Specification of fetal liver endothelial progenitors to functional zonated adult sinusoids requires c-Maf induction

Blood vessels adapt to the requirements of each organ. In the liver, this adaptation is a progressive specialized transition from fetal to postnatal development, which is facilitated by the transcription factor c-Maf. In vitro c-Maf induces a liver-like vascular phenotype, allowing long-term hepatocyte survival and functionality.