many animal groups independently of each other. One group that has many venomous species is Hymenoptera, an insect order that also includes aculeates (stinging insects) such as bees, wasps and ants. Hymenoptera is very species-rich, with over 6,000 species of bees alone.
The largest review of papers for brain cancer that has spread from the lungs has found abnormalities in the brain cancer and for which licensed drugs could be clinically trialled to find out if they could treat the disease.
The method identified promising targets for precision oncology in two types of cancer
Far too many antibiotics are used around the world. As a result, bacteria are becoming resistant. Curing bacterial diseases is becoming more difficult than before, because antibiotics are perhaps our foremost weapons in the fight against them.
Research on fruit flies has implications for this poorly understood process in humans
In a new Cell study, scientists at La Jolla Institute for Immunology (LJI) and Massachusetts General Hospital, Harvard Medical School, show how a protein called IKAROS helps "weave" the genome.
Cedars-Sinai investigators found no established link between the use of assisted reproductive technologies and potential problems in DNA methylation that might impact genetic expression or embryonic development.
A gene previously linked to autism spectrum disorder (ASD) by UT Southwestern Medical Center researchers appears to play an important role in steering cells in the brain’s hippocampus toward their ultimate identities, the same team reported in a new study.
The Wnt signaling pathway, a system present in living organisms, plays a pivotal role in cell growth, differentiation, and migration. It has a long history dating back to 1982 when the first Wnt gene, which is essential for cellular growth, was discovered.
Stay informed! Keep up with the latest research on the COVID-19 virus in the Coronavirus channel on Newswise.
Bladder cancer, notorious for being one of the most costly malignancies to manage, often results in patient discomfort and frequent, invasive, and expensive procedures.
A Yale-led analysis of the genomes of more than 1 million people has shed light on the underlying biology of cannabis use disorder and its links to psychiatric disorders, abuse of other substances such as tobacco, and possibly even an elevated risk of developing lung cancer.
Scientists at St. Jude Children’s Research Hospital mapped the difference in chromatin accessibility and regulation in different pediatric acute lymphoblastic leukemia subtypes.
Feeding dogs raw (uncooked) meat increases their risk of excreting E. coli that cannot be killed by a widely used antibiotic - ciprofloxacin - researchers at the University of Bristol have found from a study of 600 healthy pet dogs.
Researchers at the University of Pittsburgh and KU Leuven have discovered a suite of genes that influence head shape in humans.
For over 20 years, a research team at Lund University in Sweden has studied the common bluetail damselfly. Females occur in three different colour forms – one with a male-like appearance, something that protects them from mating harassment. In a new study, an international research team found that this genetic colour variation that is shared between several species arose through changes in a specific genomic region at least five million years ago.
Every cell in the human body contains the same genetic instructions, encoded in its DNA. However, out of about 30,000 genes, each cell expresses only those genes that it needs to become a nerve cell, immune cell, or any of the other hundreds of cell types in the body.
In a new study, researchers at the Georgia Institute of Technology investigated whether 25 rare gene variants known to be associated with inflammatory bowel disease (IBD) play a role in risk for African Americans.
US and IRB Barcelona researchers have shown for the first time that these hybrids are clearly a source of cancer-associated mutations
A new study involving University of Portsmouth researchers has uncovered key molecular defects underlying a rare developmental brain condition in children.
Patients with advanced prostate cancer with tumors harboring RB1 gene loss or neuroendocrine features often have a poor prognosis and limited treatment options.
The world’s total population is expected to reach 9.9 billion by 2050. This rapid increase in population is boosting the demand for agriculture to cater for the increased demand. Below are some of the latest research and features on agriculture and farming in the Agriculture channel on Newswise.
With today’s fast and automated analysis tools, the field of biology is bursting at the seams with datasets about gene sequences and expression in the microbiomes around us – and inside us.
St. Jude scientists mapped the gene regulatory networks responsible for progressive differentiation states of tumor-infiltrating T cells, using a technology known as single-cell CRISPR screening to knock out or genetically perturb multiple genes potentially involved.
