Feature Channels: Diabetes

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Insulin triggers genome-wide changes in gene expression via an unexpected mechanism. The insulin receptor is transported from the cell surface to the cell nucleus, where it helps initiate the expression of thousands of genes. Targeted genes are involved in insulin-related functions and disease but surprisingly not carbohydrate metabolism. Findings outline a set of potential therapeutic targets for insulin-related diseases and establish a wide range of future avenues for the study of insulin signaling.

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Researchers from Queen’s University have discovered a new way of treating major diseases of the eye caused by the abnormal growth of new blood vessels.

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Michael Snyder, PhD, of Stanford University is the recipient of the 2019 Genetics Society of America (GSA) George W. Beadle Award for developing and disseminating widely-used technology for the simultaneous analysis of thousands of genes, RNA molecules, and proteins. The Beadle Award recognizes significant, sustained service to the genetics community that goes beyond an exemplary individual research career.

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Endocrine Society member and diabetes expert Alvin C. Powers, MD, will testify before the House Energy & Commerce Subcommittee on Oversight and Investigations Tuesday about the rising cost of insulin and the challenges this poses for individuals with diabetes who depend on the life-saving drug.

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Los investigadores y los colaboradores de Mayo Clinic demostraron que cuando se eliminan las células senescentes, también conocidas como “células zombi”, del tejido graso en ratones con obesidad, la gravedad de la diabetes y un rango de sus causas o consecuencias disminuyen o desaparecen.

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It’s gory, sticky and undoubtedly on the nose, but a blend of icing sugar, chicken stock and flexible resin is proving to be the just the right recipe for creating realistic foot ulcers as part of a world-first podiatric training initiative at the University of South Australia.

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To function properly, proteins must morph into specific 3D shapes through a biophysical phenomenon called protein folding. Researchers at ORNL are using various deep-learning techniques to study the intermediate protein stages between the initial unfolded state and the final folded state, which are notoriously difficult to characterize. These methods could also help identify factors that cause proteins to “misfold” into dysfunctional shapes, a phenomenon often attributed as a leading factor in the development of diseases including Alzheimer’s, cardiovascular disorders, and diabetes.

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Mayo Clinic researchers and their collaborators have shown that when senescent cells — also known as “zombie cells” — are removed from fat tissue in obese mice, severity of diabetes and a range of its causes or consequences decline or disappear.

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A new automated drug delivery system can help prevent dangerously low blood sugar in patients who have undergone weight-loss surgery, according to a study to be presented Monday, March 25 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.

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Scientists have discovered a novel molecular pathway for an enzyme inhibitor in humans that plays a direct role in the development of high cholesterol and nonalcoholic fatty liver disease, which they then were able to reverse in mice with an investigational drug. The study results will be presented Monday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La., by researchers from Northwestern University Feinberg School of Medicine in Chicago, Ill.

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Changing when you eat rather than what you eat may prove to be a dietary intervention against breast cancer, suggests a new mouse study to be presented Saturday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.

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Walking downhill after eating can reduce bone resorption, the process in which old bone is broken down and removed from the body, in postmenopausal women with diabetes, according to research to be presented Sunday, March 24 at ENDO 2019, the annual meeting of the Endocrine Society, in New Orleans, La. Walking uphill does not have the same benefit, the study found.

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Teens who sit for hours watching TV, using the computer or playing video games while eating unhealthy snacks are at increased risk for a group of risk factors for heart disease and diabetes, according to research to be presented Monday, March 25 at ENDO 2019, the annual meeting of the Endocrine Society, in New Orleans, La.

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Caucasians and Hispanics with diabetes have a greater risk of fracture compared to those without diabetes, while African Americans with diabetes have little to no additional fracture risk, according to a study to be presented Saturday, March 23 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.

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Obesity may play a role in reproductive problems in women with type 1 diabetes, according to a new study to be presented Saturday, March 23 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.

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Symptoms of polycystic ovary syndrome (PCOS) improved with exposure to healthy bacteria in the gut, according to a study in a mouse model of this common women’s endocrine disorder. The study results will be presented Monday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.

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Using the hemoglobin A1c blood test to diagnose diabetes tends to underestimate the prevalence of the disease, according to a new study to be presented Saturday, March 23 at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.

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Among first-time users of a new insulin pump that automatically delivers insulin to people with type 1 diabetes, nearly one-fifth stopped using the device, primarily because of difficulties meeting the technical demands system, researchers say. Results of a real-world study of the hybrid closed loop insulin pump (Medtronic MiniMed 670G) will be presented Sunday at the Endocrine Society’s annual meeting in New Orleans, La.

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Older adults with type 1 diabetes typically have low blood sugar, or hypoglycemia, for more than an hour a day, suggests research to be presented Monday, March 25 at ENDO 2019, the annual meeting of the Endocrine Society, in New Orleans, La.

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Simplifying medication regimens and tailoring glycemic targets in older adults with diabetes improves adherence and avoids treatment-related complications, according to a Clinical Practice Guideline issued today by the Endocrine Society. The Society debuted the guideline during a press conference on the opening day of ENDO 2019, its annual meeting in New Orleans, La.