To help mitigate the world’s biodiversity crisis, Arizona State University’s Julie Ann Wrigley Global Futures Laboratory has recruited Harris Lewin, a prominent genome scientist currently spearheading one of biology’s most ambitious ‘moonshot’ goals, a complete DNA catalog of the genetic code for life on Earth by the end of this decade.
The Department of Immunology and Immunotherapy and the Icahn Genomics Institute (IGI) at the Icahn School of Medicine at Mount Sinai have been awarded a $5 million grant from the National Cancer Institute (NCI) of the National Institutes of Health to establish a state-of-the-art center dedicated to the discovery and development of cutting-edge targets for cancer therapy.
A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 20, entitled, “Alcohol consumption and epigenetic age acceleration across human adulthood.”
Genomic surveillance of AMR pathogens has the potential to revolutionize AMR control, but barriers such as lack of resources and training need to be overcome.
A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA—loops of DNA found outside of regular chromosomes—are twice as likely to relapse and three times as likely to die within five years of diagnosis.
A novel assay that detects a unique molecular marker in patients with acute myeloid leukemia (AML) may revolutionize the way this disease is detected and treated according to a new report in The Journal of Molecular Diagnostics published by Elsevier.
Researchers at Gladstone Institutes have discovered that a rare genetic variant known as the “Christchurch mutation” can block detrimental effects of apolipoprotein E4, the best-established risk factor for the most common form of Alzheimer’s disease.
Researchers at the Mount Sinai Center for Transformative Disease Modeling have released a groundbreaking study identifying 4,749 key gene clusters, termed “prognostic modules,” that significantly influence the progression of 32 different types of cancer. The study, published in Genome Research, serves as a comprehensive resource and lays the foundation for the development of next-generation cancer treatments and diagnostic markers.
A new conservation tool from the University of Illinois Urbana-Champaign is helping protect lions across Africa, where populations have plummeted in recent decades due to poaching and other factors.
UCI researchers identified a gene critical for muscle repair, paving the way for lab-grown muscle to treat muscle disorders and injuries.
A multicenter study led by researchers at Sylvester Comprehensive Cancer Center shows how interactions between tumor cells and immune components of the microenvironment can impact treatment responses and outcomes in patients newly diagnosed with multiple myeloma who undergo combination treatments that include targeted immunotherapy.
Researchers at Lund University, together with colleagues at the NIST Synchrotron Facility in the USA, have mapped on an atomic level what happens in a virus particle when the temperature is raised.
Scientists synthesize a yeast chromosome as part of a global project to create the world's first synthetic eukaryotic genome.
Waterhemp, the aggressive weed threatening Corn Belt crop production, is throwing curveballs once again, according to researchers at the University of Illinois Urbana-Champaign. The weed has famously developed resistance to not one or two, but seven herbicide sites-of-action classes, nearly exhausting the chemical tools farmers can use to defend their livelihood.
Children’s Hospital Los Angeles has launched a new clinical trial to investigate a potential treatment for Dup15q syndrome, a rare genetic condition that causes developmental delays, autism spectrum disorder and epilepsy.
SMU nanotechnology expert MinJun Kim and his team have been awarded a $1.8 million, R01 grant from the National Institutes of Health (NIH) for research related to gene therapy.
Whole genome sequencing of North American song sparrows has revealed the genetic underpinnings for a stunning range of body sizes found throughout the bird’s westernmost range—an adaptation that may make the birds more resilient to climate change. This work is the first output from a larger research effort to sequence song sparrow genomes from across North America, spanning nearly all of the 25 recognized subspecies.
The November issue of AJG highlights new clinical science and reviews including additional colonoscopy quality measures, higher infliximab concentrations in IBD patients with higher visceral adipose tissue (VAT), an automated tissue systems pathology test for Barrett’s esophagus, and opioid-related constipation.
Simon Fraser University researchers studying the evolutionary history of flu viruses have found that a new quantitative analysis of how they evolved may help predict future strains.
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